{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:12:36Z","timestamp":1788516756044,"version":"build-2803163510"},"reference-count":78,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e0 degli Studi di Roma La Sapienza"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The 2022 European Association for Haematopathology\/Society for Hematopathology lymphoma workshop session on cavity-based lymphomas included sixty-eight cases in seven sections. The disease entities discussed include primary effusion lymphomas (PEL), extracavitary primary effusion lymphomas and confounding entities (ECPEL), HHV8-negative B-lineage lymphomas-effusion based (EBV-negative, EBV-positive, and plasmablastic types), diffuse large B-cell lymphoma associated with chronic inflammation, fibrin-associated diffuse large B-cell lymphoma (FA-DLBCL), breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), and other lymphomas presenting as an effusion. All entities above are discussed; however, three are delved into greater detail given the challenges with classification: ECPEL, HHV8-negative effusion-based lymphomas, and FA-DLBCL. Cases exemplifying the diagnostic difficulty in differentiating ECPEL from HHV8-positive diffuse large B-cell lymphoma and germinotropic lymphoproliferative disorder were discussed. The more recently recognized effusion-based HHV8-negative large B-cell lymphoma is explored, with several cases submitted raising the question if this subset should be carved out as a specific entity, and if so, what should be the refining diagnostic criteria. Case submissions to the FA-DLBCL section yielded one of the largest case series to date, including classic cases, cases furthering the discussion on disease sites and prognosis, as well as novel concepts to be considered in this entity. The 2022 EA4HP\/SH workshop cases allowed for further confirmation of the characteristics of some of the more historically accepted cavity-based lymphomas, as well as further inquiry and debate on relatively new or evolving entities.<\/jats:p>","DOI":"10.1007\/s00428-023-03599-2","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T03:01:46Z","timestamp":1691550106000},"page":"299-316","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Cavity-based lymphomas: challenges and novel concepts. A report of the 2022 EA4HP\/SH lymphoma workshop"],"prefix":"10.1007","volume":"483","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3159-5380","authenticated-orcid":false,"given":"Arianna","family":"Di Napoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Soma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7156-5365","authenticated-orcid":false,"given":"Leticia","family":"Quintanilla-Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"de Leval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Leoncini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6203-7966","authenticated-orcid":false,"given":"Alberto","family":"Zam\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6051-6410","authenticated-orcid":false,"given":"Siok-Bian","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9431-2889","authenticated-orcid":false,"given":"Sarah L.","family":"Ondrejka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4360-8388","authenticated-orcid":false,"given":"Fina","family":"Climent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Wotherspoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Dirnhofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"3599_CR1","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues (Revised 4th Edition)","author":"H Steven","year":"2017","unstructured":"Steven H, Swerdlow EC, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, Siebert R (2017) WHO classification of tumours of haematopoietic and lymphoid tissues (Revised 4th Edition). IARC, Lyon"},{"issue":"2","key":"3599_CR2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/ajcp\/aqw218","volume":"147","author":"A Chadburn","year":"2017","unstructured":"Chadburn A, Said J, Gratzinger D et al (2017) HHV8\/KSHV-positive lymphoproliferative disorders and the spectrum of plasmablastic and plasma cell neoplasms: 2015 SH\/EAHP workshop report-part 3. Am J Clin Pathol 147(2):171\u2013187","journal-title":"Am J Clin Pathol"},{"issue":"5","key":"3599_CR3","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00428-019-02698-3","volume":"476","author":"RL King","year":"2020","unstructured":"King RL, Goodlad JR, Calaminici M et al (2020) Lymphomas arising in immune-privileged sites: insights into biology, diagnosis, and pathogenesis. Virchows Arch 476(5):647\u2013665","journal-title":"Virchows Arch"},{"issue":"7","key":"3599_CR4","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","volume":"36","author":"R Alaggio","year":"2022","unstructured":"Alaggio R, Amador C, Anagnostopoulos I et al (2022) The 5th edition of the World Health Organization classification of haematolymphoid tumours: lymphoid neoplasms. Leukemia 36(7):1720\u20131748","journal-title":"Leukemia"},{"issue":"11","key":"3599_CR5","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1182\/blood.2022015851","volume":"140","author":"E Campo","year":"2022","unstructured":"Campo E, Jaffe ES, Cook JR et al (2022) The international consensus classification of mature lymphoid neoplasms: a report from the clinical advisory committee. Blood 140(11):1229\u20131253","journal-title":"Blood"},{"issue":"5","key":"3599_CR6","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1084\/jem.183.5.2385","volume":"183","author":"EA Mesri","year":"1996","unstructured":"Mesri EA, Cesarman E, Arvanitakis L et al (1996) Human herpesvirus-8\/Kaposi\u2019s sarcoma-associated herpesvirus is a new transmissible virus that infects B cells. J Exp Med 183(5):2385\u20132390","journal-title":"J Exp Med"},{"issue":"7","key":"3599_CR7","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1182\/blood.2020005470","volume":"139","author":"E Cesarman","year":"2022","unstructured":"Cesarman E, Chadburn A, Rubinstein PG (2022) KSHV\/HHV8-mediated hematologic diseases. Blood 139(7):1013\u20131025","journal-title":"Blood"},{"issue":"1","key":"3599_CR8","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1186\/s12885-021-08215-7","volume":"21","author":"M Zanelli","year":"2021","unstructured":"Zanelli M, Sanguedolce F, Zizzo M et al (2021) Primary effusion lymphoma occurring in the setting of transplanted patients: a systematic review of a rare, life-threatening post-transplantation occurrence. BMC Cancer 21(1):468","journal-title":"BMC Cancer"},{"issue":"3","key":"3599_CR9","doi-asserted-by":"crossref","first-page":"713","DOI":"10.3390\/diagnostics12030713","volume":"12","author":"CY Liu","year":"2022","unstructured":"Liu CY, Chen BJ, Chuang SS (2022) Primary effusion lymphoma: a timely review on the association with HIV, HHV8, and EBV. Diagnostics 12(3):713","journal-title":"Diagnostics"},{"issue":"4","key":"3599_CR10","doi-asserted-by":"crossref","first-page":"878","DOI":"10.3390\/cancers13040878","volume":"13","author":"Z Hu","year":"2021","unstructured":"Hu Z, Pan Z, Chen W et al (2021) Primary effusion lymphoma: a clinicopathological study of 70 cases. Cancers 13(4):878","journal-title":"Cancers"},{"issue":"10","key":"3599_CR11","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1182\/blood-2002-10-3090","volume":"101","author":"U Klein","year":"2003","unstructured":"Klein U, Gloghini A, Gaidano G et al (2003) Gene expression profile analysis of AIDS-related primary effusion lymphoma (PEL) suggests a plasmablastic derivation and identifies PEL-specific transcripts. Blood. 101(10):4115\u20134121","journal-title":"Blood."},{"issue":"18","key":"3599_CR12","doi-asserted-by":"crossref","first-page":"10399","DOI":"10.1073\/pnas.1630810100","volume":"100","author":"RG Jenner","year":"2003","unstructured":"Jenner RG, Maillard K, Cattini N et al (2003) Kaposi\u2019s sarcoma-associated herpesvirus-infected primary effusion lymphoma has a plasma cell gene expression profile. Proc Natl Acad Sci USA 100(18):10399\u201310404","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"3599_CR13","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1128\/JVI.79.2.1244-1251.2005","volume":"79","author":"W Fan","year":"2005","unstructured":"Fan W, Bubman D, Chadburn A, Harrington WJ Jr, Cesarman E, Knowles DM (2005) Distinct subsets of primary effusion lymphoma can be identified based on their cellular gene expression profile and viral association. J Virol 79(2):1244\u20131251","journal-title":"J Virol"},{"issue":"9","key":"3599_CR14","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/cup.12368","volume":"41","author":"U Pielasinski","year":"2014","unstructured":"Pielasinski U, Santonja C, Rodriguez-Pinilla SM, Requena L (2014) Extracavitary primary effusion lymphoma presenting as a cutaneous tumor: a case report and literature review. J Cutan Pathol 41(9):745\u2013753","journal-title":"J Cutan Pathol"},{"issue":"6","key":"3599_CR15","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1097\/DAD.0000000000001539","volume":"42","author":"A Saggini","year":"2020","unstructured":"Saggini A, Di Prete M, Facchetti S, Rapisarda VM, Anemona L (2020) Panniculitis-like presentation of extracavitary primary effusion lymphoma. Am J Dermatopathol 42(6):446\u2013451","journal-title":"Am J Dermatopathol"},{"key":"3599_CR16","doi-asserted-by":"crossref","first-page":"300657","DOI":"10.1016\/j.hpr.2022.300657","volume":"29","author":"S Twagirimana","year":"2022","unstructured":"Twagirimana S, Doucet S, Meunier C, Maietta A (2022) Expanding the spectrum of Epstein-Barr virus and human herpesvirus-8 co-infection associated large B-cell lymphomas with plasmablastic differentiation in HIV-positive patients: report of two unusual cases and review of the literature. Hum Patho Rep 29:300657","journal-title":"Hum Patho Rep"},{"issue":"5","key":"3599_CR17","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/his.13428","volume":"72","author":"W Wang","year":"2018","unstructured":"Wang W, Kanagal-Shamanna R, Medeiros LJ (2018) Lymphoproliferative disorders with concurrent HHV8 and EBV infection: beyond primary effusion lymphoma and germinotropic lymphoproliferative disorder. Histopathology 72(5):855\u2013861","journal-title":"Histopathology"},{"issue":"5","key":"3599_CR18","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/modpathol.2016.233","volume":"30","author":"B Gonzalez-Farre","year":"2017","unstructured":"Gonzalez-Farre B, Martinez D, Lopez-Guerra M et al (2017) HHV8-related lymphoid proliferations: a broad spectrum of lesions from reactive lymphoid hyperplasia to overt lymphoma. Mod Pathol 30(5):745\u2013760","journal-title":"Mod Pathol"},{"issue":"10","key":"3599_CR19","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1007\/s00277-020-04024-3","volume":"99","author":"M Zanelli","year":"2020","unstructured":"Zanelli M, Zizzo M, Bisagni A et al (2020) Germinotropic lymphoproliferative disorder: a systematic review. Ann Hematol 99(10):2243\u20132253","journal-title":"Ann Hematol"},{"issue":"6","key":"3599_CR20","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1097\/PAS.0000000000000823","volume":"41","author":"T Bhavsar","year":"2017","unstructured":"Bhavsar T, Lee JC, Perner Y et al (2017) KSHV-associated and EBV-associated germinotropic lymphoproliferative disorder: new findings and review of the literature. Am J Surg Pathol 41(6):795\u2013800","journal-title":"Am J Surg Pathol"},{"issue":"7","key":"3599_CR21","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1177\/1066896920921238","volume":"28","author":"C Martinez-Ciarpaglini","year":"2020","unstructured":"Martinez-Ciarpaglini C, Valkov A, Hurtado M, Agusti J, Malave G, Ferrandez A (2020) Intrasinusoidal HHV8-EBV-positive large B-cell lymphoma with features of germinotropic lymphoproliferative disorder. Int J Surg Pathol 28(7):804\u2013811","journal-title":"Int J Surg Pathol"},{"issue":"9","key":"3599_CR22","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1182\/blood-2002-02-0487","volume":"100","author":"MQ Du","year":"2002","unstructured":"Du MQ, Diss TC, Liu H et al (2002) KSHV- and EBV-associated germinotropic lymphoproliferative disorder. Blood 100(9):3415\u20133418","journal-title":"Blood"},{"issue":"6","key":"3599_CR23","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1111\/his.14551","volume":"79","author":"M Granai","year":"2021","unstructured":"Granai M, Facchetti M, Mancini V et al (2021) Epstein-Barr virus reactivation influences clonal evolution in human herpesvirus-8-related lymphoproliferative disorders. Histopathology 79(6):1099\u20131107","journal-title":"Histopathology"},{"issue":"6","key":"3599_CR24","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1309\/AJCPULI3W6WUGGPY","volume":"142","author":"EL Courville","year":"2014","unstructured":"Courville EL, Sohani AR, Hasserjian RP, Zukerberg LR, Harris NL, Ferry JA (2014) Diverse clinicopathologic features in human herpesvirus 8-associated lymphomas lead to diagnostic problems. Am J Clin Pathol 142(6):816\u2013829","journal-title":"Am J Clin Pathol"},{"issue":"8","key":"3599_CR25","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/pin.12951","volume":"70","author":"Y Nakaya","year":"2020","unstructured":"Nakaya Y, Ishii N, Kasamatsu Y et al (2020) Human herpesvirus 8-positive multicentric Castleman disease with germinotropic plasmablastic aggregates: overlapping spectrum of human herpesvirus 8-associated lymphoproliferative disorder. Pathol Int 70(8):574\u2013580","journal-title":"Pathol Int"},{"issue":"1","key":"3599_CR26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jasc.2014.10.002","volume":"4","author":"A Usmani","year":"2015","unstructured":"Usmani A, Walts AE, Patel S, Alkan S, Kitahara S (2015) HHV8-negative effusion based lymphoma: a series of 17 cases at a single institution. J Am Soc Cytopathol 4(1):37\u201343","journal-title":"J Am Soc Cytopathol"},{"issue":"2","key":"3599_CR27","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1309\/AJCPHZ3CHO4HUWET","volume":"140","author":"W Wu","year":"2013","unstructured":"Wu W, Youm W, Rezk SA, Zhao X (2013) Human herpesvirus 8-unrelated primary effusion lymphoma-like lymphoma: report of a rare case and review of 54 cases in the literature. Am J Clin Pathol 140(2):258\u2013273","journal-title":"Am J Clin Pathol"},{"issue":"18","key":"3599_CR28","doi-asserted-by":"crossref","first-page":"4442","DOI":"10.1182\/bloodadvances.2020002293","volume":"4","author":"D Kaji","year":"2020","unstructured":"Kaji D, Ota Y, Sato Y et al (2020) Primary human herpesvirus 8-negative effusion-based lymphoma: a large B-cell lymphoma with favorable prognosis. Blood Adv 4(18):4442\u20134450","journal-title":"Blood Adv"},{"issue":"2","key":"3599_CR29","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/PAS.0b013e318267fabc","volume":"37","author":"S Alexanian","year":"2013","unstructured":"Alexanian S, Said J, Lones M, Pullarkat ST (2013) KSHV\/HHV8-negative effusion-based lymphoma, a distinct entity associated with fluid overload states. Am J Surg Pathol 37(2):241\u2013249","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"3599_CR30","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1038\/s41379-022-01091-x","volume":"35","author":"SD Gisriel","year":"2022","unstructured":"Gisriel SD, Yuan J, Braunberger RC et al (2022) Human herpesvirus 8-negative effusion-based large B-cell lymphoma: a distinct entity with unique clinicopathologic characteristics. Mod Pathol 35(10):1411\u20131422","journal-title":"Mod Pathol"},{"issue":"4","key":"3599_CR31","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1182\/blood-2017-12-822171","volume":"133","author":"M Mendeville","year":"2019","unstructured":"Mendeville M, Roemer MGM, van den Hout M et al (2019) Aggressive genomic features in clinically indolent primary HHV8-negative effusion-based lymphoma. Blood 133(4):377\u2013380","journal-title":"Blood"},{"issue":"12","key":"3599_CR32","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1097\/PAS.0000000000001168","volume":"42","author":"T Kubota","year":"2018","unstructured":"Kubota T, Sasaki Y, Shiozawa E, Takimoto M, Hishima T, Chong JM (2018) Age and CD20 expression are significant prognostic factors in human herpes virus-8-negative effusion-based lymphoma. Am J Surg Pathol 42(12):1607\u20131616","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"3599_CR33","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.clml.2016.09.012","volume":"17","author":"JE Cortes","year":"2017","unstructured":"Cortes JE, Jimenez CA, Mauro MJ, Geyer A, Pinilla-Ibarz J, Smith BD (2017) Pleural effusion in dasatinib-treated patients with chronic myeloid leukemia in chronic phase: identification and management. Clin Lymphoma Myeloma Leuk 17(2):78\u201382","journal-title":"Clin Lymphoma Myeloma Leuk"},{"issue":"1","key":"3599_CR34","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s12185-022-03449-y","volume":"117","author":"K Hayashino","year":"2023","unstructured":"Hayashino K, Meguri Y, Yukawa R et al (2023) Spontaneous regression of dasatinib-related primary effusion lymphoma-like lymphoma. Int J Hematol 117(1):137\u2013142","journal-title":"Int J Hematol"},{"issue":"2","key":"3599_CR35","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3390\/biology10020152","volume":"10","author":"S Fiori","year":"2021","unstructured":"Fiori S, Todisco E, Ramadan S et al (2021) HHV8-negative effusion-based large B cell lymphoma arising in chronic myeloid leukemia patients under dasatinib treatment: a report of two cases. Biology 10(2):152","journal-title":"Biology"},{"issue":"6","key":"3599_CR36","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/cyt.12890","volume":"31","author":"D Miyagi","year":"2020","unstructured":"Miyagi D, Chen WY, Chen BJ et al (2020) Dasatinib-related effusion lymphoma in a patient treated for chronic myeloid leukaemia. Cytopathology 31(6):602\u2013606","journal-title":"Cytopathology"},{"issue":"2","key":"3599_CR37","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3960\/jslrt.17020","volume":"57","author":"M Kojima","year":"2017","unstructured":"Kojima M, Nakamura N, Amaki J et al (2017) Human herpesvirus 8-unrelated primary effusion lymphoma-like lymphoma following tyrosine kinase inhibitor treatment for chronic myelogenous leukemia. J Clin Exp Hematop 57(2):69\u201373","journal-title":"J Clin Exp Hematop"},{"issue":"4","key":"3599_CR38","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/cncr.23597","volume":"114","author":"A Carbone","year":"2008","unstructured":"Carbone A, Gloghini A (2008) PEL and HHV8-unrelated effusion lymphomas: classification and diagnosis. Cancer 114(4):225\u2013227","journal-title":"Cancer"},{"issue":"1","key":"3599_CR39","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1093\/annonc\/mdl349","volume":"18","author":"H Narimatsu","year":"2007","unstructured":"Narimatsu H, Ota Y, Kami M et al (2007) Clinicopathological features of pyothorax-associated lymphoma; a retrospective survey involving 98 patients. Ann Oncol 18(1):122\u2013128","journal-title":"Ann Oncol"},{"issue":"3","key":"3599_CR40","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/(SICI)1096-9896(199711)183:3<287::AID-PATH932>3.0.CO;2-Q","volume":"183","author":"C Copie-Bergman","year":"1997","unstructured":"Copie-Bergman C, Niedobitek G, Mangham DC et al (1997) Epstein-Barr virus in B-cell lymphomas associated with chronic suppurative inflammation. J Pathol 183(3):287\u2013292","journal-title":"J Pathol"},{"issue":"6","key":"3599_CR41","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1097\/01.pas.0000157747.10967.f4","volume":"29","author":"W Cheuk","year":"2005","unstructured":"Cheuk W, Chan AC, Chan JK, Lau GT, Chan VN, Yiu HH (2005) Metallic implant-associated lymphoma: a distinct subgroup of large B-cell lymphoma related to pyothorax-associated lymphoma? Am J Surg Pathol 29(6):832\u2013836","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"3599_CR42","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/j.1440-1827.2008.02288.x","volume":"58","author":"M Fujimoto","year":"2008","unstructured":"Fujimoto M, Haga H, Okamoto M et al (2008) EBV-associated diffuse large B-cell lymphoma arising in the chest wall with surgical mesh implant. Pathol Int 58(10):668\u2013671","journal-title":"Pathol Int"},{"issue":"20","key":"3599_CR43","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1200\/JCO.2002.09.021","volume":"20","author":"S Nakatsuka","year":"2002","unstructured":"Nakatsuka S, Yao M, Hoshida Y, Yamamoto S, Iuchi K, Aozasa K (2002) Pyothorax-associated lymphoma: a review of 106 cases. J Clin Oncol 20(20):4255\u20134260","journal-title":"J Clin Oncol"},{"issue":"6","key":"3599_CR44","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1097\/00000478-200206000-00005","volume":"26","author":"B Petitjean","year":"2002","unstructured":"Petitjean B, Jardin F, Joly B et al (2002) Pyothorax-associated lymphoma: a peculiar clinicopathologic entity derived from B cells at late stage of differentiation and with occasional aberrant dual B- and T-cell phenotype. Am J Surg Pathol 26(6):724\u2013732","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"3599_CR45","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/j.1349-7006.2003.tb01367.x","volume":"94","author":"T Takakuwa","year":"2003","unstructured":"Takakuwa T, Luo WJ, Ham MF, Mizuki M, Iuchi K, Aozasa K (2003) Establishment and characterization of unique cell lines derived from pyothorax-associated lymphoma which develops in long-standing pyothorax and is strongly associated with Epstein-Barr virus infection. Cancer Sci 94(10):858\u2013863","journal-title":"Cancer Sci"},{"issue":"6","key":"3599_CR46","first-page":"1105","volume":"58","author":"T Hongyo","year":"1998","unstructured":"Hongyo T, Kurooka M, Taniguchi E et al (1998) Frequent p53 mutations at dipyrimidine sites in patients with pyothorax-associated lymphoma. Cancer Res 58(6):1105\u20131107","journal-title":"Cancer Res"},{"issue":"2","key":"3599_CR47","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1046\/j.1365-2559.2001.01197.x","volume":"39","author":"H Yamato","year":"2001","unstructured":"Yamato H, Ohshima K, Suzumiya J, Kikuchi M (2001) Evidence for local immunosuppression and demonstration of c-myc amplification in pyothorax-associated lymphoma. Histopathology 39(2):163\u2013171","journal-title":"Histopathology"},{"issue":"3","key":"3599_CR48","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/PAS.0000000000000775","volume":"41","author":"DF Boyer","year":"2017","unstructured":"Boyer DF, McKelvie PA, de Leval L et al (2017) Fibrin-associated EBV-positive large B-cell lymphoma: an indolent neoplasm with features distinct from diffuse large B-cell lymphoma associated with chronic inflammation. Am J Surg Pathol 41(3):299\u2013312","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"3599_CR49","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1186\/s12885-019-6123-1","volume":"19","author":"M Zanelli","year":"2019","unstructured":"Zanelli M, Zizzo M, Montanaro M et al (2019) Fibrin-associated large B-cell lymphoma: first case report within a cerebral artery aneurysm and literature review. BMC Cancer 19(1):916","journal-title":"BMC Cancer"},{"issue":"3","key":"3599_CR50","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/PAS.0b013e3181ce9128","volume":"34","author":"DV Miller","year":"2010","unstructured":"Miller DV, Firchau DJ, McClure RF, Kurtin PJ, Feldman AL (2010) Epstein-Barr virus-associated diffuse large B-cell lymphoma arising on cardiac prostheses. Am J Surg Pathol 34(3):377\u2013384","journal-title":"Am J Surg Pathol"},{"issue":"7","key":"3599_CR51","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1097\/PAS.0b013e3182515fb5","volume":"36","author":"N Boroumand","year":"2012","unstructured":"Boroumand N, Ly TL, Sonstein J, Medeiros LJ (2012) Microscopic diffuse large B-cell lymphoma (DLBCL) occurring in pseudocysts: do these tumors belong to the category of DLBCL associated with chronic inflammation? Am J Surg Pathol 36(7):1074\u20131080","journal-title":"Am J Surg Pathol"},{"issue":"8","key":"3599_CR52","doi-asserted-by":"crossref","first-page":"e412","DOI":"10.3324\/haematol.2019.232355","volume":"105","author":"SM Rodriguez-Pinilla","year":"2020","unstructured":"Rodriguez-Pinilla SM, Garcia FJS, Balague O, Rodriguez-Justo M, Piris MA (2020) Breast implant-associated Epstein-Barr virus-positive large B-cell lymphomas: a report of three cases. Haematologica 105(8):e412\u2013e414","journal-title":"Haematologica"},{"issue":"8","key":"3599_CR53","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.hrcr.2020.05.013","volume":"6","author":"A Keyser","year":"2020","unstructured":"Keyser A, Schopka S, Stadlbauer A, Zerdzitzki M, Jungbauer C, Schmid C (2020) B-Cell lymphoma at the site of pacemaker generator. HeartRhythm Case Rep 6(8):528\u2013530","journal-title":"HeartRhythm Case Rep"},{"issue":"4","key":"3599_CR54","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/BF02982649","volume":"77","author":"N Hojo","year":"2003","unstructured":"Hojo N, Yakushijin Y, Narumi H et al (2003) Non-Hodgkin\u2019s lymphoma developing in a pacemaker pocket. Int J Hematol 77(4):387\u2013390","journal-title":"Int J Hematol"},{"issue":"12","key":"3599_CR55","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1038\/s41379-021-00863-1","volume":"34","author":"LJ Medeiros","year":"2021","unstructured":"Medeiros LJ, Marques-Piubelli ML, Sangiorgio VFI et al (2021) Epstein-Barr-virus-positive large B-cell lymphoma associated with breast implants: an analysis of eight patients suggesting a possible pathogenetic relationship. Mod Pathol 34(12):2154\u20132167","journal-title":"Mod Pathol"},{"issue":"1","key":"3599_CR56","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13000-020-01034-7","volume":"15","author":"EM Moreno","year":"2020","unstructured":"Moreno EM, Ferrer-Gomez A, Arias HP, Garcia IG, Garcia-Cosio M (2020) Fibrin-associated diffuse large B-cell lymphoma with plasmacytic differentiation: case report and literature review. Diagn Pathol 15(1):117","journal-title":"Diagn Pathol"},{"issue":"1","key":"3599_CR57","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1510\/icvts.2009.204628","volume":"9","author":"IN Bagwan","year":"2009","unstructured":"Bagwan IN, Desai S, Wotherspoon A, Sheppard MN (2009) Unusual presentation of primary cardiac lymphoma. Interact Cardiovasc Thorac Surg 9(1):127\u2013129","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"10","key":"3599_CR58","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1097\/PAS.0b013e31825d53b5","volume":"36","author":"AM Gruver","year":"2012","unstructured":"Gruver AM, Huba MA, Dogan A, Hsi ED (2012) Fibrin-associated large B-cell lymphoma: part of the spectrum of cardiac lymphomas. Am J Surg Pathol 36(10):1527\u20131537","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"3599_CR59","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1177\/10668969211014959","volume":"30","author":"L Baugh","year":"2022","unstructured":"Baugh L, Brown N, Song JY, Pandya S, Montoya V, Perry AM (2022) Fibrin-associated, EBV-negative diffuse large B-cell lymphoma arising in atrial myxoma: expanding the spectrum of the entity. Int J Surg Pathol 30(1):39\u201345","journal-title":"Int J Surg Pathol"},{"issue":"Suppl 3","key":"3599_CR60","first-page":"525","volume":"11","author":"H Kanno","year":"1997","unstructured":"Kanno H, Naka N, Yasunaga Y, Aozasa K (1997) Role of an immunosuppressive cytokine, interleukin-10, in the development of pyothorax-associated lymphoma. Leukemia 11(Suppl 3):525\u2013526","journal-title":"Leukemia"},{"issue":"6","key":"3599_CR61","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.4049\/jimmunol.1801420","volume":"203","author":"H Auclair","year":"2019","unstructured":"Auclair H, Ouk-Martin C, Roland L et al (2019) EBV latency III-transformed B cells are inducers of conventional and unconventional regulatory T cells in a PD-L1-dependent manner. J Immunol 203(6):1665\u20131674","journal-title":"J Immunol"},{"key":"3599_CR62","unstructured":"Administration USFD. Medical device reports of breast implant-associated anaplastic large cell lymphoma. 2022. (https:\/\/www.fda.gov\/medical-devices\/breast-implants\/medical-device-reports-breast-implant-associated-anaplastic-large-cell-lymphoma#:~:text=Medical%20Device%20Reports%20of%20Breast%20Implant%2DAssociated%20Anaplastic%20Large%20Cell%20Lymphoma,-Share&text=As%20of%20April%201%2C%202022,lymphoma%20(BIA%2DALCL).\u00a0Accessed 30 April 2023"},{"issue":"2","key":"3599_CR63","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1200\/JCO.2015.63.3412","volume":"34","author":"MW Clemens","year":"2016","unstructured":"Clemens MW, Medeiros LJ, Butler CE et al (2016) Complete surgical excision is essential for the management of patients with breast implant-associated anaplastic large-cell lymphoma. J Clin Oncol 34(2):160\u2013168","journal-title":"J Clin Oncol"},{"issue":"2","key":"3599_CR64","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/s41379-018-0130-7","volume":"32","author":"A Di Napoli","year":"2019","unstructured":"Di Napoli A, De Cecco L, Piccaluga PP et al (2019) Transcriptional analysis distinguishes breast implant-associated anaplastic large cell lymphoma from other peripheral T-cell lymphomas. Mod Pathol 32(2):216\u2013230","journal-title":"Mod Pathol"},{"issue":"5","key":"3599_CR65","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1182\/blood-2017-12-821868","volume":"132","author":"N Oishi","year":"2018","unstructured":"Oishi N, Brody GS, Ketterling RP et al (2018) Genetic subtyping of breast implant-associated anaplastic large cell lymphoma. Blood 132(5):544\u2013547","journal-title":"Blood"},{"issue":"17","key":"3599_CR66","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1158\/1078-0432.CCR-12-0101","volume":"18","author":"MG Lechner","year":"2012","unstructured":"Lechner MG, Megiel C, Church CH et al (2012) Survival signals and targets for therapy in breast implant-associated ALK\u2013anaplastic large cell lymphoma. Clin Cancer Res 18(17):4549\u20134559","journal-title":"Clin Cancer Res"},{"issue":"6","key":"3599_CR67","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.3324\/haematol.2019.245860","volume":"106","author":"N Oishi","year":"2021","unstructured":"Oishi N, Hundal T, Phillips JL et al (2021) Molecular profiling reveals a hypoxia signature in breast implant-associated anaplastic large cell lymphoma. Haematologica 106(6):1714\u20131724","journal-title":"Haematologica"},{"issue":"9","key":"3599_CR68","doi-asserted-by":"crossref","first-page":"e387","DOI":"10.3324\/haematol.2016.146118","volume":"101","author":"P Blombery","year":"2016","unstructured":"Blombery P, Thompson ER, Jones K et al (2016) Whole exome sequencing reveals activating JAK1 and STAT3 mutations in breast implant-associated anaplastic large cell lymphoma anaplastic large cell lymphoma. Haematologica 101(9):e387\u2013e390","journal-title":"Haematologica"},{"issue":"5","key":"3599_CR69","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/bjh.14431","volume":"180","author":"A Di Napoli","year":"2018","unstructured":"Di Napoli A, Jain P, Duranti E et al (2018) Targeted next generation sequencing of breast implant-associated anaplastic large cell lymphoma reveals mutations in JAK\/STAT signalling pathway genes, TP53 and DNMT3A. Br J Haematol 180(5):741\u2013744","journal-title":"Br J Haematol"},{"issue":"4","key":"3599_CR70","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00428-018-2352-y","volume":"473","author":"A Letourneau","year":"2018","unstructured":"Letourneau A, Maerevoet M, Milowich D et al (2018) Dual JAK1 and STAT3 mutations in a breast implant-associated anaplastic large cell lymphoma. Virchows Arch 473(4):505\u2013511","journal-title":"Virchows Arch"},{"issue":"5","key":"3599_CR71","first-page":"360","volume":"135","author":"C Laurent","year":"2020","unstructured":"Laurent C, Nicolae A, Laurent C et al (2020) Gene alterations in epigenetic modifiers and JAK-STAT signaling are frequent in breast implant-associated ALCL. Blood 135(5):360\u2013370","journal-title":"Blood"},{"issue":"4","key":"3599_CR72","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/tbj.14205","volume":"27","author":"AE Quesada","year":"2021","unstructured":"Quesada AE, Zhang Y, Ptashkin R et al (2021) Next generation sequencing of breast implant-associated anaplastic large cell lymphomas reveals a novel STAT3-JAK2 fusion among other activating genetic alterations within the JAK-STAT pathway. Breast J 27(4):314\u2013321","journal-title":"Breast J"},{"issue":"25","key":"3599_CR73","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1182\/blood.2020005372","volume":"136","author":"GT Los-de Vries","year":"2020","unstructured":"Los-de Vries GT, de Boer M, van Dijk E et al (2020) Chromosome 20 loss is characteristic of breast implant-associated anaplastic large cell lymphoma. Blood 136(25):2927\u20132932","journal-title":"Blood"},{"key":"3599_CR74","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.humpath.2019.05.007","volume":"90","author":"V Tabanelli","year":"2019","unstructured":"Tabanelli V, Corsini C, Fiori S et al (2019) Recurrent PDL1 expression and PDL1 (CD274) copy number alterations in breast implant-associated anaplastic large cell lymphomas. Hum Pathol 90:60\u201369","journal-title":"Hum Pathol"},{"issue":"2","key":"3599_CR75","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1200\/JCO.2013.52.7911","volume":"32","author":"RN Miranda","year":"2014","unstructured":"Miranda RN, Aladily TN, Prince HM et al (2014) Breast implant-associated anaplastic large-cell lymphoma: long-term follow-up of 60 patients. J Clin Oncol 32(2):114\u2013120","journal-title":"J Clin Oncol"},{"issue":"3","key":"3599_CR76","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/PAS.0000000000000985","volume":"42","author":"MC Ferrufino-Schmidt","year":"2018","unstructured":"Ferrufino-Schmidt MC, Medeiros LJ, Liu H et al (2018) Clinicopathologic features and prognostic impact of lymph node involvement in patients with breast implant-associated anaplastic large cell lymphoma. Am J Surg Pathol 42(3):293\u2013305","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"3599_CR77","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/annonc\/mdv575","volume":"27","author":"C Laurent","year":"2016","unstructured":"Laurent C, Delas A, Gaulard P et al (2016) Breast implant-associated anaplastic large cell lymphoma: two distinct clinicopathological variants with different outcomes. Ann Oncol 27(2):306\u2013314","journal-title":"Ann Oncol"},{"issue":"24","key":"3599_CR78","doi-asserted-by":"crossref","first-page":"6174","DOI":"10.3390\/cancers13246174","volume":"13","author":"A Di Napoli","year":"2021","unstructured":"Di Napoli A, Vacca D, Bertolazzi G et al (2021) RNA sequencing of primary cutaneous and breast-implant associated anaplastic large cell lymphomas reveals infrequent fusion transcripts and upregulation of PI3K\/AKT signaling via neurotrophin pathway genes. Cancers 13(24):6174","journal-title":"Cancers"}],"updated-by":[{"DOI":"10.1007\/s00428-023-03664-w","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000}}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-023-03599-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-023-03599-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-023-03599-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T09:06:41Z","timestamp":1695978401000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00428-023-03599-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,9]]},"references-count":78,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["3599"],"URL":"https:\/\/doi.org\/10.1007\/s00428-023-03599-2","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,9]]},"assertion":[{"value":"8 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2023","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00428-023-03664-w","URL":"https:\/\/doi.org\/10.1007\/s00428-023-03664-w","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}