{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:01:58Z","timestamp":1780376518905,"version":"3.54.1"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1007\/s00428-023-03642-2","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T20:35:37Z","timestamp":1695155737000},"page":"635-643","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Heterogeneity of TPIT expression in ACTH-secreting extra-pituitary neuroendocrine tumors (NETs) supports the existence of different cellular programs in pancreatic and pulmonary NETs"],"prefix":"10.1007","volume":"483","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5714-7295","authenticated-orcid":false,"given":"Silvia","family":"Uccella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4297-9432","authenticated-orcid":false,"given":"Eleonora","family":"Leoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6972-5080","authenticated-orcid":false,"given":"Roberta","family":"Maragliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Valerio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2130-6669","authenticated-orcid":false,"given":"Laura","family":"Libera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7551-1751","authenticated-orcid":false,"given":"Maria Laura","family":"Tanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0719-105X","authenticated-orcid":false,"given":"Marco","family":"Volante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4375-3718","authenticated-orcid":false,"given":"Dario","family":"Diviani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1941-2403","authenticated-orcid":false,"given":"Stefano","family":"La Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,19]]},"reference":[{"key":"3642_CR1","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/s0092-8674(01)00282-3","volume":"104","author":"B Lamolet","year":"2001","unstructured":"Lamolet B, Pulichino AM, Lamonerie T, Gauthier Y, Brue T, Enjalbert A, Drouin J (2001) A pituitary cell-restricted T box factor, TPIT, activates POMC transcription in cooperation with Pitx homeoproteins. Cell 104:849\u2013859. https:\/\/doi.org\/10.1016\/s0092-8674(01)00282-3","journal-title":"Cell"},{"key":"3642_CR2","doi-asserted-by":"publisher","first-page":"3050","DOI":"10.1210\/jc.2002-021934","volume":"88","author":"S Vallette-Kasic","year":"2003","unstructured":"Vallette-Kasic S, Figarella-Branger D, Grino M, Pulichino AM, Dufour H, Grisoli F, Enjalbert A, Drouin J, Brue T (2003) Differential regulation of proopiomelanocortin and pituitary-restricted transcription factor (TPIT), a new marker of normal and adenomatous human corticotrophs. J Clin Endocrinol Metab 88:3050\u20133056. https:\/\/doi.org\/10.1210\/jc.2002-021934","journal-title":"J Clin Endocrinol Metab"},{"key":"3642_CR3","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1007\/s00428-019-02655-0","volume":"475","author":"C Villa","year":"2019","unstructured":"Villa C, Vasiljevic A, Jaffrain-Rea ML, Ansorge O, Asioli S, Barresi V, Chinezu L, Gardiman MP, Lania A, Lapshina AM, Poliani L, Reiniger L, Righi A, Saeger W, Soukup J, Theodoropoulou M, Uccella S, Trouillas J, Roncaroli F (2019) A standardised diagnostic approach to pituitary neuroendocrine tumours (PitNETs): a European Pituitary Pathology Group (EPPG) proposal. Virchows Arch 475:687\u2013692. https:\/\/doi.org\/10.1007\/s00428-019-02655-0. (Epub 2019 Oct 2)","journal-title":"Virchows Arch"},{"key":"3642_CR4","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1038\/s41379-021-00820-y","volume":"34","author":"SL Asa","year":"2021","unstructured":"Asa SL, Mete O, Cusimano MD et al (2021) Pituitary neuroendocrine tumors: a model for neuroendocrine tumor classification. Mod Pathol 34:1634\u20131650. https:\/\/doi.org\/10.1038\/s41379-021-00820-y","journal-title":"Mod Pathol"},{"key":"3642_CR5","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s12022-022-09703-7","volume":"33","author":"SL Asa","year":"2022","unstructured":"Asa SL, Mete O, Perry A, Osamura RY (2022) Overview of the 2022 WHO classification of pituitary tumors. Endocr Pathol 33:6\u201326. https:\/\/doi.org\/10.1007\/s12022-022-09703-7","journal-title":"Endocr Pathol"},{"key":"3642_CR6","doi-asserted-by":"publisher","first-page":"R29","DOI":"10.1530\/EJE-19-0877","volume":"182","author":"J Young","year":"2020","unstructured":"Young J, Haissaguerre M, Viera-Pinto O, Chabre O, Baudin E, Tabarin A (2020) Management of endocrine disease: Cushing\u2019s syndrome due to ectopic ACTH secretion: an expert operational opinion. Eur J Endocrinol 182:R29\u2013R58. https:\/\/doi.org\/10.1530\/EJE-19-0877","journal-title":"Eur J Endocrinol"},{"key":"3642_CR7","doi-asserted-by":"publisher","unstructured":"Kasajima A, Pfarr N, von Werder A, Schwamborn K, Gschwend J, Din NU, Esposito I, Weichert W, Pavel M, Agaimy A, Kl\u00f6ppel G (2023) Renal neuroendocrine tumors: clinical and molecular pathology with an emphasis on frequent association with ectopic Cushing syndrome. Virchows Arch Jul 5. https:\/\/doi.org\/10.1007\/s00428-023-03596-5. Epub ahead of print.","DOI":"10.1007\/s00428-023-03596-5"},{"key":"3642_CR8","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1210\/jc.2018-00688","volume":"104","author":"J Drummond","year":"2019","unstructured":"Drummond J, Roncaroli F, Grossman AB, Korbonits M (2019) Clinical and pathological aspects of silent pituitary adenomas. J Clin Endocrinol Metab 104:2473\u20132489. https:\/\/doi.org\/10.1210\/jc.2018-00688","journal-title":"J Clin Endocrinol Metab"},{"key":"3642_CR9","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/s00428-019-02612-x","volume":"475","author":"S La Rosa","year":"2019","unstructured":"La Rosa S, Volante M, Uccella S, Maragliano R, Rapa I, Rotolo N, Inzani F, Siciliani A, Granone P, Rindi G, Dominioni L, Capella C, Papotti M, Sessa F, Imperatori A (2019) ACTH-producing tumorlets and carcinoids of the lung: clinico-pathologic study of 63 cases and review of the literature. Virchows Arch 475:587\u2013597. https:\/\/doi.org\/10.1007\/s00428-019-02612-x","journal-title":"Virchows Arch"},{"key":"3642_CR10","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1530\/ERC-16-0206","volume":"23","author":"T Araki","year":"2016","unstructured":"Araki T, Liu NA, Tone Y, Cuevas-Ramos D, Heltsley R, Tone M, Melmed S (2016) E2F1-mediated human POMC expression in ectopic Cushing\u2019s syndrome. Endocr Relat Cancer 23:857\u2013870. https:\/\/doi.org\/10.1530\/ERC-16-0206","journal-title":"Endocr Relat Cancer"},{"key":"3642_CR11","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1097\/PAS.0000000000000340","volume":"39","author":"R Maragliano","year":"2015","unstructured":"Maragliano R, Vanoli A, Albarello L, Milione M, Basturk O, Klimstra DS, Wachtel A, Uccella S, Vicari E, Milesi M, Dav\u00ec MV, Scarpa A, Sessa F, Capella C, La Rosa S (2015) ACTH-secreting pancreatic neoplasms associated with Cushing syndrome: clinicopathologic study of 11 cases and review of the literature. Am J Surg Pathol 39:374\u2013382. https:\/\/doi.org\/10.1097\/PAS.0000000000000340","journal-title":"Am J Surg Pathol"},{"key":"3642_CR12","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s11102-018-0864-8","volume":"21","author":"A Ben-Shlomo","year":"2018","unstructured":"Ben-Shlomo A, Cooper O (2018) Silent corticotroph adenomas. Pituitary 21:183\u2013193","journal-title":"Pituitary"},{"key":"3642_CR13","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1369\/jhc.5A6770.2006","volume":"54","author":"S Uccella","year":"2006","unstructured":"Uccella S, Cerutti R, Vigetti D, Furlan D, Oldrini R, Carnevali I, Pelosi G, La Rosa S, Passi A, Capella C (2006) Histidine decarboxylase, DOPA decarboxylase, and vesicular monoamine transporter 2 expression in neuroendocrine tumors: immunohistochemical study and gene expression analysis. J Histochem Cytochem 54:863\u2013875. https:\/\/doi.org\/10.1369\/jhc.5A6770.2006","journal-title":"J Histochem Cytochem"},{"key":"3642_CR14","doi-asserted-by":"publisher","first-page":"e3346","DOI":"10.1210\/clinem\/dgab387","volume":"106","author":"T Araki","year":"2021","unstructured":"Araki T, Tone Y, Yamamoto M, Kameda H, Ben-Shlomo A, Yamada S, Takeshita A, Yamamoto M, Kawakami Y, Tone M, Melmed S (2021) Two distinctive POMC promoters modify gene expression in Cushing disease. J Clin Endocrinol Metab 106:e3346\u2013e3363. https:\/\/doi.org\/10.1210\/clinem\/dgab387","journal-title":"J Clin Endocrinol Metab"},{"key":"3642_CR15","doi-asserted-by":"publisher","first-page":"bqac086","DOI":"10.1210\/endocr\/bqac086","volume":"163","author":"T Araki","year":"2022","unstructured":"Araki T, Wang J, Lawrence R, Kawakami Y (2022) Aberrant nuclear translocation of E2F1 and its association in Cushing\u2019s disease. Endocrinology 163:bqac086. https:\/\/doi.org\/10.1210\/endocr\/bqac086","journal-title":"Endocrinology"},{"key":"3642_CR16","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s00428-022-03484-4","volume":"482","author":"A Agaimy","year":"2023","unstructured":"Agaimy A, Kasajima A, Stoehr R, Haller F, Schubart C, T\u00f6gel L, Pfarr N, von Werder A, Pavel ME, Sessa F, Uccella S, La Rosa S, Kl\u00f6ppel G (2023) Gene fusions are frequent in ACTH-secreting neuroendocrine neoplasms of the pancreas, but not in their non-pancreatic counterparts. Virchows Arch 482:507\u2013516. https:\/\/doi.org\/10.1007\/s00428-022-03484-4","journal-title":"Virchows Arch"},{"key":"3642_CR17","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1210\/clinem\/dgaa488","volume":"106","author":"PF Elliott","year":"2021","unstructured":"Elliott PF, Berhane T, Ragnarsson O, Falhammar H (2021) Ectopic ACTH- and\/or CRH-producing pheochromocytomas. J Clin Endocrinol Metab 106:598\u2013608. https:\/\/doi.org\/10.1210\/clinem\/dgaa488","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-023-03642-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-023-03642-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-023-03642-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T07:06:52Z","timestamp":1700809612000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00428-023-03642-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,19]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["3642"],"URL":"https:\/\/doi.org\/10.1007\/s00428-023-03642-2","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,19]]},"assertion":[{"value":"11 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed according to the clinical standards of the 1975 and 1983 Declaration of Helsinki and was approved by the Ethical Committee of the ASST dei Sette Laghi, Varese, Italy.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.The authors declare that the submitted work is original and has not been published or submitted elsewhere in any form or language (partially or in full).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}