{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:59:05Z","timestamp":1793642345738,"version":"4.5.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>SMARCB1-deficient sinonasal adenocarcinoma is a rare variant of SWI\/SNF-deficient malignancies with SMARCB1 loss and adenocarcinoma features. More than 200 high-grade epithelial sinonasal malignancies were retrieved. A total of 14 cases exhibited complete SMARCB1 (INI1) loss and glandular differentiation. SMARCA2 and SMARCA4 were normal, except for one case with a loss of SMARCA2. Next-generation sequencing (NGS) and\/or fluorescence in situ hybridization (FISH) revealed an alteration in the <jats:italic>SMARCB1<\/jats:italic> gene in 9\/13 cases, while 2\/13 were negative. Two tumors harbored <jats:italic>SMARCB1<\/jats:italic> mutations in c.157C\u2009&gt;\u2009T p.(Arg53Ter) and c.842G\u2009&gt;\u2009A p.(Trp281Ter). One harbored <jats:italic>ARID1B<\/jats:italic> mutations in c.1469G\u2009&gt;\u2009A p.(Trp490Ter) and <jats:italic>MGA<\/jats:italic> c.3724C\u2009&gt;\u2009T p.(Arg1242Ter). Seven tumors had a <jats:italic>SMARCB1<\/jats:italic> deletion. One carried an <jats:italic>ESR1<\/jats:italic> mutation in <jats:italic>c.644-2A<\/jats:italic>\u2009&gt;\u2009<jats:italic>T<\/jats:italic>, and another carried a <jats:italic>POLE<\/jats:italic> mutation in c.352_374del p.(Ser118GlyfsTer78). One case had a <jats:italic>PAX3<\/jats:italic> mutation in c.44del p.(Gly15AlafsTer95). Histomorphology of SMARCB1-deficient adenocarcinoma was oncocytoid\/rhabdoid and glandular, solid, or trabecular in 9\/14 cases. Two had basaloid\/blue cytoplasm and one showed focal signet ring cells. Yolk sac tumor-like differentiation with Schiller-Duval-like bodies was seen in 6\/14 cases, with 2 cases showing exclusively reticular-microcystic yolk sac pattern. Follow-up of a maximum of 26\u00a0months (median 10\u00a0months) was available for 8\/14 patients. Distant metastasis to the lung, liver, mediastinum, bone, and\/or retroperitoneum was seen in 4\/8 cases. Locoregional failure was seen in 75% of patients, with 6\/8 local recurrences and 3 cervical lymph node metastases. At the last follow-up, 5 of 8 (62%) patients had died of their disease 2 to 20\u00a0months after diagnosis (median 8.2\u00a0months), and 3 were alive with the disease. The original diagnosis was usually high-grade non-intestinal-type adenocarcinoma or high-grade myoepithelial carcinoma. A correct diagnosis of these aggressive tumors could lead to improved targeted therapies with potentially better overall disease-specific survival.<\/jats:p>","DOI":"10.1007\/s00428-023-03650-2","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T10:07:45Z","timestamp":1702375665000},"page":"245-256","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["SMARCB1-deficient sinonasal adenocarcinoma: a rare variant of SWI\/SNF-deficient malignancy often misclassified as high-grade non-intestinal-type sinonasal adenocarcinoma or myoepithelial carcinoma"],"prefix":"10.1007","volume":"485","author":[{"given":"Alena","family":"Sk\u00e1lov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Touraj","family":"Taheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Bradov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"Van\u011b\u010dek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Franchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Slouka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"Kostliv\u00fd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisele","family":"de Rezende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslav","family":"Mich\u00e1lek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lie","family":"Klub\u00ed\u010dkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Pt\u00e1kov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f3nia","family":"Nemcov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Michal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Agaimy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilmo","family":"Leivo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,12]]},"reference":[{"issue":"2","key":"3650_CR1","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1097\/PAP.0000000000000258","volume":"27","author":"A Agaimy","year":"2020","unstructured":"Agaimy A, Franchi A, Lund VJ, Sk\u00e1lov\u00e1 A, Bishop JA, Triantafyllou A, Andreasen S, Gnepp DR, Hellquist H, Thompson LDR, Rinaldo A, Ferlito A (2020) Sinonasal undifferentiated carcinoma (SNUC): from an entity to morphologic pattern and back again-a historical perspective. Adv Anat Pathol 27(2):51\u201360","journal-title":"Adv Anat Pathol"},{"issue":"4","key":"3650_CR2","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1002\/path.4915","volume":"242","author":"S Dogan","year":"2017","unstructured":"Dogan S, Chute DJ, Xu B et al (2017) Frequent IDH2 R172 mutations in undifferentiated and poorly-differentiated sinonasal carcinomas. J Pathol 242(4):400\u2013408","journal-title":"J Pathol"},{"issue":"8","key":"3650_CR3","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1097\/PAS.0000000000001064","volume":"42","author":"JK Mito","year":"2018","unstructured":"Mito JK, Bishop JA, Sadow PM et al (2018) Immunohistochemical detection and molecular characterization of IDH-mutant sinonasal undifferentiated carcinomas. Am J Surg Pathol 42(8):1067\u20131075","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"3650_CR4","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.cancergencyto.2010.06.007","volume":"203","author":"CA French","year":"2010","unstructured":"French CA (2010) NUT midline carcinoma. Cancer Genet Cytogenet 203(1):16\u201320","journal-title":"Cancer Genet Cytogenet"},{"key":"3650_CR5","unstructured":"Bishop JA, Thompson LDR, Loney EL (eds) (2022) Chapter 2: nasal, paranasal, and skull base tumours. In: WHO classification of tumours editorial board. Head and neck tumours. [Internet; beta version ahead of print]. Lyon (France): International Agency for Research on Cancer; [cited 2023 May 8]. (WHO classification of tumours series, 5th ed.; vol. 9). Available from: https:\/\/tumourclassification.iarc.who.int\/chapters\/52\/1"},{"issue":"2","key":"3650_CR6","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1097\/PAP.0000000000000372","volume":"30","author":"A Agaimy","year":"2023","unstructured":"Agaimy A (2023) SWI\/SNF-deficient sinonasal carcinomas. Adv Anat Pathol 30(2):95\u2013103","journal-title":"Adv Anat Pathol"},{"key":"3650_CR7","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1097\/PAS.0000000000000236","volume":"38","author":"A Agaimy","year":"2014","unstructured":"Agaimy A, Koch M, Lell M et al (2014) SMARCB1(INI1)-deficient sinonasal basaloid carcinoma: a novel member of the expanding family of SMARCB1-deficient neoplasms. Am J Surg Pathol 38:1274\u20131281","journal-title":"Am J Surg Pathol"},{"key":"3650_CR8","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1097\/PAS.0000000000000285","volume":"38","author":"JA Bishop","year":"2014","unstructured":"Bishop JA, Antonescu CR, Westra WH (2014) SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract. Am J Surg Pathol 38:1282\u20131289","journal-title":"Am J Surg Pathol"},{"key":"3650_CR9","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1097\/PAS.0000000000000797","volume":"41","author":"A Agaimy","year":"2017","unstructured":"Agaimy A, Hartmann A, Antonescu CR et al (2017) SMARCB1 (INI-1)-deficient sinonasal carcinoma: a series of 39 cases expanding the morphologic and clinicopathologic spectrum of a recently described entity. Am J Surg Pathol 41:458\u2013471","journal-title":"Am J Surg Pathol"},{"key":"3650_CR10","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1007\/s12105-016-0694-9","volume":"10","author":"I Leivo","year":"2016","unstructured":"Leivo I (2016) Sinonasal adenocarcinoma: update on classifcation, immunophenotype and molecular features. Head Neck Pathol 10:68\u201374","journal-title":"Head Neck Pathol"},{"issue":"1","key":"3650_CR11","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1007\/s12105-007-0025-2","volume":"1","author":"I Leivo","year":"2007","unstructured":"Leivo I (2007) Update on sinonasal adenocarcinoma: classification and advances in immunophenotype and molecular genetic make-up. Head Neck Pathol 1(1):38\u201343","journal-title":"Head Neck Pathol"},{"key":"3650_CR12","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1097\/PAS.0b013e31821cbd72","volume":"35","author":"EB Stelow","year":"2011","unstructured":"Stelow EB, Jo VY, Mills SE et al (2011) A histologic and immunohistochemical study describing the diversity of tumors classifed as sinonasal high-grade nonintestinal adenocarcinomas. Am J Surg Pathol 35:971\u2013980","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"3650_CR13","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1097\/PAS.0000000000001048","volume":"42","author":"M Baneckova","year":"2018","unstructured":"Baneckova M, Agaimy A, Andreasen S et al (2018) Mammary analog secretory carcinoma of the nasal cavity: characterization of 2 cases and their distinction from other low-grade sinonasal adenocarcinomas. Am J Surg Pathol 42(6):735\u2013743","journal-title":"Am J Surg Pathol"},{"key":"3650_CR14","doi-asserted-by":"crossref","unstructured":"Klub\u00ed\u010dkov\u00e1 N, Mosaieby E, Pt\u00e1kov\u00e1 N et al (n.d.) High-grade non-intestinal type sinonasal adenocarcinoma with ETV6::NTRK3 fusion, distinct from secretory carcinoma by immunoprofile and morphology. Virchows Arch 2023 in press","DOI":"10.1007\/s00428-023-03587-6"},{"issue":"2","key":"3650_CR15","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s12105-019-01065-7","volume":"14","author":"AA Shah","year":"2020","unstructured":"Shah AA, Jain D, Ababneh E, Agaimy A, Hoschar AP, Griffith CC, Magliocca KR, Wenig BM, Rooper LM, Bishop JA (2020) SMARCB1 (INI-1)-deficient adenocarcinoma of the sinonasal tract: a potentially under-recognized form of sinonasal adenocarcinoma with occasional yolk sac tumor-like features. Head Neck Pathol 14(2):465\u2013472","journal-title":"Head Neck Pathol"},{"key":"3650_CR16","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1177\/1066896917741549","volume":"26","author":"M Zamecnik","year":"2018","unstructured":"Zamecnik M, Rychnovsky J, Syrovatka J (2018) Sinonasal SMARCB1 (INI1) deficient carcinoma with yolk sac tumor diferentiation: report of a case and comparison with INI1 expression in gonadal germ cell tumors. Int J Surg Pathol 26:245\u2013249","journal-title":"Int J Surg Pathol"},{"key":"3650_CR17","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.2147\/OTT.S302613","volume":"14","author":"CY Li","year":"2021","unstructured":"Li CY, Han YM, Xu K et al (2021) Case report: SMARCB1 (INI-1)-deficient carcinoma of the nasal cavity with pure yolk sac tumor differentiation and elevated serum AFP levels. Onco Targets Ther 14:2227\u20132233","journal-title":"Onco Targets Ther"},{"key":"3650_CR18","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1007\/s12105-021-01375-9","volume":"16","author":"B Hazir","year":"2022","unstructured":"Hazir B, \u015e\u00edmsek B, Erdem\u00edr A et al (2022) Sinonasal SMARCB1 (INI1) deficient carcinoma with yolk sac tumor differentiation: a case report and treatment options. Head Neck Pathol 16:596\u2013601","journal-title":"Head Neck Pathol"},{"key":"3650_CR19","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1007\/s12105-022-01423-y","volume":"16","author":"JKM Ng","year":"2022","unstructured":"Ng JKM, Chan JYK, Li JJX et al (2022) SMARCB1 (INI1)-deficient sinonasal carcinoma with yolk sac differentiation showing co-loss of SMARCA4 immunostaining- a case report and literature review. Head Neck Pathol 16:934\u2013941","journal-title":"Head Neck Pathol"},{"key":"3650_CR20","doi-asserted-by":"publisher","unstructured":"Skalova A, Agaimy, A, Van\u011b\u010dek T, Klub\u00ed\u010dkov\u00e1 N, Kiss, K, Baneckova M, Michal M (2023) SMARCB1-deficient sinonasal adenocarcinoma: rare variant of SWI\/SNF-deficient malignancy often misclassified as high-grade non-intestinal adenocarcinoma or myoepithelial carcinoma. Laboratory Investigation, (USCAP 2022 Abstracts: Head and Neck Pathology (1014\u20131081)), 1072\u20131073. https:\/\/doi.org\/10.1016\/j.labinv.2023.100092","DOI":"10.1016\/j.labinv.2023.100092"},{"key":"3650_CR21","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1177\/0194599812440932","volume":"147","author":"DA Reiersen","year":"2012","unstructured":"Reiersen DA, Pahilan ME, Devaiah AK (2012) Meta-analysis of treatment outcomes for sinonasal undifferentiated carcinoma. Otolaryngol Head Neck Surg 147:7\u201314","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"1","key":"3650_CR22","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s12105-013-0428-1","volume":"7","author":"CA French","year":"2013","unstructured":"French CA (2013) The importance of diagnosing NUT midline carcinoma. Head Neck Pathol 7(1):11\u201316","journal-title":"Head Neck Pathol"},{"issue":"2","key":"3650_CR23","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1097\/PAP.0000000000000391","volume":"30","author":"B Alzumaili","year":"2023","unstructured":"Alzumaili B, Sadow PM (2023) IDH2 -Mutated sinonasal tumors: a review. Adv Anat Pathol 30(2):104\u2013111","journal-title":"Adv Anat Pathol"},{"issue":"3","key":"3650_CR24","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1097\/PAP.0000000000000366","volume":"30","author":"A Agaimy","year":"2023","unstructured":"Agaimy A (2023) SWI\/SNF-deficient Malignancies: optimal candidates for immune-oncological therapy? Adv Anat Pathol 30(3):211\u2013217","journal-title":"Adv Anat Pathol"},{"issue":"D1","key":"3650_CR25","doi-asserted-by":"publisher","first-page":"D1062","DOI":"10.1093\/nar\/gkx1153","volume":"46","author":"MJ Landrum","year":"2018","unstructured":"Landrum MJ, Lee JM, Benson M, Brown GR, Chao C, Chitipiralla S, Gu B, Hart J, Hoffman D, Jang W, Karapetyan K, Katz K, Liu C, Maddipatla Z, Malheiro A, McDaniel K, Ovetsky M, Riley G, Zhou G, Holmes JB, Kattman BL, Maglott DR (2018) ClinVar: improving access to variant interpretations and supporting evidence. Nucleic Acids Res 46(D1):D1062\u2013D1067. https:\/\/doi.org\/10.1093\/nar\/gkx1153","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"3650_CR26","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s00428-018-2349-6","volume":"473","author":"P \u0160teiner","year":"2018","unstructured":"\u0160teiner P, Andreasen S, Grossmann P et al (2018) Prognostic significance of 1p36 locus deletion in adenoid cystic carcinoma of the salivary glands. Virchows Arch 473(4):471\u2013480. https:\/\/doi.org\/10.1007\/s00428-018-2349-6","journal-title":"Virchows Arch"},{"issue":"4","key":"3650_CR27","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/0022-2836(84)90315-2","volume":"178","author":"M Stern","year":"1984","unstructured":"Stern M, Jensen R, Herskowitz I (1984) Five SWI genes are required for expression of the HO gene in yeast. J Mol Biol 178(4):853\u201368","journal-title":"J Mol Biol"},{"key":"3650_CR28","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-023-10102-5","author":"D Reddy","year":"2023","unstructured":"Reddy D, Bhattacharya S, Workman JL (2023) (mis)-Targeting of SWI\/SNF complex(es) in cancer. Cancer Metastasis Rev. https:\/\/doi.org\/10.1007\/s10555-023-10102-5","journal-title":"Cancer Metastasis Rev"},{"key":"3650_CR29","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1111\/jcmm.17709","volume":"27","author":"Z Li","year":"2023","unstructured":"Li Z, Zhao J, Tang Y (2023) Advances in the role of SWI\/SNF complexes in tumours. J Cell Mol Med 27:1023\u20131031","journal-title":"J Cell Mol Med"},{"issue":"2","key":"3650_CR30","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0092-8674(00)00030-1","volume":"102","author":"DA Bochar","year":"2000","unstructured":"Bochar DA, Wang L, Beniya H, Kinev A, Xue Y, Lane WS, Wang W, Kashanchi F, Shiekhattar R (2000) BRCA1 is associated with a human SWI\/SNF-related complex: linking chromatin remodeling to breast cancer. Cell 102(2):257\u201365","journal-title":"Cell"},{"issue":"25","key":"3650_CR31","doi-asserted-by":"publisher","first-page":"22330","DOI":"10.1074\/jbc.M111987200","volume":"277","author":"D Lee","year":"2002","unstructured":"Lee D, Kim JW, Seo T, Hwang SG, Choi EJ, Choe J (2002) SWI\/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription. J Biol Chem 277(25):22330\u201322337","journal-title":"J Biol Chem"},{"key":"3650_CR32","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/s41571-020-0357-3","volume":"17","author":"P Mittal","year":"2020","unstructured":"Mittal P, Roberts CWM (2020) The SWI\/SNF complex in cancer - biology, biomarkers and therapy. Nat Rev Clin Oncol 17:435\u2013448","journal-title":"Nat Rev Clin Oncol"},{"issue":"11","key":"3650_CR33","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.1093\/nar\/27.11.2393","volume":"27","author":"J Brzeski","year":"1999","unstructured":"Brzeski J, Podstolski W, Olczak K, Jerzmanowski A (1999) Identification and analysis of the Arabidopsis thaliana BSH gene, a member of the SNF5 gene family. Nucleic Acids Res 27(11):2393\u20132399","journal-title":"Nucleic Acids Res"},{"key":"3650_CR34","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/28212","volume":"394","author":"I Versteege","year":"1998","unstructured":"Versteege I, S\u00e9venet N, Lange J et al (1998) Truncating mutations of hSNF5\/INI1 in aggressive paediatric cancer. Nature 394:203\u2013206","journal-title":"Nature"},{"issue":"15","key":"3650_CR35","doi-asserted-by":"publisher","first-page":"3645","DOI":"10.3390\/cancers14153645","volume":"14","author":"GW Cooper","year":"2022","unstructured":"Cooper GW, Hong AL (2022) SMARCB1-Deficient cancers: novel molecular insights and therapeutic vulnerabilities. Cancers (Basel) 14(15):3645","journal-title":"Cancers (Basel)"},{"issue":"834","key":"3650_CR36","doi-asserted-by":"publisher","first-page":"146638","DOI":"10.1016\/j.gene.2022.146638","volume":"5","author":"N Wang","year":"2022","unstructured":"Wang N, Qin Y, Du F, Wang X, Song C (2022) Prevalence of SWI\/SNF genomic alterations in cancer and association with the response to immune checkpoint inhibitors: a systematic review and meta-analysis. Gene 5(834):146638","journal-title":"Gene"},{"issue":"1","key":"3650_CR37","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1007\/s12105-022-01416-x","volume":"16","author":"A Agaimy","year":"2022","unstructured":"Agaimy A (2022) Proceedings of the North American Society of Head and Neck Pathology, Los Angeles, CA, March 20, 2022: SWI\/SNF-deficient Sinonasal Neoplasms: An Overview. Head Neck Pathol 16(1):168\u2013178","journal-title":"Head Neck Pathol"},{"issue":"2","key":"3650_CR38","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.ccell.2019.01.006","volume":"35","author":"A Carugo","year":"2019","unstructured":"Carugo A, Minelli R, Sapio L, Soeung M, Carbone F, Robinson FS, Tepper J, Chen Z, Lovisa S, Svelto M, Amin S, Srinivasan S, Del Poggetto E, Loponte S, Puca F, Dey P, Malouf GG, Su X, Li L, Lopez-Terrada D, Rakheja D, Lazar AJ, Netto GJ, Rao P, Sgambato A, Maitra A, Tripathi DN, Walker CL, Karam JA, Heffernan TP, Viale A, Roberts CWM, Msaouel P, Tannir NM, Draetta GF, Genovese G (2019) p53 is a master regulator of proteostasis in SMARCB1-deficient malignant rhabdoid tumors. Cancer Cell 35(2):204-220.e9","journal-title":"Cancer Cell"},{"issue":"3","key":"3650_CR39","doi-asserted-by":"publisher","first-page":"650","DOI":"10.3390\/biomedicines10030650","volume":"10","author":"C Ngo","year":"2022","unstructured":"Ngo C, Postel-Vinay S (2022) Immunotherapy for SMARCB1-deficient sarcomas: current evidence and future developments. Biomedicines 10(3):650","journal-title":"Biomedicines"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-023-03650-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-023-03650-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-023-03650-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T06:05:04Z","timestamp":1723788304000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00428-023-03650-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,12]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["3650"],"URL":"https:\/\/doi.org\/10.1007\/s00428-023-03650-2","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,12]]},"assertion":[{"value":"4 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the institutional review board of the Faculty of Medicine in Pilsen, Charles University. The procedures used in this study adhere to the tenets of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"No patient consent was required for this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}