{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:35:08Z","timestamp":1788878108683,"version":"build-2803163510"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Science Foundation of Peking University Cancer Hospital","award":["PY202303"],"award-info":[{"award-number":["PY202303"]}]},{"name":"General Program of National Natural Science Foundation of China","award":["82073247"],"award-info":[{"award-number":["82073247"]}]},{"name":"Beijing Municipal Administration of Hospitals Incubating Program","award":["PX2019038"],"award-info":[{"award-number":["PX2019038"]}]},{"name":"Beijing Youth Program for Outstanding Talents","award":["2018000021469G262"],"award-info":[{"award-number":["2018000021469G262"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s00428-024-03754-3","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T04:30:43Z","timestamp":1707798643000},"page":"243-255","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Heterogeneity of molecular subtyping and therapy-related marker expression in primary tumors and paired lymph node metastases of small cell lung cancer"],"prefix":"10.1007","volume":"486","author":[{"given":"Yanli","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiwen","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minglei","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1671-2622","authenticated-orcid":false,"given":"Dongmei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"issue":"1","key":"3754_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41572-020-00235-0","volume":"7","author":"CM Rudin","year":"2021","unstructured":"Rudin CM, Brambilla E, Faivre-Finn C, Sage J (2021) Small-cell lung cancer. Nat Rev Dis Primers 7(1):3. https:\/\/doi.org\/10.1038\/s41572-020-00235-0","journal-title":"Nat Rev Dis Primers"},{"issue":"5","key":"3754_CR2","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/s41568-019-0133-9","volume":"19","author":"CM Rudin","year":"2019","unstructured":"Rudin CM, Poirier JT, Byers LA, Dive C, Dowlati A, George J, Heymach JV, Johnson JE, Lehman JM, MacPherson D, Massion PP, Minna JD, Oliver TG, Quaranta V, Sage J, Thomas RK, Vakoc CR, Gazdar AF (2019) Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. Nat Rev Cancer 19(5):289\u2013297. https:\/\/doi.org\/10.1038\/s41568-019-0133-9","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"3754_CR3","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.ccell.2020.12.014","volume":"39","author":"CM Gay","year":"2021","unstructured":"Gay CM, Stewart CA, Park EM, Diao L, Groves SM, Heeke S, Nabet BY, Fujimoto J, Solis LM, Lu W, Xi Y, Cardnell RJ, Wang Q, Fabbri G, Cargill KR, Vokes NI, Ramkumar K, Zhang B, Della CC, Robson P, Swisher SG, Roth JA, Glisson BS, Shames DS, Wistuba II, Wang J, Quaranta V, Minna J, Heymach JV, Byers LA (2021) Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities. Cancer Cell 39(3):346\u2013360. https:\/\/doi.org\/10.1016\/j.ccell.2020.12.014","journal-title":"Cancer Cell"},{"issue":"2","key":"3754_CR4","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.ccell.2016.12.005","volume":"31","author":"G Mollaoglu","year":"2017","unstructured":"Mollaoglu G, Guthrie MR, B\u00f6hm S, Br\u00e4gelmann J, Can I, Ballieu PM, Marx A, George J, Heinen C, Chalishazar MD, Cheng H, Ireland AS, Denning KE, Mukhopadhyay A, Vahrenkamp JM, Berrett KC, Mosbruger TL, Wang J, Kohan JL, Salama ME, Witt BL, Peifer M, Thomas RK, Gertz J, Johnson JE, Gazdar AF, Wechsler-Reya RJ, Sos ML, Oliver TG (2017) MYC drives progression of small cell lung cancer to a variant neuroendocrine subtype with vulnerability to aurora kinase inhibition. Cancer Cell 31(2):270\u2013285. https:\/\/doi.org\/10.1016\/j.ccell.2016.12.005","journal-title":"Cancer Cell"},{"issue":"4","key":"3754_CR5","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.jtho.2020.01.016","volume":"15","author":"JT Poirier","year":"2020","unstructured":"Poirier JT, George J, Owonikoko TK, Berns A, Brambilla E, Byers LA, Carbone D, Chen HJ, Christensen CL, Dive C, Farago AF, Govindan R, Hann C, Hellmann MD, Horn L, Johnson JE, Ju YS, Kang S, Krasnow M, Lee J, Lee SH, Lehman J, Lok B, Lovly C, MacPherson D, McFadden D, Minna J, Oser M, Park K, Park KS, Pommier Y, Quaranta V, Ready N, Sage J, Scagliotti G, Sos ML, Sutherland KD, Travis WD, Vakoc CR, Wait SJ, Wistuba I, Wong KK, Zhang H, Daigneault J, Wiens J, Rudin CM, Oliver TG (2020) New approaches to SCLC therapy: from the laboratory to the clinic. J Thorac Oncol 15(4):520\u2013540. https:\/\/doi.org\/10.1016\/j.jtho.2020.01.016","journal-title":"J Thorac Oncol"},{"key":"3754_CR6","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.omto.2021.02.004","volume":"20","author":"A Schwendenwein","year":"2021","unstructured":"Schwendenwein A, Megyesfalvi Z, Barany N, Valko Z, Bugyik E, Lang C, Ferencz B, Paku S, Lantos A, Fillinger J, Rezeli M, Marko-Varga G, Bogos K, Galffy G, Renyi-Vamos F, Hoda MA, Klepetko W, Hoetzenecker K, Laszlo V, Dome B (2021) Molecular profiles of small cell lung cancer subtypes: therapeutic implications. Mol Ther Oncol 20:470\u2013483. https:\/\/doi.org\/10.1016\/j.omto.2021.02.004","journal-title":"Mol Ther Oncol"},{"key":"3754_CR7","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.lungcan.2017.11.018","volume":"115","author":"K Tanaka","year":"2018","unstructured":"Tanaka K, Isse K, Fujihira T, Takenoyama M, Saunders L, Bheddah S, Nakanishi Y, Okamoto I (2018) Prevalence of Delta-like protein 3 expression in patients with small cell lung cancer. Lung Cancer 115:116\u2013120. https:\/\/doi.org\/10.1016\/j.lungcan.2017.11.018","journal-title":"Lung Cancer"},{"issue":"5","key":"3754_CR8","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1158\/1078-0432.CCR-20-2845","volume":"27","author":"MJ Giffin","year":"2021","unstructured":"Giffin MJ, Cooke K, Lobenhofer EK, Estrada J, Zhan J, Deegen P, Thomas M, Murawsky CM, Werner J, Liu S, Lee F, Homann O, Friedrich M, Pearson JT, Raum T, Yang Y, Caenepeel S, Stevens J, Beltran PJ, Canon J, Coxon A, Bailis JM, Hughes PE (2021) AMG 757, a half-life extended, DLL3-targeted bispecific T-cell engager, shows high potency and sensitivity in preclinical models of small-cell lung cancer. Clin Cancer Res 27(5):1526\u20131537. https:\/\/doi.org\/10.1158\/1078-0432.CCR-20-2845","journal-title":"Clin Cancer Res"},{"issue":"1","key":"3754_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2020.100883","volume":"14","author":"P Vitorino","year":"2021","unstructured":"Vitorino P, Chuang CH, Iannello A, Zhao X, Anderson W, Ferrando R, Zhang Z, Madhavan S, Karsunky H, Saunders LR (2021) Rova-T enhances the anti-tumor activity of anti-PD1 in a murine model of small cell lung cancer with endogenous Dll3 expression. Transl Oncol 14(1):100883. https:\/\/doi.org\/10.1016\/j.tranon.2020.100883","journal-title":"Transl Oncol"},{"issue":"2","key":"3754_CR10","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.jtho.2019.10.013","volume":"15","author":"TK Owonikoko","year":"2020","unstructured":"Owonikoko TK, Niu H, Nackaerts K, Csoszi T, Ostoros G, Mark Z, Baik C, Joy AA, Chouaid C, Jaime JC, Kolek V, Majem M, Roubec J, Santos ES, Chiang AC, Speranza G, Belani CP, Chiappori A, Patel MR, Czebe K, Byers L, Bahamon B, Li C, Sheldon-Waniga E, Kong EF, Williams M, Badola S, Shin H, Bedford L, Ecsedy JA, Bryant M, Jones S, Simmons J, Leonard EJ, Ullmann CD, Spigel DR (2020) Randomized phase II study of paclitaxel plus alisertib versus paclitaxel plus placebo as second-line therapy for SCLC: primary and correlative biomarker analyses. J Thorac Oncol 15(2):274\u2013287. https:\/\/doi.org\/10.1016\/j.jtho.2019.10.013","journal-title":"J Thorac Oncol"},{"issue":"23","key":"3754_CR11","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1056\/NEJMoa1809064","volume":"379","author":"L Horn","year":"2018","unstructured":"Horn L, Mansfield AS, Szcz\u0119sna A, Havel L, Krzakowski M, Hochmair MJ, Huemer F, Losonczy G, Johnson ML, Nishio M, Reck M, Mok T, Lam S, Shames DS, Liu J, Ding B, Lopez-Chavez A, Kabbinavar F, Lin W, Sandler A, Liu SV (2018) First-line atezolizumab plus chemotherapy in extensive-stage small-cell lung cancer. N Engl J Med 379(23):2220\u20132229. https:\/\/doi.org\/10.1056\/NEJMoa1809064","journal-title":"N Engl J Med"},{"issue":"10212","key":"3754_CR12","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1016\/S0140-6736(19)32222-6","volume":"394","author":"L Paz-Ares","year":"2019","unstructured":"Paz-Ares L, Dvorkin M, Chen Y, Reinmuth N, Hotta K, Trukhin D, Statsenko G, Hochmair MJ, \u00d6zg\u00fcro\u011flu M, Ji JH, Voitko O, Poltoratskiy A, Ponce S, Verderame F, Havel L, Bondarenko I, Kazarnowicz A, Losonczy G, Conev NV, Armstrong J, Byrne N, Shire N, Jiang H, Goldman JW (2019) Durvalumab plus platinum-etoposide versus platinum-etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial. Lancet 394(10212):1929\u20131939. https:\/\/doi.org\/10.1016\/S0140-6736(19)32222-6","journal-title":"Lancet"},{"issue":"8","key":"3754_CR13","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1158\/2159-8290.CD-20-0913","volume":"11","author":"NR Mahadevan","year":"2021","unstructured":"Mahadevan NR, Knelson EH, Wolff JO, Vajdi A, Saig\u00ed M, Campisi M, Hong D, Thai TC, Piel B, Han S, Reinhold BB, Duke-Cohan JS, Poitras MJ, Taus LJ, Lizotte PH, Portell A, Quadros V, Santucci AD, Murayama T, Ca\u00f1adas I, Kitajima S, Akitsu A, Fridrikh M, Watanabe H, Reardon B, Gokhale PC, Paweletz CP, Awad MM, Van Allen EM, Lako A, Wang XT, Chen B, Hong F, Sholl LM, Tolstorukov MY, Pfaff K, J\u00e4nne PA, Gjini E, Edwards R, Rodig S, Reinherz EL, Oser MG, Barbie DA (2021) Intrinsic immunogenicity of small cell lung carcinoma revealed by its cellular plasticity. Cancer Discov 11(8):1952\u20131969. https:\/\/doi.org\/10.1158\/2159-8290.CD-20-0913","journal-title":"Cancer Discov"},{"issue":"9","key":"3754_CR14","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1016\/j.jtho.2023.05.008","volume":"18","author":"CM Rudin","year":"2023","unstructured":"Rudin CM, Balli D, Lai WV, Richards AL, Nguyen E, Egger JV, Choudhury NJ, Sen T, Chow A, Poirier JT, Geese WJ, Hellmann MD, Forslund A (2023) Clinical benefit from immunotherapy in patients with SCLC is associated with tumor capacity for antigen presentation. J Thorac Oncol 18(9):1222\u20131232. https:\/\/doi.org\/10.1016\/j.jtho.2023.05.008","journal-title":"J Thorac Oncol"},{"issue":"1","key":"3754_CR15","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.ccell.2020.05.001","volume":"38","author":"AS Ireland","year":"2020","unstructured":"Ireland AS, Micinski AM, Kastner DW, Guo B, Wait SJ, Spainhower KB, Conley CC, Chen OS, Guthrie MR, Soltero D, Qiao Y, Huang X, Tarapcs\u00e1k S, Devarakonda S, Chalishazar MD, Gertz J, Moser JC, Marth G, Puri S, Witt BL, Spike BT, Oliver TG (2020) MYC drives temporal evolution of small cell lung cancer subtypes by reprogramming neuroendocrine fate. Cancer Cell 38(1):60\u201378. https:\/\/doi.org\/10.1016\/j.ccell.2020.05.001","journal-title":"Cancer Cell"},{"issue":"12","key":"3754_CR16","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1016\/j.jtho.2020.09.009","volume":"15","author":"MK Baine","year":"2020","unstructured":"Baine MK, Hsieh MS, Lai WV, Egger JV, Jungbluth AA, Daneshbod Y, Beras A, Spencer R, Lopardo J, Bodd F, Montecalvo J, Sauter JL, Chang JC, Buonocore DJ, Travis WD, Sen T, Poirier JT, Rudin CM, Rekhtman N (2020) SCLC subtypes defined by ASCL1, NEUROD1, POU2F3, and YAP1: a comprehensive immunohistochemical and histopathologic characterization. J Thorac Oncol 15(12):1823\u20131835. https:\/\/doi.org\/10.1016\/j.jtho.2020.09.009","journal-title":"J Thorac Oncol"},{"issue":"1","key":"3754_CR17","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.jtho.2021.08.763","volume":"17","author":"S Qu","year":"2022","unstructured":"Qu S, Fetsch P, Thomas A, Pommier Y, Schrump DS, Miettinen MM, Chen H (2022) Molecular subtypes of primary SCLC tumors and their associations with neuroendocrine and therapeutic markers. J Thorac Oncol 17(1):141\u2013153. https:\/\/doi.org\/10.1016\/j.jtho.2021.08.763","journal-title":"J Thorac Oncol"},{"issue":"5","key":"3754_CR18","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1002\/path.5922","volume":"257","author":"Z Megyesfalvi","year":"2022","unstructured":"Megyesfalvi Z, Barany N, Lantos A, Valko Z, Pipek O, Lang C, Schwendenwein A, Oberndorfer F, Paku S, Ferencz B, Dezso K, Fillinger J, Lohinai Z, Moldvay J, Galffy G, Szeitz B, Rezeli M, Rivard C, Hirsch FR, Brcic L, Popper H, Kern I, Kovacevic M, Skarda J, Mittak M, Marko-Varga G, Bogos K, Renyi-Vamos F, Hoda MA, Klikovits T, Hoetzenecker K, Schelch K, Laszlo V, Dome B (2022) Expression patterns and prognostic relevance of subtype-specific transcription factors in surgically resected small-cell lung cancer: an international multicenter study. J Pathol 257(5):674\u2013686. https:\/\/doi.org\/10.1002\/path.5922","journal-title":"J Pathol"},{"key":"3754_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.779276","volume":"12","author":"J Qi","year":"2022","unstructured":"Qi J, Zhang J, Liu N, Zhao L, Xu B (2022) Prognostic implications of molecular subtypes in primary small cell lung cancer and their correlation with cancer immunity. Front Oncol 12:779276. https:\/\/doi.org\/10.3389\/fonc.2022.779276","journal-title":"Front Oncol"},{"issue":"9","key":"3754_CR20","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.jtho.2022.06.004","volume":"17","author":"MK Baine","year":"2022","unstructured":"Baine MK, Febres-Aldana CA, Chang JC, Jungbluth AA, Sethi S, Antonescu CR, Travis WD, Hsieh MS, Roh MS, Homer RJ, Ladanyi M, Egger JV, Lai WV, Rudin CM, Rekhtman N (2022) POU2F3 in SCLC: clinicopathologic and genomic analysis with a focus on its diagnostic utility in neuroendocrine-low SCLC. J Thorac Oncol 17(9):1109\u20131121. https:\/\/doi.org\/10.1016\/j.jtho.2022.06.004","journal-title":"J Thorac Oncol"},{"issue":"6","key":"3754_CR21","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1111\/his.14872","volume":"82","author":"T Handa","year":"2023","unstructured":"Handa T, Hayashi T, Ura A, Watanabe I, Takamochi K, Onagi H, Kishi M, Matsumoto N, Tajima K, Kishikawa S, Saito T, Takahashi K, Suzuki K, Yao T (2023) Comparison of ASCL1, NEUROD1, and POU2F3 expression in surgically resected specimens, paired tissue microarrays, and lymph node metastases in small cell lung carcinoma. Histopathology 82(6):860\u2013869. https:\/\/doi.org\/10.1111\/his.14872","journal-title":"Histopathology"},{"issue":"7","key":"3754_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2023.100184","volume":"36","author":"S Hwang","year":"2023","unstructured":"Hwang S, Hong TH, Kim HK, Choi YS, Zo JI, Shim YM, Han J, Chan AY, Pyo H, Noh JM, Lee HY, Kim HJ, Park S, Ahn MJ, Park K, Lee SH, Choi YL, Kim J (2023) Whole-section landscape analysis of molecular subtypes in curatively resected small cell lung cancer: clinicopathologic features and prognostic significance. Mod Pathol 36(7):100184. https:\/\/doi.org\/10.1016\/j.modpat.2023.100184","journal-title":"Mod Pathol"},{"key":"3754_CR23","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.lungcan.2020.05.012","volume":"146","author":"Y Ikematsu","year":"2020","unstructured":"Ikematsu Y, Tanaka K, Toyokawa G, Ijichi K, Ando N, Yoneshima Y, Iwama E, Inoue H, Tagawa T, Nakanishi Y, Okamoto I (2020) NEUROD1 is highly expressed in extensive-disease small cell lung cancer and promotes tumor cell migration. Lung Cancer 146:97\u2013104. https:\/\/doi.org\/10.1016\/j.lungcan.2020.05.012","journal-title":"Lung Cancer"},{"issue":"6","key":"3754_CR24","doi-asserted-by":"publisher","first-page":"938","DOI":"10.21037\/tlcr.2019.11.30","volume":"8","author":"Z Lohinai","year":"2019","unstructured":"Lohinai Z, Megyesfalvi Z, Suda K, Harko T, Ren S, Moldvay J, Laszlo V, Rivard C, Dome B, Hirsch FR (2019) Comparative expression analysis in small cell lung carcinoma reveals neuroendocrine pattern change in primary tumor versus lymph node metastases. Transl Lung Cancer Res 8(6):938\u2013950. https:\/\/doi.org\/10.21037\/tlcr.2019.11.30","journal-title":"Transl Lung Cancer Res"},{"issue":"1","key":"3754_CR25","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1038\/s41467-022-29517-9","volume":"13","author":"D Lissa","year":"2022","unstructured":"Lissa D, Takahashi N, Desai P, Manukyan I, Schultz CW, Rajapakse V, Velez MJ, Mulford D, Roper N, Nichols S, Vilimas R, Sciuto L, Chen Y, Guha U, Rajan A, Atkinson D, El MR, Weaver OZ, Thomas A (2022) Heterogeneity of neuroendocrine transcriptional states in metastatic small cell lung cancers and patient-derived models. Nat Commun 13(1):2023. https:\/\/doi.org\/10.1038\/s41467-022-29517-9","journal-title":"Nat Commun"},{"issue":"22","key":"3754_CR26","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1056\/NEJMc2004224","volume":"382","author":"HJ de Koning","year":"2020","unstructured":"de Koning HJ, van der Aalst CM, Oudkerk M (2020) Lung-Cancer Screening and the NELSON Trial. Reply N Engl J Med 382(22):2165\u20132166. https:\/\/doi.org\/10.1056\/NEJMc2004224","journal-title":"Reply N Engl J Med"},{"issue":"7","key":"3754_CR27","doi-asserted-by":"publisher","first-page":"4457","DOI":"10.1007\/s00330-022-08589-7","volume":"32","author":"A Kerpel-Fronius","year":"2022","unstructured":"Kerpel-Fronius A, Monostori Z, Kovacs G, Ostoros G, Horvath I, Solymosi D, Pipek O, Szatmari F, Kovacs A, Markoczy Z, Rojko L, Renyi-Vamos F, Hoetzenecker K, Bogos K, Megyesfalvi Z, Dome B (2022) Nationwide lung cancer screening with low-dose computed tomography: implementation and first results of the HUNCHEST screening program. Eur Radiol 32(7):4457\u20134467. https:\/\/doi.org\/10.1007\/s00330-022-08589-7","journal-title":"Eur Radiol"},{"key":"3754_CR28","unstructured":"Travis WD, Beasley MB, Cree IA, Papotti M, Rekhtman A, Rossi G (2021) The WHO Classifications of Tumours Editorial Board (ed) Thoracic tumours, 5th edn. International Agency for Research on Cancer, Lyon, pp 139"},{"key":"3754_CR29","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1186\/s13000-014-0221-9","volume":"9","author":"N Fedchenko","year":"2014","unstructured":"Fedchenko N, Reifenrath J (2014) Different approaches for interpretation and reporting of immunohistochemistry analysis results in the bone tissue - a review. Diagn Pathol 9:221. https:\/\/doi.org\/10.1186\/s13000-014-0221-9","journal-title":"Diagn Pathol"},{"issue":"1","key":"3754_CR30","doi-asserted-by":"publisher","first-page":"32","DOI":"10.21037\/tlcr.2018.02.02","volume":"7","author":"W Zhang","year":"2018","unstructured":"Zhang W, Girard L, Zhang YA, Haruki T, Papari-Zareei M, Stastny V, Ghayee HK, Pacak K, Oliver TG, Minna JD, Gazdar AF (2018) Small cell lung cancer tumors and preclinical models display heterogeneity of neuroendocrine phenotypes. Transl Lung Cancer Res 7(1):32\u201349. https:\/\/doi.org\/10.21037\/tlcr.2018.02.02","journal-title":"Transl Lung Cancer Res"},{"issue":"10","key":"3754_CR31","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1111\/cas.13013","volume":"107","author":"T Ito","year":"2016","unstructured":"Ito T, Matsubara D, Tanaka I, Makiya K, Tanei ZI, Kumagai Y, Shiu SJ, Nakaoka HJ, Ishikawa S, Isagawa T, Morikawa T, Shinozaki-Ushiku A, Goto Y, Nakano T, Tsuchiya T, Tsubochi H, Komura D, Aburatani H, Dobashi Y, Nakajima J, Endo S, Fukayama M, Sekido Y, Niki T, Murakami Y (2016) Loss of YAP1 defines neuroendocrine differentiation of lung tumors. Cancer Sci 107(10):1527\u20131538. https:\/\/doi.org\/10.1111\/cas.13013","journal-title":"Cancer Sci"},{"issue":"1","key":"3754_CR32","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s12957-022-02528-y","volume":"20","author":"XL Ding","year":"2022","unstructured":"Ding XL, Su YG, Yu L, Bai ZL, Bai XH, Chen XZ, Yang X, Zhao R, He JX, Wang YY (2022) Clinical characteristics and patient outcomes of molecular subtypes of small cell lung cancer (SCLC). World J Surg Oncol 20(1):54. https:\/\/doi.org\/10.1186\/s12957-022-02528-y","journal-title":"World J Surg Oncol"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-024-03754-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-024-03754-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-024-03754-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T13:23:49Z","timestamp":1741008229000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00428-024-03754-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,13]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["3754"],"URL":"https:\/\/doi.org\/10.1007\/s00428-024-03754-3","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,13]]},"assertion":[{"value":"25 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by the Ethics Committee of Peking University Cancer Hospital and the local review board (No. 2023KT23).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The need for individual informed consent for this retrospective study was waived.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}