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Previous studies have demonstrated the impact of epigenomic analyses in the diagnostics of sellar neoplasms and characterized the close relationship of epigenomic signatures and cellular origins of PitNET\/adenomas. As of today, little is known about the pathogenesis of ectopic PitNET\/adenomas, and epigenomic analyses have not been performed in these rare tumors. We report on the clinical course of an 81-year-old patient with sphenoid ectopic sparsely granulated corticotroph PitNET\/adenoma and deploy genome-wide DNA methylation analysis to compare its methylation profile to a reference cohort of sellar neoplasms. Genome-wide methylation analysis revealed an epigenomic profile analogous to reference sellar corticotroph PitNET\/adenomas, and the copy number variation profile showed loss of chromosomes 18 and 22. The methylation profile shows concordance with sellar corticotroph PitNET\/adenomas suggesting a common cellular origin and confirming the reliability of methylation analyses as a diagnostic method in these rare tumors. This is the first data suggesting that epigenetic profiles of ectopic PitNET\/adenoma do not differ from their sellar counterparts.<\/jats:p>","DOI":"10.1007\/s00428-024-03760-5","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T23:02:07Z","timestamp":1707778927000},"page":"393-398","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparative epigenomics indicate a common origin of ectopic and intrasellar corticotroph pituitary neuroendocrine tumors\/adenomas: a case report"],"prefix":"10.1007","volume":"486","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9988-4667","authenticated-orcid":false,"given":"Alonso","family":"Barrantes-Freer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Braune","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Sandner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Dottermusch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Lindner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"key":"3760_CR1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1111\/j.1365-2265.1979.tb03047.x","volume":"11","author":"P Rasmussen","year":"1979","unstructured":"Rasmussen P, Lindholm J (1979) Ectopic pituitary adenomas. 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The report is based on surgically removed tissue in the context of routine diagnostic workup and represents a retrospective observational study of a single case. Therefore, the Ethics Committee of the medical faculty of the University Medical Center Leipzig (UKL) has confirmed that no ethical approval is required as regulated by paragraph 15 of the professional regulation of the Medical Association of Saxony, Germany (\u00a715 BO, SL\u00c4K).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from the participant included in the report and the participant has consented to the submission of the case report to the journal.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}