{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:18:38Z","timestamp":1792001918595,"version":"4.4.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s00428-024-03904-7","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T02:02:13Z","timestamp":1725328933000},"page":"721-727","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Insulinoma-associated protein-1 (INSM-1) is a useful diagnostic marker for the evaluation of primary thymic neuroendocrine neoplasms: an immunohistochemical study of 27 cases"],"prefix":"10.1007","volume":"486","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7986-4340","authenticated-orcid":false,"given":"David","family":"Suster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davis","family":"Chacko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"VanderLaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Mino-Kenudson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin P.","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,3]]},"reference":[{"key":"3904_CR1","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1097\/PAS.0000000000000916","volume":"41","author":"LM Rooper","year":"2017","unstructured":"Rooper LM, Sharma R, Li QK, Illei PB, Westra WH (2017) INSM1 demonstrates superior performance to the individual and combined use of synaptophysin, chromogranin, and CD56 for diagnosing neuroendocrine tumors of the thoracic cavity. Am J Surg Pathol 41:1561\u20131569","journal-title":"Am J Surg Pathol"},{"key":"3904_CR2","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.3390\/ijms24021418","volume":"24","author":"A-A Gheorghistan-Galateanu","year":"2023","unstructured":"Gheorghistan-Galateanu A-A, Iliesiu A, Lambrescu IM, Tapoi DA (2023) The complex histopathological and immunohistochemical spectrum of neuroendocrine tumors \u2013 an overview of the latest classifications. Int J Mol Sci 24:1418","journal-title":"Int J Mol Sci"},{"key":"3904_CR3","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s12022-020-09645-y","volume":"31","author":"CC Juhlin","year":"2020","unstructured":"Juhlin CC, Zedenius J, Hoog A (2020) Clinical routine application of the second-generation neuroendocrine markers ISL1, INSM1, and secretagogin in neuroendocrine neoplasia: staining outcomes and potential clues for determining tumor origin. Endocr Pathol 31:401\u2013410","journal-title":"Endocr Pathol"},{"key":"3904_CR4","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1093\/ajcp\/aqx071","volume":"148","author":"JE Love","year":"2017","unstructured":"Love JE, Thompson K, Kilgore MR, Westerhoff M, Murphy CE, Papanicolao-Sengos A et al (2017) CD200 expression in neuroendocrine neoplasms. Am J Clin Pathol 148:236\u2013242","journal-title":"Am J Clin Pathol"},{"key":"3904_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2024.100442","volume":"37","author":"A Grass","year":"2024","unstructured":"Grass A, Kasajima A, Foersch S, Kriegsmann M, Brobeil A, Schmitt M et al (2024) PITX2 as a sensitive and specific marker of midgut neuroendocrine tumors: results from a cohort of 1157 primary neuroendocrine neoplasms. Mod Pathol 37:100442","journal-title":"Mod Pathol"},{"key":"3904_CR6","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1038\/s41416-023-02448-y","volume":"129","author":"M Shen","year":"2023","unstructured":"Shen M, Liu S, Toland A, Hsu E-C, Hartono AB, Alabi BR et al (2023) ACAA2 is a novel molecular indicator for cancers with neuroendocrine phenotype. Bri J Cancer 129:1818\u20131828","journal-title":"Bri J Cancer"},{"key":"3904_CR7","doi-asserted-by":"publisher","first-page":"288","DOI":"10.5858\/arpa.2015-0489-OA","volume":"141","author":"D Altree-Tacha","year":"2017","unstructured":"Altree-Tacha D, Tyrell J, Li F (2017) mASH1 is highly specific for neuroendocrine carcinomas: an immunohistochemical evaluation of normal and various neoplastic tissues. Arch Pathol Lab Med 141:288\u2013292","journal-title":"Arch Pathol Lab Med"},{"key":"3904_CR8","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1309\/AJCPGZWXXBSNL4VD","volume":"144","author":"JN Rosenbaum","year":"2015","unstructured":"Rosenbaum JN, Guo Z, Baus RM, Werner H, Rehrauer WM, Lloyd RV (2015) INSM1: a novel immunohistochemical and molecular marker for neuroendocrine and neuroepithelial neoplasms. Am J Clin Pathol 144:579\u2013591","journal-title":"Am J Clin Pathol"},{"key":"3904_CR9","doi-asserted-by":"publisher","first-page":"15252","DOI":"10.1016\/S0021-9258(18)42173-4","volume":"267","author":"Y Goto","year":"1992","unstructured":"Goto Y, De Silva MG, Toscani A, Prabhakar BS, Notkins AL, Lan MS (1992) A novel human insulinoma-associated cDNA, IA-1, encodes a protein with \u201czinc-finger\u201d DNA binding motifs. J Biol Chem 267:15252\u201315257","journal-title":"J Biol Chem"},{"issue":"581","key":"3904_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2023.112106","volume":"1","author":"K Moller","year":"2024","unstructured":"Moller K, Uhlig R, Gorbokon N, Dum D, Menz A, Buscheck F et al (2024) Comparison of INSM1 immunostaining with established neuroendocrine markers synaptophysin and chromogranin A in over 14,000 neuroendocrine and non-neuroendocrine tumors. Mol Cell Endocrinol 1(581):112106","journal-title":"Mol Cell Endocrinol"},{"key":"3904_CR11","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41379-018-0122-7","volume":"32","author":"S Mukhopadhayay","year":"2019","unstructured":"Mukhopadhayay S, Dermawan JK, Lanigan CP, Farver CF (2019) Insulinoma-associated protein-1 (INSM1) is a sensitive and highly specific marker of neuroendocrine differentiation in primary lung neoplasms: an immunohistochemical study of 345 cases, including 292 whole-tissue sections. Mod Pathol 32:100\u2013109","journal-title":"Mod Pathol"},{"key":"3904_CR12","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.5858\/arpa.2019-0250-OA","volume":"144","author":"J Staaf","year":"2020","unstructured":"Staaf J, Tran L, Soderlund L, Nodin B, Jirstrom K, Vidarsdottir H, Planck M, Mattsson JSM, Botling J, Micke P, Brunnstrom H (2020) Diagnostic value of Insulinoma-associated protein 1 (INSM1) and comparison with established neuroendocrine markers. Arch Pathol Lab Med 144:1075\u20131085","journal-title":"Arch Pathol Lab Med"},{"key":"3904_CR13","doi-asserted-by":"publisher","first-page":"8110820","DOI":"10.1093\/ajcp\/aqaa014","volume":"153","author":"KE McHugh","year":"2020","unstructured":"McHugh KE, Mukhopadhyay S, Doxtader EE, Lanigan C, Allende DS (2020) INSM1 is a highly specific marker of neuroendocrine differentiation in primary neoplasms of the gastrointestinal tract, appendix, and pancreas. Am J Clin Pathol 153:8110820","journal-title":"Am J Clin Pathol"},{"key":"3904_CR14","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.humpath.2019.12.002","volume":"96","author":"AM Bellizi","year":"2020","unstructured":"Bellizi AM (2020) Immunohistochemistry in the diagnosis and classification of neuroendocrine neoplasms: what can brown do for you? Hum Pathol 96:8\u201333","journal-title":"Hum Pathol"},{"key":"3904_CR15","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.jasc.2019.06.002","volume":"8","author":"K Viswanathan","year":"2019","unstructured":"Viswanathan K, Sidiqqi M, Borczuk A (2019) Insulinoma-associated protein-1 is a sensitive and specific marker for lung neuroendocrine tumors in cytological and surgical specimens. J Am Soc Cytopathol 8:299\u2013308","journal-title":"J Am Soc Cytopathol"},{"key":"3904_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11912-022-01346-5","volume":"25","author":"A Weissferdt","year":"2023","unstructured":"Weissferdt A, Sepesi B, Ning J, Hermsen M, Ferraroto R, Glisson B, Hanna E, Bell D (2023) Optimal combination of neuroendocrine markers for the detection of high-grade neuroendocrine tumors of the sinonasal tract and lung. Current Oncol Rep 25:1\u201310","journal-title":"Current Oncol Rep"},{"key":"3904_CR17","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1002\/jso.25960","volume":"122","author":"K Minami","year":"2020","unstructured":"Minami K, Jimbo N, Tanaka Y, Ogawa H, Hokka D, Nishio W et al (2020) Insulinoma-associated protein 1 is a prognostic biomarker in pulmonary high-grade neuroendocrine carcinoma. J Surg Oncol 122:243\u2013253","journal-title":"J Surg Oncol"},{"key":"3904_CR18","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1038\/s41379-020-0517-0","volume":"33","author":"HK Tsai","year":"2020","unstructured":"Tsai HK, Hornick JL, Vivero M (2020) INSM1 expression in a subset of thoracic malignancies and small round cell tumors: rare potential pitfalls for small cell carcinoma. Mod Pathol 33:1571\u20131580","journal-title":"Mod Pathol"},{"key":"3904_CR19","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1007\/s00428-022-03437-x","volume":"481","author":"J Kashima","year":"2022","unstructured":"Kashima J, Hashimoto T, Yoshida A, Goto Y, Ushiku T, Ohe Y et al (2022) Insulinoma-associated-1 (INSDM1) expression in thymic squamous cell carcinoma. Virchows Arch 481:893\u2013901","journal-title":"Virchows Arch"},{"key":"3904_CR20","volume-title":"Thoracic Tumours","author":"WHO Classification Tumours Editorial Board","year":"2021","unstructured":"WHO Classification Tumours Editorial Board (2021) Thoracic tumours. International Agency for Research on Cancer, Lyon"},{"key":"3904_CR21","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1309\/3PDN-PMT5-EQTM-H0CD","volume":"114","author":"CA Moran","year":"2000","unstructured":"Moran CA, Suster S (2000) Neuroendocrine carcinomas (thymic carcinoid) of the thymus: clinicopathologic study of 80 cases. Am J Clin Pathol 114:100\u2013110","journal-title":"Am J Clin Pathol"},{"issue":"Suppl. 1","key":"3904_CR22","first-page":"17","volume":"115","author":"S Suster","year":"2001","unstructured":"Suster S, Moran CA (2001) Neuroendocrine neoplasms of the mediastinum. Am J Clin Pathol 115(Suppl. 1):17\u201327","journal-title":"Am J Clin Pathol"},{"key":"3904_CR23","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1097\/00000478-200209000-00009","volume":"26","author":"SA Nicholson","year":"2002","unstructured":"Nicholson SA, Beasley MB, Brambilla E et al (2002) Small cell lung carcinoma (SCLC): a clinicopathologic study of 100 cases with surgical specimens. Am J Surg Pathol 26:1184\u20131197","journal-title":"Am J Surg Pathol"},{"key":"3904_CR24","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1038\/sj.emboj.7601011","volume":"25","author":"G Mellitzer","year":"2006","unstructured":"Mellitzer G, Bonne S, Luco RF et al (2006) IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas. EMBO J 25:1344\u20131352","journal-title":"EMBO J"},{"key":"3904_CR25","doi-asserted-by":"publisher","first-page":"E2662","DOI":"10.1002\/lary.29554","volume":"131","author":"C Yuan","year":"2021","unstructured":"Yuan C, Jiao F, Zhai C, Zhang J, Wang S, Zhu L (2021) Application of INSM1 in diagnosis and grading of laryngeal neuroendocrine carcinoma. Laryngoscope 131:E2662\u2013E2668","journal-title":"Laryngoscope"},{"key":"3904_CR26","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s12105-021-01367-9","volume":"16","author":"M Bal","year":"2020","unstructured":"Bal M, Sharma A, Rane SU, Mittal N, Chaukar D, Prabash K, Patil A (2020) Neuroendocrine neoplasms of the larynx: a clinicopathologic analysis of 27 neuroendocrine tumors and neuroendocrine carcinomas. Head Neck Pathol 16:375\u2013387","journal-title":"Head Neck Pathol"},{"key":"3904_CR27","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1007\/s12022-021-09682-1","volume":"32","author":"J Metovic","year":"2021","unstructured":"Metovic J, Castellano I, Marinelli E, Osella-Abate S, Sapino A, Cassoni P, Papotti M (2021) INSM1 expression in breast neoplasms with neuroendocrine features. Endocr Pathol 32:452\u2013460","journal-title":"Endocr Pathol"},{"key":"3904_CR28","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.humpath.2022.06.003","volume":"127","author":"E Zhong","year":"2022","unstructured":"Zhong E, Pareja F, Hanna MG, Jungbluth A, Rekhman N, Brogi E (2022) Expression of novel neuroendocrine markers in breast carcinomas: a study of ISNM1, ASCL1, and POU2F3. Hum Pathol 127:102\u2013111","journal-title":"Hum Pathol"},{"key":"3904_CR29","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1007\/s00795-017-0167-6","volume":"51","author":"M Tanigawa","year":"2018","unstructured":"Tanigawa M, Nakayama M, Taira T et al (2018) Insulinoma-associated protein 1 (INSM1) is a useful marker for pancreatic neuroendocrine tumor. Med Mol Morphol 51:32\u201340","journal-title":"Med Mol Morphol"},{"key":"3904_CR30","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s00428-021-03211-5","volume":"480","author":"B Konukiewitz","year":"2022","unstructured":"Konukiewitz B, Jesinghaus M, Kasajima A, Kloppel G (2022) Neuroendocrine neoplasms of the pancreas: diagnosis and pitfalls. Virchows Arch 480:247\u2013257","journal-title":"Virchows Arch"},{"key":"3904_CR31","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.anndiagpath.2019.04.002","volume":"40","author":"C Leblebici","year":"2019","unstructured":"Leblebici C, Yeni B, Savli TC, Aydin O, Gune P, Cinel L, Simsek BC, Yildiz P, Tuncel D, Kayahan S (2019) A new immunohistochemical marker, insulinoma-associated protein-1 (INSM1), for Merkel cell carcinoma: evaluation of 24 cases. Ann Diagn Pathol 40:53\u201358","journal-title":"Ann Diagn Pathol"},{"key":"3904_CR32","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41379-021-00921-8","volume":"35","author":"K Goto","year":"2022","unstructured":"Goto K, Kukita Y, Honma K, Ohike N, Komori T, Ishida Y et al (2022) Sweat-gland carcinoma with neuroendocrine differentiation (SCAND): a clinicopathologic study of 13 cases with genetic analysis. Mod Pathol 35:33\u201343","journal-title":"Mod Pathol"},{"key":"3904_CR33","doi-asserted-by":"publisher","first-page":"11","DOI":"10.5114\/pjp.2021.106440","volume":"72","author":"SA Hakim","year":"2021","unstructured":"Hakim SA, Abn Raboh NM (2021) The diagnostic utility of INSM1 and GATA3 in discriminating problematic medullary thyroid carcinoma, thyroid, and parathyroid lesions. Pol J Pathol 72:11\u201322","journal-title":"Pol J Pathol"},{"key":"3904_CR34","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1097\/PGP.0000000000000722","volume":"40","author":"C-H Ting","year":"2021","unstructured":"Ting C-H, Wang T-Y, Wu P-S (2021) Insulinoma-associated protein 1 expression and its diagnostic significance in female genital tract neuroendocrine carcinomas. Int J Gynec Pathol 40:452\u2013459","journal-title":"Int J Gynec Pathol"},{"key":"3904_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2020.152993","volume":"216","author":"J-F Chen","year":"2020","unstructured":"Chen J-F, Yang C, Sun Y, Cao D (2020) Expression of novel neuroendocrine marker insulinoma-associated protein 1 (INSM1) in genitourinary high-grade neuroendocrine carcinomas: an immunohistochemical study with specificity analysis and comparison to chromogranin, synaptophysin, and CD56. Pathol Res Pract 216:152993","journal-title":"Pathol Res Pract"},{"key":"3904_CR36","doi-asserted-by":"publisher","unstructured":"Suster DI, Mackinnon AC, Suster S (2024) Insulinoma-associated protein-1 expression in lymphoepithelial carcinoma of the thymus: a potential pitfall for diagnosis with neuroendocrine carcinomas of the thymus. Arch Pathol Lab Med.\u00a0https:\/\/doi.org\/10.5858\/arpa.2024-0045-OA","DOI":"10.5858\/arpa.2024-0045-OA"},{"key":"3904_CR37","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1093\/ajcp\/102.4.406","volume":"102","author":"DJ Guinee","year":"1994","unstructured":"Guinee DJ, Fishback NF, Koss MN, Abbondanzo SL, Travis WD (1994) The spectrum of immunohistochemical staining of small cell lung carcinoma in specimens from transbronchial and open lung biopsies. Am J Clin Pathol 102:406\u2013414","journal-title":"Am J Clin Pathol"},{"key":"3904_CR38","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1093\/ajcp\/98.1.88","volume":"98","author":"E Brambilla","year":"1992","unstructured":"Brambilla E, Veale D, Moro D, Morel F, Dubois F, Branbilla C (1992) Neuroendocrine phenotype in lung cancers. Comparison of immunohistochemistry with biochemical determination of enolase isoenzymes. Am J Clin Pathol 98:88\u201397","journal-title":"Am J Clin Pathol"},{"key":"3904_CR39","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1111\/his.13800","volume":"74","author":"JL Derks","year":"2019","unstructured":"Derks JL, Dingemans AC, van Suylen RJ, den Bakker MA, Damhuis RAM, van den Broeck EC, Speel EJ et al (2019) Is the sum of positive neuroendocrine immunohistochemical stains useful for diagnosis of large cell neuroendocrine carcinoma (LCNEC) on biopsy specimens? Histopathology 74:555\u2013566","journal-title":"Histopathology"},{"key":"3904_CR40","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.humpath.2023.05.001","volume":"137","author":"L Gerykova","year":"2023","unstructured":"Gerykova L, Vebr T, Kudelka L, Poczos P, Cesak T, Gabalec F, Hornychova H, Soukup J (2023) Expression of neuroendocrine markers in meningeal and extrameningeal solitary fibrous tumors: a potential diagnostic pitfall. Hum Pathol 137:79\u201384","journal-title":"Hum Pathol"},{"key":"3904_CR41","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.humpath.2022.12.005","volume":"134","author":"J Lenz","year":"2023","unstructured":"Lenz J, Klubickova N, Ptakova N, Hajkova V, Grossman P, Steiner P et al (2023) Extraskeletal myxoid chondrosarcoma: a study of 17 cases focusing on the diagnostic utility of INSM1 expression and presenting rare morphologic variants associated with non-EWSR1::NR4A fusions. Hum Pathol 134:19\u201329","journal-title":"Hum Pathol"},{"key":"3904_CR42","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1093\/ajcp\/aqaa250","volume":"156","author":"M Dridi","year":"2021","unstructured":"Dridi M, Boutonnat J, Dumollard JM, Peoc\u2019h M, Karpathiou G (2021) INSM1 expression in chordomas. Am J Clin Pathol 156:334\u2013339","journal-title":"Am J Clin Pathol"},{"key":"3904_CR43","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1093\/ajcp\/aqaa168","volume":"155","author":"LM Warmke","year":"2021","unstructured":"Warmke LM, Tinkham EG, Ingram DR, Lazar AJ, Panse G, Wang W-L (2021) INSM1 expression in angiosarcoma. Am J Clin Pathol 155:575\u2013580","journal-title":"Am J Clin Pathol"},{"key":"3904_CR44","doi-asserted-by":"publisher","unstructured":"Rekhi B, Dermawan JK, Fritchie KJ, Zimpfer A, Mohammad TM, Ali FS et al (2024) EWSR1::ATF1 fusions characterize a group of extra-abdominal epithelioid and round cell mesenchymal neoplasms, phenotypically overlapping with sclerosing epithelioid fibrosarcomas, and intra-abdominal FET::CREB fusion neoplasms. Virchows Arch.\u00a0https:\/\/doi.org\/10.1007\/s00428-024-03879-5","DOI":"10.1007\/s00428-024-03879-5"},{"key":"3904_CR45","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1038\/s41379-020-0646-5","volume":"33","author":"P Argani","year":"2020","unstructured":"Argani P, Harvey I, Nielsen GP, Takano A, Suurmeijer AJH, Voltaggio L et al (2020) EWSR1\/FUS-CREB fusions define a distinctive malignant epithelioid neoplasm with predilection for mesothelial-lined cavities. Mod Pathol 33:2233\u20132243","journal-title":"Mod Pathol"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-024-03904-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-024-03904-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-024-03904-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T07:03:16Z","timestamp":1745391796000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00428-024-03904-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,3]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["3904"],"URL":"https:\/\/doi.org\/10.1007\/s00428-024-03904-7","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,3]]},"assertion":[{"value":"19 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted under institutional review board approval.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"DIS receives royalty payments from Elsevier for textbook authorship. DIS is an editorial board member of Virchow Archiv. PV, MMK, and YPH have no conflicts of interest to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}