{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:30:50Z","timestamp":1783474250275,"version":"3.55.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s00428-024-03954-x","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T02:01:53Z","timestamp":1730772113000},"page":"1221-1233","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Gastric-like (pseudopyloric and pseudofoveolar) metaplasia and Paneth cell hyperplasia\u2014neglected histological features of chronic ileal inflammation"],"prefix":"10.1007","volume":"486","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9434-2989","authenticated-orcid":false,"given":"Anita","family":"Sejben","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gnes","family":"B\u00e0thori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8734-3633","authenticated-orcid":false,"given":"Fanni","family":"Heged\u0171s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8499-8442","authenticated-orcid":false,"given":"B\u00e9la","family":"Vasas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0897-5385","authenticated-orcid":false,"given":"Gregory Y","family":"Lauwers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4498-8781","authenticated-orcid":false,"given":"Bence","family":"K\u0151v\u00e1ri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"3954_CR1","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1097\/PAP.0000000000000325","volume":"29","author":"B K\u0151v\u00e1ri","year":"2022","unstructured":"K\u0151v\u00e1ri B, B\u00e1thori \u00c1, Friedman MS, Lauwers GY (2022) Histologic diagnosis of inflammatory bowel diseases. Adv Anat Pathol 29:48\u201361. https:\/\/doi.org\/10.1097\/PAP.0000000000000325","journal-title":"Adv Anat Pathol"},{"key":"3954_CR2","doi-asserted-by":"publisher","unstructured":"Khor TS, Claudtiz TS, K\u0151v\u00e1ri B, Lauwers GY, Wallace MB, Kumarasinghe P (2021) Inflammatory conditions of the colon. In: Lauwers GY, Wallace MB, Claudtiz TS (eds) Gastrointestinal pathology: correlative endoscopic and histologic assessment, 1st edn. Wiley, New York, pp 235\u2013305. https:\/\/doi.org\/10.1002\/9781119073048.ch10","DOI":"10.1002\/9781119073048.ch10"},{"key":"3954_CR3","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s00428-014-1543-4","volume":"464","author":"C Langner","year":"2014","unstructured":"Langner C, Magro F, Driessen A, Ensari A, Mantzaris GJ, Villanacci V, Becheanu G et al (2014) The histopathological approach to inflammatory bowel disease: a practice guide. Virchows Arch 464:511\u2013527. https:\/\/doi.org\/10.1007\/s00428-014-1543-4","journal-title":"Virchows Arch"},{"key":"3954_CR4","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1111\/j.1440-1827.1997.tb04517.x","volume":"47","author":"R Kushima","year":"1997","unstructured":"Kushima R, Borchard F, Hattori T (1997) A new aspect of gastric metaplasia in Crohn\u2019s disease: bidirectional (foveolar and pyloric) differentiation in so-called \u2018pyloric metaplasia\u2019 in the ileum. Pathol Int 47:416\u2013419. https:\/\/doi.org\/10.1111\/j.1440-1827.1997.tb04517.x","journal-title":"Pathol Int"},{"key":"3954_CR5","doi-asserted-by":"publisher","first-page":"553","DOI":"10.14670\/HH-18-167","volume":"35","author":"S Meditskou","year":"2020","unstructured":"Meditskou S, Grekou A, Toskas A, Papamitsou T, Miliaras D (2020) Pyloric and foveolar type metaplasia are important diagnostic features in Crohn\u2019s disease that are frequently missed in routine pathology. Histol Histopathol 35:553\u2013558. https:\/\/doi.org\/10.14670\/HH-18-167","journal-title":"Histol Histopathol"},{"key":"3954_CR6","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1136\/gut.46.5.632","volume":"46","author":"R Shaoul","year":"2000","unstructured":"Shaoul R (2000) The pathogenesis of duodenal gastric metaplasia: the role of local goblet cell transformation. Gut 46:632\u2013638. https:\/\/doi.org\/10.1136\/gut.46.5.632","journal-title":"Gut"},{"key":"3954_CR7","doi-asserted-by":"publisher","first-page":"C947","DOI":"10.1152\/ajpcell.00415.2019","volume":"319","author":"E Teal","year":"2020","unstructured":"Teal E, Dua-Awereh M, Hirshorn ST, Zavros Y (2020) Role of metaplasia during gastric regeneration. A J Physiol-Cell Physiol 319:C947\u2013C954. https:\/\/doi.org\/10.1152\/ajpcell.00415.2019","journal-title":"A J Physiol-Cell Physiol"},{"key":"3954_CR8","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1002\/path.1700870207","volume":"87","author":"FD Lee","year":"1964","unstructured":"Lee FD (1964) Pyloric metaplasia in the small intestine. J Pathol 87:267\u2013277. https:\/\/doi.org\/10.1002\/path.1700870207","journal-title":"J Pathol"},{"key":"3954_CR9","first-page":"205","volume":"51","author":"AF Liber","year":"1951","unstructured":"Liber AF (1951) Aberrant pyloric glands in regional ileitis. AMA Arch Pathol 51:205\u2013212","journal-title":"AMA Arch Pathol"},{"key":"3954_CR10","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1136\/gut.18.3.214","volume":"18","author":"I Yokoyama","year":"1977","unstructured":"Yokoyama I, Kozuka S, Ito K, Kubota K, Yokoyama Y (1977) Gastric gland metaplasia in the small and large intestine. Gut 18:214\u2013218. https:\/\/doi.org\/10.1136\/gut.18.3.214","journal-title":"Gut"},{"key":"3954_CR11","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.2353\/ajpath.2010.100328","volume":"177","author":"JKM Lennerz","year":"2010","unstructured":"Lennerz JKM, Kim S-H, Oates EL, Huh WJ, Doherty JM, Tian X, Bredemeyer AJ et al (2010) The transcription factor MIST1 is a novel human gastric chief cell marker whose expression is lost in metaplasia, dysplasia, and carcinoma. Am J Pathol 177:1514\u20131533. https:\/\/doi.org\/10.2353\/ajpath.2010.100328","journal-title":"Am J Pathol"},{"key":"3954_CR12","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1002\/path.5258","volume":"248","author":"S Thorsvik","year":"2019","unstructured":"Thorsvik S, Van Beelen GA, Svendsen TD, Bakke I, R\u00f8yset ES, Flo TH, Dam\u00e5s JK et al (2019) Ulcer-associated cell lineage expresses genes involved in regeneration and is hallmarked by high neutrophil gelatinase-associated lipocalin (NGAL) levels. J Pathol 248:316\u2013325. https:\/\/doi.org\/10.1002\/path.5258","journal-title":"J Pathol"},{"key":"3954_CR13","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1002\/path.5066","volume":"245","author":"JR Goldenring","year":"2018","unstructured":"Goldenring JR (2018) Pyloric metaplasia, pseudopyloric metaplasia, ulcer-associated cell lineage and spasmolytic polypeptide-expressing metaplasia: reparative lineages in the gastrointestinal mucosa. J Pathol 245:132\u2013137. https:\/\/doi.org\/10.1002\/path.5066","journal-title":"J Pathol"},{"key":"3954_CR14","doi-asserted-by":"publisher","first-page":"A241","DOI":"10.1093\/ajcp\/138.suppl1.225","volume":"138","author":"RM Ziegler","year":"2012","unstructured":"Ziegler RM, Frankel WL, Wenzke JT, Lehman A, Yearsley MM (2012) Paneth cell hyperplasia in inflamed terminal ileum is a feature of chronic mucosal injury: a histopathologic study of 88 cases. Am J Clin Pathol 138:A241\u2013A241. https:\/\/doi.org\/10.1093\/ajcp\/138.suppl1.225","journal-title":"Am J Clin Pathol"},{"key":"3954_CR15","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1136\/gutjnl-2013-306508","volume":"63","author":"DL Lavery","year":"2014","unstructured":"Lavery DL, Nicholson AM, Poulsom R, Jeffery R, Hussain A, Gay LJ, Jankowski JA et al (2014) The stem cell organisation, and the proliferative and gene expression profile of Barrett\u2019s epithelium, replicates pyloric-type gastric glands. Gut 63:1854\u20131863. https:\/\/doi.org\/10.1136\/gutjnl-2013-306508","journal-title":"Gut"},{"key":"3954_CR16","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/modpathol.2010.59","volume":"23","author":"IS Brown","year":"2010","unstructured":"Brown IS, Whiteman DC, Lauwers GY (2010) Foveolar type dysplasia in Barrett esophagus. Mod Pathol 23:834\u2013843. https:\/\/doi.org\/10.1038\/modpathol.2010.59","journal-title":"Mod Pathol"},{"key":"3954_CR17","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1097\/PAT.0b013e32835cc22c","volume":"45","author":"M Bettington","year":"2013","unstructured":"Bettington M, Brown I (2013) Autoimmune gastritis: novel clues to histological diagnosis. Pathology 45:145\u2013149. https:\/\/doi.org\/10.1097\/PAT.0b013e32835cc22c","journal-title":"Pathology"},{"key":"3954_CR18","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s00428-018-2454-6","volume":"473","author":"H El-Zimaity","year":"2018","unstructured":"El-Zimaity H, Choi W-T, Lauwers GY, Riddell R (2018) The differential diagnosis of Helicobacter pylori negative gastritis. Virchows Arch 473:533\u2013550. https:\/\/doi.org\/10.1007\/s00428-018-2454-6","journal-title":"Virchows Arch"},{"key":"3954_CR19","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/343082a0","volume":"343","author":"NA Wright","year":"1990","unstructured":"Wright NA, Pike C, Elia G (1990) Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells. Nature 343:82\u201385. https:\/\/doi.org\/10.1038\/343082a0","journal-title":"Nature"},{"key":"3954_CR20","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s10735-007-9149-7","volume":"39","author":"Y Kaneko","year":"2008","unstructured":"Kaneko Y, Nakamura T, Hayama M, Hosaka N, Akamatsu T, Ota H (2008) Altered expression of CDX-2, PDX-1 and mucin core proteins in \u201culcer-associated cell lineage (UACL)\u201d in Crohn\u2019s disease. J Mol Hist 39:161\u2013168. https:\/\/doi.org\/10.1007\/s10735-007-9149-7","journal-title":"J Mol Hist"},{"key":"3954_CR21","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s00428-021-03033-5","volume":"479","author":"Y Wada","year":"2021","unstructured":"Wada Y, Nakajima S, Kushima R, Takemura S, Mori N, Hasegawa H, Nakayama T et al (2021) Pyloric, pseudopyloric, and spasmolytic polypeptide-expressing metaplasias in autoimmune gastritis: a case series of 22 Japanese patients. Virchows Arch 479:169\u2013178. https:\/\/doi.org\/10.1007\/s00428-021-03033-5","journal-title":"Virchows Arch"},{"key":"3954_CR22","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/modpathol.2011.120","volume":"25","author":"G Soucy","year":"2012","unstructured":"Soucy G, Wang HH, Farraye FA, Schmidt JF, Farris AB, Lauwers GY, Cerda SR et al (2012) Clinical and pathological analysis of colonic Crohn\u2019s disease, including a subgroup with ulcerative colitis-like features. Mod Pathol 25:295\u2013307. https:\/\/doi.org\/10.1038\/modpathol.2011.120","journal-title":"Mod Pathol"},{"key":"3954_CR23","first-page":"5","volume":"13","author":"SR Prabhu","year":"1994","unstructured":"Prabhu SR, Ranganathan S, Parikh SS, Kalro RH (1994) Gastric metaplasia and Helicobacter pylori infection in intestinal tuberculosis. Indian J Gastroenterol 13:5\u20136","journal-title":"Indian J Gastroenterol"},{"key":"3954_CR24","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1111\/j.1365-2036.2010.04249.x","volume":"31","author":"R Kariv","year":"2010","unstructured":"Kariv R, Plesec TP, Gaffney K, Lian L, Fazio VW, Remzi FH, Lopez R et al (2010) Pyloric gland metaplasia and pouchitis in patients with ileal pouch-anal anastomoses. Aliment Pharmacol Ther 31:862\u2013873. https:\/\/doi.org\/10.1111\/j.1365-2036.2010.04249.x","journal-title":"Aliment Pharmacol Ther"},{"key":"3954_CR25","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1097\/00000478-198612000-00007","volume":"10","author":"RG Lee","year":"1986","unstructured":"Lee RG (1986) The colitis of Behget\u02bcs syndrome. Am J Surg Pathol 10:888\u2013893. https:\/\/doi.org\/10.1097\/00000478-198612000-00007","journal-title":"Am J Surg Pathol"},{"key":"3954_CR26","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1055\/s-0034-1390798","volume":"47","author":"L Setaffy","year":"2014","unstructured":"Setaffy L, Osuna M, Plieschnegger W, Rial MPF, Geboes K, Langner C (2014) Cryptogenic multifocal ulcerous stenosing enteritis (CMUSE), and neuromuscular and vascular hamartoma (NMVH): two sides of the same coin? Endoscopy 47:345\u2013348. https:\/\/doi.org\/10.1055\/s-0034-1390798","journal-title":"Endoscopy"},{"key":"3954_CR27","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1097\/01.pas.0000176435.19197.88","volume":"29","author":"H Haskell","year":"2005","unstructured":"Haskell H, Andrews CW, Reddy SI, Dendrinos K, Farraye FA, Stucchi AF, Becker JM et al (2005) Pathologic features and clinical significance of \u201cbackwash\u201d ileitis in ulcerative colitis. Am J Surg Pathol 29:1472\u20131481. https:\/\/doi.org\/10.1097\/01.pas.0000176435.19197.88","journal-title":"Am J Surg Pathol"},{"key":"3954_CR28","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1038\/ajg.2017.182","volume":"112","author":"DT Patil","year":"2017","unstructured":"Patil DT, Odze RD (2017) Backwash is hogwash: the clinical significance of ileitis in ulcerative colitis. Am J Gastroenterol 112:1211\u20131214. https:\/\/doi.org\/10.1038\/ajg.2017.182","journal-title":"Am J Gastroenterol"},{"key":"3954_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1001\/jama.1936.02770010003001","volume":"106","author":"BB Crohn","year":"1936","unstructured":"Crohn BB (1936) A combined form of ileitis and colitis. JAMA 106:1. https:\/\/doi.org\/10.1001\/jama.1936.02770010003001","journal-title":"JAMA"},{"key":"3954_CR30","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1007\/s10350-005-0160-3","volume":"48","author":"AS Abdelrazeq","year":"2005","unstructured":"Abdelrazeq AS, Wilson TR, Leitch DL, Lund JN, Leveson SH (2005) Ileitis in ulcerative colitis: is it a backwash? Dis Colon Rectum 48:2038\u20132046. https:\/\/doi.org\/10.1007\/s10350-005-0160-3","journal-title":"Dis Colon Rectum"},{"key":"3954_CR31","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1309\/UAXMW3428PGN9HJ3","volume":"126","author":"N Goldstein","year":"2006","unstructured":"Goldstein N, Dulai M (2006) Contemporary morphologic definition of backwash ileitis in ulcerative colitis and features that distinguish it from Crohn disease. Am J Clin Pathol 126:365\u2013376. https:\/\/doi.org\/10.1309\/UAXMW3428PGN9HJ3","journal-title":"Am J Clin Pathol"},{"key":"3954_CR32","doi-asserted-by":"publisher","first-page":"2448","DOI":"10.1097\/MIB.0000000000000911","volume":"22","author":"MJ Hamilton","year":"2016","unstructured":"Hamilton MJ, Makrauer FM, Golden K, Wang H, Friedman S, Burakoff RB, Levine JS et al (2016) Prospective evaluation of terminal ileitis in a surveillance population of patients with ulcerative colitis. Inflamm Bowel Dis 22:2448\u20132455. https:\/\/doi.org\/10.1097\/MIB.0000000000000911","journal-title":"Inflamm Bowel Dis"},{"key":"3954_CR33","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1098\/rstb.1998.0257","volume":"353","author":"NA Wright","year":"1998","unstructured":"Wright NA (1998) Aspects of the biology of regeneration and repair in the human gastrointestinal tract. Phil Trans R Soc Lond B 353:925\u2013933. https:\/\/doi.org\/10.1098\/rstb.1998.0257","journal-title":"Phil Trans R Soc Lond B"},{"key":"3954_CR34","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1146\/annurev-physiol-021115-105447","volume":"79","author":"E Aihara","year":"2017","unstructured":"Aihara E, Engevik KA, Montrose MH (2017) Trefoil factor peptides and gastrointestinal function. Annu Rev Physiol 79:357\u2013380. https:\/\/doi.org\/10.1146\/annurev-physiol-021115-105447","journal-title":"Annu Rev Physiol"},{"key":"3954_CR35","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1016\/0016-5085(93)90956-D","volume":"105","author":"AM Hanby","year":"1993","unstructured":"Hanby AM, Poulsom R, Singh S, Elia G, Jeffery RE, Wright NA (1993) Spasmolytic polypeptide is a major antral peptide: distribution of the trefoil peptides human spasmolytic polypeptide and pS2 in the stomach. Gastroenterology 105:1110\u20131116. https:\/\/doi.org\/10.1016\/0016-5085(93)90956-D","journal-title":"Gastroenterology"},{"key":"3954_CR36","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1111\/his.14294","volume":"78","author":"D Pereira","year":"2021","unstructured":"Pereira D, K\u0151v\u00e1ri B, Brown I, Chaves P, Choi WT, Clauditz T, Ghayouri M et al (2021) Non-conventional dysplasias of the tubular gut: a review and illustration of their histomorphological spectrum. Histopathology 78:658\u2013675. https:\/\/doi.org\/10.1111\/his.14294","journal-title":"Histopathology"},{"key":"3954_CR37","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/modpathol.3880138","volume":"13","author":"SP Kilgore","year":"2000","unstructured":"Kilgore SP, Sigel JE, Goldblum JR (2000) Hyperplastic-like mucosal change in Crohn\u2019s disease: an unusual form of dysplasia? Mod Pathol 13:797\u2013801. https:\/\/doi.org\/10.1038\/modpathol.3880138","journal-title":"Mod Pathol"},{"key":"3954_CR38","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s00428-021-03109-2","volume":"479","author":"G Arpa","year":"2021","unstructured":"Arpa G, Vanoli A, Grillo F, Fiocca R, Klersy C, Furlan D, Sessa F et al (2021) Prognostic relevance and putative histogenetic role of cytokeratin 7 and MUC5AC expression in Crohn\u2019s disease-associated small bowel carcinoma. Virchows Arch 479:667\u2013678. https:\/\/doi.org\/10.1007\/s00428-021-03109-2","journal-title":"Virchows Arch"},{"key":"3954_CR39","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.humpath.2023.05.008","volume":"138","author":"N Harpaz","year":"2023","unstructured":"Harpaz N, Goldblum JR, Shepherd NA, Riddell RH, Rubio CA, Vieth M, Wang HH et al (2023) Colorectal dysplasia in chronic inflammatory bowel disease: a contemporary consensus classification and interobserver study. Hum Patholo 138:49\u201361. https:\/\/doi.org\/10.1016\/j.humpath.2023.05.008","journal-title":"Hum Patholo"},{"key":"3954_CR40","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/s41379-022-01036-4","volume":"35","author":"B K\u0151v\u00e1ri","year":"2022","unstructured":"K\u0151v\u00e1ri B, Clauditz T, Kamaradova K, B\u00e1thori \u00c1, Heged\u0171s F, Miller G, Salomano M et al (2022) Hypermucinous dysplasia in inflammatory bowel disease: a heterogeneous condition with frequent foveolar differentiation. USCAP 2022 Abstracts: Gastrointestinal Pathology (372\u2013507). Mod Pathol 35:481\u2013482. https:\/\/doi.org\/10.1038\/s41379-022-01036-4","journal-title":"Mod Pathol"},{"key":"3954_CR41","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.humpath.2023.11.011","volume":"143","author":"E Musulen","year":"2024","unstructured":"Musulen E, Gen\u00e9 M, Cuatrecasas M, Amat I, Veiga JA, Fern\u00e1ndez-Ace\u00f1ero MJ, Chimisana VF et al (2024) Gastric metaplasia as a precursor of nonconventional dysplasia in inflammatory bowel disease. Hum Pathol 143:50\u201361. https:\/\/doi.org\/10.1016\/j.humpath.2023.11.011","journal-title":"Hum Pathol"},{"key":"3954_CR42","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/1471-230X-14-93","volume":"14","author":"N Simmonds","year":"2014","unstructured":"Simmonds N, Furman M, Karanika E, Phillips A, Bates AWH (2014) Paneth cell metaplasia in newly diagnosed inflammatory bowel disease in children. BMC Gastroenterol 14:93. https:\/\/doi.org\/10.1186\/1471-230X-14-93","journal-title":"BMC Gastroenterol"},{"key":"3954_CR43","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1046\/j.1440-1746.2001.02629.x","volume":"16","author":"M Tanaka","year":"2001","unstructured":"Tanaka M, Saito H, Kusumi T, Fukuda S, Shimoyama T, Sasaki Y, Suto K et al (2001) Spatial distribution and histogenesis of colorectal Paneth cell metaplasia in idiopathic flammatory bowel disease. J Gastroenterol Hepatol 16:1353\u20131359. https:\/\/doi.org\/10.1046\/j.1440-1746.2001.02629.x","journal-title":"J Gastroenterol Hepatol"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-024-03954-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-024-03954-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-024-03954-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T05:58:02Z","timestamp":1751349482000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00428-024-03954-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,5]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["3954"],"URL":"https:\/\/doi.org\/10.1007\/s00428-024-03954-x","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,5]]},"assertion":[{"value":"22 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was performed in agreement with the guidelines of the Declaration of Helsinki and was approved by the Regional and International Review Board of Human Investigations of the University of Szeged (#4988).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"AS, \u00c1B, FH, BV, and BK declare no conflicts of interest. GYL has received consulting fees from Alimentiv Inc.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}