{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:24:37Z","timestamp":1792009477527,"version":"4.4.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["MH CZ DRO-VFN 64165"],"award-info":[{"award-number":["MH CZ DRO-VFN 64165"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009553","name":"Agentura Pro Zdravotnick\u00fd V\u00fdzkum \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["AZV NU21-03-00122"],"award-info":[{"award-number":["AZV NU21-03-00122"]}],"id":[{"id":"10.13039\/501100009553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["Project UNCE 24\/MED\/018"],"award-info":[{"award-number":["Project UNCE 24\/MED\/018"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["EF16_013\/0001674"],"award-info":[{"award-number":["EF16_013\/0001674"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["BBMRI_CZ LM2023033"],"award-info":[{"award-number":["BBMRI_CZ LM2023033"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007397","name":"Charles University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Uterine sarcomas with\n                    <jats:italic>KAT6B\/A::KANSL1<\/jats:italic>\n                    fusion represent a new entity characterized by bland morphology, commonly with hybrid features of low-grade endometrial stromal sarcoma (LG-ESS) and tumors with smooth muscle differentiation. In our study, we performed a detailed morphological, immunohistochemical, and molecular analysis of 9 cases of these tumors. Six of those had been originally diagnosed as LG-ESS, one as leiomyoma, one as leiomyosarcoma, and the remaining case as sarcoma with the\n                    <jats:italic>KAT6B\/A::KANSL1<\/jats:italic>\n                    fusion. Seven cases showed overlapping features between endometrial stromal and smooth muscle tumors, one case resembled cellular leiomyoma, and one case resembled high-grade endometrial stromal sarcoma. Immunohistochemically, the tumors showed a common expression of smooth muscle markers and endometrial stromal markers. Molecular findings showed the\n                    <jats:italic>KAT6B\/A::KANSL1<\/jats:italic>\n                    fusion in all cases (by NGS and FISH). In addition, mutations affecting genes such as\n                    <jats:italic>TP53<\/jats:italic>\n                    ,\n                    <jats:italic>PDGFRB<\/jats:italic>\n                    ,\n                    <jats:italic>NF1<\/jats:italic>\n                    ,\n                    <jats:italic>RB1<\/jats:italic>\n                    ,\n                    <jats:italic>PTEN<\/jats:italic>\n                    ,\n                    <jats:italic>ATM<\/jats:italic>\n                    ,\n                    <jats:italic>RB1, FANCD2,<\/jats:italic>\n                    and\n                    <jats:italic>TSC1<\/jats:italic>\n                    were present in all 5 cases with aggressive behavior. One patient with no evidence of disease showed no additional mutations, while another harbored a mutation of a single gene (\n                    <jats:italic>ERCC3<\/jats:italic>\n                    ). Of the 8 patients with available follow-up, two died of disease, 3 are currently alive with disease, and 3 have no evidence of disease. The correct recognition of tumors with the\n                    <jats:italic>KAT6B\/A::KANSL1<\/jats:italic>\n                    fusion is essential because despite the bland morphological features of most cases, these tumors have a propensity for aggressive behavior.\n                  <\/jats:p>","DOI":"10.1007\/s00428-024-03994-3","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T20:07:40Z","timestamp":1733256460000},"page":"551-562","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Uterine sarcoma with KAT6B\/A::KANSL1 fusion: a molecular and clinicopathological study on 9 cases"],"prefix":"10.1007","volume":"486","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8940-6124","authenticated-orcid":false,"given":"Pavel","family":"Dundr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u0159\u00ed","family":"Dvo\u0159\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Krausov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Hojn\u00fd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"H\u00e1jkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Stru\u017einsk\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krist\u00fdna","family":"N\u011bmejcov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ond\u0159ej","family":"Ondi\u010d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Michal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kv\u011btoslava","family":"Michalov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Berj\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Jedryka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Ksi\u0105\u017cek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tymoteusz","family":"Poprawski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz","family":"Ry\u015b","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliya","family":"Volodko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Zapardiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"Zima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cibula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Poncov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radoslav","family":"Mat\u011bj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Kendall B\u00e1rt\u016f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"3994_CR1","doi-asserted-by":"publisher","unstructured":"Dundr P, Matej R, Hojny J, Hajkova N, Nemejcova K, Kendall Bartu M (2024) The spectrum of fusions occurring in non-smooth muscle mesenchymal uterine tumors: a review of the current knowledge. Arch Pathol Lab Med Mar 15, Online ahead of print. https:\/\/doi.org\/10.5858\/arpa.2023-0324-RA","DOI":"10.5858\/arpa.2023-0324-RA"},{"issue":"5","key":"3994_CR2","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1097\/PAS.0000000000001215","volume":"43","author":"P Cotzia","year":"2019","unstructured":"Cotzia P, Benayed R, Mullaney K et al (2019) Undifferentiated uterine sarcomas represent under-recognized high-grade endometrial stromal sarcomas. Am J Surg Pathol 43(5):662\u2013669. https:\/\/doi.org\/10.1097\/PAS.0000000000001215","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"3994_CR3","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.path.2019.01.004","volume":"12","author":"C Parra-Herran","year":"2019","unstructured":"Parra-Herran C, Howitt BE (2019) Uterine mesenchymal tumors: update on classification, staging, and molecular features. Surg Pathol Clin 12(2):363\u2013396. https:\/\/doi.org\/10.1016\/j.path.2019.01.004","journal-title":"Surg Pathol Clin"},{"issue":"2","key":"3994_CR4","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.ygyno.2022.07.031","volume":"167","author":"S Croce","year":"2022","unstructured":"Croce S, Devouassoux-Shisheboran M, Pautier P et al (2022) Uterine sarcomas and rare uterine mesenchymal tumors with malignant potential. Diagnostic guidelines of the french sarcoma group and the rare gynecological tumors group. Gynecol Oncol 167(2):373\u2013389. https:\/\/doi.org\/10.1016\/j.ygyno.2022.07.031","journal-title":"Gynecol Oncol"},{"issue":"3","key":"3994_CR5","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1097\/PAS.0000000000000593","volume":"40","author":"C Parra-Herran","year":"2016","unstructured":"Parra-Herran C, Schoolmeester JK, Yuan L et al (2016) Myxoid leiomyosarcoma of the uterus: a clinicopathologic analysis of 30 cases and review of the literature with reappraisal of its distinction from other uterine myxoid mesenchymal neoplasms. Am J Surg Pathol 40(3):285\u2013301. https:\/\/doi.org\/10.1097\/PAS.0000000000000593","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"3994_CR6","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s00428-018-2470-6","volume":"473","author":"J Ferreira","year":"2018","unstructured":"Ferreira J, Felix A, Lennerz JK, Oliva E (2018) Recent advances in the histological and molecular classification of endometrial stromal neoplasms. Virchows Arch 473(6):665\u2013678. https:\/\/doi.org\/10.1007\/s00428-018-2470-6","journal-title":"Virchows Arch"},{"issue":"1","key":"3994_CR7","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/his.14008","volume":"76","author":"A Momeni-Boroujeni","year":"2020","unstructured":"Momeni-Boroujeni A, Chiang S (2020) Uterine mesenchymal tumours: recent advances. Histopathology 76(1):64\u201375. https:\/\/doi.org\/10.1111\/his.14008","journal-title":"Histopathology"},{"key":"3994_CR8","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.humpath.2022.03.007","volume":"124","author":"H Yoshida","year":"2022","unstructured":"Yoshida H, Kikuchi A, Tsuda H et al (2022) Discrepancies in pathological diagnosis of endometrial stromal sarcoma: a multi-institutional retrospective study from the Japanese clinical oncology group. Hum Pathol 124:24\u201335. https:\/\/doi.org\/10.1016\/j.humpath.2022.03.007","journal-title":"Hum Pathol"},{"issue":"9","key":"3994_CR9","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1097\/pas.0000000000001915","volume":"46","author":"A Agaimy","year":"2022","unstructured":"Agaimy A, Clarke BA, Kolin DL et al (2022) Recurrent KAT6B\/A::KANSL1 fusions characterize a potentially aggressive uterine sarcoma morphologically overlapping with low-grade endometrial stromal sarcoma. Am J Surg Pathol 46(9):1298\u20131308. https:\/\/doi.org\/10.1097\/pas.0000000000001915","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"3994_CR10","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1007\/s00428-024-03935-0","volume":"485","author":"FKF Kommoss","year":"2024","unstructured":"Kommoss FKF, Charbel A, Kolin DL et al (2024) Uterine mesenchymal tumours harboring the KAT6B\/A::KANSL1 gene fusion represent a distinct type of uterine sarcoma based on DNA methylation profiles. Virchows Arch 485(5):793\u2013803. https:\/\/doi.org\/10.1007\/s00428-024-03935-0","journal-title":"Virchows Arch"},{"key":"3994_CR11","doi-asserted-by":"publisher","first-page":"100243","DOI":"10.1016\/j.modpat.2023.100243","volume":"2023","author":"A Trecourt","year":"2023","unstructured":"Trecourt A, Azmani R, Hostein I et al (2023) The KAT6B::KANSL1 fusion defines a new uterine sarcoma with hybrid endometrial stromal tumor and smooth muscle tumor features. Mod Pathol 2023:100243. https:\/\/doi.org\/10.1016\/j.modpat.2023.100243","journal-title":"Mod Pathol"},{"issue":"1","key":"3994_CR12","doi-asserted-by":"publisher","first-page":"e0117010","DOI":"10.1371\/journal.pone.0117010","volume":"10","author":"I Panagopoulos","year":"2015","unstructured":"Panagopoulos I, Gorunova L, Bjerkehagen B, Heim S (2015) Novel KAT6B-KANSL1 fusion gene identified by RNA sequencing in retroperitoneal leiomyoma with t(10;17)(q22;q21). PLoS ONE 10(1):e0117010. https:\/\/doi.org\/10.1371\/journal.pone.0117010","journal-title":"PLoS ONE"},{"issue":"1","key":"3994_CR13","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s13000-019-0809-1","volume":"14","author":"AJ Ainsworth","year":"2019","unstructured":"Ainsworth AJ, Dashti NK, Mounajjed T et al (2019) Leiomyoma with KAT6B-KANSL1 fusion: case report of a rapidly enlarging uterine mass in a postmenopausal woman. Diagn Pathol 14(1):32. https:\/\/doi.org\/10.1186\/s13000-019-0809-1","journal-title":"Diagn Pathol"},{"key":"3994_CR14","doi-asserted-by":"publisher","unstructured":"Choi J, Manzano A, Dong W, et al (2021) Integrated mutational landscape analysis of uterine leiomyosarcomas. Proc Natl Acad Sci U S A 118(15). https:\/\/doi.org\/10.1073\/pnas.2025182118","DOI":"10.1073\/pnas.2025182118"},{"key":"3994_CR15","doi-asserted-by":"publisher","unstructured":"Flidrova M, Hajkova N, Hojny J, et al (2024) Unraveling the molecular landscape of UTROSCT: Insights from a clinicopathological, morphological, immunohistochemical, and molecular analysis of 35 cases. Mod Pathol 100611. https:\/\/doi.org\/10.1016\/j.modpat.2024.100611","DOI":"10.1016\/j.modpat.2024.100611"},{"issue":"1","key":"3994_CR16","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s13000-023-01358-0","volume":"18","author":"I Struzinska","year":"2023","unstructured":"Struzinska I, Hajkova N, Hojny J et al (2023) A comprehensive molecular analysis of 113 primary ovarian clear cell carcinomas reveals common therapeutically significant aberrations. Diagn Pathol 18(1):72. https:\/\/doi.org\/10.1186\/s13000-023-01358-0","journal-title":"Diagn Pathol"},{"issue":"1","key":"3994_CR17","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/s42003-024-06454-5","volume":"7","author":"F Koopmans","year":"2024","unstructured":"Koopmans F (2024) GOAT: efficient and robust identification of gene set enrichment. Commun Biol 7(1):744. https:\/\/doi.org\/10.1038\/s42003-024-06454-5","journal-title":"Commun Biol"},{"issue":"1","key":"3994_CR18","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner M, Ball CA, Blake JA et al (2000) Gene ontology: tool for the unification of biology The Gene Ontology Consortium. Nat Genet 25(1):25\u201329. https:\/\/doi.org\/10.1038\/75556","journal-title":"Nat Genet"},{"issue":"D1","key":"3994_CR19","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","volume":"51","author":"D Szklarczyk","year":"2023","unstructured":"Szklarczyk D, Kirsch R, Koutrouli M et al (2023) The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res 51(D1):D638\u2013D646. https:\/\/doi.org\/10.1093\/nar\/gkac1000","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"3994_CR20","doi-asserted-by":"publisher","first-page":"2995","DOI":"10.1038\/s41467-023-38785-y","volume":"14","author":"P Liu","year":"2023","unstructured":"Liu P, Ewald J, Pang Z et al (2023) ExpressAnalyst: a unified platform for RNA-sequencing analysis in non-model species. Nat Commun 14(1):2995. https:\/\/doi.org\/10.1038\/s41467-023-38785-y","journal-title":"Nat Commun"},{"issue":"4","key":"3994_CR21","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s00428-018-2349-6","volume":"473","author":"P Steiner","year":"2018","unstructured":"Steiner P, Andreasen S, Grossmann P et al (2018) Prognostic significance of 1p36 locus deletion in adenoid cystic carcinoma of the salivary glands. Virchows Arch 473(4):471\u2013480. https:\/\/doi.org\/10.1007\/s00428-018-2349-6","journal-title":"Virchows Arch"},{"issue":"2","key":"3994_CR22","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/0165-4608(88)90289-0","volume":"32","author":"P Dal Cin","year":"1988","unstructured":"Dal Cin P, Boghosian L, Crickard K, Sandberg AA (1988) t(10;17) as the sole chromosome change in a uterine leiomyosarcoma. Cancer Genet Cytogenet 32(2):263\u2013266. https:\/\/doi.org\/10.1016\/0165-4608(88)90289-0","journal-title":"Cancer Genet Cytogenet"},{"issue":"2","key":"3994_CR23","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/0165-4608(93)90089-5","volume":"69","author":"YY Ozisik","year":"1993","unstructured":"Ozisik YY, Meloni AM, Surti U, Sandberg AA (1993) Involvement of 10q22 in leiomyoma. Cancer Genet Cytogenet 69(2):132\u2013135. https:\/\/doi.org\/10.1016\/0165-4608(93)90089-5","journal-title":"Cancer Genet Cytogenet"},{"issue":"16","key":"3994_CR24","doi-asserted-by":"publisher","first-page":"5570","DOI":"10.1158\/0008-5472.CAN-04-0050","volume":"64","author":"SD Moore","year":"2004","unstructured":"Moore SD, Herrick SR, Ince TA et al (2004) Uterine leiomyomata with t(10;17) disrupt the histone acetyltransferase MORF. Cancer Res 64(16):5570\u20135577. https:\/\/doi.org\/10.1158\/0008-5472.CAN-04-0050","journal-title":"Cancer Res"},{"issue":"2","key":"3994_CR25","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s00428-021-03217-z","volume":"480","author":"P Dundr","year":"2022","unstructured":"Dundr P, Gregova M, Hojny J et al (2022) Uterine cellular leiomyomas are characterized by common HMGA2 aberrations, followed by chromosome 1p deletion and MED12 mutation: morphological, molecular, and immunohistochemical study of 52 cases. Virchows Arch 480(2):281\u2013291. https:\/\/doi.org\/10.1007\/s00428-021-03217-z","journal-title":"Virchows Arch"},{"issue":"3","key":"3994_CR26","doi-asserted-by":"publisher","first-page":"e0283159","DOI":"10.1371\/journal.pone.0283159","volume":"18","author":"SB Jacobsen","year":"2023","unstructured":"Jacobsen SB, Tfelt-Hansen J, Smerup MH, Andersen JD, Morling N (2023) Comparison of whole transcriptome sequencing of fresh, frozen, and formalin-fixed, paraffin-embedded cardiac tissue. PLoS ONE 18(3):e0283159. https:\/\/doi.org\/10.1371\/journal.pone.0283159","journal-title":"PLoS ONE"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-024-03994-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-024-03994-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-024-03994-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T03:46:25Z","timestamp":1743306385000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00428-024-03994-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,4]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["3994"],"URL":"https:\/\/doi.org\/10.1007\/s00428-024-03994-3","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,4]]},"assertion":[{"value":"29 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study has been approved by the Ethics Committee of General University Hospital in Prague in compliance with the Helsinki Declaration (No. 2140\/19 S-IV). The Ethics Committee waived the requirement for informed consent, as according to the Czech Law (Act. no. 373\/11, and its amendment Act no. 202\/17), it is not necessary to obtain informed consent in fully anonymized studies.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}