{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T07:23:48Z","timestamp":1764055428542,"version":"3.45.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006447","name":"University of Zurich","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006447","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A growing number of mesenchymal uterine tumours are defined by a specific molecular aberration. We present the case of a 65-year-old woman who presented with postmenopausal bleeding and a large intramural uterine tumour. Histopathological analysis of the resected uterus revealed an intramural, mesenchymal neoplasm comprising\u00a0of spindle and epithelioid cells, with no immunohistochemical expression of lineage-specific markers and low proliferative activity. Molecular testing using next-generation sequencing (NGS) revealed an\n                    <jats:italic>EWSR1::CTBP1<\/jats:italic>\n                    gene fusion, which was confirmed by the presence of\n                    <jats:italic>EWSR1<\/jats:italic>\n                    gene rearrangement detected using fluorescence in situ hybridisation (FISH). Staging revealed no further tumour manifestations, and the 3-year follow-up was uneventful. The\n                    <jats:italic>EWSR1::CTBP1<\/jats:italic>\n                    gene fusion has never previously been reported in uterine tumours, having been reported in the literature only once, in the context of a gastroblastoma. The presented case expands the range of the gene-fusion-associated mesenchymal tumours of the uterus.\n                  <\/jats:p>","DOI":"10.1007\/s00428-025-04205-3","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:17:52Z","timestamp":1760145472000},"page":"1137-1141","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Uterine mesenchymal tumour with a novel EWSR1::CTBP1 gene fusion"],"prefix":"10.1007","volume":"487","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3329-4186","authenticated-orcid":false,"given":"Beata","family":"Bode-Lesniewska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Illigen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias S.","family":"Matter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,11]]},"reference":[{"key":"4205_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60071085","author":"AA Alodaini","year":"2024","unstructured":"Alodaini AA (2024) Uterine mesenchymal tumors: updates on pathology, molecular landscape, and therapeutics. medicina (Kaunas). https:\/\/doi.org\/10.3390\/medicina60071085","journal-title":"medicina (Kaunas)"},{"key":"4205_CR2","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1158\/1535-7163.MCT-16-0592","volume":"16","author":"MA Blevins","year":"2017","unstructured":"Blevins MA, Huang M, Zhao R (2017) The role of CtBP1 in oncogenic processes and its potential as a therapeutic target. 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Surg Pathol Clin 15:315\u2013340. https:\/\/doi.org\/10.1016\/j.path.2022.02.008","journal-title":"Surg Pathol Clin"},{"key":"4205_CR6","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1002\/gcc.22973","volume":"60","author":"SC Koo","year":"2021","unstructured":"Koo SC, LaHaye S, Kovari BP, Schieffer KM, Ranalli MA, Aldrink JH, Michalsky MP, Colace S, Miller KE, Bedrosian TA, Leraas KM, Voytovich K, Wheeler G, Brennan P, Fitch J, Kelly BJ, McGrath SD, Miller AR, White P, Magrini V, Wilson RK, Mardis ER, Lauwers GY, Baker PB, Cottrell CE (2021) Gastroblastoma with a novel EWSR1-CTBP1 fusion presenting in adolescence. Genes Chromosomes Cancer 60:640\u2013646. https:\/\/doi.org\/10.1002\/gcc.22973","journal-title":"Genes Chromosomes Cancer"},{"key":"4205_CR7","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-024-03534-y","volume":"22","author":"Z Luo","year":"2024","unstructured":"Luo Z, Cui J, Ma F, Li Z, Yin S, Wang Z, Zhao G (2024) Gastroblastoma - a case report and literature review. World J Surg Oncol 22. https:\/\/doi.org\/10.1186\/s12957-024-03534-y","journal-title":"World J Surg Oncol"},{"key":"4205_CR8","unstructured":"Matias-Guiu X, Oliva E, McCluggage WG, Nucci MR, Longacre TA (2020 [cited 2025 March, 16th]) Tumours of the uterine corpus. In: Oliva E, Matias-Guiu X (eds) In: WHO Classification of Tumours Editorial Board. Female genital tumours [Internet]. International Agency for Research on Cancer, Lyon (France), pp."},{"key":"4205_CR9","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.anndiagpath.2017.04.001","volume":"28","author":"M Mohamed","year":"2017","unstructured":"Mohamed M, Fisher C, Thway K (2017) Low-grade fibromyxoid sarcoma: clinical, morphologic and genetic features. Ann Diagn Pathol 28:60\u201367. https:\/\/doi.org\/10.1016\/j.anndiagpath.2017.04.001","journal-title":"Ann Diagn Pathol"},{"key":"4205_CR10","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/his.14008","volume":"76","author":"A Momeni-Boroujeni","year":"2020","unstructured":"Momeni-Boroujeni A, Chiang S (2020) Uterine mesenchymal tumours: recent advances. 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S. M. has received speaker\u2019s honoraria from ThermoFisher. Otherwise, the authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}