{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T09:29:20Z","timestamp":1786786160401,"version":"build-2736575974"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["DRO-VFN 64165"],"award-info":[{"award-number":["DRO-VFN 64165"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019214","name":"l\u00e9ka\u0159sk\u00e1 fakulta Univerzity Karlovy","doi-asserted-by":"publisher","award":["UNCE\/24\/MED\/018"],"award-info":[{"award-number":["UNCE\/24\/MED\/018"]}],"id":[{"id":"10.13039\/100019214","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["BBMRI_CZ LM2023033"],"award-info":[{"award-number":["BBMRI_CZ LM2023033"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007397","name":"Charles University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Synchronous mucinous metaplasia and neoplasia of the female genital tract (SMMN-FGT) is a rare disorder defined as mucinous lesions affecting at least two sites in the female genital tract. We report a case of SMMN-FGT in a Caucasian 65-year-old patient with a right adnexal mass. The patient underwent radical surgery and histological examination showed mucinous ovarian carcinoma combined with mucinous metaplasia of the fallopian tube. The carcinomatous infiltration also affected the left ovary, peritoneum, and omentum. Molecular analysis revealed a shared\n                    <jats:italic>STK11<\/jats:italic>\n                    mutation in both the ovarian carcinoma and tubal metaplasia, and other mutations (including\n                    <jats:italic>KRAS<\/jats:italic>\n                    ) that differed between these tissues. The patient received adjuvant chemotherapy combined with bevacizumab. As there is limited experience with SMMN-FGT, standard diagnostic and treatment protocols have not yet been established. Although association with Peutz-Jeghers syndrome (PJS) was described, our patient had no clinical signs of PJS and the detected\n                    <jats:italic>STK11<\/jats:italic>\n                    mutation was likely somatic.\n                  <\/jats:p>","DOI":"10.1007\/s00428-025-04236-w","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T03:59:44Z","timestamp":1756871984000},"page":"525-530","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synchronous mucinous metaplasia and neoplasia of the ovarium and fallopian tube with STK11 and KRAS mutations: a case report"],"prefix":"10.1007","volume":"489","author":[{"given":"Miroslava","family":"Fl\u00eddrov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Krkavcov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"H\u00e1jkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krist\u00fdna","family":"N\u011bmejcov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Dundr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5869-3618","authenticated-orcid":false,"given":"Michaela","family":"Kendall B\u00e1rt\u016f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"issue":"2","key":"4236_CR1","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1111\/j.1365-2559.2008.03202.x","volume":"54","author":"Y Mikami","year":"2009","unstructured":"Mikami Y, Kiyokawa T, Sasajima Y et al (2009) Reappraisal of synchronous and multifocal mucinous lesions of the female genital tract: a close association with gastric metaplasia. Histopathology 54(2):184\u2013191. https:\/\/doi.org\/10.1111\/j.1365-2559.2008.03202.x","journal-title":"Histopathology"},{"key":"4236_CR2","doi-asserted-by":"publisher","first-page":"1246821","DOI":"10.3389\/fonc.2023.1246821","volume":"13","author":"R Wang","year":"2023","unstructured":"Wang R, Yu H, Liu M, Hao T, Wang X, Cao L (2023) Synchronous mucinous metaplasia and neoplasia of the female genital tract with both pulmonary metastases and STK11\/KRAS gene mutations: a case report. Front Oncol 13:1246821. https:\/\/doi.org\/10.3389\/fonc.2023.1246821","journal-title":"Front Oncol"},{"issue":"2","key":"4236_CR3","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3892\/etm.2022.11772","volume":"25","author":"H Xu","year":"2022","unstructured":"Xu H, Chen Y, Zhou S et al (2022) Synchronous mucinous metaplasia and neoplasia of the female genital tract (SMMN FGT): a case report and literature review. Exp Ther Med 25(2):73. https:\/\/doi.org\/10.3892\/etm.2022.11772","journal-title":"Exp Ther Med"},{"key":"4236_CR4","doi-asserted-by":"publisher","unstructured":"Zhou Y, Wang X, Li Y, et al. When synchronous mucinous metaplasia and neoplasia of the female genital tract and peutz-jeghers syndrome meet: a case report and literature reviews. BMC Womens Health. Jun 28 2024;24(1):375. https:\/\/doi.org\/10.1186\/s12905-024-03184-y","DOI":"10.1186\/s12905-024-03184-y"},{"issue":"1","key":"4236_CR5","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.ygyno.2003.10.005","volume":"92","author":"G Mangili","year":"2004","unstructured":"Mangili G, Taccagni G, Garavaglia E, Carnelli M, Montoli S (2004) An unusual admixture of neoplastic and metaplastic lesions of the female genital tract in the Peutz-Jeghers syndrome. Gynecol Oncol 92(1):337\u2013342. https:\/\/doi.org\/10.1016\/j.ygyno.2003.10.005","journal-title":"Gynecol Oncol"},{"issue":"8","key":"4236_CR6","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1097\/PAS.0000000000001677","volume":"45","author":"JA Bennett","year":"2021","unstructured":"Bennett JA, Young RH, Howitt BE et al (2021) A distinctive adnexal (usually paratubal) neoplasm often associated with Peutz-Jeghers syndrome and characterized by STK11 alterations (STK11 adnexal tumor): a report of 22 cases. 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The Ethics Committee waived the requirement for informed consent as, according to Czech Law (Act. no. 373\/11, and its amendment Act no. 202\/17), it is not necessary to obtain informed consent in fully anonymised studies.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}