{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:14:35Z","timestamp":1778739275703,"version":"3.51.4"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Ningbo Top Medical and Health Research Program","award":["2023010211"],"award-info":[{"award-number":["2023010211"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s00428-025-04246-8","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T03:33:44Z","timestamp":1757388824000},"page":"1157-1163","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An unusual spindle cell variant of papillary thyroid carcinoma with KIF5B::MET fusion: report of a case"],"prefix":"10.1007","volume":"488","author":[{"given":"Qi","family":"Ding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongli","family":"Gan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5971-7303","authenticated-orcid":false,"given":"Ming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"issue":"1","key":"4246_CR1","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1097\/PAP.0b013e3182026da6","volume":"18","author":"E Khanafshar","year":"2011","unstructured":"Khanafshar E, Lloyd RV (2011) The spectrum of papillary thyroid carcinoma variants. Adv Anat Pathol 18(1):90\u201397. https:\/\/doi.org\/10.1097\/PAP.0b013e3182026da6","journal-title":"Adv Anat Pathol"},{"key":"4246_CR2","unstructured":"Mete O, Fadda G, Kakudo K, et al (2025) Papillary thyroid carcinoma. In: WHO Classification of Tumours Editorial Board (ed) WHO Classification of Tumours Endocrine and Neuroendocrine Tumours, 5th edn. Vol. 10, International Agency for Research on Cancer (IARC), Lyon, France"},{"issue":"2","key":"4246_CR3","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1309\/XFN3-2E1B-21VW-8X28","volume":"117","author":"J Vergilio","year":"2002","unstructured":"Vergilio J, Baloch ZW, LiVolsi VA (2002) Spindle cell metaplasia of the thyroid arising in association with papillary carcinoma and follicular adenoma. Am J Clin Pathol 117(2):199\u2013204. https:\/\/doi.org\/10.1309\/XFN3-2E1B-21VW-8X28","journal-title":"Am J Clin Pathol"},{"issue":"4","key":"4246_CR4","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1111\/j.1365-2559.2004.01916.x","volume":"45","author":"C Woenckhaus","year":"2004","unstructured":"Woenckhaus C, Cameselle-Teijeiro J et al (2004) Spindle cell variant of papillary thyroid carcinoma. Histopathology 45(4):424\u2013427. https:\/\/doi.org\/10.1111\/j.1365-2559.2004.01916.x","journal-title":"Histopathology"},{"issue":"2","key":"4246_CR5","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1007\/s12022-012-9193-z","volume":"23","author":"ED Rossi","year":"2012","unstructured":"Rossi ED, Martini M, Cingolani N et al (2012) Images in endocrine pathology: spindle cell lesion of the thyroid gland. Endocr Pathol 23(2):132\u2013134. https:\/\/doi.org\/10.1007\/s12022-012-9193-z","journal-title":"Endocr Pathol"},{"issue":"3","key":"4246_CR6","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s12022-013-9290-7","volume":"25","author":"S Corrado","year":"2014","unstructured":"Corrado S, Corsello SM, Maiorana A et al (2014) Papillary thyroid carcinoma with predominant spindle cell component: report of two rare cases and discussion on the differential diagnosis with other spindled thyroid neoplasm. Endocr Pathol 25(3):307\u2013314. https:\/\/doi.org\/10.1007\/s12022-013-9290-7","journal-title":"Endocr Pathol"},{"issue":"10","key":"4246_CR7","first-page":"13528","volume":"8","author":"X Ma","year":"2015","unstructured":"Ma X, Xia C, Liu H, Zhu W (2015) Primary thyroid spindle cell tumors: spindle cell variant of papillary thyroid carcinoma? Int J Clin Exp Pathol 8(10):13528\u201313531","journal-title":"Int J Clin Exp Pathol"},{"issue":"4","key":"4246_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12040855","volume":"12","author":"KW Leong","year":"2022","unstructured":"Leong KW, Abdullah Suhaimi SN, Tan GC et al (2022) Papillary thyroid carcinoma with spindle cell metaplasia: a rare encounter. Diagnostics 12(4):855. https:\/\/doi.org\/10.3390\/diagnostics12040855","journal-title":"Diagnostics"},{"issue":"Suppl 2","key":"4246_CR9","doi-asserted-by":"publisher","first-page":"S881","DOI":"10.4103\/jcrt.jcrt_66_23","volume":"19","author":"S Khan","year":"2023","unstructured":"Khan S, Hassan MJ, Hameed S et al (2023) Spindle cell variant of papillary thyroid carcinoma: a diagnostic challenge - a rare case report with brief review of literature. J Cancer Res Ther 19(Suppl 2):S881\u2013S885. https:\/\/doi.org\/10.4103\/jcrt.jcrt_66_23","journal-title":"J Cancer Res Ther"},{"issue":"Suppl","key":"4246_CR10","doi-asserted-by":"publisher","first-page":"S95","DOI":"10.1309\/4DQW6RQX3C6KRX1J","volume":"125","author":"G Papi","year":"2006","unstructured":"Papi G, Corrado S, LiVolsi VA (2006) Primary spindle cell lesions of the thyroid gland; an overview. Am J Clin Pathol 125(Suppl):S95\u2013123. https:\/\/doi.org\/10.1309\/4DQW6RQX3C6KRX1J","journal-title":"Am J Clin Pathol"},{"key":"4246_CR11","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-025-04095-5","author":"A Feraco","year":"2025","unstructured":"Feraco A, Vegni F, Urtueta BP et al (2025) Spindle lesions in the thyroid: a cytological and histological review. Virchows Arch. https:\/\/doi.org\/10.1007\/s00428-025-04095-5","journal-title":"Virchows Arch"},{"issue":"2","key":"4246_CR12","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1097\/01.pas.0000176432.73455.1b","volume":"30","author":"AJ Adeniran","year":"2006","unstructured":"Adeniran AJ, Zhu Z, Gandhi M et al (2006) Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas. Am J Surg Pathol 30(2):216\u2013222. https:\/\/doi.org\/10.1097\/01.pas.0000176432.73455.1b","journal-title":"Am J Surg Pathol"},{"issue":"3","key":"4246_CR13","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/nrc3431","volume":"13","author":"M Xing","year":"2013","unstructured":"Xing M (2013) Molecular pathogenesis and mechanisms of thyroid cancer. Nat Rev Cancer 13(3):184\u2013199. https:\/\/doi.org\/10.1038\/nrc3431","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"4246_CR14","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.cell.2014.09.050","volume":"159","author":"Cancer Genome Atlas Research Network","year":"2014","unstructured":"Cancer Genome Atlas Research Network (2014) Integrated genomic characterization of papillary thyroid carcinoma. Cell 159(3):676\u2013690. https:\/\/doi.org\/10.1016\/j.cell.2014.09.050","journal-title":"Cell"},{"issue":"2","key":"4246_CR15","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1002\/path.5005","volume":"244","author":"J Liang","year":"2018","unstructured":"Liang J, Cai W, Feng D et al (2018) Genetic landscape of papillary thyroid carcinoma in the Chinese population. J Pathol 244(2):215\u2013226. https:\/\/doi.org\/10.1002\/path.5005","journal-title":"J Pathol"},{"issue":"12","key":"4246_CR16","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1089\/thy.2019.0802","volume":"30","author":"B Pekova","year":"2020","unstructured":"Pekova B, Sykorova V, Dvorakova S et al (2020) RET, NTRK, ALK, BRAF, and MET fusions in a large cohort of pediatric papillary thyroid carcinomas. Thyroid 30(12):1771\u20131780. https:\/\/doi.org\/10.1089\/thy.2019.0802","journal-title":"Thyroid"},{"issue":"22","key":"4246_CR17","doi-asserted-by":"publisher","first-page":"5625","DOI":"10.1158\/0008-5472.CAN-21-0761","volume":"81","author":"A Stosic","year":"2021","unstructured":"Stosic A, Fuligni F, Anderson ND et al (2021) Diverse oncogenic fusions and distinct gene expression patterns define the genomic landscape of pediatric papillary thyroid carcinoma. Cancer Res 81(22):5625\u20135637. https:\/\/doi.org\/10.1158\/0008-5472.CAN-21-0761","journal-title":"Cancer Res"},{"issue":"12","key":"4246_CR18","doi-asserted-by":"publisher","first-page":"2458","DOI":"10.1038\/s41379-020-0638-5","volume":"33","author":"YH Chu","year":"2020","unstructured":"Chu YH, Wirth LJ, Farahani AA et al (2020) Clinicopathologic features of kinase fusion-related thyroid carcinomas: an integrative analysis with molecular characterization. Mod Pathol 33(12):2458\u20132472. https:\/\/doi.org\/10.1038\/s41379-020-0638-5","journal-title":"Mod Pathol"},{"issue":"14","key":"4246_CR19","doi-asserted-by":"publisher","first-page":"2845","DOI":"10.1038\/s41388-020-1193-8","volume":"39","author":"JP Koch","year":"2020","unstructured":"Koch JP, Aebersold DM, Zimmer Y et al (2020) MET targeting: time for a rematch. Oncogene 39(14):2845\u20132862. https:\/\/doi.org\/10.1038\/s41388-020-1193-8","journal-title":"Oncogene"},{"issue":"4","key":"4246_CR20","doi-asserted-by":"publisher","first-page":"263","DOI":"10.3390\/biomedicines2040263","volume":"2","author":"L Ruco","year":"2014","unstructured":"Ruco L, Scarpino S (2014) The pathogenetic role of the HGF\/c-Met system in papillary carcinoma of the thyroid. Biomedicines 2(4):263\u2013274. https:\/\/doi.org\/10.3390\/biomedicines2040263","journal-title":"Biomedicines"},{"issue":"1","key":"4246_CR21","doi-asserted-by":"publisher","first-page":"87","DOI":"10.5858\/2004-128-87-SCTOPC","volume":"128","author":"MS Brandwein-Gensler","year":"2004","unstructured":"Brandwein-Gensler MS, Wang BY et al (2004) Spindle cell transformation of papillary carcinoma: an aggressive entity distinct from anaplastic thyroid carcinoma. Arch Pathol Lab Med 128(1):87\u201389. https:\/\/doi.org\/10.5858\/2004-128-87-SCTOPC","journal-title":"Arch Pathol Lab Med"},{"issue":"8","key":"4246_CR22","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/j.neo.2018.06.007","volume":"20","author":"CH Gow","year":"2018","unstructured":"Gow CH, Liu YN, Li HY et al (2018) Oncogenic function of a KIF5B-MET fusion variant in non-small cell lung cancer. Neoplasia 20(8):838\u2013847. https:\/\/doi.org\/10.1016\/j.neo.2018.06.007","journal-title":"Neoplasia"},{"issue":"5","key":"4246_CR23","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1007\/s40265-021-01477-2","volume":"81","author":"EB Garon","year":"2021","unstructured":"Garon EB, Brodrick P (2021) Targeted therapy approaches for MET abnormalities in non-small cell lung cancer. Drugs 81(5):547\u2013554. https:\/\/doi.org\/10.1007\/s40265-021-01477-2","journal-title":"Drugs"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-025-04246-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-025-04246-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-025-04246-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:58:50Z","timestamp":1778738330000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00428-025-04246-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,9]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["4246"],"URL":"https:\/\/doi.org\/10.1007\/s00428-025-04246-8","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,9]]},"assertion":[{"value":"25 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was performed in accordance with the Declaration of Helsinki. This study was approved by the Institutional Review Boards Committee from Ningbo Clinical Pathology Diagnosis Center, China. Written informed consent for participation was not required for this study in accordance with the institutional requirements.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}