{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:14:33Z","timestamp":1778739273564,"version":"3.51.4"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005743","name":"Universit\u00e0 Cattolica del Sacro Cuore","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005743","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Thyroid nodules are frequently encountered, mostly detected during ultrasound evaluation of the head and neck, frequently performed for other reasons. Albeit most nodules arise in the setting of multinodular goiter, hypoechoic subcentimeter nodules can be recognized that show suspicious features, requiring them to undergo fine needle aspiration cytology (FNAC) evaluation. ATA guidelines suggest performing FNAC only on nodules greater than 1.5\u00a0cm. Nevertheless, the issue emerges if these subcentimeter lesions are aspirated and diagnosed as follicular neoplasms (FN). Herein, we describe an algorithm used to approach such subcentimeter thyroid nodules in our tertiary medical center. All subcentimeter thyroid nodules sampled by FNAC were retrieved, performed between 2014 and 2023 with a diagnosis of indeterminate lesion of high-risk malignancy (Italian Classification system) that corresponds to follicular neoplasm (FN) in the Bethesda Reporting System. These cases were processed only with liquid-based cytology (LBC) with immunocytochemistry (ICC) and molecular testing performed when necessary. The series included 174 indeterminate subcentimeter nodules analyzed with FNAC, based on suspicious ultrasound criteria. The cytological diagnosis included 101 cases with atypia of undetermined significance (AUS) and 74 FN. All FN cases underwent surgery, and the subsequent histological diagnoses revealed 24 (32%) benign and 49 malignant lesions including 38 papillary thyroid carcinoma (PTC) and its variants as well as 11 cases of invasive follicular variant of PTC (I-FVPTC). Furthermore, 30.6% (15\/49) of these malignant lesions had lymph node involvement, and 34.6% were multifocal. Among the histological malignant cases, only three (6.1%) cases had a moderate positivity for VE1-BRAF, with eight (16.3%) cases showing a concordant positive HMBE1 and Galectin-3 panel. Although some guidelines do not recommend sampling subcentimeter thyroid nodules, in clinical practice, these may undergo FNAC to help elucidate concerning ultrasound findings. In our series, in the presence of suspicious ultrasound criteria, 66% of the nodules turned out to be malignant. Although ICC is unable to help make a definitive diagnosis, it serves as a useful pathology ancillary tool in the algorithmic work-up of subcentimeter thyroid lesions.<\/jats:p>","DOI":"10.1007\/s00428-025-04308-x","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:44:38Z","timestamp":1760949878000},"page":"1101-1109","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Histopathologic and ancillary findings of subcentimeter thyroid nodules diagnosed as follicular neoplasms: a retrospective institutional study"],"prefix":"10.1007","volume":"488","author":[{"given":"Angela","family":"Feraco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belen Padial","family":"Urtueta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Cioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Pontecorvi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Raffaelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Fadda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Mul\u00e8","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liron","family":"Pantanowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3819-4229","authenticated-orcid":false,"given":"Esther Diana","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"issue":"2","key":"4308_CR1","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.jvir.2022.11.005","volume":"34","author":"TK Woon","year":"2023","unstructured":"Woon TK, Zhou K, Tan BS, Matchar DB (2023) High-suspicion subcentimeter thyroid nodules: cost effectiveness of active surveillance versus fine needle aspiration. J Vasc Interv Radiol 34(2):173\u2013181","journal-title":"J Vasc Interv Radiol"},{"issue":"8","key":"4308_CR2","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1002\/cncy.22015","volume":"126","author":"VL Weiss","year":"2018","unstructured":"Weiss VL, Andreotti RF, Ely KA (2018) Use of the thyroid imaging, reporting, and data system (TI-RADS) scoring system for the evaluation of subcentimeter thyroid nodules. Cancer Cytopathol 126(8):518\u2013524","journal-title":"Cancer Cytopathol"},{"issue":"6","key":"4308_CR3","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1089\/thy.2008.0100","volume":"18","author":"EL Mazzaferri","year":"2008","unstructured":"Mazzaferri EL, Sipos J (2008) Should all patients with subcentimeter thyroid nodules undergo fine-needle aspiration biopsy and preoperative neck ultrasonography to define the extent of tumor invasion? Thyroid 18(6):597\u2013602","journal-title":"Thyroid"},{"issue":"1","key":"4308_CR4","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s12020-010-9405-6","volume":"39","author":"D Berker","year":"2011","unstructured":"Berker D, Isik S, Ozuguz U, Tutuncu YA, Kucukler K, Akbaba G, Aydin Y, Guler S (2011) Prevalence of incidental thyroid cancer and its ultrasonographic features in subcentimeter thyroid nodules of patients with hyperthyroidism. Endocrine 39(1):13\u201320","journal-title":"Endocrine"},{"issue":"6","key":"4308_CR5","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1245\/s10434-016-5728-8","volume":"24","author":"HM Gweon","year":"2017","unstructured":"Gweon HM, Son EJ, Kim JA, Youk JH (2017) Predictive factors for active surveillance of subcentimeter thyroid nodules with highly suspicious US features. Ann Surg Oncol 24(6):1540\u20131545","journal-title":"Ann Surg Oncol"},{"key":"4308_CR6","doi-asserted-by":"crossref","unstructured":"Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al. 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid. 16 Jan;26((1)):1\u2013133","DOI":"10.1089\/thy.2015.0020"},{"key":"4308_CR7","doi-asserted-by":"crossref","unstructured":"Huang P, Han L, Shi X, Xiao F, Shen Q, Li X, Zhang F. Predictive value of the single most suspicious ultrasound feature in\u00a0subcentimeter\u00a0thyroid\u00a0nodules: a retrospective observational cohort study.J Cancer Res Clin Oncol. 2024 Aug 6;150(8):384.","DOI":"10.1007\/s00432-024-05895-z"},{"key":"4308_CR8","doi-asserted-by":"crossref","unstructured":"Fiorentino V, Dell' Aquila M, Musarra T et al. The role of cytology in the diagnosis of\u00a0subcentimeter\u00a0thyroid\u00a0lesions.Diagnostics (Basel). 2021 Jun 6;11(6):1043.","DOI":"10.3390\/diagnostics11061043"},{"key":"4308_CR9","doi-asserted-by":"crossref","unstructured":"Papaioannou C, Lamnisos D, Kyriacou K, et al. Lymph node metastasis and extrathyroidal Extension in papillary\u00a0thyroid\u00a0microcarcinoma in Cyprus: suspicious\u00a0subcentimeter\u00a0nodules\u00a0should undergo FNA when multifocality is suspected..J Thyroid Res. 2020 Mar 24;2020:3567658","DOI":"10.1155\/2020\/3567658"},{"key":"4308_CR10","doi-asserted-by":"crossref","unstructured":"Ding J, Jiang L, Fang J et al. Predictors for malignancy risk in\u00a0subcentimeter\u00a0thyroid\u00a0nodules\u00a0categorized as atypia\/follicular lesion of undetermined significance by fine needle aspiration..Sci Rep. 2019 Oct 18;9(1):14973.","DOI":"10.1038\/s41598-019-50597-z"},{"key":"4308_CR11","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-60570-8","volume-title":"The Bethesda system for reporting thyroid cytopathology","author":"S Ali","year":"2018","unstructured":"Ali S, Cibas ES (2018) The Bethesda system for reporting thyroid cytopathology, 2nd edn. Springer, Berlin","edition":"2"},{"key":"4308_CR12","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-28046-7","volume-title":"The Bethesda system for reporting thyroid cytopathology","author":"S Ali","year":"2023","unstructured":"Ali S, Vanderlaan P (2023) The Bethesda system for reporting thyroid cytopathology, 3rd edn. Springer, Berlin","edition":"3"},{"key":"4308_CR13","unstructured":"Perros P, Boelaert K, Colley S et al. Guidelines for the management of thyroid cancer. Report of the Thyroid Cancer Guidelines Update Group. British Thyroid Association, Royal College of Physicians. London. 2007, 3rd edition"},{"key":"4308_CR14","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1007\/s40618-014-0062-0","volume":"37","author":"F Nardi","year":"2014","unstructured":"Nardi F, Basolo F, Crescenzi A, Fadda G, Frasoldati A, Orlandi F et al (2014) Italian consensus for the classification and reporting of thyroid cytology. J Endocrinol Invest 37:593\u2013599","journal-title":"J Endocrinol Invest"},{"issue":"8","key":"4308_CR15","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1080\/02841850903062724","volume":"50","author":"JY Kwak","year":"2009","unstructured":"Kwak JY, Kim EK, Kim MJ, Son EJ (2009) Significance of sonographic characterization for managing subcentimeter thyroid nodules. Acta Radiol 50(8):917\u2013923","journal-title":"Acta Radiol"},{"issue":"5","key":"4308_CR16","first-page":"e273","volume":"6","author":"R Hu","year":"2020","unstructured":"Hu R, Xu G, Stricker T, Li B, Weiss VL, Bischoff L (2020Sep 21) In revealing subcentimeter papillary thyroid carcinoma. Incidental pulmonary metastasesAACE Clin Case Rep 6(5):e273\u2013e278","journal-title":"Incidental pulmonary metastasesAACE Clin Case Rep"},{"issue":"8","key":"4308_CR17","doi-asserted-by":"publisher","first-page":"857","DOI":"10.4158\/EP-2019-0590","volume":"26","author":"N Genere","year":"2020","unstructured":"Genere N, Hurtado MD, Cortes T, Athimulam S, Al Ward R, Callstrom MR, Stan MN, Morris JC, Brito JP (2020) Drivers of the decision to biopsy and follow-up of small suspicious thyroid nodules. Endocr Pract 26(8):857\u2013868","journal-title":"Endocr Pract"},{"issue":"12","key":"4308_CR18","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1089\/thy.2012.0586","volume":"23","author":"HG Kim","year":"2013","unstructured":"Kim HG, Moon HJ, Kwak JY, Kim EK (2013) Diagnostic accuracy of the ultrasonographic features for subcentimeter thyroid nodules suggested by the revised American Thyroid Association guidelines. Thyroid 23(12):1583\u20131589","journal-title":"Thyroid"},{"issue":"7","key":"4308_CR19","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1002\/dc.24170","volume":"47","author":"B\u0130 Aydo\u011fan","year":"2019","unstructured":"Aydo\u011fan B\u0130, \u015eahin M, Ceyhan K (2019) The influence of thyroid nodule size on the diagnostic efficacy and accuracy of ultrasound guided fine needle-aspiration cytology. Diagn Cytopathol 47(7):682\u2013687","journal-title":"Diagn Cytopathol"},{"issue":"3","key":"4308_CR20","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1007\/s12020-020-02416-z","volume":"70","author":"JH Yoon","year":"2020","unstructured":"Yoon JH, Lee HS, Kim EK, Moon HJ, Park VY, Kwak JY (2020) Cytopathologic criteria and size should be considered in comparison of fine-needle aspiration vs. core-needle biopsy for thyroid nodules: results based on large surgical series. Endocrine 70(3):558\u2013565","journal-title":"Endocrine"},{"issue":"1083","key":"4308_CR21","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20170642","volume":"91","author":"GF Mendes","year":"2018","unstructured":"Mendes GF, Garcia MR, Falsarella PM, Rahal A, Cavalcante Junior FA, Nery DR, Garcia RG (2018) Fine needle aspiration biopsy of thyroid nodule smaller than 1.0 cm: accuracy of TIRADS classification system in more than 1000 nodules. Br J Radiol 91(1083):20170642","journal-title":"Br J Radiol"},{"issue":"2","key":"4308_CR22","doi-asserted-by":"publisher","first-page":"237","DOI":"10.3346\/jkms.2011.26.2.237","volume":"26","author":"YH Bo","year":"2011","unstructured":"Bo YH, Ahn HY, Lee YH (2011) Malignancy rate in sonographically suspicious thyroid nodules of less than a centimeter in size does not decrease with decreasing size. J Korean Med Sci 26(2):237\u2013242","journal-title":"J Korean Med Sci"},{"issue":"1","key":"4308_CR23","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1177\/000313481808400135","volume":"84","author":"AP Marrero","year":"2018","unstructured":"Marrero AP, Gracia A, M\u00e9ndez W (2018Jan 1) The sonographic subcentimeter malignant thyroid nodule: what does it stand for? Am Surg 84(1):137\u2013139","journal-title":"Am Surg"},{"key":"4308_CR24","first-page":"622","volume":"22","author":"H Gharib","year":"2016","unstructured":"Gharib H, Papini E, Garber JR et al (2016) American Association of Clinical Endocrinologist, American College of Endocrinology, and Associazione Medici Endocrinologi medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: 2016 update. Endocrin Pract 22:622\u2013639","journal-title":"Endocrin Pract"},{"key":"4308_CR25","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1159\/000325920","volume":"50","author":"G Fadda","year":"2006","unstructured":"Fadda G, Rossi ED, Mule\u2019 A, Miraglia A, Vecchio FM, Capelli A (2006) Diagnostic efficacy of immunocytochemistry on fine needle aspiration biopsies processed by thin layer cytology. Acta Cytol 50:129\u2013135","journal-title":"Acta Cytol"},{"key":"4308_CR26","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1159\/000329029","volume":"55","author":"G Fadda","year":"2011","unstructured":"Fadda G, Rossi ED (2011) Liquid based cytology in fine-needle aspiration biopsies of the thyroid gland. Acta Cytol 55:389\u2013400","journal-title":"Acta Cytol"},{"key":"4308_CR27","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1002\/cncy.21416","volume":"122","author":"ED Rossi","year":"2014","unstructured":"Rossi ED, Martini M, Capodimonti S, Cenci T, Straccia P, Angrisani B et al (2014) Analysis of immunocytochemical and molecular BRAF expression in thyroid carcinomas: a cyto-histological institutional experience. Cancer Cytopathol 122:52\u201356","journal-title":"Cancer Cytopathol"},{"key":"4308_CR28","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1111\/cyt.12555","volume":"29","author":"ED Rossi","year":"2018","unstructured":"Rossi ED, Martini M, Capodimonti S, Cenci T, Bilotta M, Pierconti F et al (2018) Morphology combined with ancillary techniques: an algorithm approach for thyroid nodules. Cytopathology 29:418\u2013427","journal-title":"Cytopathology"},{"key":"4308_CR29","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/cncy.21258","volume":"121","author":"ED Rossi","year":"2013","unstructured":"Rossi ED, Martini M, Capodimonti S, Lombardi CP, Pontecorvi A, Vellone VG et al (2013) Braf (v600e) mutation analysis on LBC-processed aspiration biopsies predicts bilaterality and nodal involvement in papillary thyroid microcarcinoma. Cancer Cytopathol 121:291\u2013297","journal-title":"Cancer Cytopathol"},{"issue":"1","key":"4308_CR30","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s12022-022-09707-3","volume":"33","author":"ZW Baloch","year":"2022","unstructured":"Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Sim\u00f5es M, Tallini G, Mete O (2022) Overview of the 2022 WHO classification of thyroid neoplasms. Endocr Pathol 33(1):27\u201364","journal-title":"Endocr Pathol"},{"issue":"1","key":"4308_CR31","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s12022-023-09756-2","volume":"34","author":"ED Rossi","year":"2023","unstructured":"Rossi ED, Baloch Z (2023) The impact of the 2022 WHO classification of thyroid neoplasms on everyday practice of cytopathology. Endocr Pathol 34(1):23\u201333","journal-title":"Endocr Pathol"},{"issue":"8","key":"4308_CR32","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1001\/jamaoncol.2016.0386","volume":"2","author":"YE Nikiforov","year":"2016","unstructured":"Nikiforov YE, Seethala RR, Tallini G, Baloch ZW, Basolo F, Thompson LD et al (2016) Nomenclature revision for encapsulated follicular variant of papillary thyroid carcinoma: a paradigm shift to reduce overtreatment of indolent tumors. JAMA Oncol 2(8):1023\u20131029","journal-title":"JAMA Oncol"},{"key":"4308_CR33","unstructured":"American Joint Commission on Cancer (AJCC) Cancer Staging Atlas, 2017 8th Edition."},{"key":"4308_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/1176935118765132","volume":"17","author":"MA Al Dawish","year":"2018","unstructured":"Al Dawish MA, Rober AA, Thabet MA, Braham R (2018) Thyroid nodule management: thyroid-stimulating hormone, ultrasound and cytological classification system for predicting malignancy. Cancer Inform 17:1\u20139","journal-title":"Cancer Inform"},{"key":"4308_CR35","doi-asserted-by":"crossref","unstructured":"Grani G, Sponziello M, Pecce v, Ramundo V, Durante C. Contemporary thyroid evaluation and management. J Clin Endocrinol Metab. 2020; 105: 2869\u201383","DOI":"10.1210\/clinem\/dgaa322"},{"key":"4308_CR36","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1002\/cncy.22634","volume":"130","author":"KS Wong","year":"2022","unstructured":"Wong KS, Barletta JA (2022) The new endocrine WHO classification: what does this mean for thyroid cytology? Cancer Cytopathol 130:658\u2013662","journal-title":"Cancer Cytopathol"},{"key":"4308_CR37","doi-asserted-by":"publisher","first-page":"e1240","DOI":"10.1210\/clinem\/dgaa887","volume":"106","author":"CY Zhu","year":"2021","unstructured":"Zhu CY, Donangel I, Gupta D et al (2021) Outcomes of indeterminate thyroid nodules managed nonoperatively after molecular testing. J Clin Endocrinol Metab 106:e1240\u2013e1247","journal-title":"J Clin Endocrinol Metab"},{"key":"4308_CR38","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1002\/dc.24522","volume":"48","author":"N Kumar","year":"2020","unstructured":"Kumar N, Gupta R, Gupta S (2020) Molecular testing in diagnosis of indeterminate thyroid cytology: trends and drivers. Diagn Cytopathol 48:1144\u20131151","journal-title":"Diagn Cytopathol"},{"key":"4308_CR39","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1002\/cncy.22542","volume":"130","author":"HN Gokozan","year":"2022","unstructured":"Gokozan HN, Dilcher TL, Alperstein S et al (2022) Combining molecular testing and the Bethesda category III:VI ratio for thyroid fine-needle aspirates: a quality-assurance metric for evaluating diagnostic performance in a cytopathology laboratory. Cancer Cytopathol 130:259\u2013274","journal-title":"Cancer Cytopathol"},{"issue":"4","key":"4308_CR40","doi-asserted-by":"publisher","first-page":"446","DOI":"10.5858\/arpa.2017-0174-RA","volume":"142","author":"M Nishino","year":"2018","unstructured":"Nishino M, Nikiforova M (2018Apr) Update on molecular testing for cytologically indetrminate thyroid nodules. Arch Pathol Lab Med 142(4):446\u2013457","journal-title":"Arch Pathol Lab Med"},{"key":"4308_CR41","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1002\/cncy.22012","volume":"126","author":"ED Rossi","year":"2018","unstructured":"Rossi ED, Larocca LM, Pantanowitz L (2018) Ancillary molecular testing of indeterminate thyroid nodules. Cancer Cytopathol 126:654\u2013671","journal-title":"Cancer Cytopathol"},{"key":"4308_CR42","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1159\/000496502","volume":"64","author":"M Nishino","year":"2020","unstructured":"Nishino M, Krane J (2020) Role of ancillary techniques in thyroid cytology specimens. Acta Cytol 64:40\u201351","journal-title":"Acta Cytol"},{"key":"4308_CR43","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/cncy.22684","volume":"131","author":"E Hall","year":"2023","unstructured":"Hall E, Hartzband P, Vnaderlaan P, Nishino M (2023) Risk stratification of cytologically indeterminate thyroid nodules with nondiagnostic or benign cytology on repeat FNA: implications for molecular testing and surveillance. Cancer Cytopathol 131:313\u2013324","journal-title":"Cancer Cytopathol"},{"key":"4308_CR44","doi-asserted-by":"crossref","unstructured":"Rossi ED, Locantore P, Bruno C et al. Molecular characterization of thyroid follicular lesions in the era of \"next-generation\" techniques front endocrinol (Lausanne). 2022 May 12;13:834456.","DOI":"10.3389\/fendo.2022.834456"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-025-04308-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-025-04308-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-025-04308-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:58:46Z","timestamp":1778738326000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00428-025-04308-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,20]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["4308"],"URL":"https:\/\/doi.org\/10.1007\/s00428-025-04308-x","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,20]]},"assertion":[{"value":"20 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}