{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T17:30:44Z","timestamp":1769103044849,"version":"3.49.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"DOI":"10.1007\/s00428-025-04387-w","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T08:11:53Z","timestamp":1767773513000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Uterine cellular leiomyoma with a novel HMGA2::PLCZ1 fusion and aberrant cyclin D1 expression: expanding the molecular spectrum and highlighting a diagnostic pitfall"],"prefix":"10.1007","author":[{"given":"Antonio","family":"d\u2019Amati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Narducci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Minucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"De Bonis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Perrucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"Catena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Nero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian Franco","family":"Zannoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"4387_CR1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-025-03974-y","volume":"25","author":"Z Zhang","year":"2025","unstructured":"Zhang Z, Huang H, Jiang K, Liu W, Xuan Y, Lu W (2025) Global, regional and national uterine fibroid burdens from 1990 to 2021 and projections until 2050: results from the GBD study. BMC Womens Health 25:423. https:\/\/doi.org\/10.1186\/s12905-025-03974-y","journal-title":"BMC Womens Health"},{"key":"4387_CR2","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1007\/s00428-023-03603-9","volume":"484","author":"P Dundr","year":"2024","unstructured":"Dundr P, Machado-Lopez A, Mas A, V\u011bckov\u00e1 Z, M\u00e1ra M, Richt\u00e1rov\u00e1 A et al (2024) Uterine leiomyoma with RAD51B::NUDT3 fusion: a report of 2 cases. Virchows Arch 484:1015\u20131022. https:\/\/doi.org\/10.1007\/s00428-023-03603-9","journal-title":"Virchows Arch"},{"key":"4387_CR3","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1111\/his.14732","volume":"81","author":"BB Griffin","year":"2022","unstructured":"Griffin BB, Feng Y, Saini P, Lu X, Bulun S, Chakravarti D et al (2022) Histological and molecular analysis of cellular leiomyoma with sclerosis: linked to HMGA2 overexpression. Histopathology 81:587\u2013599. https:\/\/doi.org\/10.1111\/his.14732","journal-title":"Histopathology"},{"key":"4387_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0672-1","volume":"16","author":"N M\u00e4kinen","year":"2017","unstructured":"M\u00e4kinen N, K\u00e4mpj\u00e4rvi K, Frizzell N, B\u00fctzow R, Vahteristo P (2017) Characterization of MED12, HMGA2, and FH alterations reveals molecular variability in uterine smooth muscle tumors. Mol Cancer 16:101. https:\/\/doi.org\/10.1186\/s12943-017-0672-1","journal-title":"Mol Cancer"},{"key":"4387_CR5","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s00428-021-03217-z","volume":"480","author":"P Dundr","year":"2022","unstructured":"Dundr P, Gregov\u00e1 M, Hojn\u00fd J, Krkavcov\u00e1 E, Mich\u00e1lkov\u00e1 R, N\u011bmejcov\u00e1 K et al (2022) Uterine cellular leiomyomas are characterized by common HMGA2 aberrations, followed by chromosome 1p deletion and MED12 mutation: morphological, molecular, and immunohistochemical study of 52 cases. Virchows Arch 480:281\u2013291. https:\/\/doi.org\/10.1007\/s00428-021-03217-z","journal-title":"Virchows Arch"},{"key":"4387_CR6","doi-asserted-by":"publisher","first-page":"572.e1","DOI":"10.1016\/j.ajog.2014.01.011","volume":"210","author":"JC Hodge","year":"2014","unstructured":"Hodge JC, Pearce KE, Clayton AC, Taran FA, Stewart EA (2014) Uterine cellular leiomyomata with chromosome 1p deletions represent a distinct entity. Am J Obstet Gynecol 210:572.e1-572.e7. https:\/\/doi.org\/10.1016\/j.ajog.2014.01.011","journal-title":"Am J Obstet Gynecol"},{"key":"4387_CR7","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1007\/s00428-005-0037-9","volume":"447","author":"M Nilsson","year":"2005","unstructured":"Nilsson M, Panagopoulos I, Mertens F, Mandahl N (2005) Fusion of the HMGA2 and NFIB genes in lipoma. Virchows Arch 447:855\u2013858. https:\/\/doi.org\/10.1007\/s00428-005-0037-9","journal-title":"Virchows Arch"},{"key":"4387_CR8","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1002\/gcc.20674","volume":"48","author":"X Wang","year":"2009","unstructured":"Wang X, Hulshizer RL, Erickson-Johnson MR, Flynn HC, Jenkins RB, Lloyd RV et al (2009) Identification of novel HMGA2 fusion sequences in lipoma: evidence that deletion of let-7 miRNA consensus binding site 1 in the HMGA2 3\u2019 UTR is not critical for HMGA2 transcriptional upregulation. Genes Chromosomes Cancer 48:673\u2013678. https:\/\/doi.org\/10.1002\/gcc.20674","journal-title":"Genes Chromosomes Cancer"},{"key":"4387_CR9","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1002\/gcc.22885","volume":"59","author":"MK Afshari","year":"2020","unstructured":"Afshari MK, Fehr A, Nevado PT, Andersson MK, Stenman G (2020) Activation of PLAG1 and HMGA2 by gene fusions involving the transcriptional regulator gene NFIB. Genes Chromosomes Cancer 59:652\u2013660. https:\/\/doi.org\/10.1002\/gcc.22885","journal-title":"Genes Chromosomes Cancer"},{"key":"4387_CR10","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.cancergencyto.2010.06.002","volume":"202","author":"GVN Velagaleti","year":"2010","unstructured":"Velagaleti GVN, Tonk VS, Hakim NM, Wang X, Zhang H, Erickson-Johnson MR et al (2010) Fusion of HMGA2 to COG5 in uterine leiomyoma. Cancer Genet Cytogenet 202:11\u201316. https:\/\/doi.org\/10.1016\/j.cancergencyto.2010.06.002","journal-title":"Cancer Genet Cytogenet"},{"key":"4387_CR11","doi-asserted-by":"publisher","unstructured":"Hodgson A, Swanson D, Tang S, Dickson BC, Turashvili G (2020) Gene fusions characterize a subset of uterine cellular leiomyomas. Genes Chromosomes Cancer. https:\/\/doi.org\/10.1002\/gcc.22888","DOI":"10.1002\/gcc.22888"},{"key":"4387_CR12","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1097\/PAS.0b013e31825fa931","volume":"36","author":"C-H Lee","year":"2012","unstructured":"Lee C-H, Ali RH, Rouzbahman M, Marino-Enriquez A, Zhu M, Guo X et al (2012) Cyclin D1 as a diagnostic immunomarker for endometrial stromal sarcoma with YWHAE-FAM22 rearrangement. Am J Surg Pathol 36:1562\u20131570. https:\/\/doi.org\/10.1097\/PAS.0b013e31825fa931","journal-title":"Am J Surg Pathol"},{"key":"4387_CR13","unstructured":"Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer (2025) Mitelman F, Johansson B and Mertens F (eds).  https:\/\/mitelmandatabase.isb-cgc.org. Accessed 29 Sept 2025"},{"key":"4387_CR14","doi-asserted-by":"publisher","first-page":"698","DOI":"10.3390\/vetsci10120698","volume":"10","author":"RA Gonzalez-Castro","year":"2023","unstructured":"Gonzalez-Castro RA, Carnevale EM (2023) Phospholipase C zeta 1 (PLCZ1): the function and potential for fertility assessment and in vitro embryo production in cattle and horses. Vet Sci 10:698. https:\/\/doi.org\/10.3390\/vetsci10120698","journal-title":"Vet Sci"},{"key":"4387_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/genes12020269","volume":"12","author":"B Mansoori","year":"2021","unstructured":"Mansoori B, Mohammadi A, Ditzel HJ, Duijf PHG, Khaze V, Gjerstorff MF et al (2021) HMGA2 as a critical regulator in cancer development. Genes 12:269. https:\/\/doi.org\/10.3390\/genes12020269","journal-title":"Genes"},{"key":"4387_CR16","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1111\/cas.13613","volume":"109","author":"H Tsuyoshi","year":"2018","unstructured":"Tsuyoshi H, Yoshida Y (2018) Molecular biomarkers for uterine leiomyosarcoma and endometrial stromal sarcoma. Cancer Sci 109:1743\u20131752. https:\/\/doi.org\/10.1111\/cas.13613","journal-title":"Cancer Sci"},{"key":"4387_CR17","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s42047-020-00065-0","volume":"3","author":"MA Alabiad","year":"2020","unstructured":"Alabiad MA, Harb OA, Abdelfattah MT, El-Shafaay BSh, El-Taher AK, El-Hendawy EI (2020) The values of transgelin, stathmin, BCOR and cyclin-D1 expression in differentiation between uterine leiomyosarcoma (ULMS) and endometrial stromal sarcoma (ESS); diagnostic and prognostic implications. Surg Exp Pathol 3:13.","journal-title":"Surg Exp Pathol"}],"updated-by":[{"DOI":"10.1007\/s00428-026-04418-0","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000}}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-025-04387-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-025-04387-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-025-04387-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T01:43:39Z","timestamp":1768959819000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00428-025-04387-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,7]]},"references-count":17,"alternative-id":["4387"],"URL":"https:\/\/doi.org\/10.1007\/s00428-025-04387-w","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,7]]},"assertion":[{"value":"28 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 December 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2026","order":6,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":7,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00428-026-04418-0","URL":"https:\/\/doi.org\/10.1007\/s00428-026-04418-0","order":9,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with Good Clinical Practice guidelines, the Declaration of Helsinki, and current laws and regulations. Written informed consent for publication was obtained from the patient.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}