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The aim of this study was to evaluate differential miRNA expression in a single-center series of pediatric B-AL\/B-Ly. Expression profiles of 800 miRNAs in 33 B-AL\/B-Ly samples were evaluated using the NanoString nCounter System. Further validation was performed by qPCR utilizing miRNA-specific TaqMan assays. Significantly expressed miRNAs in B-AL\/B-Ly were evaluated in silico to identify predicted targeted cancer-related pathways. Analysis of miRNAs deregulated in B-AL\/B-Ly compared to normal control lymphoid tissue (NCLT) identified a consistent set of differentially expressed miRNAs, including miR-494-3p, miR-4286, and miR-19a-3p among the higher expressed miRNAs and miR-150-5p, miR-450b-5p, and miR-342-3p among the lower expressed miRNAs in B-AL\/B-Ly compared to NCLT (FC\u2009&gt;\u20091.5,\n                    <jats:italic>p<\/jats:italic>\n                    -adj\u2009&lt;\u20090.05). In silico, the main predicted cancer-related signaling pathways targeted by these miRNAs included the MAPK, PI3K-Akt, JAK-STAT, VEGF, TP53, Fas, TGF-\u03b2, and MYC signaling pathways (\n                    <jats:italic>p<\/jats:italic>\n                    -adj\u2009&lt;\u20090.05). B-AL and B-Ly segregated into two major miRNA clusters with sets of significantly overexpressed miRNAs (miR-223-3p, miR-451a, miR-150-5p, miR-144-3p, miR-142-3p, and miR-15a-5p) and lower expressed miRNAs (miR-494-3p, miR-4286, miR-1915-3p, miR-125b-5p, and miR-100-5p) in B-AL compared to B-Ly (FC\u2009&gt;\u20091.5,\n                    <jats:italic>p<\/jats:italic>\n                    -adj\u2009&lt;\u20090.05). Notably, significant downregulation of miR-10a-5p (FC\u2009&gt;\u20091.5,\n                    <jats:italic>p-<\/jats:italic>\n                    adj\u2009&lt;\u20090.05) was observed in the unfavorable outcome group. In summary, new miRNA signatures of relevance in B-AL and B-Ly could be recognized in this study. Studies in larger cohorts are required to further validate these findings.\n                  <\/jats:p>","DOI":"10.1007\/s00428-026-04426-0","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T08:30:04Z","timestamp":1770366604000},"page":"941-951","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["miRNA profiling in pediatric and young adult Burkitt leukemia and lymphoma"],"prefix":"10.1007","volume":"489","author":[{"given":"Bj\u00f6rn","family":"Schneider","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Redwanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Celis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Esperanza-Cebollada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Montesdeoca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itziar","family":"Salaverria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Planas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Conde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Cam\u00f3s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Arnau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Lopez-Guillermo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Maletzki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Jou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Erbersdobler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olia","family":"Shokraie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almut","family":"Meyer-Bahlburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Ballmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Mora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Campo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl Friedrich","family":"Classen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2142-6898","authenticated-orcid":false,"given":"Teresa M.","family":"Cardesa-Salzmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"4426_CR1","doi-asserted-by":"publisher","first-page":"443","DOI":"10.3322\/caac.21357","volume":"66","author":"LR Teras","year":"2016","unstructured":"Teras LR et al (2016) 2016 US lymphoid malignancy statistics by World Health Organization subtypes. 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