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Scientific literature focusing on a comparison of these two tumor groups is largely lacking so far. This 2-part review article presents a comparison of both tumor groups, investigating similarities and discrepancies in their clinical aspects, terminology, (immune)-histology, and molecular pathology. An initial comparison of the basic microscopic and functional anatomy of normal salivary and cutaneous adnexal structures is followed by a topographic assessment of practical differential diagnostic difficulties, anatomically highlighted in the overlapping periparotid and perioral areas. Altogether, 21 of 36 benign and malignant salivary tumor entities display histological similarities to adnexal tumors of eccrine, apocrine, and rarely sebaceous, but not trichofollicular differentiation. In this first part of the review on related tumor entities, major histological and partly terminological and\/or molecular similarities are compared for salivary pleomorphic adenoma\/myoepithelioma versus cutaneous mixed tumor\/myoepithelioma, for basal cell adenoma and carcinoma versus spiradenoma, cylindroma, and spiradenocarcinoma, as well as for the principle of secondary malignant transformation ex different types of benign adenomas.<\/jats:p>","DOI":"10.1007\/s00428-026-04454-w","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:17:55Z","timestamp":1776133075000},"page":"949-963","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comprehensive comparison of salivary gland and cutaneous adnexal tumors: analogous versus discrepant clinical, terminological, histological, and molecular features"],"prefix":"10.1007","volume":"488","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6183-0249","authenticated-orcid":false,"given":"Stephan","family":"Ihrler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Greber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Agaimy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Haas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Jurmeister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almut","family":"B\u00f6er-Auer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"4454_CR1","volume-title":"WHO Classification of Tumours, 5th Edition, Volume 9:\u00a0Head and Neck Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2024","unstructured":"WHO Classification of Tumours Editorial Board (2024) WHO Classification of Tumours, 5th Edition, Volume 9:\u00a0Head and Neck Tumours. 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