{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T12:48:31Z","timestamp":1774702111576,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"DOI":"10.1007\/s00428-026-04496-0","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T11:53:36Z","timestamp":1774698816000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Complex aberrant expression of planar nuclear polarity factors in intraductal papillary mucinous neoplasm of the pancreas"],"prefix":"10.1007","author":[{"given":"Takaaki","family":"Tamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibu","family":"Matsuzaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fid\u00e8le Yambayamba","family":"Musangile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Itonaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiko","family":"Ashida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiyoshi","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Kitano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9862-3051","authenticated-orcid":false,"given":"Shin-ichi","family":"Murata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,28]]},"reference":[{"key":"4496_CR1","first-page":"348","volume":"20","author":"K Ohashi","year":"1982","unstructured":"Ohashi K, Murakami Y, Maruyama M, Takekoshi T, Ohta H, Ohashi I (1982) Four cases of mucus-secreting pancreatic cancer. Prog Dig Endosc 20:348\u2013351","journal-title":"Prog Dig Endosc"},{"key":"4496_CR2","unstructured":"Basturk O, Hong S, Esposito I, Kloppel G, Fukushima M, Maitra A, Furukawa T, Zamboni G (2019) Pancreatic intraductal papillary mucinous neoplasm. In: board t (ed) Digestive system tumours, 5.edn. World health organization, Lyon, pp 310\u2013314"},{"key":"4496_CR3","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.pan.2017.07.007","volume":"17","author":"M Tanaka","year":"2017","unstructured":"Tanaka M, Fernandez-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL (2017) Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas. Pancreatology 17:738\u2013753. https:\/\/doi.org\/10.1016\/j.pan.2017.07.007","journal-title":"Pancreatology"},{"key":"4496_CR4","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1136\/gutjnl-2016-313127","volume":"67","author":"ML Kromrey","year":"2018","unstructured":"Kromrey ML, Bulow R, Hubner J, Paperlein C, Lerch MM, Ittermann T, Volzke H, Mayerle J, Kuhn JP (2018) Prospective study on the incidence, prevalence and 5-year pancreatic-related mortality of pancreatic cysts in a population-based study. Gut 67:138\u2013145. https:\/\/doi.org\/10.1136\/gutjnl-2016-313127","journal-title":"Gut"},{"key":"4496_CR5","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1245\/s10434-022-12870-w","volume":"30","author":"T Pollini","year":"2023","unstructured":"Pollini T, Wong P, Maker AV (2023) The landmark series: intraductal papillary mucinous neoplasms of the pancreas-from prevalence to early cancer detection. Ann Surg Oncol 30:1453\u20131462. https:\/\/doi.org\/10.1245\/s10434-022-12870-w","journal-title":"Ann Surg Oncol"},{"key":"4496_CR6","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1245\/s10434-018-6425-6","volume":"25","author":"RE Khoury","year":"2018","unstructured":"Khoury RE, Kabir C, Maker VK, Banulescu M, Wasserman M, Maker AV (2018) What is the incidence of malignancy in resected intraductal papillary mucinous neoplasms? An analysis of over 100 US institutions in a single year. Ann Surg Oncol 25:1746\u20131751. https:\/\/doi.org\/10.1245\/s10434-018-6425-6","journal-title":"Ann Surg Oncol"},{"key":"4496_CR7","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a027946","author":"I Bernascone","year":"2017","unstructured":"Bernascone I, Hachimi M, Martin-Belmonte F (2017) Signaling networks in epithelial tube formation. Cold Spring Harb Perspect Biol. https:\/\/doi.org\/10.1101\/cshperspect.a027946","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"4496_CR8","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/bs.ctdb.2020.09.002","volume":"143","author":"C Camelo","year":"2021","unstructured":"Camelo C, Luschnig S (2021) Cells into tubes: molecular and physical principles underlying lumen formation in tubular organs. Curr Top Dev Biol 143:37\u201374. https:\/\/doi.org\/10.1016\/bs.ctdb.2020.09.002","journal-title":"Curr Top Dev Biol"},{"key":"4496_CR9","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1016\/j.biocel.2011.09.004","volume":"43","author":"I Dupin","year":"2011","unstructured":"Dupin I, Etienne-Manneville S (2011) Nuclear positioning: mechanisms and functions. Int J Biochem Cell Biol 43:1698\u20131707. https:\/\/doi.org\/10.1016\/j.biocel.2011.09.004","journal-title":"Int J Biochem Cell Biol"},{"key":"4496_CR10","doi-asserted-by":"publisher","unstructured":"Pelaseyed T, Bretscher A (2018) Regulation of actin-based apical structures on epithelial cells. J Cell Sci 131. https:\/\/doi.org\/10.1242\/jcs.221853","DOI":"10.1242\/jcs.221853"},{"key":"4496_CR11","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.semcdb.2017.09.026","volume":"81","author":"K VanderVorst","year":"2018","unstructured":"VanderVorst K, Hatakeyama J, Berg A, Lee H, Carraway KL 3rd (2018) Cellular and molecular mechanisms underlying planar cell polarity pathway contributions to cancer malignancy. Semin Cell Dev Biol 81:78\u201387. https:\/\/doi.org\/10.1016\/j.semcdb.2017.09.026","journal-title":"Semin Cell Dev Biol"},{"key":"4496_CR12","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s00428-015-1744-5","volume":"466","author":"S Murata","year":"2015","unstructured":"Murata S, Warigaya K, Matsuzaki I, Itonaga M, Shimizu Y, Shuto M (2015) Microtubule-organizing center-mediated nuclear polarity in various normal and neoplastic human tissues. Virchows Arch 466:625\u2013635","journal-title":"Virchows Arch"},{"key":"4496_CR13","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s00428-020-02895-5","volume":"478","author":"SI Murata","year":"2021","unstructured":"Murata SI, Kuroda M, Kawamura N, Warigaya K, Musangile FY, Matsuzaki I, Kojima F (2021) Microtubule-organizing center-mediated structural atypia in low- and high-grade urothelial carcinoma. Virchows Arch 478:327\u2013334. https:\/\/doi.org\/10.1007\/s00428-020-02895-5","journal-title":"Virchows Arch"},{"key":"4496_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/jdb12020012","author":"S Kacker","year":"2024","unstructured":"Kacker S, Parsad V, Singh N, Hordiichuk D, Alvarez S, Gohar M, Kacker A, Rai SK (2024) Planar cell polarity signaling: coordinated crosstalk for cell orientation. J Dev Biol. https:\/\/doi.org\/10.3390\/jdb12020012","journal-title":"J Dev Biol"},{"key":"4496_CR15","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202308069","author":"F Peglion","year":"2024","unstructured":"Peglion F, Etienne-Manneville S (2024) Cell polarity changes in cancer initiation and progression. J Cell Biol. https:\/\/doi.org\/10.1083\/jcb.202308069","journal-title":"J Cell Biol"},{"key":"4496_CR16","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-023-04836-2","volume":"80","author":"A Varga","year":"2023","unstructured":"Varga A, Madacsy T, Gorog M, Kiss A, Susanszki P, Szabo V, Jojart B, Dudas K, Farkas G Jr., Szederkenyi E, Lazar G, Farkas A, Ayaydin F, Pallagi P, Maleth J (2023) Human pancreatic ductal organoids with controlled polarity provide a novel ex vivo tool to study epithelial cell physiology. Cell Mol Life Sci 80:192. https:\/\/doi.org\/10.1007\/s00018-023-04836-2","journal-title":"Cell Mol Life Sci"},{"key":"4496_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2020.111960","volume":"390","author":"BH Sliker","year":"2020","unstructured":"Sliker BH, Goetz BT, Barnes R, King H, Maurer HC, Olive KP, Solheim JC (2020) Hla-B influences integrin beta-1 expression and pancreatic cancer cell migration. Exp Cell Res 390:111960. https:\/\/doi.org\/10.1016\/j.yexcr.2020.111960","journal-title":"Exp Cell Res"},{"key":"4496_CR18","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1136\/gutjnl-2011-300123","volume":"61","author":"M Schumann","year":"2012","unstructured":"Schumann M, Gunzel D, Buergel N, Richter JF, Troeger H, May C, Fromm A, Sorgenfrei D, Daum S, Bojarski C, Heyman M, Zeitz M, Fromm M, Schulzke JD (2012) Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in coeliac disease. Gut 61:220\u2013228. https:\/\/doi.org\/10.1136\/gutjnl-2011-300123","journal-title":"Gut"},{"key":"4496_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01347-8","volume":"15","author":"Y Huang","year":"2022","unstructured":"Huang Y, Hong W, Wei X (2022) The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis. J Hematol Oncol 15:129. https:\/\/doi.org\/10.1186\/s13045-022-01347-8","journal-title":"J Hematol Oncol"},{"key":"4496_CR20","doi-asserted-by":"publisher","first-page":"6958","DOI":"10.1038\/onc.2008.346","volume":"27","author":"G Moreno-Bueno","year":"2008","unstructured":"Moreno-Bueno G, Portillo F, Cano A (2008) Transcriptional regulation of cell polarity in EMT and cancer. Oncogene 27:6958\u20136969. https:\/\/doi.org\/10.1038\/onc.2008.346","journal-title":"Oncogene"},{"key":"4496_CR21","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1002\/cm.20393","volume":"66","author":"G Bellett","year":"2009","unstructured":"Bellett G, Carter JM, Keynton J, Goldspink D, James C, Moss DK, Mogensen MM (2009) Microtubule plus-end and minus-end capture at adherens junctions is involved in the assembly of apico-basal arrays in polarised epithelial cells. Cell Motil Cytoskeleton 66:893\u2013908. https:\/\/doi.org\/10.1002\/cm.20393","journal-title":"Cell Motil Cytoskeleton"},{"key":"4496_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/biom13101430","author":"N Thapa","year":"2023","unstructured":"Thapa N, Wen T, Cryns VL, Anderson RA (2023) Regulation of cell adhesion and migration via microtubule cytoskeleton organization, cell polarity, and phosphoinositide signaling. Biomolecules. https:\/\/doi.org\/10.3390\/biom13101430","journal-title":"Biomolecules"},{"key":"4496_CR23","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/921564","volume":"2014","author":"TS Wong","year":"2014","unstructured":"Wong TS, Gao W, Chan JY (2014) Transcription regulation of E-cadherin by zinc finger E-box binding homeobox proteins in solid tumors. Biomed Res Int 2014:921564. https:\/\/doi.org\/10.1155\/2014\/921564","journal-title":"Biomed Res Int"},{"key":"4496_CR24","doi-asserted-by":"publisher","first-page":"20380","DOI":"10.18632\/oncotarget.14608","volume":"8","author":"Z Zhao","year":"2017","unstructured":"Zhao Z, Rahman MA, Chen ZG, Shin DM (2017) Multiple biological functions of Twist1 in various cancers. Oncotarget 8:20380\u201320393. https:\/\/doi.org\/10.18632\/oncotarget.14608","journal-title":"Oncotarget"},{"key":"4496_CR25","doi-asserted-by":"publisher","first-page":"7073","DOI":"10.1111\/febs.15710","volume":"288","author":"E Martin","year":"2021","unstructured":"Martin E, Girardello R, Dittmar G, Ludwig A (2021) New insights into the organization and regulation of the apical polarity network in mammalian epithelial cells. FEBS J 288:7073\u20137095. https:\/\/doi.org\/10.1111\/febs.15710","journal-title":"FEBS J"},{"key":"4496_CR26","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s11033-025-10372-y","volume":"52","author":"MJ Saadh","year":"2025","unstructured":"Saadh MJ, Ahmed HH, Kareem RA, Bishoyi AK, Roopashree R, Shit D, Arya R, Sharma A, Khaitov K, Sameer HN, Yaseen A, Athab ZH, Adil M (2025) Molecular mechanisms of Hippo pathway in tumorigenesis: therapeutic implications. Mol Biol Rep 52:267. https:\/\/doi.org\/10.1007\/s11033-025-10372-y","journal-title":"Mol Biol Rep"},{"key":"4496_CR27","doi-asserted-by":"publisher","first-page":"30396","DOI":"10.18632\/oncotarget.8878","volume":"7","author":"D Dragoi","year":"2016","unstructured":"Dragoi D, Krattenmacher A, Mishra VK, Schmidt JM, Kloos UJ, Meixner LK, Hauck SM, Buggenthin F, Schwartz D, Marr C, Johnsen SA, Scheel CH (2016) Twist1 induces distinct cell states depending on TGFBR1-activation. Oncotarget 7:30396\u201330407. https:\/\/doi.org\/10.18632\/oncotarget.8878","journal-title":"Oncotarget"},{"key":"4496_CR28","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.115.134965","volume":"94","author":"B Kim","year":"2016","unstructured":"Kim B, Breton S (2016) The MAPK\/ERK-signaling pathway regulates the expression and distribution of tight junction proteins in the mouse proximal epididymis. Biol Reprod 94:22. https:\/\/doi.org\/10.1095\/biolreprod.115.134965","journal-title":"Biol Reprod"},{"key":"4496_CR29","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1080\/19491034.2015.1004947","volume":"6","author":"W Chang","year":"2015","unstructured":"Chang W, Antoku S, Ostlund C, Worman HJ, Gundersen GG (2015) Linker of nucleoskeleton and cytoskeleton (LINC) complex-mediated actin-dependent nuclear positioning orients centrosomes in migrating myoblasts. Nucleus 6:77\u201388. https:\/\/doi.org\/10.1080\/19491034.2015.1004947","journal-title":"Nucleus"},{"key":"4496_CR30","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/ncb3285","volume":"18","author":"F Farina","year":"2016","unstructured":"Farina F, Gaillard J, Guerin C, Coute Y, Sillibourne J, Blanchoin L, Thery M (2016) The centrosome is an actin-organizing centre. Nat Cell Biol 18:65\u201375. https:\/\/doi.org\/10.1038\/ncb3285","journal-title":"Nat Cell Biol"},{"key":"4496_CR31","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201899630","author":"D Inoue","year":"2019","unstructured":"Inoue D, Obino D, Pineau J, Farina F, Gaillard J, Guerin C, Blanchoin L, Lennon-Dumenil AM, Thery M (2019) Actin filaments regulate microtubule growth at the centrosome. EMBO J. https:\/\/doi.org\/10.15252\/embj.201899630","journal-title":"EMBO J"},{"key":"4496_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/cells9030578","author":"IY Zhitnyak","year":"2020","unstructured":"Zhitnyak IY, Rubtsova SN, Litovka NI, Gloushankova NA (2020) Early events in actin cytoskeleton dynamics and E-cadherin-mediated cell-cell adhesion during epithelial-mesenchymal transition. Cells. https:\/\/doi.org\/10.3390\/cells9030578","journal-title":"Cells"},{"key":"4496_CR33","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/modpathol.3800763","volume":"20","author":"H Yamaguchi","year":"2007","unstructured":"Yamaguchi H, Inoue T, Eguchi T, Miyasaka Y, Ohuchida K, Mizumoto K, Yamada T, Yamaguchi K, Tanaka M, Tsuneyoshi M (2007) Fascin overexpression in intraductal papillary mucinous neoplasms (adenomas, borderline neoplasms, and carcinomas) of the pancreas, correlated with increased histological grade. Mod Pathol 20:552\u2013561. https:\/\/doi.org\/10.1038\/modpathol.3800763","journal-title":"Mod Pathol"},{"key":"4496_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1136227","volume":"13","author":"C Wang","year":"2023","unstructured":"Wang C, Wu N, Pei B, Ma X, Yang W (2023) Claudin and pancreatic cancer. Front Oncol 13:1136227. https:\/\/doi.org\/10.3389\/fonc.2023.1136227","journal-title":"Front Oncol"},{"key":"4496_CR35","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.bbadis.2017.10.019","volume":"1864","author":"YF Pei","year":"2018","unstructured":"Pei YF, Yin XM, Liu XQ (2018) TOP2A induces malignant character of pancreatic cancer through activating beta-catenin signaling pathway. Biochim Biophys Acta Mol Basis Dis 1864:197\u2013207. https:\/\/doi.org\/10.1016\/j.bbadis.2017.10.019","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"4496_CR36","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-023-05099-7","volume":"81","author":"W Xue","year":"2024","unstructured":"Xue W, Yang L, Chen C, Ashrafizadeh M, Tian Y, Sun R (2024) Wnt\/beta-catenin-driven EMT regulation in human cancers. Cell Mol Life Sci 81:79. https:\/\/doi.org\/10.1007\/s00018-023-05099-7","journal-title":"Cell Mol Life Sci"},{"key":"4496_CR37","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1056\/NEJMc2409512","volume":"391","author":"K Shitara","year":"2024","unstructured":"Shitara K, Shah MA, Lordick F, Van Cutsem E, Ilson DH, Klempner SJ, Kang YK, Lonardi S, Hung YP, Yamaguchi K, Enzinger P, Nakajima T, Matsangou M, Cao Y, Li R, Moran D, Pophale R, Oh M, Ranganath R, Ajani JA, Xu RH (2024) Zolbetuximab in gastric or gastroesophageal junction adenocarcinoma. N Engl J Med 391:1159\u20131162. https:\/\/doi.org\/10.1056\/NEJMc2409512","journal-title":"N Engl J Med"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-026-04496-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-026-04496-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-026-04496-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T11:53:38Z","timestamp":1774698818000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00428-026-04496-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,28]]},"references-count":37,"alternative-id":["4496"],"URL":"https:\/\/doi.org\/10.1007\/s00428-026-04496-0","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,28]]},"assertion":[{"value":"5 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of Wakayama Medical University (approval no. 3593).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All subjects in this study, including those excluded during the research process, were provided with a detailed explanation of this study, and written informed consent was obtained from all subjects.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}