{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T18:12:30Z","timestamp":1784052750401,"version":"3.55.0"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005279","name":"Universidade Federal Do Piau\u00ed","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005279","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We analyzed 25 eccrine neoplasms from two patients with hereditary epidermodysplasia verruciformis (EDV), representing the largest series reported to date. All lesions shared a reproducible architecture with multifocal epidermal connections, anastomosing epithelial strands of basaloid\u2013poroid cells, and a myxoid fibrovascular stroma. Additional findings included focal clear cell change and intraepithelial atypia (20% of cases). Immunohistochemically, EMA and CEA confirmed ductal differentiation, while preserved YAP1 and negative NUT staining supported a lineage distinct from conventional poroma. p53 overexpression and diffuse p16 labeling were confined to atypical foci. These findings broaden the morphologic spectrum of this emerging entity and support the use of targeted immunohistochemistry to recognize atypical foci in EDV-associated eccrine neoplasms.<\/jats:p>","DOI":"10.1007\/s00428-026-04511-4","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:40:55Z","timestamp":1776400855000},"page":"251-257","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidermodysplasia verruciformis\u2013associated eccrine neoplasm: morphologic and immunohistochemical characterization of 25 lesions in two patients"],"prefix":"10.1007","volume":"489","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5075-5986","authenticated-orcid":false,"given":"Eric Ara\u00fajo Lucas de","family":"Barros","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1590-9670","authenticated-orcid":false,"given":"Robert Louren\u00e7o Stoque","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7661-0984","authenticated-orcid":false,"given":"Juliana de S\u00e1 Pires","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1974-9797","authenticated-orcid":false,"given":"Isabelly Cristina Honorato de","family":"Queiroz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5092-2180","authenticated-orcid":false,"given":"Carla Riama Lopes de P\u00e1dua","family":"Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2260-1179","authenticated-orcid":false,"given":"Rafael de Deus","family":"Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"4511_CR1","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1016\/j.jaad.2016.12.035","volume":"76","author":"J Przybyszewska","year":"2017","unstructured":"Przybyszewska J, Zlotogorski A, Ramot Y (2017) Re-evaluation of epidermodysplasia verruciformis: reconciling more than 90 years of debate. J Am Acad Dermatol 76:1161\u20131175. https:\/\/doi.org\/10.1016\/j.jaad.2016.12.035","journal-title":"J Am Acad Dermatol"},{"key":"4511_CR2","doi-asserted-by":"publisher","first-page":"418","DOI":"10.4103\/ijd.ijd_954_21","volume":"67","author":"Y Singh","year":"2022","unstructured":"Singh Y, Rajamohanan RR, Phinehas EM, Kiran MCM, Kuruvila S (2022) Epidermodysplasia verruciformis-report of familial occurrence and a rare association with eccrine porocarcinoma. Indian J Dermatol 67:418\u2013419. https:\/\/doi.org\/10.4103\/ijd.ijd_954_21","journal-title":"Indian J Dermatol"},{"key":"4511_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1565977","volume":"12","author":"Z Zhang","year":"2025","unstructured":"Zhang Z, Liu C, Li J (2025) Case report: epidermodysplasia verruciformis with multiple squamous and basal cell carcinomas. Front Med (Lausanne) 12:1565977. https:\/\/doi.org\/10.3389\/fmed.2025.1565977","journal-title":"Front Med (Lausanne)"},{"key":"4511_CR4","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s00428-024-03785-w","volume":"484","author":"E Russell-Goldman","year":"2024","unstructured":"Russell-Goldman E, Baranov E, Siegmund S, Yang CS, Laga AC, Hanna J (2024) Epidermodysplasia verruciformis-associated eccrine neoplasm: a rare entity with distinctive clinical and histopathologic features. Virchows Arch 484:423\u2013427. https:\/\/doi.org\/10.1007\/s00428-024-03785-w","journal-title":"Virchows Arch"},{"key":"4511_CR5","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1097\/DAD.0000000000000816","volume":"39","author":"T Tan","year":"2017","unstructured":"Tan T, Guitart J, Liu LL, Brieva JC, Amin S, Rani M, Gerami P, Yazdan P (2017) Eccrine syringofibroadenoma in association with acquired epidermodysplasia verruciformis. 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Informed consent was obtained from all individual participants included in the study.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Artificial intelligence\u2013based tools were used solely for language editing and grammatical revision. These tools did not influence data analysis, interpretation, or conclusions.","order":3,"name":"Ethics","label":"Artificial intelligence statement","group":{"name":"EthicsHeading","label":"Declarations"}}]}}