{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T09:22:33Z","timestamp":1778059353638,"version":"3.51.4"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Kangbuk Samsung Hospital","award":["Kangbuk Samsung Hospital"],"award-info":[{"award-number":["Kangbuk Samsung Hospital"]}]},{"name":"IITP\/MSIT","award":["RS-2020-II201373"],"award-info":[{"award-number":["RS-2020-II201373"]}]},{"name":"IITP\/MSIT","award":["RS-2023-00220628"],"award-info":[{"award-number":["RS-2023-00220628"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"DOI":"10.1007\/s00428-026-04546-7","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T09:07:19Z","timestamp":1778058439000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Histology-defined activated cancer-associated fibroblasts are associated with poor survival in diffuse-type gastric adenocarcinoma"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0092-8370","authenticated-orcid":false,"given":"Joon Young","family":"Hur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6372-9267","authenticated-orcid":false,"given":"Yung-Kyun","family":"Noh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6209-8339","authenticated-orcid":false,"given":"Young-Woong","family":"Won","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9299-5476","authenticated-orcid":false,"given":"Byoung Kwan","family":"Son","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1020-5838","authenticated-orcid":false,"given":"Sung Hak","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5506-1682","authenticated-orcid":false,"given":"Young Chan","family":"Wi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3484-6595","authenticated-orcid":false,"given":"Mi Jung","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4757-9211","authenticated-orcid":false,"given":"Kyueng-Whan","family":"Min","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5939-2211","authenticated-orcid":false,"given":"Hyung Suk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5722-6703","authenticated-orcid":false,"given":"Dong-Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"key":"4546_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21708","volume":"72","author":"RL Siegel","year":"2022","unstructured":"Siegel RL, Miller KD, Fuchs HE, Jemal A (2022) Cancer statistics, 2022. CA Cancer J Clin 72:7\u201333. https:\/\/doi.org\/10.3322\/caac.21708","journal-title":"CA Cancer J Clin"},{"key":"4546_CR2","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1007\/s12032-013-0514-y","volume":"30","author":"XY Feng","year":"2013","unstructured":"Feng XY, Chen YB, Wang W, Guan YX, Li YF, Chen S et al (2013) Time-varying pattern of recurrence risk for gastric cancer. patients Med Oncol 30:514. https:\/\/doi.org\/10.1007\/s12032-013-0514-y","journal-title":"patients Med Oncol"},{"key":"4546_CR3","doi-asserted-by":"publisher","first-page":"5591","DOI":"10.1242\/jcs.116392","volume":"125","author":"FR Balkwill","year":"2012","unstructured":"Balkwill FR, Capasso M, Hagemann T (2012) The tumor microenvironment at a glance. J Cell Sci 125:5591\u20135596. https:\/\/doi.org\/10.1242\/jcs.116392","journal-title":"J Cell Sci"},{"key":"4546_CR4","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1038\/nm.3394","volume":"19","author":"DF Quail","year":"2013","unstructured":"Quail DF, Joyce JA (2013) Microenvironmental regulation of tumor progression and metastasis. Nat Med 19:1423\u20131437. https:\/\/doi.org\/10.1038\/nm.3394","journal-title":"Nat Med"},{"key":"4546_CR5","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1007\/s00535-014-0952-0","volume":"49","author":"T Ishimoto","year":"2014","unstructured":"Ishimoto T, Sawayama H, Sugihara H, Baba H (2014) Interaction between gastric cancer stem cells and the tumor microenvironment. J Gastroenterol 49:1111\u20131120. https:\/\/doi.org\/10.1007\/s00535-014-0952-0","journal-title":"J Gastroenterol"},{"key":"4546_CR6","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1042\/BST20160387","volume":"45","author":"B Erdogan","year":"2017","unstructured":"Erdogan B, Webb DJ (2017) Cancer-associated fibroblasts modulate growth factor signaling and extracellular matrix remodeling to regulate tumor metastasis. Biochem Soc Trans 45:229\u2013236. https:\/\/doi.org\/10.1042\/BST20160387","journal-title":"Biochem Soc Trans"},{"key":"4546_CR7","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s12943-023-01860-5","volume":"22","author":"H Zhang","year":"2023","unstructured":"Zhang H, Yue X, Chen Z, Liu C, Wu W, Zhang N et al (2023) Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials. Mol Cancer 22:159. https:\/\/doi.org\/10.1186\/s12943-023-01860-5","journal-title":"Mol Cancer"},{"key":"4546_CR8","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1007\/s10120-021-01259-5","volume":"25","author":"T Zhang","year":"2022","unstructured":"Zhang T, Li X, He Y, Wang Y, Shen J, Wang S et al (2022) Cancer-associated fibroblasts-derived HAPLN1 promotes tumour invasion through extracellular matrix remodeling in gastric cancer. Gastric Cancer 25:346\u2013359. https:\/\/doi.org\/10.1007\/s10120-021-01259-5","journal-title":"Gastric Cancer"},{"key":"4546_CR9","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nrm809","volume":"3","author":"JJ Tomasek","year":"2002","unstructured":"Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA (2002) Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 3:349\u2013363. https:\/\/doi.org\/10.1038\/nrm809","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4546_CR10","doi-asserted-by":"publisher","first-page":"2676","DOI":"10.1158\/1078-0432.CCR-05-1770","volume":"12","author":"ML Tejada","year":"2006","unstructured":"Tejada ML, Yu L, Dong J, Jung K, Meng G, Peale FV et al (2006) Tumor-driven paracrine platelet-derived growth factor receptor alpha signaling is a key determinant of stromal cell recruitment in a model of human lung carcinoma. Clin Cancer Res 12:2676\u20132688. https:\/\/doi.org\/10.1158\/1078-0432.CCR-05-1770","journal-title":"Clin Cancer Res"},{"key":"4546_CR11","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1038\/s12276-023-01013-0","volume":"55","author":"D Yang","year":"2023","unstructured":"Yang D, Liu J, Qian H, Zhuang Q (2023) Cancer-associated fibroblasts: from basic science to anticancer therapy. Exp Mol Med 55:1322\u20131332. https:\/\/doi.org\/10.1038\/s12276-023-01013-0","journal-title":"Exp Mol Med"},{"key":"4546_CR12","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.ccell.2023.02.015","volume":"41","author":"G Caligiuri","year":"2023","unstructured":"Caligiuri G, Tuveson DA (2023) Activated fibroblasts in cancer: Perspectives and challenges. Cancer Cell 41:434\u2013449. https:\/\/doi.org\/10.1016\/j.ccell.2023.02.015","journal-title":"Cancer Cell"},{"key":"4546_CR13","doi-asserted-by":"publisher","first-page":"1113378","DOI":"10.3389\/fphar.2023.1113378","volume":"14","author":"C Zhang","year":"2023","unstructured":"Zhang C, Fei Y, Wang H, Hu S, Liu C, Hu R et al (2023) CAFs orchestrates tumor immune microenvironment-A new target in cancer therapy? Front Pharmacol 14:1113378. https:\/\/doi.org\/10.3389\/fphar.2023.1113378","journal-title":"Front Pharmacol"},{"key":"4546_CR14","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s10120-021-01270-w","volume":"25","author":"Y Yang","year":"2022","unstructured":"Yang Y, Ma Y, Yan S, Wang P, Hu J, Chen S et al (2022) CAF promotes chemoresistance through NRP2 in gastric cancer. Gastric Cancer 25:503\u2013514. https:\/\/doi.org\/10.1007\/s10120-021-01270-w","journal-title":"Gastric Cancer"},{"key":"4546_CR15","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1111\/febs.16381","volume":"290","author":"M Takasugi","year":"2023","unstructured":"Takasugi M, Yoshida Y, Hara E, Ohtani N (2023) The role of cellular senescence and SASP in tumour microenvironment. FEBS J 290:1348\u20131361. https:\/\/doi.org\/10.1111\/febs.16381","journal-title":"FEBS J"},{"key":"4546_CR16","doi-asserted-by":"publisher","first-page":"6162","DOI":"10.1038\/s41467-024-50441-7","volume":"15","author":"B Assouline","year":"2024","unstructured":"Assouline B, Kahn R, Hodali L, Condiotti R, Engel Y, Elyada E et al (2024) Senescent cancer-associated fibroblasts in pancreatic adenocarcinoma restrict CD8(+) T cell activation and limit responsiveness to immunotherapy in mice. Nat Commun 15:6162. https:\/\/doi.org\/10.1038\/s41467-024-50441-7","journal-title":"Nat Commun"},{"key":"4546_CR17","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/apm.1965.64.1.31","volume":"64","author":"P Lauren","year":"1965","unstructured":"Lauren P (1965) The Two Histological Main Types of Gastric Carcinoma: Diffuse and So-Called Intestinal-Type Carcinoma. An Attempt at a Histo-Clinical Classification. Acta Pathol Microbiol Scand 64:31\u201349. https:\/\/doi.org\/10.1111\/apm.1965.64.1.31","journal-title":"Acta Pathol Microbiol Scand"},{"key":"4546_CR18","volume-title":"Digestive System Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2019","unstructured":"WHO Classification of Tumours Editorial Board (2019) Digestive System Tumours. International Agency for Research on Cancer, Lyon"},{"key":"4546_CR19","doi-asserted-by":"publisher","first-page":"16779","DOI":"10.1038\/s41598-021-96344-1","volume":"11","author":"KW Min","year":"2021","unstructured":"Min KW, Kim DH, Noh YK, Son BK, Kwon MJ, Moon JY (2021) Cancer-associated fibroblasts are associated with poor prognosis in solid type of lung adenocarcinoma in a machine learning analysis. Sci Rep 11:16779. https:\/\/doi.org\/10.1038\/s41598-021-96344-1","journal-title":"Sci Rep"},{"key":"4546_CR20","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1245\/s10434-023-14715-6","volume":"31","author":"HS Kim","year":"2024","unstructured":"Kim HS, Noh YK, Min KW, Kim DH, Kwon MJ, Pyo JS et al (2024) Cancer-Associated Fibroblasts Together with a Decline in CD8\u2009+\u2009T Cells Predict a Worse Prognosis for Breast Cancer Patients. Ann Surg Oncol 31:2114\u20132126. https:\/\/doi.org\/10.1245\/s10434-023-14715-6","journal-title":"Ann Surg Oncol"},{"key":"4546_CR21","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/modpathol.2011.198","volume":"25","author":"J Ruschoff","year":"2012","unstructured":"Ruschoff J, Hanna W, Bilous M, Hofmann M, Osamura RY, Penault-Llorca F et al (2012) HER2 testing in gastric cancer: a practical approach. Mod Pathol 25:637\u2013650. https:\/\/doi.org\/10.1038\/modpathol.2011.198","journal-title":"Mod Pathol"},{"key":"4546_CR22","doi-asserted-by":"publisher","first-page":"330","DOI":"10.5858\/arpa.2018-0043-OA","volume":"143","author":"K Kulangara","year":"2019","unstructured":"Kulangara K, Zhang N, Corigliano E, Guerrero L, Waldroup S, Jaiswal D et al (2019) Clinical Utility of the Combined Positive Score for Programmed Death Ligand-1 Expression and the Approval of Pembrolizumab for Treatment of Gastric Cancer Arch. Pathol Lab Med 143:330\u2013337. https:\/\/doi.org\/10.5858\/arpa.2018-0043-OA","journal-title":"Pathol Lab Med"},{"key":"4546_CR23","doi-asserted-by":"publisher","unstructured":"Shitara K, Lordick F, Bang YJ, Enzinger P, Ilson D, Shah MA et al (2023) Zolbetuximab plus mFOLFOX6 in patients with CLDN18.2-positive, HER2-negative, untreated, locally advanced unresectable or metastatic gastric or gastro-oesophageal junction adenocarcinoma (SPOTLIGHT): a multicentre, randomised, double-blind, phase 3 trial Lancet. 401:1655\u20131668. https:\/\/doi.org\/10.1016\/S0140-6736(23)00620-7","DOI":"10.1016\/S0140-6736(23)00620-7"},{"key":"4546_CR24","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1038\/s41419-022-05320-8","volume":"13","author":"H Sun","year":"2022","unstructured":"Sun H, Wang X, Wang X, Xu M, Sheng W (2022) The role of cancer-associated fibroblasts in tumorigenesis of gastric cancer. Cell Death Dis 13:874. https:\/\/doi.org\/10.1038\/s41419-022-05320-8","journal-title":"Cell Death Dis"},{"key":"4546_CR25","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/s41416-019-0566-7","volume":"121","author":"A Chatterjee","year":"2019","unstructured":"Chatterjee A, Jana S, Chatterjee S, Wastall LM, Mandal G, Nargis N et al (2019) MicroRNA-222 reprogrammed cancer-associated fibroblasts enhance growth and metastasis of breast cancer. Br J Cancer 121:679\u2013689. https:\/\/doi.org\/10.1038\/s41416-019-0566-7","journal-title":"Br J Cancer"},{"key":"4546_CR26","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1016\/j.immuni.2022.07.001","volume":"55","author":"Z Gong","year":"2022","unstructured":"Gong Z, Li Q, Shi J, Wei J, Li P, Chang CH et al (2022) Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune. microenvironment Immun 55:1483\u20131500e9. https:\/\/doi.org\/10.1016\/j.immuni.2022.07.001","journal-title":"microenvironment Immun"},{"key":"4546_CR27","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/s41586-022-05169-z","volume":"610","author":"H Su","year":"2022","unstructured":"Su H, Yang F, Fu R, Trinh B, Sun N, Liu J et al (2022) Collagenolysis-dependent DDR1 signalling dictates pancreatic. cancer outcome Nat 610:366\u2013372. https:\/\/doi.org\/10.1038\/s41586-022-05169-z","journal-title":"cancer outcome Nat"},{"key":"4546_CR28","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.semcancer.2013.12.008","volume":"25","author":"A Calon","year":"2014","unstructured":"Calon A, Tauriello DV, Batlle E (2014) TGF-beta in CAF-mediated tumor growth and metastasis. Semin Cancer Biol 25:15\u201322. https:\/\/doi.org\/10.1016\/j.semcancer.2013.12.008","journal-title":"Semin Cancer Biol"},{"key":"4546_CR29","doi-asserted-by":"publisher","first-page":"162","DOI":"10.3816\/CGC.2006.n.034","volume":"5","author":"LW Chung","year":"2006","unstructured":"Chung LW, Huang WC, Sung SY, Wu D, Odero-Marah V, Nomura T et al (2006) Stromal-epithelial interaction in prostate cancer progression. Clin Genitourin Cancer 5:162\u2013170. https:\/\/doi.org\/10.3816\/CGC.2006.n.034","journal-title":"Clin Genitourin Cancer"},{"key":"4546_CR30","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1038\/s41419-022-04935-1","volume":"13","author":"H Xu","year":"2022","unstructured":"Xu H, Zhao J, Li J, Zhu Z, Cui Z, Liu R et al (2022) Cancer associated fibroblast-derived CCL5 promotes hepatocellular carcinoma metastasis through activating HIF1alpha\/ZEB1 axis. Cell Death Dis 13:478. https:\/\/doi.org\/10.1038\/s41419-022-04935-1","journal-title":"Cell Death Dis"},{"key":"4546_CR31","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/nm.1908","volume":"15","author":"P Farmer","year":"2009","unstructured":"Farmer P, Bonnefoi H, Anderle P, Cameron D, Wirapati P, Becette V et al (2009) A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer. Nat Med 15:68\u201374. https:\/\/doi.org\/10.1038\/nm.1908","journal-title":"Nat Med"},{"key":"4546_CR32","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1158\/1078-0432.CCR-13-1256","volume":"20","author":"DJ Cheon","year":"2014","unstructured":"Cheon DJ, Tong Y, Sim MS, Dering J, Berel D, Cui X et al (2014) A collagen-remodeling gene signature regulated by TGF-beta signaling is associated with metastasis and poor survival in serous ovarian cancer. Clin Cancer Res 20:711\u2013723. https:\/\/doi.org\/10.1158\/1078-0432.CCR-13-1256","journal-title":"Clin Cancer Res"},{"key":"4546_CR33","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1038\/ng.3398","volume":"47","author":"RA Moffitt","year":"2015","unstructured":"Moffitt RA, Marayati R, Flate EL, Volmar KE, Loeza SG, Hoadley KA et al (2015) Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma. Nat Genet 47:1168\u20131178. https:\/\/doi.org\/10.1038\/ng.3398","journal-title":"Nat Genet"},{"key":"4546_CR34","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1038\/ng.3225","volume":"47","author":"A Calon","year":"2015","unstructured":"Calon A, Lonardo E, Berenguer-Llergo A, Espinet E, Hernando-Momblona X, Iglesias M et al (2015) Stromal gene expression defines poor-prognosis subtypes in colorectal cancer. Nat Genet 47:320\u2013329. https:\/\/doi.org\/10.1038\/ng.3225","journal-title":"Nat Genet"},{"key":"4546_CR35","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1517\/14728220903103841","volume":"13","author":"E Pure","year":"2009","unstructured":"Pure E (2009) The road to integrative cancer therapies: emergence of a tumor-associated fibroblast protease as a potential therapeutic target in cancer Expert. Opin Ther Targets 13:967\u2013973. https:\/\/doi.org\/10.1517\/14728220903103841","journal-title":"Opin Ther Targets"},{"key":"4546_CR36","doi-asserted-by":"publisher","first-page":"3613","DOI":"10.1172\/JCI38988","volume":"119","author":"AM Santos","year":"2009","unstructured":"Santos AM, Jung J, Aziz N, Kissil JL, Pure E (2009) Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice. J Clin Invest 119:3613\u20133625. https:\/\/doi.org\/10.1172\/JCI38988","journal-title":"J Clin Invest"},{"key":"4546_CR37","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/nrc745","volume":"2","author":"M Egeblad","year":"2002","unstructured":"Egeblad M, Werb Z (2002) New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2:161\u2013174. https:\/\/doi.org\/10.1038\/nrc745","journal-title":"Nat Rev Cancer"},{"issue":"Suppl 3","key":"4546_CR38","doi-asserted-by":"publisher","first-page":"S433","DOI":"10.1245\/s10434-012-2734-3","volume":"20","author":"KW Min","year":"2013","unstructured":"Min KW, Kim DH, Do SI, Pyo JS, Kim K, Chae SW et al (2013) Diagnostic and prognostic relevance of MMP-11 expression in the stromal fibroblast-like cells adjacent to invasive ductal carcinoma of the breast. Ann Surg Oncol 20(Suppl 3):S433\u2013S442. https:\/\/doi.org\/10.1245\/s10434-012-2734-3","journal-title":"Ann Surg Oncol"},{"key":"4546_CR39","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1111\/apm.12285","volume":"122","author":"KW Min","year":"2014","unstructured":"Min KW, Kim DH, Do SI, Kim K, Lee HJ, Chae SW et al (2014) Expression patterns of stromal MMP-2 and tumoural MMP-2 and \u2013\u20099 are significant prognostic factors in invasive ductal carcinoma of the breast. APMIS 122:1196\u20131206. https:\/\/doi.org\/10.1111\/apm.12285","journal-title":"APMIS"},{"key":"4546_CR40","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1126\/science.1067100","volume":"295","author":"LM Coussens","year":"2002","unstructured":"Coussens LM, Fingleton B, Matrisian LM (2002) Matrix metalloproteinase inhibitors and cancer: trials. tribulations Sci 295:2387\u20132392. https:\/\/doi.org\/10.1126\/science.1067100","journal-title":"tribulations Sci"},{"key":"4546_CR41","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1158\/1535-7163.MCT-17-0646","volume":"17","author":"A Winer","year":"2018","unstructured":"Winer A, Adams S, Mignatti P (2018) Matrix Metalloproteinase Inhibitors in Cancer Therapy: Turning Past Failures Into Future Successes. Mol Cancer Ther 17:1147\u20131155. https:\/\/doi.org\/10.1158\/1535-7163.MCT-17-0646","journal-title":"Mol Cancer Ther"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-026-04546-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-026-04546-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-026-04546-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T09:07:20Z","timestamp":1778058440000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00428-026-04546-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,6]]},"references-count":41,"alternative-id":["4546"],"URL":"https:\/\/doi.org\/10.1007\/s00428-026-04546-7","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,6]]},"assertion":[{"value":"12 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study (including human participants) was approved by the Ethics Committee of Hanyang University Guri Hospital, Korea (GURI 2025-01-020). The patients\u2019 medical records and samples from the Institutional Review Board of Hanyang University Guri Hospital were completely anonymized prior to access in September 2018.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}},{"value":"The authors have no potential conflicts of interest to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}]}}