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Since then, vast majority of\n                    <jats:italic>MED15::TFE3<\/jats:italic>\n                    RCCs were reported to have characteristic extensively cystic appearance, with the septa being lined by tumor cells with optically clear cytoplasm and inconspicuous nucleoli, morphologically mimicking multilocular cystic renal neoplasm of low malignant potential and clear cell RCC with extensive cystic changes. IHC stains are helpful in such diagnostic scenario, as\n                    <jats:italic>MED15::TFE3<\/jats:italic>\n                    RCCs are negative for carbonic anhydrase IX (CAIX) and are positive for melanocytic markers and TFE3. However, the current\n                    <jats:italic>MED15::TFE3<\/jats:italic>\n                    RCCs case series includes two solid\n                    <jats:italic>MED15::TFE3<\/jats:italic>\n                    RCCs, which are morphologically, immunohistochemically and molecularly different from the conventional\n                    <jats:italic>MED15::TFE3<\/jats:italic>\n                    RCCs that are extensively cystic. One case is purely solid with nests of tumor cells with clear cytoplasm mimicking clear cell RCC. This purely solid\n                    <jats:italic>MED15::TFE3<\/jats:italic>\n                    RCC is positive for TFE3, focally positive for CAIX with box-like membranous staining, and negative for Melan A. Another case is mostly solid and tubulopapillary with minor cystic components, is positive for TFE3, and negative for Melan A and CAIX. The non-cystic\n                    <jats:italic>MED15::TFE3<\/jats:italic>\n                    RCCs also have unique fusion transcripts that are different from those seen in the conventional\n                    <jats:italic>MED15::TFE3<\/jats:italic>\n                    RCCs. The phenotypic variation of\n                    <jats:italic>MED15::TFE3<\/jats:italic>\n                    RCCs may be due to the property of the fusion transcripts, although additional studies are required to validate this finding.\n                  <\/jats:p>","DOI":"10.1007\/s00428-026-04576-1","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T07:29:16Z","timestamp":1778484556000},"page":"669-680","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comprehensive analysis of six MED15::TFE3 renal cell carcinomas including two novel solid MED15::TFE3 renal cell carcinomas, highlighting their morphologic, immunohistochemical and molecular differences from their cystic counterparts"],"prefix":"10.1007","volume":"489","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1793-2732","authenticated-orcid":false,"given":"Jung Woo","family":"Kwon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Mae","family":"Lammert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley","family":"Zullow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa Yuwono","family":"Tjota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0455-9413","authenticated-orcid":false,"given":"Tatjana","family":"Antic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"4576_CR1","unstructured":"WHO Classification of Tumours, 5th Edition (2022), Volume 8: Urinary and Male Genital Tumours."},{"issue":"6","key":"4576_CR2","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1097\/PAS.0000000000000631","volume":"40","author":"P Argani","year":"2016","unstructured":"Argani P, Zhong M, Reuter VE et al (2016) TFE3-fusion variant analysis defines specific clinicopathologic associations among Xp11 translocation cancers. 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