{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:36:44Z","timestamp":1790635004622,"version":"4.1.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"DOI":"10.1007\/s00428-026-04620-0","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T04:02:49Z","timestamp":1781236969000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Immunohistochemical characterization of the tumor immune microenvironment in laryngeal premalignancy: insights into early immune alterations in carcinogenesis"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0701-7182","authenticated-orcid":false,"given":"Mario","family":"Berr\u00edos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1940-4884","authenticated-orcid":false,"given":"Blanca","family":"Vivanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3063-0890","authenticated-orcid":false,"given":"Juan Pablo","family":"Rodrigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7019-9746","authenticated-orcid":false,"given":"Fernando","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"4620_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nutres.2022.02.005","volume":"102","author":"LD Murad","year":"2022","unstructured":"Murad LD, Silva T, Schilithz AOC, Murad LB et al (2022) Low body mass index is associated with reduced intratumoral CD4\u2009+\u2009T-lymphocyte infiltration in laryngeal squamous cell carcinoma patients. Nutr Res 102:1\u201312. https:\/\/doi.org\/10.1016\/j.nutres.2022.02.005","journal-title":"Nutr Res"},{"issue":"16","key":"4620_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241612913","volume":"24","author":"C Liberale","year":"2023","unstructured":"Liberale C, Soloperto D, Marchioni A et al (2023) Updates on larynx cancer: risk factors and oncogenesis. Int J Mol Sci 24(16):12913. https:\/\/doi.org\/10.3390\/ijms241612913","journal-title":"Int J Mol Sci"},{"issue":"7","key":"4620_CR3","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1093\/jjco\/hyab097","volume":"51","author":"H Charvat","year":"2021","unstructured":"Charvat H, Saito E (2021) Age-specific larynx cancer incidence rate in the world. Jpn J Clin Oncol 51(7):1181\u20131182. https:\/\/doi.org\/10.1093\/jjco\/hyab097","journal-title":"Jpn J Clin Oncol"},{"key":"4620_CR4","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21590","volume":"70","author":"RL Siegel","year":"2020","unstructured":"Siegel RL, Miller KD, Jemal A (2020) Cancer statistics, 2020. CA Cancer J Clin 70:7\u201330. https:\/\/doi.org\/10.3322\/caac.21590","journal-title":"CA Cancer J Clin"},{"key":"4620_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2023.04.003","author":"VS Ladke","year":"2023","unstructured":"Ladke VS, Kumbhar G, Kheur SM, Chougule H (2023) Evaluation of tumor-infiltrating T & B lymphocytes and their association and distribution in oral squamous cell carcinoma tumor microenvironment: an in vitro immunohistochemical study. Oral Surg Oral Med Oral Pathol Oral Radiol. https:\/\/doi.org\/10.1016\/j.oooo.2023.04.003","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"4620_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13050726","volume":"13","author":"M Ferrari","year":"2023","unstructured":"Ferrari M, Alessandrini L, Savietto E et al (2023) The prognostic role of the immune microenvironment in sinonasal intestinal-type adenocarcinoma: a computer-assisted image analysis of CD3\u2009+\u2009and CD8\u2009+\u2009tumor-infiltrating lymphocytes. J Pers Med 13:726. https:\/\/doi.org\/10.3390\/jpm13050726","journal-title":"J Pers Med"},{"key":"4620_CR7","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","volume":"41","author":"KE de Visser","year":"2023","unstructured":"de Visser KE, Joyce JA (2023) The evolving tumor microenvironment: from cancer initiation to metastatic outgrowth. Cancer Cell 41:374\u2013403. https:\/\/doi.org\/10.1016\/j.ccell.2023.02.016","journal-title":"Cancer Cell"},{"issue":"3","key":"4620_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol32030143","volume":"32","author":"T Moura","year":"2025","unstructured":"Moura T, Laranjeira P, Caramelo O et al (2025) Breast cancer and tumor microenvironment: the crucial role of immune cells. Curr Oncol 32(3):143. https:\/\/doi.org\/10.3390\/curroncol32030143","journal-title":"Curr Oncol"},{"issue":"12","key":"4620_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17121925","volume":"17","author":"K Prajzendanc","year":"2025","unstructured":"Prajzendanc K (2025) DCIS progression and the tumor microenvironment: molecular insights and prognostic challenges. Cancers (Basel) 17(12):1925. https:\/\/doi.org\/10.3390\/cancers17121925","journal-title":"Cancers (Basel)"},{"key":"4620_CR10","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-025-03288-3","volume":"16","author":"L Wang","year":"2025","unstructured":"Wang L, Yang Y, Song Y et al (2025) Decoding tumor-infiltrating lymphocytes heterogeneity in ductal carcinoma in situ: immune microenvironment dynamics and prognostic insights. Discov Oncol 16:1435. https:\/\/doi.org\/10.1007\/s12672-025-03288-3","journal-title":"Discov Oncol"},{"key":"4620_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1194020","author":"R Li","year":"2023","unstructured":"Li R, Cao L (2023) The role of tumor-infiltrating lymphocytes in triple-negative breast cancer and the research progress of adoptive cell therapy. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2023.1194020","journal-title":"Front Immunol"},{"key":"4620_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.923481","volume":"13","author":"B Xu","year":"2022","unstructured":"Xu B, Sun H, Song X et al (2022) Mapping the tumor microenvironment in TNBC and deep exploration for M1 macrophages-associated prognostic genes. Front Immunol 13:923481. https:\/\/doi.org\/10.3389\/fimmu.2022.923481","journal-title":"Front Immunol"},{"issue":"98","key":"4620_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01103-4","volume":"14","author":"T Fu","year":"2021","unstructured":"Fu T, Dai LJ, Wu SY et al (2021) Spatial architecture of the immune microenvironment orchestrates tumor immunity and therapeutic response. J Hematol Oncol 14(98):98. https:\/\/doi.org\/10.1186\/s13045-021-01103-4","journal-title":"J Hematol Oncol"},{"key":"4620_CR14","doi-asserted-by":"publisher","unstructured":"Rodrigo JP, S\u00e1nchez-Canteli M, L\u00f3pez F et al (2021) Tumor-infiltrating lymphocytes in the tumor microenvironment of laryngeal squamous cell carcinoma: systematic review and meta-analysis. Biomedicines 9(5):486, 486. https:\/\/doi.org\/10.3390\/biomedicines9050486","DOI":"10.3390\/biomedicines9050486"},{"key":"4620_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cancers13030395","volume":"13","author":"FJ Su\u00e1rez-S\u00e1nchez","year":"2021","unstructured":"Su\u00e1rez-S\u00e1nchez FJ, Lequerica-Fern\u00e1ndez P, Rodrigo JP et al (2021) Tumor-infiltrating CD20\u2009+\u2009B lymphocytes: significance and prognostic implications in oral cancer microenvironment. Cancers (Basel) 13:1\u201316. https:\/\/doi.org\/10.3390\/cancers13030395","journal-title":"Cancers (Basel)"},{"key":"4620_CR16","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1038\/s41423-020-00565-9","volume":"18","author":"ST Paijens","year":"2021","unstructured":"Paijens ST, Vledder A, de Bruyn M, Nijman HW (2021) Tumor-infiltrating lymphocytes in the immunotherapy era. Cell Mol Immunol 18:842\u2013859. https:\/\/doi.org\/10.1038\/s41423-020-00565-9","journal-title":"Cell Mol Immunol"},{"key":"4620_CR17","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.21873\/anticanres.17518","volume":"45","author":"R Bhala","year":"2025","unstructured":"Bhala R, Cando LF, Verma P, Bhala RHEA et al (2025) Biomarkers predicting progression and prognosis of ductal carcinoma in situ (DCIS). Anticancer Res 45:1305\u20131328. https:\/\/doi.org\/10.21873\/anticanres.17518","journal-title":"Anticancer Res"},{"key":"4620_CR18","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s12105-021-01405-6","volume":"16","author":"N Zidar","year":"2022","unstructured":"Zidar N, Gale N (2022) Update from the 5th edition of the World Health Organization classification of head and neck tumors: hypopharynx, larynx, trachea and parapharyngeal space. Head Neck Pathol 16:31\u201339. https:\/\/doi.org\/10.1007\/s12105-021-01405-6","journal-title":"Head Neck Pathol"},{"key":"4620_CR19","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1007\/s00405-020-06406-9","volume":"278","author":"HE Eckel","year":"2021","unstructured":"Eckel HE, Simo R, Quer M et al (2021) European Laryngological Society position paper on laryngeal dysplasia Part II: diagnosis, treatment, and follow-up. Eur Arch Otorhinolaryngol 278:1723\u20131732. https:\/\/doi.org\/10.1007\/s00405-020-06406-9","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"4620_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15041117","author":"F Chu","year":"2023","unstructured":"Chu F, Maffini F, Lepanto D et al (2023) The genetic and immunologic landscape underlying the risk of malignant progression in laryngeal dysplasia. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers15041117","journal-title":"Cancers (Basel)"},{"key":"4620_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-50691-3","author":"H Klimza","year":"2024","unstructured":"Klimza H, Jackowska J, Pietruszewska W et al (2024) Vocal fold leukoplakia recurrence risk model. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-023-50691-3","journal-title":"Sci Rep"},{"key":"4620_CR22","unstructured":"Zidar N, Fujii S, Gale N, Hernandez-Prera JC, Nadal A (2023) Laryngeal and hypopharyngeal epithelial dysplasia. In: Head and Neck Tumours, 5th ed. International Agency for Research on Cancer, Lyon, France. https:\/\/tumourclassification.iarc.who.int\/chaptercontent\/52\/42. Accessed 05 Dec 2024"},{"key":"4620_CR23","doi-asserted-by":"publisher","first-page":"8491","DOI":"10.1097\/PAP.0000000000000106","volume":"2","author":"N Gale","year":"2016","unstructured":"Gale N, Gnepp DR, Mario Poljak wz et al (2016) Laryngeal Squamous Intraepithelial Lesions: An Updated Review on Etiology, Classification, Molecular Changes, and Treatment. Adv Anat Pathol 2:8491. https:\/\/doi.org\/10.1097\/PAP.0000000000000106","journal-title":"Adv Anat Pathol"},{"key":"4620_CR24","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1007\/s12105-020-01149-9","volume":"14","author":"N Gale","year":"2020","unstructured":"Gale N, Cardesa A, Hernandez-Prera JC et al (2020) Laryngeal dysplasia: persisting dilemmas, disagreements and unsolved problems\u2014a short review. Head Neck Pathol 14:1046\u20131051. https:\/\/doi.org\/10.1007\/s12105-020-01149-9","journal-title":"Head Neck Pathol"},{"key":"4620_CR25","unstructured":"Nadal A, Bishop JA, Brandwein-Weber M et al (2023) Conventional squamous cell carcinoma. In: Head and Neck Tumours, 5th ed. International Agency for Research on Cancer, Lyon, France. https:\/\/tumourclassification.iarc.who.int\/chaptercontent\/52\/45. Accessed 05 Dec 2024"},{"key":"4620_CR26","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2024.1008","author":"G Horton","year":"2024","unstructured":"Horton G, Philteos J, Lin RJ (2024) Malignant transformation of dysplastic vocal fold lesions. JAMA Otolaryngol Head Neck Surg. https:\/\/doi.org\/10.1001\/jamaoto.2024.1008","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"4620_CR27","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1002\/hed.27631","volume":"46","author":"L Juesas Iglesias","year":"2024","unstructured":"Juesas Iglesias L, S\u00e1nchez-Canteli M, Pedregal Mallo D et al (2024) Prognostic value of preoperative inflammatory ratios in early glottic cancer treated with transoral laser surgery. Head Neck 46:819\u2013830. https:\/\/doi.org\/10.1002\/hed.27631","journal-title":"Head Neck"},{"key":"4620_CR28","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1177\/01945998211013765","volume":"166","author":"ME Heft Neal","year":"2022","unstructured":"Heft Neal ME, Smith JD, Birkeland AC et al (2022) Tumor-infiltrating lymphocytes in patients with advanced laryngeal cancer undergoing bioselection. Otolaryngol Head Neck Surg 166:498\u2013505. https:\/\/doi.org\/10.1177\/01945998211013765","journal-title":"Otolaryngol Head Neck Surg"},{"key":"4620_CR29","doi-asserted-by":"publisher","unstructured":"Fang Y, Chen M, Li G, Chen J et al (2022) Cancer-associated fibroblast-like fibroblasts in vocal fold leukoplakia suppress CD8\u2009+\u2009T cell functions by inducing IL-6 autocrine loop and interacting with Th17 cells. Cancer Lett. https:\/\/doi.org\/10.1016\/j.canlet.2022.215839","DOI":"10.1016\/j.canlet.2022.215839"},{"issue":"1","key":"4620_CR30","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41514-023-00105-5","volume":"9","author":"I Marin","year":"2023","unstructured":"Marin I, Serrano M, Pietrocola F (2023) Recent insights into the crosstalk between senescent cells and CD8 T lymphocytes. npj Aging 9:8. https:\/\/doi.org\/10.1038\/s41514-023-00105-5","journal-title":"npj Aging"},{"key":"4620_CR31","doi-asserted-by":"publisher","unstructured":"Zhang B, Wang X, Cheng C (2023) The ratio of intratumour to stromal infiltrating lymphocytes better predicts prognosis in breast cancer. Clin Transl Med 13. https:\/\/doi.org\/10.1002\/ctm2.1265","DOI":"10.1002\/ctm2.1265"},{"key":"4620_CR32","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1158\/2159-8290.CD-17-0222","volume":"7","author":"CR Gil Del Alcazar","year":"2017","unstructured":"Gil Del Alcazar CR, Huh SJ, Ekram MB et al (2017) Immune escape in breast cancer during in situ to invasive carcinoma transition. Cancer Discov 7:1098\u20131115. https:\/\/doi.org\/10.1158\/2159-8290.CD-17-0222","journal-title":"Cancer Discov"},{"key":"4620_CR33","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/nature12626","volume":"501","author":"MR Junttila","year":"2013","unstructured":"Junttila MR, De Sauvage FJ (2013) Influence of tumour micro-environment heterogeneity on therapeutic response. Nature 501:346\u2013354. https:\/\/doi.org\/10.1038\/nature12626","journal-title":"Nature"},{"key":"4620_CR34","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s00262-020-02481-3","volume":"69","author":"EJ de Ruiter","year":"2020","unstructured":"de Ruiter EJ, de Roest RH, Brakenhoff RH et al (2020) Digital pathology-aided assessment of tumor-infiltrating T lymphocytes in advanced stage, HPV-negative head and neck tumors. Cancer Immunol Immunother 69:581\u2013591. https:\/\/doi.org\/10.1007\/s00262-020-02481-3","journal-title":"Cancer Immunol Immunother"},{"key":"4620_CR35","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s00262-018-2256-3","volume":"68","author":"JE Mann","year":"2019","unstructured":"Mann JE, Smith JD, Birkeland AC et al (2019) Analysis of tumor-infiltrating CD103 resident memory T-cell content in recurrent laryngeal squamous cell carcinoma. Cancer Immunol Immunother 68:213\u2013220. https:\/\/doi.org\/10.1007\/s00262-018-2256-3","journal-title":"Cancer Immunol Immunother"},{"key":"4620_CR36","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1007\/s12105-023-01590-6","volume":"17","author":"R Bill","year":"2023","unstructured":"Bill R, Faquin WC, Pai SI (2023) Assessing PD-L1 expression in head and neck squamous cell carcinoma: trials and tribulations. Head Neck Pathol 17:969\u2013975. https:\/\/doi.org\/10.1007\/s12105-023-01590-6","journal-title":"Head Neck Pathol"},{"key":"4620_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cancers12071764","volume":"12","author":"FJ Su\u00e1rez-S\u00e1nchez","year":"2020","unstructured":"Su\u00e1rez-S\u00e1nchez FJ, Lequerica-Fern\u00e1ndez P, Su\u00e1rez-Canto J et al (2020) Macrophages in oral carcinomas: relationship with cancer stem cell markers and PD-L1 expression. Cancers (Basel) 12:1\u201314. https:\/\/doi.org\/10.3390\/cancers12071764","journal-title":"Cancers (Basel)"},{"key":"4620_CR38","doi-asserted-by":"publisher","first-page":"2965","DOI":"10.1158\/1055-9965","volume":"23","author":"Z Gatalica","year":"2014","unstructured":"Gatalica Z, Snyder C, Maney T et al (2014) Programmed cell death 1 (PD-1) and its ligand (PD-L1) in common cancers and their correlation with molecular cancer type. Cancer Epidemiol Biomarkers Prev 23:2965\u20132970. https:\/\/doi.org\/10.1158\/1055-9965","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"4620_CR39","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12020477","author":"E Guerini Rocco","year":"2022","unstructured":"Guerini Rocco E, Eccher A, Girolami I et al (2022) Concordance between three PD-L1 immunohistochemical assays in head and neck squamous cell carcinoma (HNSCC) in a multicenter study. Diagnostics (Basel). https:\/\/doi.org\/10.3390\/diagnostics12020477","journal-title":"Diagnostics (Basel)"},{"issue":"6","key":"4620_CR40","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9060653","volume":"9","author":"P Lequerica-Fern\u00e1ndez","year":"2021","unstructured":"Lequerica-Fern\u00e1ndez P, Su\u00e1rez-Canto J, Rodriguez-Santamarta T et al (2021) Prognostic relevance of CD4+, CD8\u2009+\u2009and FOXP3\u2009+\u2009TILS in oral squamous cell carcinoma and correlations with PD-L1 and cancer stem cell markers. Biomedicines 9(6):653. https:\/\/doi.org\/10.3390\/biomedicines9060653","journal-title":"Biomedicines"},{"issue":"1","key":"4620_CR41","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s12943-023-01845-4","volume":"22","author":"C Sordo-Bahamonde","year":"2023","unstructured":"Sordo-Bahamonde C, Lorenzo-Herrero S, Granda-D\u00edaz R et al (2023) Beyond the anti-PD-1\/PD-L1 era: promising role of the BTLA\/HVEM axis as a future target for cancer immunotherapy. Mol Cancer 22:142. https:\/\/doi.org\/10.1186\/s12943-023-01845-4","journal-title":"Mol Cancer"},{"key":"4620_CR42","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1007\/s00262-020-02604-w","volume":"69","author":"M Sanchez-Canteli","year":"2020","unstructured":"Sanchez-Canteli M, Granda-D\u00edaz R, del Rio-Ibisate N et al (2020) PD-L1 expression correlates with tumor-infiltrating lymphocytes and better prognosis in patients with HPV-negative head and neck squamous cell carcinomas. Cancer Immunol Immunother 69:2089\u20132100. https:\/\/doi.org\/10.1007\/s00262-020-02604-w","journal-title":"Cancer Immunol Immunother"},{"key":"4620_CR43","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/s41416-022-02119-4","volume":"128","author":"K Brummel","year":"2023","unstructured":"Brummel K, Eerkens AL, de Bruyn M, Nijman HW (2023) Tumour-infiltrating lymphocytes: from prognosis to treatment selection. Br J Cancer 128:451\u2013458. https:\/\/doi.org\/10.1038\/s41416-022-02119-4","journal-title":"Br J Cancer"},{"issue":"8","key":"4620_CR44","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s11912-020-00938-3","volume":"22","author":"NE Wondergem","year":"2020","unstructured":"Wondergem NE, Nauta IH, Muijlwijk T et al (2020) The immune microenvironment in head and neck squamous cell carcinoma: on subsets and subsites. Curr Oncol Rep 22:81. https:\/\/doi.org\/10.1007\/s11912-020-00938-3","journal-title":"Curr Oncol Rep"},{"key":"4620_CR45","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1093\/AJCP\/AQX107","volume":"149","author":"C Su","year":"2018","unstructured":"Su C, Jia S, Liu H (2018) Immunolocalization of CD163\u2009+\u2009tumor-associated macrophages and symmetric proliferation of Ki-67 as biomarkers to differentiate new different grades of laryngeal dysplasia. Am J Clin Pathol 149:8\u201316. https:\/\/doi.org\/10.1093\/AJCP\/AQX107","journal-title":"Am J Clin Pathol"},{"issue":"12","key":"4620_CR46","doi-asserted-by":"publisher","first-page":"19310","DOI":"10.18632\/oncotarget.14242","volume":"8","author":"G Karpathiou","year":"2017","unstructured":"Karpathiou G, Casteillo F, Giroult J-B et al (2017) Prognostic impact of immune microenvironment in laryngeal and pharyngeal squamous cell carcinoma: immune cell subtypes, immuno-suppressive pathways and clinicopathologic characteristics. Oncotarget 8(12):19310\u201319322. https:\/\/doi.org\/10.18632\/oncotarget.14242","journal-title":"Oncotarget"},{"key":"4620_CR47","doi-asserted-by":"publisher","unstructured":"Maffini F, Lepanto D, Chu F et al (2024) A transcriptomic analysis of laryngeal dysplasia. Int J Mol Sci 25(17):9685, 9685. https:\/\/doi.org\/10.3390\/ijms25179685","DOI":"10.3390\/ijms25179685"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-026-04620-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-026-04620-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-026-04620-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T04:02:58Z","timestamp":1781236978000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00428-026-04620-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,12]]},"references-count":47,"alternative-id":["4620"],"URL":"https:\/\/doi.org\/10.1007\/s00428-026-04620-0","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,12]]},"assertion":[{"value":"24 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from the patients involved in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}