{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:49:16Z","timestamp":1782460156418,"version":"3.54.5"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103220"],"award-info":[{"award-number":["82103220"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"DOI":"10.1007\/s00428-026-04633-9","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:18:25Z","timestamp":1782458305000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathologic characteristics of uterine malignant epithelioid neoplasms with EWSR1::CREM fusion: Report of 2 cases at a novel site with literature review"],"prefix":"10.1007","author":[{"given":"Shi-lu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-zhen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-cheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"4633_CR1","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1007\/s00428-021-03140-3","volume":"480","author":"A Agaimy","year":"2022","unstructured":"Agaimy A, Stoehr R, Otto M, Brasen JH, Pfarr N, Konukiewitz B, Kasajima A, Hartmann A, Kloppel G (2022) Intra-abdominal EWSR1\/FUS-CREM-rearranged malignant epithelioid neoplasms: two cases of an emerging aggressive entity with emphasis on misleading immunophenotype. Virchows Arch 480:481\u2013486. https:\/\/doi.org\/10.1007\/s00428-021-03140-3","journal-title":"Virchows Arch"},{"key":"4633_CR2","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1038\/s41379-020-0646-5","volume":"33","author":"P Argani","year":"2020","unstructured":"Argani P, Harvey I, Nielsen GP, Takano A, Suurmeijer AJH, Voltaggio L, Zhang L, Sung YS, Stenzinger A, Mechtersheimer G, Dickson BC, Antonescu CR (2020) EWSR1\/FUS-CREB fusions define a distinctive malignant epithelioid neoplasm with predilection for mesothelial-lined cavities. Mod Pathol 33:2233\u20132243. https:\/\/doi.org\/10.1038\/s41379-020-0646-5","journal-title":"Mod Pathol"},{"key":"4633_CR3","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1097\/PAP.0000000000000440","volume":"31","author":"JA Bennett","year":"2024","unstructured":"Bennett JA, Pinto A (2024) The \u201cother\u201d uterine mesenchymal neoplasms: recent developments and emerging entities. Adv Anat Pathol 31:380\u2013396. https:\/\/doi.org\/10.1097\/PAP.0000000000000440","journal-title":"Adv Anat Pathol"},{"key":"4633_CR4","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1097\/PAS.0000000000002046","volume":"47","author":"R Bi","year":"2023","unstructured":"Bi R, Yao Q, Ji G, Bai Q, Li A, Liu Z, Cheng Y, Tu X, Yu L, Chang B, Huang D, Ge H, Zuo K, Li H, Chang H, Cai X, Jiang W, Zhou X, Yang W (2023) Uterine tumor resembling ovarian sex cord tumors: 23 cases indicating molecular heterogeneity with variable biological behavior. Am J Surg Pathol 47:739\u2013755. https:\/\/doi.org\/10.1097\/PAS.0000000000002046","journal-title":"Am J Surg Pathol"},{"key":"4633_CR5","doi-asserted-by":"publisher","first-page":"148","DOI":"10.5114\/pjp.2019.87108","volume":"70","author":"M Braun","year":"2019","unstructured":"Braun M, Kuncman W, Szumera-Cieckiewicz A, Kosela-Paterczyk H, Musial J, Jesionek-Kupnicka D, Rys J, Kordek R (2019) Benign-looking primary fibrosarcoma of the uterus. Pol J Pathol 70:148\u2013152. https:\/\/doi.org\/10.5114\/pjp.2019.87108","journal-title":"Pol J Pathol"},{"key":"4633_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1215003","volume":"13","author":"L Campoverde","year":"2023","unstructured":"Campoverde L, Camacho F, Alessandrino F, Evans MG, Elliot A, Rosenberg A, Trent J (2023) Case report: the activity of multi-kinase VEGF inhibitor, Pazopanib, in metastatic undifferentiated round cell sarcomas harboring EWSR1::CREM fusion: clinicopathological series of two cases and literature review. Front Oncol 13:1215003. https:\/\/doi.org\/10.3389\/fonc.2023.1215003","journal-title":"Front Oncol"},{"key":"4633_CR7","doi-asserted-by":"publisher","first-page":"e1294","DOI":"10.1634\/theoncologist.2019-0236","volume":"24","author":"J Cao","year":"2019","unstructured":"Cao J, Chen L, Li H, Chen H, Yao J, Mu S, Liu W, Zhang P, Cheng Y, Liu B, Hu Z, Chen D, Kang H, Hu J, Wang A, Wang W, Yao M, Chrin G, Wang X, Zhao W, Li L, Xu L, Guo W, Jia J, Chen J, Wang K, Li G, Shi W (2019) An accurate and comprehensive clinical sequencing assay for cancer targeted and immunotherapies. Oncologist 24:e1294\u2013e1302. https:\/\/doi.org\/10.1634\/theoncologist.2019-0236","journal-title":"Oncologist"},{"key":"4633_CR8","doi-asserted-by":"publisher","DOI":"10.1200\/PO.18.00414","author":"J Cao","year":"2020","unstructured":"Cao J, Hu J, Liu S, Meric-Bernstam F, Abdel-Wahab R, Xu J, Li Q, Yan M, Feng Y, Lin J, Zhao S, Wang J, Kwong LN, Hu J, Carapeto F, Borad MJ, Wang K, Javle M, Zhao H (2020) Intrahepatic cholangiocarcinoma: genomic heterogeneity between eastern and western patients. JCO Precis Oncol. https:\/\/doi.org\/10.1200\/PO.18.00414","journal-title":"JCO Precis Oncol"},{"key":"4633_CR9","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/his.14008","volume":"76","author":"A Momeni-Boroujeni","year":"2020","unstructured":"Momeni-Boroujeni A, Chiang S (2020) Uterine mesenchymal tumours. recent Adv Histopathology 76:64\u201375. https:\/\/doi.org\/10.1111\/his.14008","journal-title":"recent Adv Histopathology"},{"key":"4633_CR10","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1097\/PAS.0000000000001742","volume":"46","author":"T Shibayama","year":"2022","unstructured":"Shibayama T, Shimoi T, Mori T, Noguchi E, Honma Y, Hijioka S, Yoshida M, Ogawa C, Yonemori K, Yatabe Y, Yoshida A (2022) Cytokeratin-positive malignant tumor in the abdomen with EWSR1\/FUS-CREB fusion: a clinicopathologic study of 8 cases. Am J Surg Pathol 46:134\u2013146. https:\/\/doi.org\/10.1097\/PAS.0000000000001742","journal-title":"Am J Surg Pathol"},{"key":"4633_CR11","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1159\/000449204","volume":"91","author":"V Subbiah","year":"2016","unstructured":"Subbiah V, Holmes O, Gowen K, Spritz D, Amini B, Wang WL, Schrock AB, Meric-Bernstam F, Zinner R, Piha-Paul S, Zarzour M, Elvin JA, Erlich RL, Stockman DL, Vergilio JA, Suh JH, Stephens PJ, Miller V, Ross JS, Ali SM (2016) Activity of c-Met\/ALK inhibitor crizotinib and multi-kinase VEGF inhibitor pazopanib in metastatic gastrointestinal neuroectodermal tumor harboring EWSR1-CREB1 fusion. Oncology (Williston Park) 91:348\u2013353. https:\/\/doi.org\/10.1159\/000449204","journal-title":"Oncology (Williston Park)"},{"key":"4633_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03318-6","volume":"20","author":"W Sun","year":"2022","unstructured":"Sun W, Wu W, Wang Q, Yao Q, Feng Q, Wang Y, Sun Y, Liu Y, Lai Q, Zhang G, Qi P, Sun Y, Qian C, Ren W, Luo Z, Chen J, Wang H, Xu Q, Zhou X, Sun W, Lin D (2022) Clinical validation of a 90-gene expression test for tumor tissue of origin diagnosis: a large-scale multicenter study of 1417 patients. J Transl Med 20:114. https:\/\/doi.org\/10.1186\/s12967-022-03318-6","journal-title":"J Transl Med"},{"key":"4633_CR13","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.path.2023.06.009","volume":"17","author":"LM Warmke","year":"2024","unstructured":"Warmke LM, Yu W, Meis JM (2024) Sclerosing epithelioid fibrosarcoma. Surg Pathol Clin 17:119\u2013139. https:\/\/doi.org\/10.1016\/j.path.2023.06.009","journal-title":"Surg Pathol Clin"},{"key":"4633_CR14","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1016\/j.jmoldx.2020.06.005","volume":"22","author":"Q Ye","year":"2020","unstructured":"Ye Q, Wang Q, Qi P, Chen J, Sun Y, Jin S, Ren W, Chen C, Liu M, Xu M, Ji G, Yang J, Nie L, Xu Q, Huang D, Du X, Zhou X (2020) Development and clinical validation of a 90-gene expression assay for identifying tumor tissue origin. J Mol Diagn 22:1139\u20131150. https:\/\/doi.org\/10.1016\/j.jmoldx.2020.06.005","journal-title":"J Mol Diagn"},{"key":"4633_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60040544","author":"H Yen","year":"2024","unstructured":"Yen H, Chou JL, Li YF, Wang DS (2024) Elucidating the diagnostic complexity of round cell sarcoma with EWSR1-CREM fusion: a comprehensive case study. Medicina (Kaunas). https:\/\/doi.org\/10.3390\/medicina60040544","journal-title":"Medicina (Kaunas)"},{"key":"4633_CR16","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1097\/PAS.0000000000001331","volume":"43","author":"A Yoshida","year":"2019","unstructured":"Yoshida A, Wakai S, Ryo E, Miyata K, Miyazawa M, Yoshida KI, Motoi T, Ogawa C, Iwata S, Kobayashi E, Watanabe SI, Kawai A, Mori T (2019) Expanding the phenotypic spectrum of mesenchymal tumors harboring the EWSR1-CREM fusion. Am J Surg Pathol 43:1622\u20131630. https:\/\/doi.org\/10.1097\/PAS.0000000000001331","journal-title":"Am J Surg Pathol"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-026-04633-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-026-04633-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-026-04633-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:18:26Z","timestamp":1782458306000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00428-026-04633-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,26]]},"references-count":16,"alternative-id":["4633"],"URL":"https:\/\/doi.org\/10.1007\/s00428-026-04633-9","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,26]]},"assertion":[{"value":"19 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}