{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:57:43Z","timestamp":1785513463667,"version":"3.56.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100015763","name":"University of Szeged","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100015763","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Invasive lobular carcinomas may demonstrate tubule formation both at the primary and at metastatic sites. A series of 135 invasive lobular carcinomas scrutinously screened for tubular elements were used, and tumours with axillary lymph node metastases were selected for review. Two observers blinded to the histology of the primary tumours independently and then together looked at all slides from lymph node metastases of 50\/52 cases having nodal involvement searching for tubular structures. Altogether 4 lymph nodes from 4 tumours were identified as harbouring tubules, 1 from a primary with tubular elements, and 3 from carcinomas without tubular elements identified in the primary. Tubule formation was generally focal (&lt;\u200910%) in most primaries (including the one with similar metastasis), therefore, by chance identification and sampling bias may be contributory factors to the discrepant primary and metastatic tubular elements, but microenvironment related factors may also be involved in a site dependent development of tubules in lobular carcinomas. Identifying tubules in a metastasis associated with a non-tubule-forming primary lobular carcinoma should not obviously mandate the search for a similar tubule-forming primary tumour.<\/jats:p>","DOI":"10.1007\/s00428-026-04649-1","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:34:27Z","timestamp":1785465267000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tubular elements in lymph node metastases from lobular carcinomas with or without tubule formation"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1344-7744","authenticated-orcid":false,"given":"G\u00e1bor","family":"Cserni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishika Judith Lourdes","family":"Sambadoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"4649_CR1","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s10549-018-4914-8","volume":"172","author":"PM Yeap","year":"2018","unstructured":"Yeap PM, Evans A, Purdie CA, Jordan LB, Vinnicombe SJ (2018) A comparison of the imaging features of pleomorphic and classical invasive lobular carcinoma. Breast Cancer Res Treat 172:381\u2013389. https:\/\/doi.org\/10.1007\/s10549-018-4914-8","journal-title":"Breast Cancer Res Treat"},{"key":"4649_CR2","doi-asserted-by":"publisher","first-page":"1631670","DOI":"10.3389\/fonc.2025.1631670","volume":"15","author":"B Yu","year":"2025","unstructured":"Yu B, Yan L, Wang H, Yang J, Yang J (2025) Invasive lobular carcinoma of the breast: metastatic patterns and treatment modalities - a review. Front Oncol 15:1631670. https:\/\/doi.org\/10.3389\/fonc.2025.1631670","journal-title":"Front Oncol"},{"key":"4649_CR3","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s10549-014-2861-6","volume":"144","author":"S Loibl","year":"2014","unstructured":"Loibl S, Volz C, Mau C et al (2014) Response and prognosis after neoadjuvant chemotherapy in 1,051 patients with infiltrating lobular breast carcinoma. Breast Cancer Res Treat 144:153\u2013162. https:\/\/doi.org\/10.1007\/s10549-014-2861-6","journal-title":"Breast Cancer Res Treat"},{"key":"4649_CR4","doi-asserted-by":"publisher","unstructured":"Christgen M, Cserni G, Floris G et al (2021) Lobular Breast Cancer: Histomorphology and Different Concepts of a Special Spectrum of Tumors. https:\/\/doi.org\/10.3390\/cancers13153695. Cancers 2021:13","DOI":"10.3390\/cancers13153695"},{"key":"4649_CR5","volume-title":"Breast Tumours","author":"World Health Organisation Classification of Tumours Editorial Board","year":"2019","unstructured":"World Health Organisation Classification of Tumours Editorial Board (2019) Breast Tumours, 5th edn. International Agency for Research on Cancer (IARC), Lyon","edition":"5"},{"key":"4649_CR6","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1002\/cjp2.253","volume":"8","author":"M Christgen","year":"2022","unstructured":"Christgen M, Kandt LD, Antonopoulos W et al (2022) Inter-observer agreement for the histological diagnosis of invasive lobular breast carcinoma. Pathol Clin Res 8:191\u2013205. https:\/\/doi.org\/10.1002\/cjp2.253","journal-title":"Pathol Clin Res"},{"key":"4649_CR7","doi-asserted-by":"publisher","first-page":"100837","DOI":"10.1016\/j.modpat.2025.100837","volume":"38","author":"G Floris","year":"2025","unstructured":"Floris G, Djerroudi L, Zels G (2025) Pitfalls in the Histological Diagnosis of Morphologic Variants of Invasive Lobular Carcinoma of the Breast. Mod Pathol 38:100837. https:\/\/doi.org\/10.1016\/j.modpat.2025.100837","journal-title":"Mod Pathol"},{"key":"4649_CR8","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1111\/his.15026","volume":"83","author":"G Cserni","year":"2023","unstructured":"Cserni G, K\u00e1lm\u00e1n E, Udvarhelyi N et al (2023) Evaluation of the routine use of E-cadherin immunohistochemistry in the typing of breast carcinomas: results of a randomized diagnostic study. Histopathology 83:810\u2013821. https:\/\/doi.org\/10.1111\/his.15026","journal-title":"Histopathology"},{"key":"4649_CR9","doi-asserted-by":"publisher","first-page":"273","DOI":"10.32074\/1591-951X-1043","volume":"116","author":"G Cserni","year":"2024","unstructured":"Cserni G (2024) Invasive lobular carcinoma of the breast: we diagnose it, but do we know what it is? Pathologica 116:273\u2013284. https:\/\/doi.org\/10.32074\/1591-951X-1043","journal-title":"Pathologica"},{"key":"4649_CR10","doi-asserted-by":"publisher","first-page":"105857","DOI":"10.1016\/j.humpath.2025.105857","volume":"162","author":"L Bai","year":"2025","unstructured":"Bai L, Troxell ML (2025) Update in lobular breast lesions: Pathological diagnosis in the molecular era. Hum Pathol 162:105857. https:\/\/doi.org\/10.1016\/j.humpath.2025.105857","journal-title":"Hum Pathol"},{"key":"4649_CR11","first-page":"987","volume":"142","author":"C Gamallo","year":"1993","unstructured":"Gamallo C, Palacios J, Suarez A (1993) Correlation of E-cadherin expression with differentiation grade and histological type in breast carcinoma. Am J Pathol 142:987\u2013993","journal-title":"Am J Pathol"},{"key":"4649_CR12","doi-asserted-by":"publisher","unstructured":"Rubtsova S, Zhitnyak I, Gloushankova N (2022) Dual role of E-cadherin in cancer cells. Tissue Barriers 2022(10). https:\/\/doi.org\/10.1080\/21688370.2021.2005420","DOI":"10.1080\/21688370.2021.2005420"},{"key":"4649_CR13","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41698-024-00508-x","volume":"2024","author":"H Dopeso","year":"2024","unstructured":"Dopeso H, Gazzo A, Derakhshan F et al (2024) Genomic and epigenomic basis of breast invasive lobular carcinomas lacking CDH1 genetic alterations. NPJ Precis Oncol 2024:8. https:\/\/doi.org\/10.1038\/s41698-024-00508-x","journal-title":"NPJ Precis Oncol"},{"key":"4649_CR14","doi-asserted-by":"publisher","first-page":"219","DOI":"10.7150\/jca.79236","volume":"14","author":"J Huang","year":"2023","unstructured":"Huang J, Wang H, Xu Y (2023) The Role of CTNNA1 in Malignancies: An Updated Review. J Cancer 14:219\u2013230. https:\/\/doi.org\/10.7150\/jca.79236","journal-title":"J Cancer"},{"key":"4649_CR15","doi-asserted-by":"publisher","first-page":"8961","DOI":"10.3390\/ijms25168961","volume":"25","author":"S Uchida","year":"2024","unstructured":"Uchida S, Sugino T (2024) Insights into E-Cadherin Impairment in CDH1-Unaltered Invasive Lobular Carcinoma: A Comprehensive Bioinformatic Study. Int J Mol Sci 25:8961. https:\/\/doi.org\/10.3390\/ijms25168961","journal-title":"Int J Mol Sci"},{"key":"4649_CR16","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1038\/s41379-020-0591-3","volume":"33","author":"M Christgen","year":"2020","unstructured":"Christgen M, Bartels S, van Luttikhuizen JL et al (2020) E-cadherin to P-cadherin switching in lobular breast cancer with tubular elements. Mod Pathol 33:2483\u20132498. https:\/\/doi.org\/10.1038\/s41379-020-0591-3","journal-title":"Mod Pathol"},{"key":"4649_CR17","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1097\/00000478-200412000-00006","volume":"28","author":"DT Wheeler","year":"2004","unstructured":"Wheeler DT, Tai LH, Bratthauer GL et al (2004) Tubulolobular carcinoma of the breast: an analysis of 27 cases of a tumor with a hybrid morphology and immunoprofile. Am J Surg Pathol 28:1587\u20131593. https:\/\/doi.org\/10.1097\/00000478-200412000-00006","journal-title":"Am J Surg Pathol"},{"key":"4649_CR18","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1007\/s00428-005-0096-y","volume":"448","author":"H Kuroda","year":"2006","unstructured":"Kuroda H, Tamaru J, Takeuchi I et al (2006) Expression of E-cadherin, alpha-catenin, and beta-catenin in tubulolobular carcinoma of the breast. Virchows Arch 448:500\u2013505. https:\/\/doi.org\/10.1007\/s00428-005-0096-y","journal-title":"Virchows Arch"},{"key":"4649_CR19","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1111\/j.1365-2559.2006.02373.x","volume":"48","author":"C Marchi\u00f2","year":"2006","unstructured":"Marchi\u00f2 C, Sapino A, Arisio R (2006) A new vision of tubular and tubulo-lobular carcinomas of the breast, as revealed by 3-D modelling. Histopathology 48:556\u2013562. https:\/\/doi.org\/10.1111\/j.1365-2559.2006.02373.x","journal-title":"Histopathology"},{"key":"4649_CR20","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/modpathol.3800721","volume":"20","author":"NN Esposito","year":"2007","unstructured":"Esposito NN, Chivukula M, Dabbs DJ (2007) The ductal phenotypic expression of the E-cadherin\/catenin complex in tubulolobular carcinoma of the breast: an immunohistochemical and clinicopathologic study. Mod Pathol 20:130\u2013138. https:\/\/doi.org\/10.1038\/modpathol.3800721","journal-title":"Mod Pathol"},{"key":"4649_CR21","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/s0046-8177(77)80096-8","volume":"8","author":"ER Fisher","year":"1977","unstructured":"Fisher ER, Gregorio RM, Redmond C et al (1977) Tubulolobular invasive breast cancer: a variant of lobular invasive cancer. Hum Pathol 8:679\u2013683. https:\/\/doi.org\/10.1016\/s0046-8177(77)80096-8","journal-title":"Hum Pathol"},{"key":"4649_CR22","doi-asserted-by":"publisher","first-page":"e12361","DOI":"10.1002\/2056-4538.12361","volume":"10","author":"M Gronewold","year":"2024","unstructured":"Gronewold M, Grote I, Bartels S et al (2024) Microenvironment-induced restoration of cohesive growth associated with focal activation of P-cadherin expression in lobular breast carcinoma metastatic to the colon. J Pathol Clin Res 10:e12361. https:\/\/doi.org\/10.1002\/2056-4538.12361","journal-title":"J Pathol Clin Res"},{"issue":"1640","key":"4649_CR23","doi-asserted-by":"publisher","first-page":"d","DOI":"10.3390\/cancers16091640","volume":"16","author":"G Cserni","year":"2024","unstructured":"Cserni G, Bori R, Ambr\u00f3zay \u00c9, Serf\u0151z\u0151 O (2024) Histological Patterns and Mammographic Presentation of Invasive Lobular Carcinoma Show No Obvious Associations. Cancers (Basel) 16(1640):d. https:\/\/doi.org\/10.3390\/cancers16091640","journal-title":"Cancers (Basel)"},{"key":"4649_CR24","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s00428-021-03128-z","volume":"480","author":"G Cserni","year":"2022","unstructured":"Cserni G, Maguire A, Bianchi S et al (2022) Sentinel lymph node assessment in breast cancer-an update on current recommendations. Virchows Arch 480:95\u2013107. https:\/\/doi.org\/10.1007\/s00428-021-03128-z","journal-title":"Virchows Arch"},{"key":"4649_CR25","doi-asserted-by":"publisher","first-page":"104125","DOI":"10.1016\/j.labinv.2025.104125","volume":"105","author":"M Radner","year":"2025","unstructured":"Radner M, Burmeister S, J\u00f3\u017awiak K et al (2025) Clinicopathological Characteristics of a Distinct Tumor Phenotype: Invasive Lobular Carcinoma With Tubular Elements in the West German Study Group ADAPTcycle Trial. Lab Invest 105:104125. https:\/\/doi.org\/10.1016\/j.labinv.2025.104125","journal-title":"Lab Invest"},{"key":"4649_CR26","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s13058-020-01384-6","volume":"23","author":"AE McCart Reed","year":"2021","unstructured":"McCart Reed AE, Kalinowski L, Simpson PT, Lakhani SR (2021) Invasive lobular carcinoma of the breast: the increasing importance of this special subtype. Breast Cancer Res 23:6. https:\/\/doi.org\/10.1186\/s13058-020-01384-6","journal-title":"Breast Cancer Res"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-026-04649-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-026-04649-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-026-04649-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:03:05Z","timestamp":1785510185000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00428-026-04649-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":26,"alternative-id":["4649"],"URL":"https:\/\/doi.org\/10.1007\/s00428-026-04649-1","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,31]]},"assertion":[{"value":"28 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors have no potential conflicts of interest.","order":1,"name":"Ethics","label":"<b>Conflicts of interest<\/b>","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures were performed in compliance with relevant laws and institutional guidelines. The study was approved by the Institutional Ethical Committee of the Albert Szent-Gy\u00f6rgyi Clinical Center of the University of Szeged (approval number 115\/2019-SZTE-RKEB), the approval includes a waiver of informed consent for this retrospective study; the privacy rights of human subjects was granted by anonymizing data before analysis, as specified in the approval.","order":2,"name":"Ethics","label":"<b>Compliance with ethical standards<\/b>","group":{"name":"EthicsHeading","label":"Declarations"}}]}}