{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:11:31Z","timestamp":1788883891506,"version":"build-2803163510"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"None","award":["None"],"award-info":[{"award-number":["None"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"DOI":"10.1007\/s00428-026-04712-x","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:46:22Z","timestamp":1788839182000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Methylation profiling in CNS tumor diagnostics: a single-centre real-world experience from Central Europe"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8052-4741","authenticated-orcid":false,"given":"Mari\u00e1n","family":"\u0160vajdler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5241-9723","authenticated-orcid":false,"given":"Tom\u00e1\u0161","family":"Van\u011b\u010dek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0276-5771","authenticated-orcid":false,"given":"Petr","family":"Mart\u00ednek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"H\u00e1jkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7169-4386","authenticated-orcid":false,"given":"Ji\u0159\u00ed","family":"Soukup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"Jir\u00e1sek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1024-7408","authenticated-orcid":false,"given":"Michal","family":"Hendrych","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Syr\u016f\u010dek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Dolinsk\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozef","family":"Bocko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9553-0105","authenticated-orcid":false,"given":"Krist\u00fdna","family":"Pivovar\u010d\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kolej\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4629-4732","authenticated-orcid":false,"given":"Jan","family":"Mra\u010dek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladim\u00edr","family":"P\u0159ib\u00e1\u0148","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"\u0160vajdler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2391-8776","authenticated-orcid":false,"given":"Miha","family":"Jerala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5536-7518","authenticated-orcid":false,"given":"Matic","family":"Bo\u0161njak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6712-3457","authenticated-orcid":false,"given":"Mari\u00e1n","family":"Grend\u00e1r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4361-7628","authenticated-orcid":false,"given":"Roman","family":"Mezencev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"4712_CR1","volume-title":"Central nervous system tumours. WHO classification of tumours series","author":"WHO Classification of Tumours Editorial Board","year":"2021","unstructured":"WHO Classification of Tumours Editorial Board (2021) Central nervous system tumours. WHO classification of tumours series, 5th edn. International Agency for Research on Cancer, Lyon","edition":"5"},{"key":"4712_CR2","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/nature26000","volume":"555","author":"D Capper","year":"2018","unstructured":"Capper D, Jones DTW, Sill M et al (2018) DNA methylation-based classification of central nervous system tumours. Nature 555:469\u2013474. https:\/\/doi.org\/10.1038\/nature26000","journal-title":"Nature"},{"key":"4712_CR3","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s00401-018-1879-y","volume":"136","author":"D Capper","year":"2018","unstructured":"Capper D, Stichel D, Sahm F et al (2018) Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience. Acta Neuropathol 136:181\u2013210. https:\/\/doi.org\/10.1007\/s00401-018-1879-y","journal-title":"Acta Neuropathol"},{"key":"4712_CR4","doi-asserted-by":"publisher","first-page":"e12838","DOI":"10.1111\/nan.12838","volume":"48","author":"E Schepke","year":"2022","unstructured":"Schepke E, Lofgren M, Pietsch T et al (2022) DNA methylation profiling improves routine diagnosis of paediatric central nervous system tumours: A prospective population-based study. Neuropathol Appl Neurobiol 48:e12838. https:\/\/doi.org\/10.1111\/nan.12838","journal-title":"Neuropathol Appl Neurobiol"},{"key":"4712_CR5","doi-asserted-by":"publisher","first-page":"e70041","DOI":"10.1111\/nan.70041","volume":"51","author":"MF Euzebio","year":"2025","unstructured":"Euzebio MF, Silva FLT, Hoffmann IL et al (2025) Use of DNA Methylation Profiling as a Molecular Classification Tool for Paediatric Central Nervous System Tumours: A Middle-Income Country Population-Based Study. Neuropathol Appl Neurobiol 51:e70041. https:\/\/doi.org\/10.1111\/nan.70041","journal-title":"Neuropathol Appl Neurobiol"},{"key":"4712_CR6","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.1038\/s41598-025-87079-4","volume":"15","author":"L Lebrun","year":"2025","unstructured":"Lebrun L, Gilis N, Dausort M et al (2025) Diagnostic impact of DNA methylation classification in adult and pediatric CNS tumors. Sci Rep 15:2857. https:\/\/doi.org\/10.1038\/s41598-025-87079-4","journal-title":"Sci Rep"},{"key":"4712_CR7","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s40478-019-0668-8","volume":"7","author":"Z Jaunmuktane","year":"2019","unstructured":"Jaunmuktane Z, Capper D, Jones DTW et al (2019) Methylation array profiling of adult brain tumours: diagnostic outcomes in a large, single centre. Acta Neuropathol Commun 7:24. https:\/\/doi.org\/10.1186\/s40478-019-0668-8","journal-title":"Acta Neuropathol Commun"},{"key":"4712_CR8","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s13148-021-01085-7","volume":"13","author":"S Ferreyra Vega","year":"2021","unstructured":"Ferreyra Vega S, Olsson Bontell T, Corell A et al (2021) DNA methylation profiling for molecular classification of adult diffuse lower-grade gliomas. Clin Epigenetics 13:102. https:\/\/doi.org\/10.1186\/s13148-021-01085-7","journal-title":"Clin Epigenetics"},{"key":"4712_CR9","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s13148-019-0766-2","volume":"11","author":"S Karimi","year":"2019","unstructured":"Karimi S, Zuccato JA, Mamatjan Y et al (2019) The central nervous system tumor methylation classifier changes neuro-oncology practice for challenging brain tumor diagnoses and directly impacts patient care. Clin Epigenetics 11:185. https:\/\/doi.org\/10.1186\/s13148-019-0766-2","journal-title":"Clin Epigenetics"},{"key":"4712_CR10","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1111\/nan.12610","volume":"46","author":"LP Priesterbach-Ackley","year":"2020","unstructured":"Priesterbach-Ackley LP, Boldt HB, Petersen JK et al (2020) Brain tumour diagnostics using a DNA methylation-based classifier as a diagnostic support tool. Neuropathol Appl Neurobiol 46:478\u2013492. https:\/\/doi.org\/10.1111\/nan.12610","journal-title":"Neuropathol Appl Neurobiol"},{"key":"4712_CR11","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.ccell.2025.11.002","volume":"44","author":"M Sill","year":"2026","unstructured":"Sill M, Schrimpf D, Patel A et al (2026) Advancing CNS tumor diagnostics with expanded DNA methylation-based classification. Cancer Cell 44:340\u2013354e342. https:\/\/doi.org\/10.1016\/j.ccell.2025.11.002","journal-title":"Cancer Cell"},{"key":"4712_CR12","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1002\/gcc.23041","volume":"61","author":"C Koelsche","year":"2022","unstructured":"Koelsche C, von Deimling A (2022) Methylation classifiers: Brain tumors, sarcomas, and what\u2019s next. Genes Chromosomes Cancer 61:346\u2013355. https:\/\/doi.org\/10.1002\/gcc.23041","journal-title":"Genes Chromosomes Cancer"},{"key":"4712_CR13","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1007\/s00401-021-02354-8","volume":"142","author":"KT Alhalabi","year":"2021","unstructured":"Alhalabi KT, Stichel D, Sievers P et al (2021) PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum. Acta Neuropathol 142:841\u2013857. https:\/\/doi.org\/10.1007\/s00401-021-02354-8","journal-title":"Acta Neuropathol"},{"key":"4712_CR14","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1177\/10668969251388390","volume":"34","author":"R Kolejak","year":"2026","unstructured":"Kolejak R, Mracek J, Subrt I et al (2026) Primary Intracranial Sarcoma, DICER1-Mutant, Diagnosed by DNA Methylation Profiling in an Adult Patient with Germline DICER1 Mutation: A Case Report. Int J Surg Pathol 34:762\u2013770. https:\/\/doi.org\/10.1177\/10668969251388390","journal-title":"Int J Surg Pathol"},{"key":"4712_CR15","unstructured":"Puchertov\u00e1 MRB, Hederov\u00e1 S, Jake\u0161ov\u00e1 S, \u0160vajdler M (2026) Diffuse midline glioma, H3K27-altered, misclassified by ependymal histomorphology and methylation profiling as posterior fossa group A ependymoma: a diagnostic pitfall. Cesk Patol. in press"},{"key":"4712_CR16","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/s41467-020-20603-4","volume":"12","author":"C Koelsche","year":"2021","unstructured":"Koelsche C, Schrimpf D, Stichel D et al (2021) Sarcoma classification by DNA methylation profiling. Nat Commun 12:498. https:\/\/doi.org\/10.1038\/s41467-020-20603-4","journal-title":"Nat Commun"},{"key":"4712_CR17","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1002\/cjp2.215","volume":"7","author":"I Lyskjaer","year":"2021","unstructured":"Lyskjaer I, De Noon S, Tirabosco R et al (2021) DNA methylation-based profiling of bone and soft tissue tumours: a validation study of the \u2018DKFZ Sarcoma Classifier\u2019. J Pathol Clin Res 7:350\u2013360. https:\/\/doi.org\/10.1002\/cjp2.215","journal-title":"J Pathol Clin Res"},{"key":"4712_CR18","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s13148-022-01365-w","volume":"14","author":"S Roohani","year":"2022","unstructured":"Roohani S, Ehret F, Perez E et al (2022) Sarcoma classification by DNA methylation profiling in clinical everyday life: the Charite experience. Clin Epigenetics 14:149. https:\/\/doi.org\/10.1186\/s13148-022-01365-w","journal-title":"Clin Epigenetics"},{"key":"4712_CR19","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1097\/PAS.0000000000002138","volume":"48","author":"M Miettinen","year":"2024","unstructured":"Miettinen M, Abdullaev Z, Turakulov R et al (2024) Assessment of The Utility of The Sarcoma DNA Methylation Classifier In Surgical Pathology. Am J Surg Pathol 48:112\u2013122. https:\/\/doi.org\/10.1097\/PAS.0000000000002138","journal-title":"Am J Surg Pathol"},{"key":"4712_CR20","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00432-019-03093-w","volume":"146","author":"FKF Kommoss","year":"2020","unstructured":"Kommoss FKF, Stichel D, Schrimpf D et al (2020) DNA methylation-based profiling of uterine neoplasms: a novel tool to improve gynecologic cancer diagnostics. J Cancer Res Clin Oncol 146:97\u2013104. https:\/\/doi.org\/10.1007\/s00432-019-03093-w","journal-title":"J Cancer Res Clin Oncol"},{"key":"4712_CR21","doi-asserted-by":"publisher","first-page":"7148","DOI":"10.1038\/s41467-022-34815-3","volume":"13","author":"P Jurmeister","year":"2022","unstructured":"Jurmeister P, Gloss S, Roller R et al (2022) DNA methylation-based classification of sinonasal tumors. Nat Commun 13:7148. https:\/\/doi.org\/10.1038\/s41467-022-34815-3","journal-title":"Nat Commun"},{"key":"4712_CR22","doi-asserted-by":"publisher","first-page":"zcad017","DOI":"10.1093\/narcan\/zcad017","volume":"5","author":"Z Zhang","year":"2023","unstructured":"Zhang Z, Lu Y, Vosoughi S et al (2023) HiTAIC: hierarchical tumor artificial intelligence classifier traces tissue of origin and tumor type in primary and metastasized tumors using DNA methylation. NAR Cancer 5:zcad017. https:\/\/doi.org\/10.1093\/narcan\/zcad017","journal-title":"NAR Cancer"},{"key":"4712_CR23","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13148-024-01638-6","volume":"16","author":"M Sun","year":"2024","unstructured":"Sun M, Xu B, Chen C et al (2024) Tissue of origin prediction for cancer of unknown primary using a targeted methylation sequencing panel. Clin Epigenetics 16:25. https:\/\/doi.org\/10.1186\/s13148-024-01638-6","journal-title":"Clin Epigenetics"},{"key":"4712_CR24","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s00401-021-02395-z","volume":"143","author":"AK Suwala","year":"2022","unstructured":"Suwala AK, Felix M, Friedel D et al (2022) Oligosarcomas, IDH-mutant are distinct and aggressive. Acta Neuropathol 143:263\u2013281. https:\/\/doi.org\/10.1007\/s00401-021-02395-z","journal-title":"Acta Neuropathol"},{"key":"4712_CR25","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s00401-022-02404-9","volume":"143","author":"D Pratt","year":"2022","unstructured":"Pratt D, Abdullaev Z, Papanicolau-Sengos A et al (2022) High-grade glioma with pleomorphic and pseudopapillary features (HPAP): a proposed type of circumscribed glioma in adults harboring frequent TP53 mutations and recurrent monosomy 13. Acta Neuropathol 143:403\u2013414. https:\/\/doi.org\/10.1007\/s00401-022-02404-9","journal-title":"Acta Neuropathol"},{"key":"4712_CR26","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1097\/PAS.0000000000002118","volume":"47","author":"A Muench","year":"2023","unstructured":"Muench A, Teichmann D, Spille D et al (2023) A Novel Type of IDH-wildtype Glioma Characterized by Gliomatosis Cerebri-like Growth Pattern, TERT Promoter Mutation, and Distinct Epigenetic Profile. Am J Surg Pathol 47:1364\u20131375. https:\/\/doi.org\/10.1097\/PAS.0000000000002118","journal-title":"Am J Surg Pathol"},{"key":"4712_CR27","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s00401-023-02558-0","volume":"145","author":"H Bogumil","year":"2023","unstructured":"Bogumil H, Sill M, Schrimpf D et al (2023) Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA): a molecularly distinct brain tumor type with recurrent NTRK gene fusions. Acta Neuropathol 145:667\u2013680. https:\/\/doi.org\/10.1007\/s00401-023-02558-0","journal-title":"Acta Neuropathol"},{"key":"4712_CR28","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1007\/s00401-025-02873-8","volume":"149","author":"O Singh","year":"2025","unstructured":"Singh O, Dampier C, Abdullaev Z et al (2025) Diffuse astrocytoma, AYA-type, frequently MAPK-altered: report of 45 patients. Acta Neuropathol 149:32. https:\/\/doi.org\/10.1007\/s00401-025-02873-8","journal-title":"Acta Neuropathol"},{"key":"4712_CR29","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s00401-022-02516-2","volume":"145","author":"MK Keck","year":"2023","unstructured":"Keck MK, Sill M, Wittmann A et al (2023) Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification. Acta Neuropathol 145:49\u201369. https:\/\/doi.org\/10.1007\/s00401-022-02516-2","journal-title":"Acta Neuropathol"},{"key":"4712_CR30","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1007\/s00401-023-02643-4","volume":"146","author":"A Tauziede-Espariat","year":"2023","unstructured":"Tauziede-Espariat A, Siegfried A, Nicaise Y et al (2023) PLAG1 fusions extend the spectrum of PLAG(L)-altered CNS tumors. Acta Neuropathol 146:841\u2013844. https:\/\/doi.org\/10.1007\/s00401-023-02643-4","journal-title":"Acta Neuropathol"},{"key":"4712_CR31","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2025-0272-OA","author":"IL Fernandes","year":"2026","unstructured":"Fernandes IL, Abdullaev Z, Quezado M et al (2026) Molecular Classification of Central Nervous System Tumors in Developing Countries: Challenges, Opportunities, and Feasibility in a Pathology Reference Laboratory. Arch Pathol Lab Med. https:\/\/doi.org\/10.5858\/arpa.2025-0272-OA","journal-title":"Arch Pathol Lab Med"},{"key":"4712_CR32","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s00401-025-02907-1","volume":"149","author":"JA Cotter","year":"2025","unstructured":"Cotter JA, Markowitz AL, Castaneda E et al (2025) CNS methylation classifiers may misclassify normal developing cerebellar cortex as medulloblastoma. Acta Neuropathol 149:66. https:\/\/doi.org\/10.1007\/s00401-025-02907-1","journal-title":"Acta Neuropathol"},{"key":"4712_CR33","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1093\/neuonc\/noy118","volume":"20","author":"H Witt","year":"2018","unstructured":"Witt H, Gramatzki D, Hentschel B et al (2018) DNA methylation-based classification of ependymomas in adulthood: implications for diagnosis and treatment. Neuro Oncol 20:1616\u20131624. https:\/\/doi.org\/10.1093\/neuonc\/noy118","journal-title":"Neuro Oncol"},{"key":"4712_CR34","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s00401-025-02944-w","volume":"150","author":"FK Aras","year":"2025","unstructured":"Aras FK, Friedel D, Keller F et al (2025) Expansion of the spectrum of tumors diagnosed as myxopapillary ependymomas. Acta Neuropathol 150:37. https:\/\/doi.org\/10.1007\/s00401-025-02944-w","journal-title":"Acta Neuropathol"},{"key":"4712_CR35","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s00401-025-02866-7","volume":"149","author":"S Purkait","year":"2025","unstructured":"Purkait S, Praeger S, Felsberg J et al (2025) Strong nuclear expression of HOXB13 is a reliable surrogate marker for DNA methylome profiling to distinguish myxopapillary ependymoma from spinal ependymoma. Acta Neuropathol 149:29. https:\/\/doi.org\/10.1007\/s00401-025-02866-7","journal-title":"Acta Neuropathol"},{"key":"4712_CR36","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s40478-024-01728-9","volume":"12","author":"R Drexler","year":"2024","unstructured":"Drexler R, Brembach F, Sauvigny J et al (2024) Unclassifiable CNS tumors in DNA methylation-based classification: clinical challenges and prognostic impact. Acta Neuropathol Commun 12:9. https:\/\/doi.org\/10.1186\/s40478-024-01728-9","journal-title":"Acta Neuropathol Commun"},{"key":"4712_CR37","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1007\/s00401-025-02939-7","volume":"150","author":"L Jurgensen","year":"2025","unstructured":"Jurgensen L, Benfatto S, Schmid S et al (2025) In silico purification improves DNA methylation-based classification rates of pediatric low-grade gliomas. Acta Neuropathol 150:34. https:\/\/doi.org\/10.1007\/s00401-025-02939-7","journal-title":"Acta Neuropathol"},{"key":"4712_CR38","doi-asserted-by":"publisher","first-page":"e13010","DOI":"10.1111\/nan.13010","volume":"50","author":"M Chirica","year":"2024","unstructured":"Chirica M, Jurmeister P, Teichmann D et al (2024) DNA methylation-array interlaboratory comparison trial demonstrates highly reproducible paediatric CNS tumour classification across 13 international centres. Neuropathol Appl Neurobiol 50:e13010. https:\/\/doi.org\/10.1111\/nan.13010","journal-title":"Neuropathol Appl Neurobiol"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-026-04712-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-026-04712-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-026-04712-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:02:52Z","timestamp":1788883372000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00428-026-04712-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,8]]},"references-count":38,"alternative-id":["4712"],"URL":"https:\/\/doi.org\/10.1007\/s00428-026-04712-x","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,8]]},"assertion":[{"value":"20 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Ethical approval was granted by the University Hospital in Pilsen (reference no. 65\/26); informed consent was waived.","order":1,"name":"Ethics","label":"Compliance with ethical standards","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare no conflict of interests for this article.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}