{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:11:36Z","timestamp":1790154696270,"version":"4.0.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"DOI":"10.1007\/s00428-026-04716-7","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:48:26Z","timestamp":1790153306000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sinonasal POU2AF3 (COLCA2)-rearranged carcinomas: a study of 11 aggressive tumors with findings supporting classification as solid adenoid cystic carcinoma"],"prefix":"10.1007","author":[{"given":"Sintawat","family":"Wangsiricharoen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly E.","family":"Craven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina M.","family":"Wakeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey O.","family":"Lowder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Raps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany G.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Blakely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross J.","family":"Taliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mena","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerben E.","family":"Breimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Agaimy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin A.","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"4716_CR1","unstructured":"Tumors With EWSR1-CREB1 and EWSR1-ATF1 Fusions (2026) American Journal of Surgical Pathology. In: Ovid. https:\/\/www.ovid.com\/jnls\/ajsp\/fulltext\/10.1097\/pas.0b013e31825485c5~tumors-with-ewsr1-creb1-and-ewsr1-atf1-fusions-the-current. Accessed 12 July 2026"},{"key":"4716_CR2","doi-asserted-by":"publisher","first-page":"100537","DOI":"10.1016\/j.modpat.2024.100537","volume":"37","author":"AL Folpe","year":"2024","unstructured":"Folpe AL, Tetzlaff MT, Billings SD et al (2024) Superficial Neurocristic EWSR1::FLI1 Fusion Tumor: A Distinctive, Clinically Indolent, S100 Protein\/SOX10-Positive Neoplasm. Mod Pathol 37:100537. https:\/\/doi.org\/10.1016\/j.modpat.2024.100537","journal-title":"Mod Pathol"},{"key":"4716_CR3","doi-asserted-by":"publisher","first-page":"100656","DOI":"10.1016\/j.modpat.2024.100656","volume":"38","author":"CA Dehner","year":"2025","unstructured":"Dehner CA, Warmke LM, Umphress B et al (2025) Superficial Neurocristic FET::ETS Fusion Tumor: Expanding the Clinicopathological and Molecular Genetic Spectrum of a Recently Described Entity. Mod Pathol 38:100656. https:\/\/doi.org\/10.1016\/j.modpat.2024.100656","journal-title":"Mod Pathol"},{"key":"4716_CR4","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.1002\/ijc.28557","volume":"134","author":"VD Peltekova","year":"2014","unstructured":"Peltekova VD, Lemire M, Qazi AM et al (2014) Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants. Int J Cancer 134:2330\u20132341. https:\/\/doi.org\/10.1002\/ijc.28557","journal-title":"Int J Cancer"},{"key":"4716_CR5","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1097\/PAS.0000000000002000","volume":"47","author":"A Agaimy","year":"2023","unstructured":"Agaimy A, Ban\u011b\u010dkov\u00e1 M, De Almeida J et al (2023) Recurrent EWSR1::COLCA2 Fusions Define a Novel Sarcoma With Spindle\/Round Cell Morphology and Strong Predilection for the Sinonasal Tract. Am J Surg Pathol 47:361\u2013369. https:\/\/doi.org\/10.1097\/PAS.0000000000002000","journal-title":"Am J Surg Pathol"},{"key":"4716_CR6","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1002\/gcc.23136","volume":"62","author":"MC Hiemenz","year":"2023","unstructured":"Hiemenz MC, Kaur J, Kuang Z et al (2023) POU2AF3-rearranged sarcomas: A novel tumor defined by fusions of EWSR1 or FUS to a gene formerly designated COLCA2. Genes Chromosomes Cancer 62:460\u2013470. https:\/\/doi.org\/10.1002\/gcc.23136","journal-title":"Genes Chromosomes Cancer"},{"key":"4716_CR7","doi-asserted-by":"publisher","first-page":"100337","DOI":"10.1016\/j.modpat.2023.100337","volume":"36","author":"O Koshyk","year":"2023","unstructured":"Koshyk O, Dehner CA, van den Hout MFCM et al (2023) EWSR1::POU2AF3(COLCA2) Sarcoma: An Aggressive, Polyphenotypic Sarcoma With a Head and Neck Predilection. Mod Pathol 36:100337. https:\/\/doi.org\/10.1016\/j.modpat.2023.100337","journal-title":"Mod Pathol"},{"key":"4716_CR8","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1007\/s00428-025-04055-z","volume":"486","author":"S \u00c7etin","year":"2025","unstructured":"\u00c7etin S, Y\u0131lmaz \u0130, Bakkalo\u011flu DV et al (2025) Sinonasal EWSR1::POU2AF3 sarcoma: a case report and literature review. Virchows Arch 486:855\u2013864. https:\/\/doi.org\/10.1007\/s00428-025-04055-z","journal-title":"Virchows Arch"},{"key":"4716_CR9","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/his.15216","volume":"85","author":"M Habenbacher","year":"2024","unstructured":"Habenbacher M, Andrianakis A, Gellner V et al (2024) Aggressive EWSR1::POU2AF3(COLCA2) spindle\/round cell sarcoma of the sinonasal tract. Histopathology 85:365\u2013368. https:\/\/doi.org\/10.1111\/his.15216","journal-title":"Histopathology"},{"key":"4716_CR10","unstructured":"Clinical and analytical validation of MI Cancer Seek\u00ae, a companion diagnostic whole exome and whole transcriptome sequencing-based comprehensive molecular profiling assay | Oncotarget. https:\/\/www.oncotarget.com\/article\/28761\/text\/. Accessed 12 July 2026"},{"key":"4716_CR11","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1007\/s12105-019-01088-0","volume":"14","author":"JA Bishop","year":"2020","unstructured":"Bishop JA, Gagan J, Baumhoer D et al (2020) Sclerosing Polycystic Adenosis of Salivary Glands: A Neoplasm Characterized by PI3K Pathway Alterations More Correctly Named Sclerosing Polycystic Adenoma. Head Neck Pathol 14:630\u2013636. https:\/\/doi.org\/10.1007\/s12105-019-01088-0","journal-title":"Head Neck Pathol"},{"key":"4716_CR12","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/gcc.22690","volume":"58","author":"BC Dickson","year":"2019","unstructured":"Dickson BC, Swanson D (2019) Targeted RNA sequencing: A routine ancillary technique in the diagnosis of bone and soft tissue neoplasms. Genes Chromosomes Cancer 58:75\u201387. https:\/\/doi.org\/10.1002\/gcc.22690","journal-title":"Genes Chromosomes Cancer"},{"key":"4716_CR13","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1007\/s12105-020-01173-9","volume":"14","author":"A Agaimy","year":"2020","unstructured":"Agaimy A, T\u00f6gel L, Haller F et al (2020) YAP1-NUTM1 Gene Fusion in Porocarcinoma of the External Auditory Canal. Head Neck Pathol 14:982\u2013990. https:\/\/doi.org\/10.1007\/s12105-020-01173-9","journal-title":"Head Neck Pathol"},{"key":"4716_CR14","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1038\/modpathol.2013.54","volume":"26","author":"R Ohtomo","year":"2013","unstructured":"Ohtomo R, Mori T, Shibata S et al (2013) SOX10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors: a clue to the histogenesis for tumor diagnosis. Mod Pathol 26:1041\u20131050. https:\/\/doi.org\/10.1038\/modpathol.2013.54","journal-title":"Mod Pathol"},{"key":"4716_CR15","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1007\/s12105-019-01046-w","volume":"14","author":"BD Adkins","year":"2019","unstructured":"Adkins BD, Geromes A, Zhang LY et al (2019) SOX10 and GATA3 in Adenoid Cystic Carcinoma and Polymorphous Adenocarcinoma. Head Neck Pathol 14:406\u2013411. https:\/\/doi.org\/10.1007\/s12105-019-01046-w","journal-title":"Head Neck Pathol"},{"key":"4716_CR16","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.ccr.2007.01.016","volume":"11","author":"M Haldar","year":"2007","unstructured":"Haldar M, Hancock JD, Coffin CM et al (2007) A Conditional Mouse Model of Synovial Sarcoma: Insights into a Myogenic Origin. Cancer Cell 11:375\u2013388. https:\/\/doi.org\/10.1016\/j.ccr.2007.01.016","journal-title":"Cancer Cell"},{"key":"4716_CR17","doi-asserted-by":"publisher","first-page":"2608","DOI":"10.1101\/gad.1243904","volume":"18","author":"C Keller","year":"2004","unstructured":"Keller C, Hansen MS, Coffin CM, Capecchi MR (2004) Pax3::Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin. Genes Dev 18:2608\u20132613. https:\/\/doi.org\/10.1101\/gad.1243904","journal-title":"Genes Dev"},{"key":"4716_CR18","doi-asserted-by":"publisher","first-page":"18740","DOI":"10.1073\/pnas.0909114106","volume":"106","author":"M Persson","year":"2009","unstructured":"Persson M, Andr\u00e9n Y, Mark J et al (2009) Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck. Proc Natl Acad Sci U S A 106:18740\u201318744. https:\/\/doi.org\/10.1073\/pnas.0909114106","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4716_CR19","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1158\/1078-0432.CCR-15-2867-T","volume":"22","author":"Y Mitani","year":"2016","unstructured":"Mitani Y, Liu B, Rao PH et al (2016) Novel MYBL1 Gene Rearrangements with Recurrent MYBL1-NFIB Fusions in Salivary Adenoid Cystic Carcinomas Lacking t(6;9) Translocations. Clin Cancer Res 22:725\u2013733. https:\/\/doi.org\/10.1158\/1078-0432.CCR-15-2867-T","journal-title":"Clin Cancer Res"},{"key":"4716_CR20","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s00428-025-04107-4","volume":"488","author":"S Wei","year":"2026","unstructured":"Wei S, Tamaki A, Pei J et al (2026) NFIB::PHACTR2, a novel atypical fusion gene identified in adenoid cystic carcinoma of the palate. Virchows Arch 488:455\u2013458. https:\/\/doi.org\/10.1007\/s00428-025-04107-4","journal-title":"Virchows Arch"},{"key":"4716_CR21","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1038\/s41379-019-0277-x","volume":"32","author":"J Pei","year":"2019","unstructured":"Pei J, Flieder DB, Patchefsky A et al (2019) Detecting MYB and MYBL1 fusion genes in tracheobronchial adenoid cystic carcinoma by targeted RNA-sequencing. Mod Pathol 32:1416\u20131420. https:\/\/doi.org\/10.1038\/s41379-019-0277-x","journal-title":"Mod Pathol"},{"key":"4716_CR22","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1007\/s00428-023-03500-1","volume":"483","author":"T Lei","year":"2023","unstructured":"Lei T, Shi Y, Da W et al (2023) A novel EWSR1-MYB fusion in an aggressive advanced breast adenoid cystic carcinoma with mixed classical and solid-basaloid components. Virchows Arch 483:717\u2013722. https:\/\/doi.org\/10.1007\/s00428-023-03500-1","journal-title":"Virchows Arch"},{"key":"4716_CR23","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1038\/modpathol.2011.86","volume":"24","author":"LB Brill","year":"2011","unstructured":"Brill LB, Kanner WA, Fehr A et al (2011) Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasms. Mod Pathol 24:1169\u20131176. https:\/\/doi.org\/10.1038\/modpathol.2011.86","journal-title":"Mod Pathol"},{"key":"4716_CR24","doi-asserted-by":"publisher","first-page":"4722","DOI":"10.1158\/1078-0432.CCR-10-0463","volume":"16","author":"Y Mitani","year":"2010","unstructured":"Mitani Y, Li J, Rao PH et al (2010) Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: Incidence, variability, and clinicopathologic significance. Clin Cancer Res 16:4722\u20134731. https:\/\/doi.org\/10.1158\/1078-0432.CCR-10-0463","journal-title":"Clin Cancer Res"},{"key":"4716_CR25","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1097\/PAS.0000000000001616","volume":"45","author":"LM Rooper","year":"2021","unstructured":"Rooper LM, Lombardo KA, Oliai BR et al (2021) MYB RNA In Situ Hybridization Facilitates Sensitive and Specific Diagnosis of Adenoid Cystic Carcinoma Regardless of Translocation Status. Am J Surg Pathol 45:488. https:\/\/doi.org\/10.1097\/PAS.0000000000001616","journal-title":"Am J Surg Pathol"},{"key":"4716_CR26","doi-asserted-by":"publisher","first-page":"e82684","DOI":"10.1371\/journal.pone.0082684","volume":"8","author":"LH Kasper","year":"2013","unstructured":"Kasper LH, Fukuyama T, Lerach S et al (2013) Genetic Interaction between Mutations in c-Myb and the KIX Domains of CBP and p300 Affects Multiple Blood Cell Lineages and Influences Both Gene Activation and Repression. PLoS ONE 8:e82684. https:\/\/doi.org\/10.1371\/journal.pone.0082684","journal-title":"PLoS ONE"},{"key":"4716_CR27","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.exphem.2016.12.003","volume":"47","author":"S Uttarkar","year":"2017","unstructured":"Uttarkar S, Frampton J, Klempnauer K-H (2017) Targeting the transcription factor Myb by small-molecule inhibitors. Exp Hematol 47:31\u201335. https:\/\/doi.org\/10.1016\/j.exphem.2016.12.003","journal-title":"Exp Hematol"},{"key":"4716_CR28","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s12105-014-0554-4","volume":"9","author":"L Rooper","year":"2015","unstructured":"Rooper L, Sharma R, Bishop JA (2015) Polymorphous low grade adenocarcinoma has a consistent p63+\/p40- immunophenotype that helps distinguish it from adenoid cystic carcinoma and cellular pleomorphic adenoma. Head Neck Pathol 9:79\u201384. https:\/\/doi.org\/10.1007\/s12105-014-0554-4","journal-title":"Head Neck Pathol"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-026-04716-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-026-04716-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-026-04716-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:48:35Z","timestamp":1790153315000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00428-026-04716-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":28,"alternative-id":["4716"],"URL":"https:\/\/doi.org\/10.1007\/s00428-026-04716-7","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]},"assertion":[{"value":"12 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Samples were used in accordance with ethical guidelines. Informed consent was not required for the study.","order":1,"name":"Ethics","label":"Ethic approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"AA is the Editor-in-Chief of Virchows Archiv. The authors declare no other competing interests.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}