{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:49:12Z","timestamp":1792014552121,"version":"4.4.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"DOI":"10.1007\/s00428-026-04737-2","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:09:33Z","timestamp":1792012173000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nuclear grading of myxoid liposarcoma robustly predicts patient outcome: a study of 280 patients"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5446-1801","authenticated-orcid":false,"given":"Lukas","family":"Marcelis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Vernemmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snje\u017eana","family":"Dotli\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Jukic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory W.","family":"Charville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoebe L.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paari","family":"Murugan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Zaki","family":"Karzoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ala","family":"Abu-Dayeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luna","family":"De Sutter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annouschka","family":"Laenen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Houdek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedl","family":"Sinnaeve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazem","family":"Wafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne","family":"Hompes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Sch\u00f6ffski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Folpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"4737_CR1","volume-title":"Enzinger and Weiss\u2019s Soft Tissue Tumors","author":"AL Folpe","year":"2026","unstructured":"Folpe AL, Nielsen GP (2026) Enzinger and Weiss\u2019s Soft Tissue Tumors, 8th edn. Elsevier, St. Louis, MO","edition":"8"},{"key":"4737_CR2","volume-title":"Soft tissue and bone tumours","author":"WHO Classification of Tumours Editorial Board","year":"2020","unstructured":"WHO Classification of Tumours Editorial Board (2020) Soft tissue and bone tumours, 5th edn. International agency for research on cancer. Lyon, France","edition":"5"},{"issue":"1","key":"4737_CR3","first-page":"24","volume":"55","author":"JC Knight","year":"1995","unstructured":"Knight JC, Renwick PJ, Dal Cin P, Van den Berghe H, Fletcher CD (1995) Translocation t(12;16)(q13;p11) in myxoid liposarcoma and round cell liposarcoma: molecular and cytogenetic analysis. Cancer Res 55(1):24\u201327.","journal-title":"Cancer Res"},{"issue":"4","key":"4737_CR4","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1002\/(SICI)1096-9896(199708)182:4<437::AID-PATH882>3.0.CO;2-X","volume":"182","author":"P Dal Cin","year":"1997","unstructured":"Dal Cin P, Sciot R, Panagopoulos I et al (1997) Additional evidence of a variant translocation t(12;22) with EWS\/CHOP fusion in myxoid liposarcoma: clinicopathological features. J Pathol 182(4):437\u2013441. https:\/\/doi.org\/10.1002\/(SICI)1096-9896(199708)182:4%3C437::AID-PATH882%3E3.0.CO;2-X","journal-title":"J Pathol"},{"issue":"7","key":"4737_CR5","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1038\/s41379-021-00782-1","volume":"34","author":"E Baranov","year":"2021","unstructured":"Baranov E, Black MA, Fletcher CDM, Charville GW, Hornick JL (2021) Nuclear expression of DDIT3 distinguishes high-grade myxoid liposarcoma from other round cell sarcomas. Mod Pathol 34(7):1367\u20131372. https:\/\/doi.org\/10.1038\/s41379-021-00782-1","journal-title":"Mod Pathol"},{"key":"4737_CR6","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1097\/00125480-199703000-00005","volume":"4","author":"CDM Fletcher","year":"1997","unstructured":"Fletcher CDM (1997) Will We ever reliably predict prognosis in a patient with myxoid and round cell liposarcoma? Adv Anat Pathol 4:108\u2013113.","journal-title":"Adv Anat Pathol"},{"issue":"8","key":"4737_CR7","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1002\/(SICI)1097-0142(19960415)77:8<1450::AID-CNCR5>3.0.CO;2-G","volume":"77","author":"SE Kilpatrick","year":"1996","unstructured":"Kilpatrick SE, Doyon J, Choong PF, Sim FH, Nascimento AG (1996) The clinicopathologic spectrum of myxoid and round cell liposarcoma. A study of 95 cases. Cancer 77(8):1450\u20131458. https:\/\/doi.org\/10.1002\/(SICI)1097-0142(19960415)77:8%3C1450::AID-CNCR5%3E3.0.CO;2-G","journal-title":"Cancer"},{"issue":"12","key":"4737_CR8","first-page":"3977","volume":"7","author":"CR Antonescu","year":"2001","unstructured":"Antonescu CR, Tschernyavsky SJ, Decuseara R et al (2001) Prognostic impact of P53 status, TLS-CHOP fusion transcript structure, and histological grade in myxoid liposarcoma: A molecular and clinicopathologic study of 82 cases. Clin Cancer Res 7(12):3977\u20133987.","journal-title":"Clin Cancer Res"},{"issue":"5","key":"4737_CR9","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/S1470-2045(16)00010-3","volume":"17","author":"D Callegaro","year":"2016","unstructured":"Callegaro D, Miceli R, Bonvalot S et al (2016) Development and external validation of two nomograms to predict overall survival and occurrence of distant metastases in adults after surgical resection of localised soft-tissue sarcomas of the extremities: A retrospective analysis. Lancet Oncol 17(5):671\u2013680. https:\/\/doi.org\/10.1016\/S1470-2045(16)00010-3","journal-title":"Lancet Oncol"},{"key":"4737_CR10","doi-asserted-by":"publisher","first-page":"100215","DOI":"10.1016\/j.eclinm.2019.11.008","volume":"17","author":"D Callegaro","year":"2019","unstructured":"Callegaro D, Miceli R, Bonvalot S et al (2019) Development and external validation of a dynamic prognostic nomogram for primary extremity soft tissue sarcoma survivors. EClinicalMedicine 17:100215. https:\/\/doi.org\/10.1016\/j.eclinm.2019.11.008","journal-title":"EClinicalMedicine"},{"issue":"5","key":"4737_CR11","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1002\/jso.27190","volume":"127","author":"MT Houdek","year":"2023","unstructured":"Houdek MT, Mallett KE, Heidenreich MJ et al (2023) Lack of radiosensitivity predicts poor disease specific survival in myxoid liposarcoma. J Surg Oncol 127(5):848\u2013854. https:\/\/doi.org\/10.1002\/jso.27190","journal-title":"J Surg Oncol"},{"key":"4737_CR12","unstructured":"Fritchie K, Wang D, Goldblum J et al (2011) Myxoid liposarcoma: A clinicopathologic study of 27 cases of primary untreated disease with particular focus on so-called transitional and round cell areas. Laboratory investigation nature publishing group 75 Varick St, 9th flr, New York, NY, USA 91:14A,10013\u2009\u2013\u20091917."},{"issue":"5","key":"4737_CR13","doi-asserted-by":"publisher","first-page":"2178","DOI":"10.1111\/cas.15729","volume":"114","author":"K Kawaguchi","year":"2023","unstructured":"Kawaguchi K, Kohashi K, Iwasaki T et al (2023) Prognostic value of nuclear morphometry in myxoid liposarcoma. Cancer Sci 114(5):2178\u20132188. https:\/\/doi.org\/10.1111\/cas.15729","journal-title":"Cancer Sci"},{"issue":"2","key":"4737_CR14","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s00428-024-03796-7","volume":"486","author":"K Kawaguchi","year":"2025","unstructured":"Kawaguchi K, Kohashi K, Iwasaki T et al (2025) Nuclear morphological atypia in biopsy accurately reflects the prognosis of myxoid liposarcoma. Virchows Arch 486(2):373\u2013380. https:\/\/doi.org\/10.1007\/s00428-024-03796-7","journal-title":"Virchows Arch"},{"issue":"1","key":"4737_CR15","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s00428-023-03631-5","volume":"484","author":"N Kojima","year":"2024","unstructured":"Kojima N, Kubo T, Mori T et al (2024) Myxoid liposarcoma with nuclear pleomorphism: A clinicopathological and molecular study. Virchows Arch 484(1):71\u201381. https:\/\/doi.org\/10.1007\/s00428-023-03631-5","journal-title":"Virchows Arch"},{"key":"4737_CR16","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-024-03796-7","author":"K Kawaguchi","year":"2024","unstructured":"Kawaguchi K, Kohashi K, Iwasaki T et al (2024) Nuclear morphological atypia in biopsy accurately reflects the prognosis of myxoid liposarcoma. Virchows Arch. https:\/\/doi.org\/10.1007\/s00428-024-03796-7","journal-title":"Virchows Arch"},{"issue":"1","key":"4737_CR17","first-page":"86","volume":"119","author":"AP Stout","year":"1944","unstructured":"Stout AP (1944) Liposarcoma-the malignant tumor of lipoblasts. Ann Surg 119(1):86\u2013107.","journal-title":"Ann Surg"},{"key":"4737_CR18","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/BF00957030","volume":"335","author":"FM Enzinger","year":"1962","unstructured":"Enzinger FM, Winslow DJ (1962) Liposarcoma. A study of 103 cases. Virchows Arch Pathol Anat Physiol Klin Med 335:367\u2013388","journal-title":"Virchows Arch Pathol Anat Physiol Klin Med"},{"issue":"6","key":"4737_CR19","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1097\/00000478-197912000-00004","volume":"3","author":"HL Evans","year":"1979","unstructured":"Evans HL (1979) Liposarcoma: a study of 55 cases with a reassessment of its classification. Am J Surg Pathol 3(6):507\u2013523. https:\/\/doi.org\/10.1097\/00000478-197912000-00004","journal-title":"Am J Surg Pathol"},{"key":"4737_CR20","first-page":"41","volume":"1","author":"H Evans","year":"1988","unstructured":"Evans H (1988) Liposarcomas and atypical lipomatous tumours: A study of 66 cases followed for a minimum of 10 years. Surg Pathol 1:41\u201354.","journal-title":"Surg Pathol"},{"issue":"3","key":"4737_CR21","first-page":"489","volume":"12","author":"I Panagopoulos","year":"1996","unstructured":"Panagopoulos I, Hoglund M, Mertens F, Mandahl N, Mitelman F, Aman P (1996) Fusion of the EWS and CHOP genes in myxoid liposarcoma. Oncogene 12(3):489\u2013494.","journal-title":"Oncogene"},{"issue":"24","key":"4737_CR22","first-page":"6500","volume":"54","author":"I Panagopoulos","year":"1994","unstructured":"Panagopoulos I, Mandahl N, Ron D et al (1994) Characterization of the CHOP breakpoints and fusion transcripts in myxoid liposarcomas with the 12;16 translocation. Cancer Res 54(24):6500\u20136503.","journal-title":"Cancer Res"},{"issue":"6430","key":"4737_CR23","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1038\/363640a0","volume":"363","author":"A Crozat","year":"1993","unstructured":"Crozat A, Aman P, Mandahl N, Ron D (1993) Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature 363(6430):640\u2013644. https:\/\/doi.org\/10.1038\/363640a0","journal-title":"Nature"},{"issue":"4","key":"4737_CR24","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1002\/gcc.2870050403","volume":"5","author":"P Aman","year":"1992","unstructured":"Aman P, Ron D, Mandahl N et al (1992) Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11). Genes Chromosomes Cancer 5(4):278\u2013285. https:\/\/doi.org\/10.1002\/gcc.2870050403","journal-title":"Genes Chromosomes Cancer"},{"issue":"9","key":"4737_CR25","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1097\/00000478-199609000-00002","volume":"20","author":"G Tallini","year":"1996","unstructured":"Tallini G, Akerman M, Dal Cin P et al (1996) Combined morphologic and karyotypic study of 28 myxoid liposarcomas. Implications for a revised morphologic typing, (a report from the CHAMP group). Am J Surg Pathol 20(9):1047\u20131055. https:\/\/doi.org\/10.1097\/00000478-199609000-00002","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"4737_CR26","first-page":"623","volume":"148","author":"CD Fletcher","year":"1996","unstructured":"Fletcher CD, Akerman M, Dal Cin P et al (1996) Correlation between clinicopathological features and karyotype in lipomatous tumors. A report of 178 cases from the chromosomes and morphology (CHAMP) collaborative study group. Am J Pathol 148(2):623\u2013630.","journal-title":"Am J Pathol"},{"issue":"2","key":"4737_CR27","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1097\/00000478-199602000-00005","volume":"20","author":"TA Smith","year":"1996","unstructured":"Smith TA, Easley KA, Goldblum JR (1996) Myxoid\/round cell liposarcoma of the extremities. A clinicopathologic study of 29 cases with particular attention to extent of round cell liposarcoma. Am J Surg Pathol 20(2):171\u2013180. https:\/\/doi.org\/10.1097\/00000478-199602000-00005","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"4737_CR28","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1245\/s10434-006-9043-7","volume":"14","author":"SE ten Heuvel","year":"2007","unstructured":"ten Heuvel SE, Hoekstra HJ, van Ginkel RJ, Bastiaannet E, Suurmeijer AJ (2007) Clinicopathologic prognostic factors in myxoid liposarcoma: A retrospective study of 49 patients with long-term follow-up. Ann Surg Oncol 14(1):222\u2013229. https:\/\/doi.org\/10.1245\/s10434-006-9043-7","journal-title":"Ann Surg Oncol"},{"issue":"12","key":"4737_CR29","doi-asserted-by":"publisher","first-page":"2522","DOI":"10.1002\/cncr.22720","volume":"109","author":"M Fiore","year":"2007","unstructured":"Fiore M, Grosso F, Lo Vullo S et al (2007) Myxoid\/round cell and pleomorphic liposarcomas: Prognostic factors and survival in a series of patients treated at a single institution. Cancer 109(12):2522\u20132531. https:\/\/doi.org\/10.1002\/cncr.22720","journal-title":"Cancer"},{"key":"4737_CR30","doi-asserted-by":"publisher","first-page":"538085","DOI":"10.1155\/2011\/538085","volume":"2011","author":"J Haniball","year":"2011","unstructured":"Haniball J, Sumathi VP, Kindblom LG et al (2011) Prognostic factors and metastatic patterns in primary myxoid\/round-cell liposarcoma. Sarcoma 2011:538085. https:\/\/doi.org\/10.1155\/2011\/538085","journal-title":"Sarcoma"},{"issue":"4","key":"4737_CR31","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1245\/s10434-011-2127-z","volume":"19","author":"LC Moreau","year":"2012","unstructured":"Moreau LC, Turcotte R, Ferguson P et al (2012) Myxoid\\round cell liposarcoma (MRCLS) revisited: An analysis of 418 primarily managed cases. Ann Surg Oncol 19(4):1081\u20131088. https:\/\/doi.org\/10.1245\/s10434-011-2127-z","journal-title":"Ann Surg Oncol"},{"issue":"4","key":"4737_CR32","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1002\/path.1848","volume":"207","author":"Y Oda","year":"2005","unstructured":"Oda Y, Yamamoto H, Takahira T et al (2005) Frequent alteration of p16(INK4a)\/p14(ARF) and p53 pathways in the round cell component of myxoid\/round cell liposarcoma: P53 gene alterations and reduced p14(ARF) expression both correlate with poor prognosis. J Pathol 207(4):410\u2013421. https:\/\/doi.org\/10.1002\/path.1848","journal-title":"J Pathol"},{"issue":"3","key":"4737_CR33","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1111\/cas.15256","volume":"113","author":"J Kunieda","year":"2022","unstructured":"Kunieda J, Yamashita K, Togashi Y et al (2022) High prevalence of TERT aberrations in myxoid liposarcoma: TERT reactivation may play a crucial role in tumorigenesis. Cancer Sci 113(3):1078\u20131089. https:\/\/doi.org\/10.1111\/cas.15256","journal-title":"Cancer Sci"},{"issue":"48","key":"4737_CR34","doi-asserted-by":"publisher","first-page":"6177","DOI":"10.1038\/onc.2016.157","volume":"35","author":"Y Nezu","year":"2016","unstructured":"Nezu Y, Hagiwara K, Yamamoto Y et al (2016) miR-135b, a key regulator of malignancy, is linked to poor prognosis in human myxoid liposarcoma. Oncogene 35(48):6177\u20136188. https:\/\/doi.org\/10.1038\/onc.2016.157","journal-title":"Oncogene"},{"key":"4737_CR35","doi-asserted-by":"publisher","unstructured":"Perrone F, Tamborini E, Suardi S, Lagonigro MS, Pilotti S, Oda RE et al (2005) Frequent alteration of p16INK4a\/p14ARF and p53 pathways in the round cell component of myxoid\/round cell liposarcoma: P53 gene alterations and reduced p14ARF expression both correlate with poor prognosis. J Pathol. 207:410\u2013421. J Pathol. 2006, 209(2):281-282. https:\/\/doi.org\/10.1002\/path.1994","DOI":"10.1002\/path.1994"},{"issue":"5","key":"4737_CR36","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1177\/030089169808400512","volume":"84","author":"S Pilotti","year":"1998","unstructured":"Pilotti S, Lavarino C, Mezzelani A et al (1998) Limited role of TP53 and TP53-related genes in myxoid liposarcoma. Tumori 84(5):571\u2013577. https:\/\/doi.org\/10.1177\/030089169808400512","journal-title":"Tumori"},{"issue":"2","key":"4737_CR37","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1038\/modpathol.2011.148","volume":"25","author":"EG Demicco","year":"2012","unstructured":"Demicco EG, Torres KE, Ghadimi MP et al (2012) Involvement of the PI3K\/Akt pathway in myxoid\/round cell liposarcoma. Mod Pathol 25(2):212\u2013221. https:\/\/doi.org\/10.1038\/modpathol.2011.148","journal-title":"Mod Pathol"},{"issue":"4","key":"4737_CR38","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1158\/1535-7163.MCT-18-0763","volume":"18","author":"M Trautmann","year":"2019","unstructured":"Trautmann M, Cyra M, Isfort I et al (2019) Phosphatidylinositol-3-kinase (PI3K)\/Akt Signaling is Functionally Essential in Myxoid Liposarcoma. Mol Cancer Ther 18(4):834\u2013844. https:\/\/doi.org\/10.1158\/1535-7163.MCT-18-0763","journal-title":"Mol Cancer Ther"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-026-04737-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-026-04737-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-026-04737-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:09:36Z","timestamp":1792012176000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-026-04737-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,14]]},"references-count":38,"alternative-id":["4737"],"URL":"https:\/\/doi.org\/10.1007\/s00428-026-04737-2","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,14]]},"assertion":[{"value":"18 August 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Ethical Committee of the University Hospitals Leuven (S70627) and was conducted according to the Declaration of Helsinki.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no competing interests to disclose.","order":2,"name":"Ethics","label":"Competing interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}