{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:40:25Z","timestamp":1791268825715,"version":"4.1.0"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2011,8,6]],"date-time":"2011-08-06T00:00:00Z","timestamp":1312588800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Struct Funct"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1007\/s00429-011-0340-y","type":"journal-article","created":{"date-parts":[[2011,8,5]],"date-time":"2011-08-05T12:05:46Z","timestamp":1312545946000},"page":"421-434","source":"Crossref","is-referenced-by-count":59,"title":["A deconvolution method to improve automated 3D-analysis of dendritic spines: application to a mouse model of Huntington\u2019s disease"],"prefix":"10.1007","volume":"217","author":[{"given":"Nicolas","family":"Heck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Betuing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vanhoutte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyne","family":"Caboche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,8,6]]},"reference":[{"issue":"1","key":"340_CR1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3389\/neuro.01.1.1.010.2007","volume":"1","author":"JI Arellano","year":"2007","unstructured":"Arellano JI, Benavides-Piccione R, Defelipe J, Yuste R (2007) Ultrastructure of dendritic spines: correlation between synaptic and spine morphologies. Front Neurosci 1(1):131\u2013143","journal-title":"Front Neurosci"},{"issue":"5","key":"340_CR3","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1016\/S0006-3495(01)76214-5","volume":"80","author":"J Boutet de Monvel","year":"2001","unstructured":"Boutet de Monvel J, Le Calvez S, Ulfendahl M (2001) Image restoration for confocal microscopy: improving the limits of deconvolution, with application to the visualization of the mammalian hearing organ. Biophys J 80(5):2455\u20132470","journal-title":"Biophys J"},{"issue":"1","key":"340_CR4","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jneumeth.2007.05.020","volume":"165","author":"J Cheng","year":"2007","unstructured":"Cheng J, Zhou X, Miller E, Witt RM, Zhu J, Sabatini BL, Wong ST (2007) A novel computational approach for automatic dendrite spines detection in two-photon laser scan microscopy. J Neurosci Methods 165(1):122\u2013134","journal-title":"J Neurosci Methods"},{"issue":"12","key":"340_CR5","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/nmeth815","volume":"2","author":"JA Conchello","year":"2005","unstructured":"Conchello JA, Lichtman JW (2005) Optical sectioning microscopy. Nat Methods 2(12):920\u2013931","journal-title":"Nat Methods"},{"issue":"3","key":"340_CR6","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.neuron.2010.12.035","volume":"69","author":"ZR Crook","year":"2011","unstructured":"Crook ZR, Housman D (2011) Huntington\u2019s disease: can mice lead the way to treatment? Neuron 69(3):423\u2013435","journal-title":"Neuron"},{"issue":"4","key":"340_CR7","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1364\/AO.41.000685","volume":"41","author":"A Diaspro","year":"2002","unstructured":"Diaspro A, Federici F, Robello M (2002) Influence of refractive-index mismatch in high-resolution three-dimensional confocal microscopy. Appl Opt 41(4):685\u2013690","journal-title":"Appl Opt"},{"key":"340_CR8","unstructured":"Donohue DE, Ascoli GA (2011) Automated reconstruction of neuronal morphology: an overview. Brain Res Rev 67(1\u20132):94\u2013102"},{"issue":"22","key":"340_CR9","doi-asserted-by":"crossref","first-page":"7507","DOI":"10.1523\/JNEUROSCI.6410-09.2010","volume":"30","author":"D Dumitriu","year":"2010","unstructured":"Dumitriu D, Hao J, Hara Y, Kaufmann J, Janssen WG, Lou W, Rapp PR, Morrison JH (2010) Selective changes in thin spine density and morphology in monkey prefrontal cortex correlate with aging-related cognitive impairment. J Neurosci 30(22):7507\u20137515","journal-title":"J Neurosci"},{"issue":"Pt 2","key":"340_CR10","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1365-2818.2007.01844.x","volume":"228","author":"E Dusch","year":"2007","unstructured":"Dusch E, Dorval T, Vincent N, Wachsmuth M, Genovesio A (2007) Three-dimensional point spread function model for line-scanning confocal microscope with high-aperture objective. J Microsc 228(Pt 2):132\u2013138","journal-title":"J Microsc"},{"issue":"1","key":"340_CR11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0165-0173(02)00158-3","volume":"39","author":"JC Fiala","year":"2002","unstructured":"Fiala JC, Spacek J, Harris KM (2002) Dendritic spine pathology: cause or consequence of neurological disorders? Brain Res Brain Res Rev 39(1):29\u201354","journal-title":"Brain Res Brain Res Rev"},{"issue":"2","key":"340_CR12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0896-6273(00)00031-3","volume":"27","author":"WB Gan","year":"2000","unstructured":"Gan WB, Grutzendler J, Wong WT, Wong RO, Lichtman JW (2000) Multicolor \u201cDiOlistic\u201d labeling of the nervous system using lipophilic dye combinations. Neuron 27(2):219\u2013225","journal-title":"Neuron"},{"issue":"2","key":"340_CR13","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.pneurobio.2007.06.002","volume":"83","author":"P Garc\u00eda-L\u00f3pez","year":"2007","unstructured":"Garc\u00eda-L\u00f3pez P, Garc\u00eda-Mar\u00edn V, Freire M (2007) The discovery of dendritic spines by Cajal in 1888 and its relevance in the present neuroscience. Prog Neurobiol 83(2):110\u2013130","journal-title":"Prog Neurobiol"},{"issue":"1","key":"340_CR14","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1364\/JOSAA.9.000154","volume":"9","author":"Lanni Gibson","year":"1991","unstructured":"Gibson Lanni (1991) Experimental test of an analytic model of aberration in an oil-immersion objective lens used in 3D light microscopy. J Opt Soc Am A 9(1):154\u2013166","journal-title":"J Opt Soc Am A"},{"key":"340_CR15","unstructured":"Gillette TA, Brown KM, Svoboda K, Liu Y, Ascoli GA (2011) DIADEMchallenge.org: A compendium of resources fostering the continuous development of automated neuronal reconstruction. Neuroinformatics 9(2\u20133):303\u2013304"},{"key":"340_CR16","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.brainres.2010.07.090","volume":"1355","author":"AW Grossman","year":"2010","unstructured":"Grossman AW, Aldridge GM, Lee KJ, Zeman MK, Jun CS, Azam HS, Arii T, Imoto K, Greenough WT, Rhyu IJ (2010) Developmental characteristics of dendritic spines in the dentate gyrus of Fmr1 knockout mice. Brain Res 1355:221\u2013227","journal-title":"Brain Res"},{"issue":"1","key":"340_CR17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S1046-2023(03)00009-4","volume":"30","author":"J Grutzendler","year":"2003","unstructured":"Grutzendler J, Tsai J, Gan WB (2003) Rapid labeling of neuronal populations by ballistic delivery of fluorescent dyes. Methods 30(1):79\u201385","journal-title":"Methods"},{"issue":"8","key":"340_CR18","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1523\/JNEUROSCI.09-08-02982.1989","volume":"9","author":"KM Harris","year":"1989","unstructured":"Harris KM, Stevens JK (1989) Dendritic spines of CA 1 pyramidal cells in the rat hippocampus: serial electron microscopy with reference to their biophysical characteristics. J Neurosci 9(8):2982\u20132997","journal-title":"J Neurosci"},{"issue":"3","key":"340_CR19","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1365-2818.1993.tb03315.x","volume":"169","author":"S Hell","year":"1993","unstructured":"Hell S, Reiner G, Cremer C, Stelzer HK (1993) Aberrations in confocal fluorescence microscopy induced by mismatches in refractive index. J Microsc 169(3):391\u2013405","journal-title":"J Microsc"},{"issue":"9","key":"340_CR20","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nrn2699","volume":"10","author":"A Holtmaat","year":"2009","unstructured":"Holtmaat A, Svoboda K (2009) Experience-dependent structural synaptic plasticity in the mammalian brain. Nat Rev Neurosci 10(9):647\u2013658","journal-title":"Nat Rev Neurosci"},{"issue":"4","key":"340_CR21","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1083\/jcb.201003008","volume":"189","author":"P Hotulainen","year":"2010","unstructured":"Hotulainen P, Hoogenraad CC (2010) Actin in dendritic spines: connecting dynamics to function. J Cell Biol 189(4):619\u2013629","journal-title":"J Cell Biol"},{"key":"340_CR22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-0-387-45524-2_1","volume-title":"Handbook of biological confocal microscopy","author":"S Inoue","year":"2006","unstructured":"Inoue S (2006) Foundations of confocal scanned imaging in light microscopy. In: Pawley JB (ed) Handbook of biological confocal microscopy, 3rd edn. Springer, New York, pp 1\u201316","edition":"3"},{"issue":"1\u20132","key":"340_CR23","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jneumeth.2007.01.016","volume":"162","author":"BG Kim","year":"2007","unstructured":"Kim BG, Dai HN, McAtee M, Vicini S, Bregman BS (2007) Labeling of dendritic spines with the carbocyanine dye DiI for confocal microscopic imaging in lightly fixed cortical slices. J Neurosci Methods 162(1\u20132):237\u2013243","journal-title":"J Neurosci Methods"},{"issue":"6","key":"340_CR24","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1152\/jn.2001.86.6.2667","volume":"86","author":"GJ Klapstein","year":"2001","unstructured":"Klapstein GJ, Fisher RS, Zanjani H, Cepeda C, Jokel ES, Chesselet MF, Levine MS (2001) Electrophysiological and morphological changes in striatal spiny neurons in R6\/2 Huntington\u2019s disease transgenic mice. J Neurophysiol 86(6):2667\u20132677","journal-title":"J Neurophysiol"},{"issue":"6","key":"340_CR25","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1162\/089976602753712945","volume":"14","author":"IY Koh","year":"2002","unstructured":"Koh IY, Lindquist WB, Zito K, Nimchinsky EA, Svoboda K (2002) An image analysis algorithm for dendritic spines. Neural Comput 14(6):1283\u20131310","journal-title":"Neural Comput"},{"issue":"Pt 1","key":"340_CR26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.0022-2720.2005.01440.x","volume":"217","author":"X Lai","year":"2005","unstructured":"Lai X, Lin Z, Ward ES, Ober RJ (2005) Noise suppression of point spread functions and its influence on deconvolution of three-dimensional fluorescence microscopy image sets. J Microsc 217(Pt 1):93\u2013108","journal-title":"J Microsc"},{"issue":"3","key":"340_CR27","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1602\/neurorx.2.3.447","volume":"2","author":"JY Li","year":"2005","unstructured":"Li JY, Popovic N, Brundin P (2005) The use of the R6 transgenic mouse models of Huntington\u2019s disease in attempts to develop novel therapeutic strategies. NeuroRx 2(3):447\u2013464","journal-title":"NeuroRx"},{"key":"340_CR28","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00429-010-0244-2","volume":"214","author":"JI Luebke","year":"2010","unstructured":"Luebke JI, Weaver CM, Rocher AB, Rodriguez A, Crimins JL, Dickstein DL, Wearne SL, Hof PR (2010) Dendritic vulnerability in neurodegenerative disease: insights from analyses of cortical pyramidal neurons in transgenic mouse models. Br Struct Funct 214:181\u2013199","journal-title":"Br Struct Funct"},{"issue":"3","key":"340_CR29","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","volume":"87","author":"L Mangiarini","year":"1996","unstructured":"Mangiarini L, Sathasivam K, Seller M, Cozens B, Harper A, Hetherington C, Lawton M, Trottier Y, Lehrach H, Davies SW, Bates GP (1996) Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 87(3):493\u2013506","journal-title":"Cell"},{"issue":"3","key":"340_CR30","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1006\/meth.1999.0873","volume":"19","author":"JG McNally","year":"1999","unstructured":"McNally JG, Karpova T, Cooper J, Conchello JA (1999) Three-dimensional imaging by deconvolution microscopy. Methods 19(3):373\u2013385","journal-title":"Methods"},{"key":"340_CR31","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/cyto.a.20895","volume":"77A","author":"E Meijering","year":"2010","unstructured":"Meijering E (2010) Neuron tracing in perspectives. Cytometry 77A:693\u2013704","journal-title":"Cytometry"},{"issue":"1","key":"340_CR32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1083\/jcb.200507103","volume":"172","author":"AJ North","year":"2006","unstructured":"North AJ (2006) Seeing is believing? A beginner\u2019s guide to practical pitfalls in image acquisition. J Cell Biol 172(1):9\u201318","journal-title":"J Cell Biol"},{"issue":"5","key":"340_CR33","doi-asserted-by":"crossref","first-page":"884","DOI":"10.2144\/00285bt01","volume":"28","author":"J Pawley","year":"2000","unstructured":"Pawley J (2000) The 39 steps: a cautionary tale of quantitative 3-D fluorescence microscopy. Biotechniques 28(5):884\u2013886","journal-title":"Biotechniques"},{"key":"340_CR34","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/978-0-387-45524-2_4","volume-title":"Handbook of biological confocal microscopy","author":"J Pawley","year":"2006","unstructured":"Pawley J (2006) Points, pixels, and gray levels: digitizing image data. In: Pawley JB (ed) Handbook of biological confocal microscopy, 3rd edn. Springer, New York, pp 59\u201379","edition":"3"},{"issue":"17","key":"340_CR35","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1093\/bioinformatics\/btn346","volume":"24","author":"H Peng","year":"2008","unstructured":"Peng H (2008) Bioimage informatics: a new area of engineering biology. Bioinformatics 24(17):1827\u20131836","journal-title":"Bioinformatics"},{"issue":"3","key":"340_CR37","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nn.2741","volume":"14","author":"P Penzes","year":"2011","unstructured":"Penzes P, Cahill ME, Jones KA, Van Leeuwen JE, Woolfrey KM (2011) Dendritic spine pathology in neuropsychiatric disorders. Nat Neurosci 14(3):285\u2013293","journal-title":"Nat Neurosci"},{"issue":"4","key":"340_CR38","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/aja.1001270402","volume":"127","author":"A Peters","year":"1970","unstructured":"Peters A, Kaiserman-Abramof IR (1970) The small pyramidal neuron of the rat cerebral cortex The perikaryon, dendrites and spines. Am J Anat 127(4):321\u2013355","journal-title":"Am J Anat"},{"issue":"2","key":"340_CR39","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1364\/JOSAA.9.000219","volume":"9","author":"C Preza","year":"1992","unstructured":"Preza C, Miller MI, Thomas LJ, McNally JG (1992) Regularized linear method for reconstruction of three-dimensional microscopic objects from optical sections. J Opt Soc Am A 9(2):219\u2013228","journal-title":"J Opt Soc Am A"},{"issue":"4","key":"340_CR40","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1038\/nprot.2006.313","volume":"1","author":"A Rodriguez","year":"2006","unstructured":"Rodriguez A, Ehlenberger DB, Hof PR, Wearne SL (2006) Rayburst sampling, an algorithm for automated three-dimensional shape analysis from laser scanning microscopy images. Nat Protoc 1(4):2152\u20132161","journal-title":"Nat Protoc"},{"issue":"4","key":"340_CR41","doi-asserted-by":"crossref","first-page":"e1997","DOI":"10.1371\/journal.pone.0001997","volume":"3","author":"A Rodriguez","year":"2008","unstructured":"Rodriguez A, Ehlenberger DB, Dickstein DL, Hof PR, Wearne SL (2008) Automated three-dimensional detection and shape classification of dendritic spines from fluorescence microscopy images. Plos One 3(4):e1997","journal-title":"Plos One"},{"issue":"3","key":"340_CR42","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s10577-008-1236-4","volume":"16","author":"O Ronneberger","year":"2008","unstructured":"Ronneberger O, Baddeley D, Scheipl F, Verveer PJ, Burkhardt H, Cremer C, Fahrmeir L, Cremer T, Joffe B (2008) Spatial quantitative analysis of fluorescently labeled nuclear structures: problems methods, pitfalls. Chromosome Res 16(3):523\u2013562","journal-title":"Chromosome Res"},{"issue":"12","key":"340_CR43","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1111\/j.1460-9568.2006.05234.x","volume":"24","author":"P Rostaing","year":"2006","unstructured":"Rostaing P, Real E, Siksou L, Lechaire JP, Boudier T, Boeckers TM, Gertler F, Gundelfinger ED, Triller A, Marty S (2006) Analysis of synaptic ultrastructure without fixative using high-pressure freezing and tomography. Eur J Neurosci 24(12):3463\u20133474","journal-title":"Eur J Neurosci"},{"key":"340_CR44","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-1-4419-6448-9_5","volume":"685","author":"E Roze","year":"2010","unstructured":"Roze E, Bonnet C, Betuing S, Caboche J (2010) Huntington\u2019s disease. Adv Exp Med Biol 685:45\u201363","journal-title":"Adv Exp Med Biol"},{"issue":"6","key":"340_CR45","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.tins.2010.02.002","volume":"33","author":"SJ Russo","year":"2010","unstructured":"Russo SJ, Dietz DM, Dumitriu D, Morrison JH, Malenka RC, Nestler EJ (2010) The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens. Trends Neurosci 33(6):267\u2013276","journal-title":"Trends Neurosci"},{"key":"340_CR46","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1109\/MSP.2006.1628876","volume":"23","author":"P Sarder","year":"2006","unstructured":"Sarder P, Nehorai A (2006) Deconvolution methods for 3-D fluorescence microscopy images. Signal Process. Mag IEEE 23:32\u201345","journal-title":"Mag IEEE"},{"issue":"24","key":"340_CR47","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1063\/1.117010","volume":"69","author":"M Schrader","year":"1996","unstructured":"Schrader M, Hell SW, van der Voort HTM (1996) Potential of confocal microscopes to resolve in the 50\u2013100\u00a0nm range. Appl Phys Lett 69(24):3644\u20133646","journal-title":"Appl Phys Lett"},{"issue":"5","key":"340_CR48","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/nprot.2008.51","volume":"3","author":"R Scorcioni","year":"2008","unstructured":"Scorcioni R, Polavaram S, Ascoli GA (2008) L-Measure: a web-accessible tool for the analysis, comparison and search of digital reconstructions of neuronal morphologies. Nat Protoc 3(5):866\u2013876","journal-title":"Nat Protoc"},{"key":"340_CR49","doi-asserted-by":"crossref","unstructured":"Seabold GK, Daunais JB, Rau A, Grant KA, Alvarez VA (2010) DiOLISTIC labeling of neurons from rodent and non-human primate brain slices. J Vis Exp (41). pii: 2081","DOI":"10.3791\/2081"},{"issue":"9","key":"340_CR50","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/BF00158201","volume":"26","author":"P Shaw","year":"1994","unstructured":"Shaw P (1994) Deconvolution in 3-D optical microscopy. Histochem J 26(9):687\u2013694","journal-title":"Histochem J"},{"issue":"2","key":"340_CR51","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1365-2818.1991.tb03168.x","volume":"163","author":"P Shaw","year":"1991","unstructured":"Shaw P, Rawlins D (1991) The point-spread function of a confocal microscope: its measurement and use in deconvolution of 3-D data. J Microsc 163(2):151\u2013165","journal-title":"J Microsc"},{"issue":"1\u20132","key":"340_CR52","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00429-008-0184-2","volume":"213","author":"H Shen","year":"2008","unstructured":"Shen H, Sesack SR, Toda S, Kalivas PW (2008) Automated quantification of dendritic spine density and spine head diameter in medium spiny neurons of the nucleus accumbens. Brain Struct Funct 213(1\u20132):149\u2013157","journal-title":"Brain Struct Funct"},{"issue":"9","key":"340_CR53","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1523\/JNEUROSCI.5638-08.2009","volume":"29","author":"HW Shen","year":"2009","unstructured":"Shen HW, Toda S, Moussawi K, Bouknight A, Zahm DS, Kalivas PW (2009) Altered dendritic spine plasticity in cocaine-withdrawn rats. J Neurosci 29(9):2876\u20132884","journal-title":"J Neurosci"},{"key":"340_CR54","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/978-0-387-45524-2_22","volume-title":"Handbook of biological confocal microscopy","author":"CJR Sheppard","year":"2006","unstructured":"Sheppard CJR, Gan X, Gu M, Roy M (2006) Signal to noise ratio in confocal microscopy. In: Pawley JB (ed) Handbook of biological confocal microscopy, 3rd edn. Springer, New York, pp 442\u2013451","edition":"3"},{"key":"340_CR55","first-page":"201","volume":"95","author":"JB Sibarita","year":"2005","unstructured":"Sibarita JB (2005) Deconvolution microscopy. Adv Biochem Eng Biotechnol 95:201\u2013243","journal-title":"Adv Biochem Eng Biotechnol"},{"issue":"11","key":"340_CR56","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.tcb.2009.08.007","volume":"19","author":"JR Swedlow","year":"2009","unstructured":"Swedlow JR, Eliceiri KW (2009) Open source bioimage informatics for cell biology. Trends Cell Biol 19(11):656\u2013660","journal-title":"Trends Cell Biol"},{"issue":"5","key":"340_CR57","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/cne.21276","volume":"501","author":"JH Tao-Cheng","year":"2007","unstructured":"Tao-Cheng JH, Gallant PE, Brightman MW, Dosemeci A, Reese TS (2007) Structural changes at synapses after delayed perfusion fixation in different regions of the mouse brain. J Comp Neurol 501(5):731\u2013740","journal-title":"J Comp Neurol"},{"issue":"2","key":"340_CR58","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1365-2818.1995.tb03593.x","volume":"178","author":"H Voort van der","year":"1995","unstructured":"van der Voort H, Strasters K (1995) Restoration of confocal images for quantitative image analysis. J Microsc 178(2):165\u2013181","journal-title":"J Microsc"},{"issue":"3","key":"340_CR59","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1046\/j.1460-9568.2000.00986.x","volume":"12","author":"M Vecellio","year":"2000","unstructured":"Vecellio M, Schwaller B, Meyer M, Hunziker W, Celio MR (2000) Alterations in Purkinje cell spines of calbindin D-28\u00a0k and parvalbumin knock-out mice. Eur J Neurosci 12(3):945\u2013954","journal-title":"Eur J Neurosci"},{"issue":"31","key":"340_CR60","doi-asserted-by":"crossref","first-page":"6928","DOI":"10.1523\/JNEUROSCI.1110-04.2004","volume":"24","author":"W Wallace","year":"2004","unstructured":"Wallace W, Bear MF (2004) A morphological correlate of synaptic scaling in visual cortex. J Neurosci 24(31):6928\u20136938","journal-title":"J Neurosci"},{"issue":"5","key":"340_CR61","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.2144\/01315bi01","volume":"31","author":"W Wallace","year":"1080","unstructured":"Wallace W, Schaefer LH (1080) Swedlow JR (2001) A working person\u2019s guide to deconvolution in light microscopy. Biotechniques 31(5):1076\u20131078 1082 passim","journal-title":"Biotechniques"},{"key":"340_CR62","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.neuroscience.2005.05.053","volume":"136","author":"SL Wearne","year":"2005","unstructured":"Wearne SL, Rodriguez A, Ehlenberger DB, Rocher AB, Henderson SC, Hof PR (2005) New techniques for imaging, digitization and analysis of three-dimensional neural morphology on multiple scales. Neuroscience 136:661\u2013680","journal-title":"Neuroscience"},{"key":"340_CR63","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/978-1-60327-345-9_15","volume":"611","author":"VC Wimmer","year":"2010","unstructured":"Wimmer VC, M\u00f6ller A (2010) High-resolution confocal imaging in tissue. Methods Mol Biol 611:183\u2013191","journal-title":"Methods Mol Biol"},{"key":"340_CR64","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0091-679X(06)81002-2","volume":"81","author":"DE Wolf","year":"2007","unstructured":"Wolf DE (2007) The optics of microscope image formation. Methods Cell Biol 81:11\u201342","journal-title":"Methods Cell Biol"},{"issue":"5","key":"340_CR65","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/cercor\/bhh016","volume":"14","author":"CC Wu","year":"2004","unstructured":"Wu CC, Reilly JF, Young WG, Morrison JH, Bloom FE (2004) High-throughput morphometric analysis of individual neurons. Cereb Cortex 14(5):543\u2013554","journal-title":"Cereb Cortex"},{"issue":"4","key":"340_CR66","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1109\/MSP.2006.1657828","volume":"23","author":"X Xu","year":"2006","unstructured":"Xu X, Wong ST (2006) Optical microscopic image processing of dendritic spines morphology. Signal Process Mag IEEE 23(4):132\u2013135","journal-title":"Signal Process Mag IEEE"},{"issue":"Pt 3","key":"340_CR67","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1365-2818.2006.01556.x","volume":"221","author":"H Yoo","year":"2006","unstructured":"Yoo H, Song I, Gweon DG (2006) Measurement and restoration of the point spread function of fluorescence confocal microscopy. J Microsc 221(Pt 3):172\u2013176","journal-title":"J Microsc"},{"issue":"4","key":"340_CR68","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s12021-009-9057-y","volume":"7","author":"X Yuan","year":"2009","unstructured":"Yuan X, Trachtenberg JT, Potter SM, Roysam B (2009) MDL constrained 3-D grayscale skeletonization algorithm for automated extraction of dendrites and spines from fluorescence confocal images. Neuroinformatics 7(4):213\u2013232","journal-title":"Neuroinformatics"},{"key":"340_CR69","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1146\/annurev.neuro.24.1.1071","volume":"24","author":"R Yuste","year":"2001","unstructured":"Yuste R, Bonhoeffer T (2001) Morphological changes in dendritic spines associated with long-term synaptic plasticity. Annu Rev Neurosci 24:1071\u20131089","journal-title":"Annu Rev Neurosci"},{"issue":"2","key":"340_CR70","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.neuroimage.2007.02.044","volume":"36","author":"Y Zhang","year":"2007","unstructured":"Zhang Y, Zhou X, Witt RM, Sabatini BL, Adjeroh D, Wong ST (2007) Dendritic spine detection using curvilinear structure detector and LDA classifier. Neuroimage 36(2):346\u2013360","journal-title":"Neuroimage"},{"issue":"4","key":"340_CR71","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/j.neuroimage.2010.01.048","volume":"50","author":"Y Zhang","year":"2010","unstructured":"Zhang Y, Chen K, Baron M, Teylan MA, Kim Y, Song Z, Greengard P, Wong ST (2010) A neurocomputational method for fully automated 3D dendritic spine detection and segmentation of medium-sized spiny neurons. Neuroimage 50(4):1472\u20131484","journal-title":"Neuroimage"}],"container-title":["Brain Structure and Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-011-0340-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00429-011-0340-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-011-0340-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T20:22:54Z","timestamp":1560457374000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00429-011-0340-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,6]]},"references-count":69,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["340"],"URL":"https:\/\/doi.org\/10.1007\/s00429-011-0340-y","relation":{},"ISSN":["1863-2653","1863-2661"],"issn-type":[{"value":"1863-2653","type":"print"},{"value":"1863-2661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,6]]}}}