{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:08:51Z","timestamp":1791198531840,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,11,16]],"date-time":"2013-11-16T00:00:00Z","timestamp":1384560000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Struct Funct"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1007\/s00429-013-0670-z","type":"journal-article","created":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T10:27:58Z","timestamp":1384511278000},"page":"501-512","source":"Crossref","is-referenced-by-count":59,"title":["Functional changes during working memory in Huntington\u2019s disease: 30-month longitudinal data from the IMAGE-HD study"],"prefix":"10.1007","volume":"220","author":[{"given":"Govinda R.","family":"Poudel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie C.","family":"Stout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F.","family":"Dom\u00ednguez D","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus A.","family":"Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louisa","family":"Salmon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Churchyard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis","family":"Chua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Borowsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary F.","family":"Egan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nellie","family":"Georgiou-Karistianis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,11,16]]},"reference":[{"key":"670_CR1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0278-5846(01)00300-1","volume":"26","author":"KE Anderson","year":"2002","unstructured":"Anderson KE, Perera GM, Hilton J, Zubin N, Dela Paz R, Stern Y (2002) Functional magnetic resonance imaging study of word recognition in normal elders. Prog Neuropsychopharmacol Biol Psychiatry 26:647\u2013650","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"670_CR2","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1006\/nimg.2000.0582","volume":"11","author":"J Ashburner","year":"2000","unstructured":"Ashburner J, Friston KJ (2000) Voxel-based morphometry\u2014the methods. NeuroImage 11:805\u2013821","journal-title":"NeuroImage"},{"key":"670_CR3","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1016\/j.neuropsychologia.2008.03.005","volume":"46","author":"ME Berryhill","year":"2008","unstructured":"Berryhill ME, Olson IR (2008) Is the posterior parietal lobe involved in working memory retrieval? Evidence from patients with bilateral parietal lobe damage. Neuropsychologia 46:1775\u20131786","journal-title":"Neuropsychologia"},{"key":"670_CR4","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nrn2459","volume":"9","author":"R Cabeza","year":"2008","unstructured":"Cabeza R, Ciaramelli E, Olson IR, Moscovitch M (2008) The parietal cortex and episodic memory: an attentional account. Nat Rev Neurosci 9:613\u2013625","journal-title":"Nat Rev Neurosci"},{"key":"670_CR5","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1176\/appi.ajp.160.4.709","volume":"160","author":"JH Callicott","year":"2003","unstructured":"Callicott JH, Egan MF, Mattay VS, Bertolino A, Bone AD, Verchinksi B, Weinberger DR (2003) Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia. Am J Psychiatry 160:709\u2013719","journal-title":"Am J Psychiatry"},{"key":"670_CR6","doi-asserted-by":"crossref","first-page":"7426","DOI":"10.1523\/JNEUROSCI.18-18-07426.1998","volume":"18","author":"JT Coull","year":"1998","unstructured":"Coull JT, Nobre AC (1998) Where and when to pay attention: the neural systems for directing attention to spatial locations and to time intervals as revealed by both PET and fMRI. J Neurosci 18:7426\u20137435","journal-title":"J Neurosci"},{"key":"670_CR7","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.nbd.2012.10.001","volume":"51","author":"N Georgiou-Karistianis","year":"2013","unstructured":"Georgiou-Karistianis N, Gray MA, Dom\u00ednguez D JF, Dymowski AR, Bohanna I, Johnston LA, Churchyard A, Chua P, Stout JC et al (2013) Automated differentiation of pre-diagnosis Huntington\u2019s disease from healthy control individuals based on quadratic discriminant analysis of the basal ganglia: the IMAGE-HD study. Neurobiol Dis 51:82\u201392","journal-title":"Neurobiol Dis"},{"key":"670_CR8","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.expneurol.2012.10.020","volume":"239","author":"MA Gray","year":"2013","unstructured":"Gray MA, Egan GF, Ando A, Churchyard A, Chua P, Stout JC, Georgiou-Karistianis N (2013) Prefrontal activity in Huntington\u2019s disease reflects cognitive and neuropsychiatric disturbances: the IMAGE-HD study. Exp Neurol 239:218\u2013228","journal-title":"Exp Neurol"},{"key":"670_CR9","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1073\/pnas.071043098","volume":"98","author":"DA Gusnard","year":"2001","unstructured":"Gusnard DA, Akbudak E, Shulman GL, Raichle ME (2001) Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proc Natl Acad Sci USA 98:4259\u20134264","journal-title":"Proc Natl Acad Sci USA"},{"key":"670_CR10","doi-asserted-by":"crossref","unstructured":"Hacker C, Perlmutter J, Criswell S, Ances B, Snyder A (2012) Resting state functional connectivity of the striatum in Parkinson\u2019s disease. Brain","DOI":"10.1093\/brain\/aws281"},{"key":"670_CR11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000182420","volume":"27","author":"SD Han","year":"2009","unstructured":"Han SD, Bangen KJ, Bondi MW (2009) Functional magnetic resonance imaging of compensatory neural recruitment in aging and risk for Alzheimer\u2019s disease: review and recommendations. Dement Geriatr Cogn Disord 27:1\u201310","journal-title":"Dement Geriatr Cogn Disord"},{"key":"670_CR12","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.neuroimage.2010.04.028","volume":"52","author":"DD Jolles","year":"2010","unstructured":"Jolles DD, Grol MJ, Van Buchem MA, Rombouts SA, Crone EA (2010) Practice effects in the brain: changes in cerebral activation after working memory practice depend on task demands. NeuroImage 52:658\u2013668","journal-title":"NeuroImage"},{"key":"670_CR13","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/brain\/awm275","volume":"131","author":"S Kloppel","year":"2008","unstructured":"Kloppel S, Draganski B, Golding CV, Chu C, Nagy Z, Cook PA, Hicks SL, Kennard C, Alexander DC et al (2008) White matter connections reflect changes in voluntary-guided saccades in pre-symptomatic Huntington\u2019s disease. Brain 131:196\u2013204","journal-title":"Brain"},{"key":"670_CR14","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1093\/brain\/awp081","volume":"132","author":"S Kloppel","year":"2009","unstructured":"Kloppel S, Draganski B, Siebner HR, Tabrizi SJ, Weiller C, Frackowiak RS (2009) Functional compensation of motor function in pre-symptomatic Huntington\u2019s disease. Brain 132:1624\u20131632","journal-title":"Brain"},{"key":"670_CR15","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1080\/02699050410001672369","volume":"18","author":"LK Laatsch","year":"2004","unstructured":"Laatsch LK, Thulborn KR, Krisky CM, Shobat DM, Sweeney JA (2004) Investigating the neurobiological basis of cognitive rehabilitation therapy with fMRI. Brain Inj 18:957\u2013974","journal-title":"Brain Inj"},{"key":"670_CR16","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1399-0004.2004.00241.x","volume":"65","author":"DR Langbehn","year":"2004","unstructured":"Langbehn DR, Brinkman RR, Falush D, Paulsen JS, Hayden MR (2004) A new model for prediction of the age of onset and penetrance for Huntington\u2019s disease based on CAG length. Clin Genet 65:267\u2013277","journal-title":"Clin Genet"},{"key":"670_CR17","doi-asserted-by":"crossref","first-page":"735","DOI":"10.2217\/fnl.10.41","volume":"5","author":"BR Miller","year":"2010","unstructured":"Miller BR, Bezprozvanny I (2010) Corticostriatal circuit dysfunction in Huntington\u2019s disease: intersection of glutamate, dopamine and calcium. Future Neurol 5:735\u2013756","journal-title":"Future Neurol"},{"key":"670_CR18","first-page":"533","volume":"7","author":"HE Nelson","year":"1992","unstructured":"Nelson HE, Willison J, Owen AM (1992) National adult reading test, 2nd edition. Int J Geriatr Psychiatry 7:533","journal-title":"Int J Geriatr Psychiatry"},{"key":"670_CR19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0028-3932(71)90067-4","volume":"9","author":"RC Oldfield","year":"1971","unstructured":"Oldfield RC (1971) The assessment and analysis of handedness: the edinburgh inventory. Neuropsychologia 9:97\u2013113","journal-title":"Neuropsychologia"},{"key":"670_CR20","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.expneurol.2008.12.015","volume":"216","author":"JS Paulsen","year":"2009","unstructured":"Paulsen JS (2009) Functional imaging in Huntington\u2019s disease. Exp Neurol 216:272\u2013277","journal-title":"Exp Neurol"},{"key":"670_CR21","first-page":"1715","volume":"25","author":"JS Paulsen","year":"2004","unstructured":"Paulsen JS, Zimbelman JL, Hinton SC, Langbehn DR, Leveroni CL, Benjamin ML, Reynolds NC, Rao SM (2004) fMRI biomarker of early neuronal dysfunction in presymptomatic Huntington\u2019s Disease. Am J Neuroradiol 25:1715\u20131721","journal-title":"Am J Neuroradiol"},{"key":"670_CR22","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/ana.410410521","volume":"41","author":"JB Penney Jr","year":"1997","unstructured":"Penney JB Jr, Vonsattel JP, MacDonald ME, Gusella JF, Myers RH (1997) CAG repeat number governs the development rate of pathology in Huntington\u2019s disease. Ann Neurol 41:689\u2013692","journal-title":"Ann Neurol"},{"key":"670_CR23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1037\/a0020937","volume":"25","author":"JC Stout","year":"2011","unstructured":"Stout JC, Paulsen JS, Queller S, Solomon AC, Whitlock KB, Campbell JC, Carlozzi N, Duff K, Beglinger LJ et al (2011) Neurocognitive signs in prodromal Huntington disease. Neuropsychology 25:1\u201314","journal-title":"Neuropsychology"},{"key":"670_CR24","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S1474-4422(09)70170-X","volume":"8","author":"SJ Tabrizi","year":"2009","unstructured":"Tabrizi SJ, Langbehn DR, Leavitt BR, Roos RA, Durr A, Craufurd D, Kennard C, Hicks SL, Fox NC et al (2009) Biological and clinical manifestations of Huntington\u2019s disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data. Lancet Neurol 8:791\u2013801","journal-title":"Lancet Neurol"},{"key":"670_CR25","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1474-4422(10)70276-3","volume":"10","author":"SJ Tabrizi","year":"2011","unstructured":"Tabrizi SJ, Scahill RI, Durr A, Roos RA, Leavitt BR, Jones R, Landwehrmeyer GB, Fox NC, Johnson H et al (2011) Biological and clinical changes in premanifest and early stage Huntington\u2019s disease in the TRACK-HD study: the 12-month longitudinal analysis. Lancet Neurol 10:31\u201342","journal-title":"Lancet Neurol"},{"key":"670_CR26","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1212\/WNL.0b013e31827689d6","volume":"79","author":"A Tessitore","year":"2012","unstructured":"Tessitore A, Esposito F, Vitale C, Santangelo G, Amboni M, Russo A, Corbo D, Cirillo G, Barone P et al (2012) Default-mode network connectivity in cognitively unimpaired patients with Parkinson disease. Neurology 79:2226\u20132232","journal-title":"Neurology"},{"key":"670_CR27","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1136\/jnnp.2006.098368","volume":"78","author":"DR Thiruvady","year":"2007","unstructured":"Thiruvady DR, Georgiou-Karistianis N, Egan GF, Ray S, Sritharan A, Farrow M, Churchyard A, Chua P, Bradshaw JL et al (2007) Functional connectivity of the prefrontal cortex in Huntington\u2019s disease. J Neurol Neurosurg Psychiatry 78:127\u2013133","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"670_CR28","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3233\/JAD-2011-110206","volume":"27","author":"ZD Threlkeld","year":"2011","unstructured":"Threlkeld ZD, Jicha GA, Smith CD, Gold BT (2011) Task deactivation reductions and atrophy within parietal default mode regions are overlapping but only weakly correlated in mild cognitive impairment. J Alzheimers Dis 27:415\u2013427","journal-title":"J Alzheimers Dis"},{"key":"670_CR29","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1093\/brain\/awm210","volume":"130","author":"RC Wolf","year":"2007","unstructured":"Wolf RC, Vasic N, Schonfeldt-Lecuona C, Landwehrmeyer GB, Ecker D (2007) Dorsolateral prefrontal cortex dysfunction in presymptomatic Huntington\u2019s disease: evidence from event-related fMRI. Brain 130:2845\u20132857","journal-title":"Brain"},{"key":"670_CR30","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.expneurol.2008.05.017","volume":"213","author":"RC Wolf","year":"2008","unstructured":"Wolf RC, Sambataro F, Vasic N, Sch\u00f6nfeldt-Lecuona C, Ecker D, Landwehrmeyer B (2008a) Aberrant connectivity of lateral prefrontal networks in presymptomatic Huntington\u2019s disease. Exp Neurol 213:137\u2013144","journal-title":"Exp Neurol"},{"key":"670_CR31","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1111\/j.1468-1331.2008.02253.x","volume":"15","author":"RC Wolf","year":"2008","unstructured":"Wolf RC, Sambataro F, Vasic N, Sch\u00f6nfeldt-Lecuona C, Ecker D, Landwehrmeyer B (2008b) Altered frontostriatal coupling in pre-manifest Huntington\u2019s disease: effects of increasing cognitive load. Eur J Neurol 15:1180\u20131190","journal-title":"Eur J Neurol"},{"key":"670_CR32","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/hbm.20502","volume":"30","author":"RC Wolf","year":"2009","unstructured":"Wolf RC, Vasic N, Carlos S-L, Ecker D, Landwehrmeyer GB (2009) Cortical dysfunction in patients with Huntington\u2019s disease during working memory performance. Hum Brain Mapp 30:327\u2013339","journal-title":"Hum Brain Mapp"},{"key":"670_CR33","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.expneurol.2011.06.011","volume":"231","author":"RC Wolf","year":"2011","unstructured":"Wolf RC, Sambataro F, Vasic N, Wolf ND, Thomann PA, Landwehrmeyer GB, Orth M (2011) Longitudinal functional magnetic resonance imaging of cognition in preclinical Huntington\u2019s disease. Exp Neurol 231:214\u2013222","journal-title":"Exp Neurol"},{"key":"670_CR34","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1002\/hbm.21348","volume":"33","author":"RC Wolf","year":"2012","unstructured":"Wolf RC, Gr\u00f6n G, Sambataro F, Vasic N, Wolf ND, Thomann PA, Saft C, Landwehrmeyer GB, Orth M (2012a) Brain activation and functional connectivity in premanifest Huntington\u2019s disease during states of intrinsic and phasic alertness. Hum Brain Mapp 33:2161\u20132173","journal-title":"Hum Brain Mapp"},{"key":"670_CR35","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.expneurol.2012.06.014","volume":"237","author":"RC Wolf","year":"2012","unstructured":"Wolf RC, Sambataro F, Vasic N, Wolf ND, Thomann PA, Saft C, Landwehrmeyer GB, Orth M (2012b) Default-mode network changes in preclinical Huntington\u2019s disease. Exp Neurol 237:191\u2013198","journal-title":"Exp Neurol"},{"key":"670_CR36","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1017\/S1355617707071214","volume":"13","author":"JL Zimbelman","year":"2007","unstructured":"Zimbelman JL, Paulsen JS, Mikos A, Reynolds NC, Hoffmann RG, Rao SM (2007) fMRI detection of early neural dysfunction in preclinical Huntington\u2019s disease. J Int Neuropsychol Soc 13:758\u2013769","journal-title":"J Int Neuropsychol Soc"}],"container-title":["Brain Structure and Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-013-0670-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00429-013-0670-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-013-0670-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T23:43:03Z","timestamp":1564702983000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00429-013-0670-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,16]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["670"],"URL":"https:\/\/doi.org\/10.1007\/s00429-013-0670-z","relation":{},"ISSN":["1863-2653","1863-2661"],"issn-type":[{"value":"1863-2653","type":"print"},{"value":"1863-2661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,16]]}}}