{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T21:48:35Z","timestamp":1785534515030,"version":"3.56.0"},"reference-count":265,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T00:00:00Z","timestamp":1512000000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"KU Leuven Research Council (BE)","award":["BOF-OT\/10\/033"],"award-info":[{"award-number":["BOF-OT\/10\/033"]}]},{"name":"Research Foundation\u2014Flanders (FWO) (BE)","award":["G.05311.10"],"award-info":[{"award-number":["G.05311.10"]}]},{"name":"Research Foundation\u2014Flanders (FWO) (BE)","award":["G0B2315N"],"award-info":[{"award-number":["G0B2315N"]}]},{"name":"Hercules Foundation (BE)","award":["AKUL-09-038"],"award-info":[{"award-number":["AKUL-09-038"]}]},{"name":"Hercules Foundation (BE)","award":["AKUL1309"],"award-info":[{"award-number":["AKUL1309"]}]},{"name":"Research Foundation Flanders (FWO) (BE)"},{"name":"Flanders Innovation and Entrepreneurship (BE)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Brain Struct Funct"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1007\/s00429-017-1571-3","type":"journal-article","created":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T06:34:07Z","timestamp":1512023647000},"page":"545-567","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Complementary research models and methods to study axonal regeneration in the vertebrate retinofugal system"],"prefix":"10.1007","volume":"223","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3313-6022","authenticated-orcid":false,"given":"Ilse","family":"Bollaerts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lien","family":"Veys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiel","family":"Geeraerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lien","family":"Andries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lies","family":"De Groef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Buyens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Salinas-Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieve","family":"Moons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Van Hove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,30]]},"reference":[{"key":"1571_CR2","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.mcn.2009.06.005","volume":"42","author":"Z Ahmed","year":"2009","unstructured":"Ahmed Z, Berry M, Logan A (2009) ROCK inhibition promotes adult retinal ganglion cell neurite outgrowth only in the presence of growth promoting factors. Mol Cell Neurosci 42:128\u2013133","journal-title":"Mol Cell Neurosci"},{"key":"1571_CR3","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.nbd.2009.10.024","volume":"37","author":"Z Ahmed","year":"2010","unstructured":"Ahmed Z, Aslam M, Lorber B, Suggate EL, Berry M, Logan A (2010) Optic nerve and vitreal inflammation are both RGC neuroprotective but only the latter is RGC axogenic. Neurobiol Dis 37:441\u2013454","journal-title":"Neurobiol Dis"},{"key":"1571_CR4","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.nurt.2007.05.011","volume":"4","author":"AL Alexander","year":"2007","unstructured":"Alexander AL, Lee JE, Lazar M, Field AS (2007) Diffusion tensor imaging of the brain. Neurotherapeutics 4:316\u2013329","journal-title":"Neurotherapeutics"},{"key":"1571_CR5","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0165-0270(95)00155-7","volume":"65","author":"A Angelucci","year":"1996","unstructured":"Angelucci A, Clasca F, Sur M (1996) Anterograde axonal tracing with the subunit B of cholera toxin: a highly sensitive immunohistochemical protocol for revealing fine axonal morphology in adult and neonatal brains. J Neurosci Methods 65:101\u2013112","journal-title":"J Neurosci Methods"},{"key":"1571_CR6","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/glia.440040109","volume":"4","author":"MD Ard","year":"1991","unstructured":"Ard MD, Bunge MB, Wood PM, Schachner M, Bunge RP (1991) Retinal neurite growth on astrocytes is not modified by extracellular matrix, anti-L1 antibody, or oligodendrocytes. Glia 4:70\u201382","journal-title":"Glia"},{"key":"1571_CR7","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.mam.2005.07.003","volume":"26","author":"JL Aschner","year":"2005","unstructured":"Aschner JL, Aschner M (2005) Nutritional aspects of manganese homeostasis. Mol Aspects Med 26:353\u2013362","journal-title":"Mol Aspects Med"},{"key":"1571_CR8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408440590905920","volume":"35","author":"M Aschner","year":"2005","unstructured":"Aschner M, Erikson KM, Dorman DC (2005) Manganese dosimetry: species differences and implications for neurotoxicity. Crit Rev Toxicol 35:1\u201332","journal-title":"Crit Rev Toxicol"},{"key":"1571_CR9","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0165-3806(98)00165-5","volume":"112","author":"J Atkinson","year":"1999","unstructured":"Atkinson J, Panni MK, Lund RD (1999) Effects of neurotrophins on embryonic retinal outgrowth. Brain Res Dev Brain Res 112:173\u2013180","journal-title":"Brain Res Dev Brain Res"},{"key":"1571_CR10","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/0014-4886(63)90093-1","volume":"7","author":"DG Attardi","year":"1963","unstructured":"Attardi DG, Sperry RW (1963) Preferential selection of central pathways by regenerating optic fibers. Exp Neurol 7:46\u201364","journal-title":"Exp Neurol"},{"key":"1571_CR11","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.mric.2009.01.011","volume":"17","author":"R Bammer","year":"2009","unstructured":"Bammer R, Holdsworth SJ, Veldhuis WB, Skare ST (2009) New methods in diffusion-weighted and diffusion tensor imaging. Magn Reson Imaging Clin N Am 17:175\u2013204","journal-title":"Magn Reson Imaging Clin N Am"},{"key":"1571_CR12","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1006\/dbio.1996.8438","volume":"181","author":"CA Bates","year":"1997","unstructured":"Bates CA, Meyer RL (1997) The neurite-promoting effect of laminin is mediated by different mechanisms in embryonic and adult regenerating mouse optic axons in vitro. Dev Biol 181:91\u2013101","journal-title":"Dev Biol"},{"key":"1571_CR13","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/nbm.782","volume":"15","author":"C Beaulieu","year":"2002","unstructured":"Beaulieu C (2002) The basis of anisotropic water diffusion in the nervous system\u2014a technical review. NMR Biomed 15:435\u2013455","journal-title":"NMR Biomed"},{"key":"1571_CR14","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/0042-6989(86)90003-9","volume":"26","author":"LD Beazley","year":"1986","unstructured":"Beazley LD, Darby JE, Perry VH (1986) Cell death in the retinal ganglion cell layer during optic nerve regeneration for the frog Rana pipiens. Vis Res 26:543\u2013556","journal-title":"Vis Res"},{"key":"1571_CR15","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1089\/089771503770802925","volume":"20","author":"LD Beazley","year":"2003","unstructured":"Beazley LD, Rodger J, Chen P, Tee LB, Stirling RV, Taylor AL, Dunlop SA (2003) Training on a visual task improves the outcome of optic nerve regeneration. J Neurotrauma 20:1263\u20131270","journal-title":"J Neurotrauma"},{"key":"1571_CR16","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1523\/JNEUROSCI.22-03-00842.2002","volume":"22","author":"CG Becker","year":"2002","unstructured":"Becker CG, Becker T (2002) Repellent guidance of regenerating optic axons by chondroitin sulfate glycosaminoglycans in zebrafish. J Neurosci 22:842\u2013853","journal-title":"J Neurosci"},{"key":"1571_CR17","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1002\/jnr.21121","volume":"85","author":"CG Becker","year":"2007","unstructured":"Becker CG, Becker T (2007) Growth and pathfinding of regenerating axons in the optic projection of adult fish. J Neurosci Res 85:2793\u20132799","journal-title":"J Neurosci Res"},{"key":"1571_CR18","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.conb.2014.03.019","volume":"27","author":"T Becker","year":"2014","unstructured":"Becker T, Becker CG (2014) Axonal regeneration in zebrafish. Curr Opin Neurobiol 27:186\u2013191","journal-title":"Curr Opin Neurobiol"},{"key":"1571_CR19","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/1096-9861(20001120)427:3<469::AID-CNE12>3.0.CO;2-N","volume":"427","author":"CG Becker","year":"2000","unstructured":"Becker CG, Meyer RL, Becker T (2000) Gradients of ephrin-A2 and ephrin-A5b mRNA during retinotopic regeneration of the optic projection in adult zebrafish. J Comp Neurol 427:469\u2013483","journal-title":"J Comp Neurol"},{"key":"1571_CR20","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.mcn.2004.03.003","volume":"26","author":"CG Becker","year":"2004","unstructured":"Becker CG, Schweitzer J, Feldner J, Schachner M, Becker T (2004) Tenascin-R as a repellent guidance molecule for newly growing and regenerating optic axons in adult zebrafish. Mol Cell Neurosci 26:376\u2013389","journal-title":"Mol Cell Neurosci"},{"key":"1571_CR21","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.cell.2015.11.036","volume":"164","author":"F Bei","year":"2016","unstructured":"Bei F, Lee HH, Liu X, Gunner G, Jin H, Ma L, Wang C, Hou L, Hensch TK, Frank E, Sanes JR, Chen C, Fagiolini M, He Z (2016) Restoration of visual function by enhancing conduction in regenerated axons. Cell 164:219\u2013232","journal-title":"Cell"},{"key":"1571_CR22","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.neuron.2015.03.060","volume":"86","author":"S Belin","year":"2015","unstructured":"Belin S, Nawabi H, Wang C, Tang S, Latremoliere A, Warren P, Schorle H, Uncu C, Woolf CJ, He Z, Steen JA (2015) Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics. Neuron 86:1000\u20131014","journal-title":"Neuron"},{"key":"1571_CR23","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/jnc.13765","volume":"139","author":"K Bell","year":"2016","unstructured":"Bell K, Wilding C, Funke S, Perumal N, Beck S, Wolters D, Holz-Muller J, Pfeiffer N, Grus FH (2016) Neuroprotective effects of antibodies on retinal ganglion cells in an adolescent retina organ culture. J Neurochem 139:256\u2013269","journal-title":"J Neurochem"},{"key":"1571_CR24","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/296150a0","volume":"296","author":"M Benfey","year":"1982","unstructured":"Benfey M, Aguayo AJ (1982) Extensive elongation of axons from rat brain into peripheral nerve grafts. Nature 296:150\u2013152","journal-title":"Nature"},{"key":"1571_CR25","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/WCO.0b013e32834c208d","volume":"24","author":"LI Benowitz","year":"2011","unstructured":"Benowitz LI, Popovich PG (2011) Inflammation and axon regeneration. Curr Opin Neurol 24:577\u2013583","journal-title":"Curr Opin Neurol"},{"key":"1571_CR26","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1002\/dneu.20515","volume":"67","author":"LI Benowitz","year":"2007","unstructured":"Benowitz LI, Yin Y (2007) Combinatorial treatments for promoting axon regeneration in the CNS: strategies for overcoming inhibitory signals and activating neurons\u2019 intrinsic growth state. Dev Neurobiol 67:1148\u20131165","journal-title":"Dev Neurobiol"},{"key":"1571_CR28","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.expneurol.2015.12.015","volume":"287","author":"LI Benowitz","year":"2017","unstructured":"Benowitz LI, He Z, Goldberg JL (2017) Reaching the brain: advances in optic nerve regeneration. Exp Neurol 287:365\u2013373","journal-title":"Exp Neurol"},{"key":"1571_CR29","doi-asserted-by":"crossref","first-page":"4368","DOI":"10.1523\/JNEUROSCI.14-07-04368.1994","volume":"14","author":"M Berkelaar","year":"1994","unstructured":"Berkelaar M, Clarke DB, Wang YC, Bray GM, Aguayo AJ (1994) Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats. J Neurosci 14:4368\u20134374","journal-title":"J Neurosci"},{"key":"1571_CR30","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.mcn.2009.09.005","volume":"42","author":"C Bermel","year":"2009","unstructured":"Bermel C, Tonges L, Planchamp V, Gillardon F, Weishaupt JH, Dietz GP, Bahr M, Lingor P (2009) Combined inhibition of Cdk5 and ROCK additively increase cell survival, but not the regenerative response in regenerating retinal ganglion cells. Mol Cell Neurosci 42:427\u2013437","journal-title":"Mol Cell Neurosci"},{"key":"1571_CR31","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF02284793","volume":"25","author":"M Berry","year":"1996","unstructured":"Berry M, Carlile J, Hunter A (1996) Peripheral nerve explants grafted into the vitreous body of the eye promote the regeneration of retinal ganglion cell axons severed in the optic nerve. J Neurocytol 25:147\u2013170","journal-title":"J Neurocytol"},{"key":"1571_CR32","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1023\/A:1007086004022","volume":"28","author":"M Berry","year":"1999","unstructured":"Berry M, Carlile J, Hunter A, Tsang W, Rosustrel P, Sievers J (1999) Optic nerve regeneration after intravitreal peripheral nerve implants: trajectories of axons regrowing through the optic chiasm into the optic tracts. J Neurocytol 28:721\u2013741","journal-title":"J Neurocytol"},{"key":"1571_CR33","first-page":"147","volume":"26","author":"M Berry","year":"2008","unstructured":"Berry M, Ahmed Z, Lorber B, Douglas M, Logan A (2008) Regeneration of axons in the visual system. Restor Neurol Neurosci 26:147\u2013174","journal-title":"Restor Neurol Neurosci"},{"key":"1571_CR34","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.mcn.2015.04.002","volume":"68","author":"S Bhumika","year":"2015","unstructured":"Bhumika S, Lemmens K, Vancamp P, Moons L, Darras VM (2015) Decreased thyroid hormone signaling accelerates the reinnervation of the optic tectum following optic nerve crush in adult zebrafish. Mol Cell Neurosci 68:92\u2013102","journal-title":"Mol Cell Neurosci"},{"key":"1571_CR35","first-page":"2021","volume":"43","author":"S Bocker-Meffert","year":"2002","unstructured":"Bocker-Meffert S, Rosenstiel P, Rohl C, Warneke N, Held-Feindt J, Sievers J, Lucius R (2002) Erythropoietin and VEGF promote neural outgrowth from retinal explants in postnatal rats. Investig Ophthalmol Vis Sci 43:2021\u20132026","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1571_CR36","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.3727\/096368914X684583","volume":"24","author":"MR Bohm","year":"2015","unstructured":"Bohm MR, Prokosch V, Bruckner M, Pfrommer S, Melkonyan H, Thanos S (2015) BetaB2-crystallin promotes axonal regeneration in the injured optic nerve in adult rats. Cell Transplant 24:1829\u20131844","journal-title":"Cell Transplant"},{"key":"1571_CR37","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/(SICI)1097-4547(19980515)52:4<405::AID-JNR4>3.0.CO;2-D","volume":"52","author":"P Bormann","year":"1998","unstructured":"Bormann P, Zumsteg VM, Roth LW, Reinhard E (1998) Target contact regulates GAP-43 and alpha-tubulin mRNA levels in regenerating retinal ganglion cells. J Neurosci Res 52:405\u2013419","journal-title":"J Neurosci Res"},{"key":"1571_CR38","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1242\/jeb.132.1.5","volume":"132","author":"GM Bray","year":"1987","unstructured":"Bray GM, Villegas-Perez MP, Vidal-Sanz M, Aguayo AJ (1987) The use of peripheral nerve grafts to enhance neuronal survival, promote growth and permit terminal reconnections in the central nervous system of adult rats. J Exp Biol 132:5\u201319","journal-title":"J Exp Biol"},{"key":"1571_CR39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0165-0270(97)02255-3","volume":"75","author":"MA Brocco","year":"1997","unstructured":"Brocco MA, Panzetta P (1997) Survival and differentiation of purified embryonic chick retinal ganglion cells cultured at low density in a chemically defined medium. J Neurosci Methods 75:15\u201320","journal-title":"J Neurosci Methods"},{"key":"1571_CR40","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0165-3806(99)00120-0","volume":"118","author":"MA Brocco","year":"1999","unstructured":"Brocco MA, Panzetta P (1999) Survival and process regrowth of purified chick retinal ganglion cells cultured in a growth factor lacking medium at low density. Modulation by extracellular matrix proteins. Brain Res Dev Brain Res 118:23\u201332","journal-title":"Brain Res Dev Brain Res"},{"key":"1571_CR41","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/exnr.1993.1042","volume":"120","author":"EP Brouillet","year":"1993","unstructured":"Brouillet EP, Shinobu L, McGarvey U, Hochberg F, Beal MF (1993) Manganese injection into the rat striatum produces excitotoxic lesions by impairing energy metabolism. Exp Neurol 120:89\u201394","journal-title":"Exp Neurol"},{"key":"1571_CR42","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-1-4939-0777-9_5","volume":"1162","author":"T Buyens","year":"2014","unstructured":"Buyens T, Gaublomme D, Van Hove I, De Groef L, Moons L (2014) Quantitative assessment of neurite outgrowth in mouse retinal explants. Methods Mol Biol 1162:57\u201371","journal-title":"Methods Mol Biol"},{"key":"1571_CR43","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1017\/S0952523807070289","volume":"24","author":"MP Callahan","year":"2007","unstructured":"Callahan MP, Mensinger AF (2007) Restoration of visual function following optic nerve regeneration in bluegill (Lepomis macrochirus) \u00d7 pumpkinseed (Lepomis gibbosus) hybrid sunfish. Vis Neurosci 24:309\u2013317","journal-title":"Vis Neurosci"},{"key":"1571_CR44","doi-asserted-by":"crossref","unstructured":"Cameron DJ, Rassamdana F, Tam P, Dang K, Yanez C, Ghaemmaghami S, Dehkordi MI (2013) The optokinetic response as a quantitative measure of visual acuity in zebrafish. J Vis Exp","DOI":"10.3791\/50832"},{"key":"1571_CR45","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1097\/WNR.0b013e328355f1d6","volume":"23","author":"LP Cen","year":"2012","unstructured":"Cen LP, Luo JM, Geng Y, Zhang M, Pang CP, Cui Q (2012) Long-term survival and axonal regeneration of retinal ganglion cells after optic nerve transection and a peripheral nerve graft. Neuroreport 23:692\u2013697","journal-title":"Neuroreport"},{"key":"1571_CR46","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.neuroimage.2008.01.002","volume":"40","author":"KC Chan","year":"2008","unstructured":"Chan KC, Fu QL, Hui ES, So KF, Wu EX (2008) Evaluation of the retina and optic nerve in a rat model of chronic glaucoma using in vivo manganese-enhanced magnetic resonance imaging. NeuroImage 40:1166\u20131174","journal-title":"NeuroImage"},{"key":"1571_CR48","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature10206","volume":"476","author":"SK Chen","year":"2011","unstructured":"Chen SK, Badea TC, Hattar S (2011) Photoentrainment and pupillary light reflex are mediated by distinct populations of ipRGCs. Nature 476:92\u201395","journal-title":"Nature"},{"key":"1571_CR49","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0165-0270(02)00098-5","volume":"117","author":"D Choi","year":"2002","unstructured":"Choi D, Li D, Raisman G (2002) Fluorescent retrograde neuronal tracers that label the rat facial nucleus: a comparison of Fast Blue, Fluoro-ruby, Fluoro-emerald, Fluoro-Gold and DiI. J Neurosci Methods 117:167\u2013172","journal-title":"J Neurosci Methods"},{"key":"1571_CR50","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/nmeth.2481","volume":"10","author":"K Chung","year":"2013","unstructured":"Chung K, Deisseroth K (2013) CLARITY for mapping the nervous system. Nat Methods 10:508\u2013513","journal-title":"Nat Methods"},{"key":"1571_CR51","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1113\/jphysiol.1989.sp017828","volume":"418","author":"BN Cohen","year":"1989","unstructured":"Cohen BN, Fain GL, Fain MJ (1989) GABA and glycine channels in isolated ganglion cells from the goldfish retina. J Physiol 418:53\u201382","journal-title":"J Physiol"},{"key":"1571_CR52","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/neu.480250805","volume":"25","author":"A Cohen","year":"1994","unstructured":"Cohen A, Bray GM, Aguayo AJ (1994) Neurotrophin-4\/5 (NT-4\/5) increases adult rat retinal ganglion cell survival and neurite outgrowth in vitro. J Neurobiol 25:953\u2013959","journal-title":"J Neurobiol"},{"key":"1571_CR53","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/978-1-4939-0777-9_6","volume-title":"Axon growth and regeneration: methods and protocols","author":"GMW Cook","year":"2014","unstructured":"Cook GMW, Jareonsettasin P, Keynes RJ (2014) Growth cone collapse assay. In: Murray AJ (ed) Axon growth and regeneration: methods and protocols. Springer, New York, pp\u00a073\u201383"},{"key":"1571_CR54","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ijdevneu.2011.08.005","volume":"30","author":"L Cubillan","year":"2012","unstructured":"Cubillan L, Obregon F, Lima L (2012) Neurites outgrowth and amino acids levels in goldfish retina under hypo-osmotic or hyper-osmotic conditions. Int J Dev Neurosci 30:55\u201361","journal-title":"Int J Dev Neurosci"},{"key":"1571_CR55","first-page":"3999","volume":"11","author":"Q Cui","year":"2000","unstructured":"Cui Q, Harvey AR (2000) CNTF promotes the regrowth of retinal ganglion cell axons into murine peripheral nerve grafts. Neuroreport 11:3999\u20134002","journal-title":"Neuroreport"},{"key":"1571_CR56","first-page":"760","volume":"40","author":"Q Cui","year":"1999","unstructured":"Cui Q, Lu Q, So KF, Yip HK (1999) CNTF, not other trophic factors, promotes axonal regeneration of axotomized retinal ganglion cells in adult hamsters. Investig Ophthalmol Vis Sci 40:760\u2013766","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1571_CR57","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1126\/science.6171034","volume":"214","author":"S David","year":"1981","unstructured":"David S, Aguayo AJ (1981) Axonal elongation into peripheral nervous system \u201cbridges\u201d after central nervous system injury in adult rats. Science 214:931\u2013933","journal-title":"Science"},{"key":"1571_CR58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01150259","volume":"14","author":"S David","year":"1985","unstructured":"David S, Aguayo AJ (1985) Axonal regeneration after crush injury of rat central nervous system fibres innervating peripheral nerve grafts. J Neurocytol 14:1\u201312","journal-title":"J Neurocytol"},{"key":"1571_CR60","doi-asserted-by":"crossref","first-page":"9149","DOI":"10.1073\/pnas.1119449109","volume":"109","author":"S Lima de","year":"2012","unstructured":"de Lima S, Koriyama Y, Kurimoto T, Oliveira JT, Yin Y, Li Y, Gilbert HY, Fagiolini M, Martinez AM, Benowitz L (2012) Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors. Proc Natl Acad Sci USA 109:9149\u20139154","journal-title":"Proc Natl Acad Sci USA"},{"key":"1571_CR61","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12974-014-0172-9","volume":"11","author":"M-F Camara de la","year":"2014","unstructured":"de la Camara M-F, Olivares-Gonzalez C, Hervas L, Salom D, Millan D, Rodrigo R (2014) Infliximab reduces Zaprinast-induced retinal degeneration in cultures of porcine retina. J Neuroinflammation 11:172","journal-title":"J Neuroinflammation"},{"key":"1571_CR62","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/BF01235752","volume":"22","author":"M Dezawa","year":"1993","unstructured":"Dezawa M, Nagano T (1993) Contacts between regenerating axons and the Schwann cells of sciatic nerve segments grafted to the optic nerve of adult rats. J Neurocytol 22:1103\u20131112","journal-title":"J Neurocytol"},{"key":"1571_CR63","first-page":"1401","volume":"38","author":"M Dezawa","year":"1997","unstructured":"Dezawa M, Kawana K, Adachi-Usami E (1997) The role of Schwann cells during retinal ganglion cell regeneration induced by peripheral nerve transplantation. Investig Ophthalmol Vis Sci 38:1401\u20131410","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1571_CR64","first-page":"251","volume":"9","author":"H Diekmann","year":"2015","unstructured":"Diekmann H, Kalbhen P, Fischer D (2015a) Active mechanistic target of rapamycin plays an ancillary rather than essential role in zebrafish CNS axon regeneration. Front Cell Neurosci 9:251","journal-title":"Front Cell Neurosci"},{"key":"1571_CR65","first-page":"118","volume":"9","author":"H Diekmann","year":"2015","unstructured":"Diekmann H, Kalbhen P, Fischer D (2015b) Characterization of optic nerve regeneration using transgenic zebrafish. Front Cell Neurosci 9:118","journal-title":"Front Cell Neurosci"},{"key":"1571_CR66","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nmeth1036","volume":"4","author":"HU Dodt","year":"2007","unstructured":"Dodt HU, Leischner U, Schierloh A, Jahrling N, Mauch CP, Deininger K, Deussing JM, Eder M, Zieglgansberger W, Becker K (2007) Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain. Nat Methods 4:331\u2013336","journal-title":"Nat Methods"},{"key":"1571_CR67","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/0896-6273(91)90066-9","volume":"6","author":"SK Doster","year":"1991","unstructured":"Doster SK, Lozano AM, Aguayo AJ, Willard MB (1991) Expression of the growth-associated protein GAP-43 in adult rat retinal ganglion cells following axon injury. Neuron 6:635\u2013647","journal-title":"Neuron"},{"key":"1571_CR68","first-page":"2171","volume":"14","author":"O Dratviman-Storobinsky","year":"2008","unstructured":"Dratviman-Storobinsky O, Hasanreisoglu M, Offen D, Barhum Y, Weinberger D, Goldenberg-Cohen N (2008) Progressive damage along the optic nerve following induction of crush injury or rodent anterior ischemic optic neuropathy in transgenic mice. Mol Vis 14:2171\u20132179","journal-title":"Mol Vis"},{"key":"1571_CR69","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0092-8674(95)90425-5","volume":"82","author":"U Drescher","year":"1995","unstructured":"Drescher U, Kremoser C, Handwerker C, Loschinger J, Noda M, Bonhoeffer F (1995) In vitro guidance of retinal ganglion cell axons by RAGS, a 25\u00a0kDa tectal protein related to ligands for Eph receptor tyrosine kinases. Cell 82:359\u2013370","journal-title":"Cell"},{"key":"1571_CR70","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.neuron.2015.02.017","volume":"85","author":"X Duan","year":"2015","unstructured":"Duan X, Qiao M, Bei F, Kim IJ, He Z, Sanes JR (2015) Subtype-specific regeneration of retinal ganglion cells following axotomy: effects of osteopontin and mTOR signaling. Neuron 85:1244\u20131256","journal-title":"Neuron"},{"key":"1571_CR71","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s11062-011-9223-3","volume":"43","author":"G Dumanskaya","year":"2011","unstructured":"Dumanskaya G, Purnyn H, Rykhal\u2019skii O, Veselovskii N (2011) Primary culture of dissociated cells of the rat retina under conditions of long-lasting culturing: properties of ganglion cells. Neurophysiology 43:321\u2013323","journal-title":"Neurophysiology"},{"key":"1571_CR72","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/cne.10782","volume":"465","author":"SA Dunlop","year":"2003","unstructured":"Dunlop SA (2003) Axonal sprouting in the optic nerve is not a prerequisite for successful regeneration. J Comp Neurol 465:319\u2013334","journal-title":"J Comp Neurol"},{"key":"1571_CR73","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0166-4328(96)00150-7","volume":"84","author":"SA Dunlop","year":"1997","unstructured":"Dunlop SA, Roberts JD, Armstrong KN, Edwards SJ, Reynolds SJ, Thom MD, Beazley LD (1997) Impaired vision for binocular tasks after unilateral optic nerve regeneration in the frog Litoria moorei. Behav Brain Res 84:195\u2013201","journal-title":"Behav Brain Res"},{"key":"1571_CR74","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/cne.20299","volume":"478","author":"SA Dunlop","year":"2004","unstructured":"Dunlop SA, Tee LB, Stirling RV, Taylor AL, Runham PB, Barber AB, Kuchling G, Rodger J, Roberts JD, Harvey AR, Beazley LD (2004) Failure to restore vision after optic nerve regeneration in reptiles: interspecies variation in response to axotomy. J Comp Neurol 478:292\u2013305","journal-title":"J Comp Neurol"},{"key":"1571_CR75","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/cne.21477","volume":"505","author":"SA Dunlop","year":"2007","unstructured":"Dunlop SA, Tee LB, Goossens MA, Stirling RV, Hool L, Rodger J, Beazley LD (2007) Regenerating optic axons restore topography after incomplete optic nerve injury. J Comp Neurol 505:46\u201357","journal-title":"J Comp Neurol"},{"key":"1571_CR76","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jchemneu.2016.05.008","volume":"77","author":"MV Duprey-Diaz","year":"2016","unstructured":"Duprey-Diaz MV, Blagburn JM, Blanco RE (2016) Optic nerve injury upregulates retinoic acid signaling in the adult frog visual system. J Chem Neuroanat 77:80\u201392","journal-title":"J Chem Neuroanat"},{"key":"1571_CR77","first-page":"31","volume":"2","author":"R Duvdevani","year":"1990","unstructured":"Duvdevani R, Rosner M, Belkin M, Sautter J, Sabel BA, Schwartz M (1990) Graded crush of the rat optic nerve as a brain injury model: combining electrophysiological and behavioral outcome. Restor Neurol Neurosci 2:31\u201338","journal-title":"Restor Neurol Neurosci"},{"key":"1571_CR78","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1523\/JNEUROSCI.3898-13.2014","volume":"34","author":"F Elsaeidi","year":"2014","unstructured":"Elsaeidi F, Bemben MA, Zhao XF, Goldman D (2014) Jak\/Stat signaling stimulates zebrafish optic nerve regeneration and overcomes the inhibitory actions of Socs3 and Sfpq. J Neurosci 34:2632\u20132644","journal-title":"J Neurosci"},{"key":"1571_CR80","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.etap.2005.03.009","volume":"20","author":"KM Erikson","year":"2005","unstructured":"Erikson KM, John CE, Jones SR, Aschner M (2005) Manganese accumulation in striatum of mice exposed to toxic doses is dependent upon a functional dopamine transporter. Environ Toxicol Pharmacol 20:390\u2013394","journal-title":"Environ Toxicol Pharmacol"},{"key":"1571_CR81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2007.05.013","volume":"308","author":"L Erskine","year":"2007","unstructured":"Erskine L, Herrera E (2007) The retinal ganglion cell axon\u2019s journey: insights into molecular mechanisms of axon guidance. Dev Biol 308:1\u201314","journal-title":"Dev Biol"},{"key":"1571_CR82","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1038\/nprot.2012.119","volume":"7","author":"A Erturk","year":"2012","unstructured":"Erturk A, Becker K, Jahrling N, Mauch CP, Hojer CD, Egen JG, Hellal F, Bradke F, Sheng M, Dodt HU (2012) Three-dimensional imaging of solvent-cleared organs using 3DISCO. Nat Protoc 7:1983\u20131995","journal-title":"Nat Protoc"},{"key":"1571_CR83","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1167\/iovs.09-4113","volume":"51","author":"A Feigenspan","year":"2010","unstructured":"Feigenspan A, Dedek K, Schlich K, Weiler R, Thanos S (2010) Expression and biophysical characterization of voltage-gated sodium channels in axons and growth cones of the regenerating optic nerve. Investig Ophthalmol Vis Sci 51:1789\u20131799","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1571_CR84","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nrn1195","volume":"4","author":"MT Filbin","year":"2003","unstructured":"Filbin MT (2003) Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS. Nat Rev Neurosci 4:703\u2013713","journal-title":"Nat Rev Neurosci"},{"key":"1571_CR85","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.preteyeres.2012.06.005","volume":"31","author":"D Fischer","year":"2012","unstructured":"Fischer D, Leibinger M (2012) Promoting optic nerve regeneration. Prog Retin Eye Res 31:688\u2013701","journal-title":"Prog Retin Eye Res"},{"key":"1571_CR86","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1523\/JNEUROSCI.5119-03.2004","volume":"24","author":"D Fischer","year":"2004","unstructured":"Fischer D, He Z, Benowitz LI (2004) Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state. J Neurosci 24:1646\u20131651","journal-title":"J Neurosci"},{"key":"1571_CR87","doi-asserted-by":"crossref","unstructured":"Fischer S, Engelmann C, Herrmann KH, Reichenbach JR, Witte OW, Weih F, Kretz A, Haenold R (2014) In vivo imaging of optic nerve fiber integrity by contrast-enhanced MRI in mice. J Vis Exp","DOI":"10.3791\/51274"},{"key":"1571_CR88","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.expneurol.2017.07.008","volume":"296","author":"D Fischer","year":"2017","unstructured":"Fischer D, Harvey AR, Pernet V, Lemmon VP, Park KK (2017) Optic nerve regeneration in mammals: regenerated or spared axons? Exp Neurol 296:83\u201388","journal-title":"Exp Neurol"},{"key":"1571_CR89","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.expneurol.2007.05.014","volume":"209","author":"MT Fitch","year":"2008","unstructured":"Fitch MT, Silver J (2008) CNS injury, glial scars, and inflammation: inhibitory extracellular matrices and regeneration failure. Exp Neurol 209:294\u2013301","journal-title":"Exp Neurol"},{"key":"1571_CR90","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.bbadis.2010.10.012","volume":"1812","author":"VC Fleisch","year":"2011","unstructured":"Fleisch VC, Fraser B, Allison WT (2011) Investigating regeneration and functional integration of CNS neurons: lessons from zebrafish genetics and other fish species. Biochim Biophys Acta 1812:364\u2013380","journal-title":"Biochim Biophys Acta"},{"key":"1571_CR91","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0165-3806(86)90071-4","volume":"393","author":"TS Ford-Holevinski","year":"1986","unstructured":"Ford-Holevinski TS, Hopkins JM, McCoy JP, Agranoff BW (1986) Laminin supports neurite outgrowth from explants of axotomized adult rat retinal neurons. Brain Res 393:121\u2013126","journal-title":"Brain Res"},{"key":"1571_CR92","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1167\/iovs.12-11207","volume":"54","author":"C Galindo-Romero","year":"2013","unstructured":"Galindo-Romero C, Valiente-Soriano FJ, Jimenez-Lopez M, Garcia-Ayuso D, Villegas-Perez MP, Vidal-Sanz M, Agudo-Barriuso M (2013) Effect of brain-derived neurotrophic factor on mouse axotomized retinal ganglion cells and phagocytic microglia. Investig Ophthalmol Vis Sci 54:974\u2013985","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1571_CR93","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.neurobiolaging.2009.03.002","volume":"32","author":"L Gasparini","year":"2011","unstructured":"Gasparini L, Crowther RA, Martin KR, Berg N, Coleman M, Goedert M, Spillantini MG (2011) Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: effects on axonal viability. Neurobiol Aging 32:419\u2013433","journal-title":"Neurobiol Aging"},{"key":"1571_CR94","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1177\/1087057112471989","volume":"18","author":"D Gaublomme","year":"2013","unstructured":"Gaublomme D, Buyens T, Moons L (2013) Automated analysis of neurite outgrowth in mouse retinal explants. J Biomol Screen 18:534\u2013543","journal-title":"J Biomol Screen"},{"key":"1571_CR95","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1111\/jnc.12703","volume":"129","author":"D Gaublomme","year":"2014","unstructured":"Gaublomme D, Buyens T, De Groef L, Stakenborg M, Janssens E, Ingvarsen S, Porse A, Behrendt N, Moons L (2014) Matrix metalloproteinase 2 and membrane type 1 matrix metalloproteinase co-regulate axonal outgrowth of mouse retinal ganglion cells. J Neurochem 129:966\u2013979","journal-title":"J Neurochem"},{"key":"1571_CR96","first-page":"201","volume":"44","author":"RM Gaze","year":"1978","unstructured":"Gaze RM, Grant P (1978) The diencephalic course of regenerating retinotectal fibres in Xenopus tadpoles. J Embryol Exp Morphol 44:201\u2013216","journal-title":"J Embryol Exp Morphol"},{"key":"1571_CR97","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1113\/jphysiol.1963.sp007072","volume":"165","author":"RM Gaze","year":"1963","unstructured":"Gaze RM, Jacobson M, Szekely C (1963) The retino-tectal projection in Xenopus with compound eyes. J Physiol 165:484\u2013499","journal-title":"J Physiol"},{"key":"1571_CR98","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1098\/rspb.1974.0021","volume":"185","author":"RM Gaze","year":"1974","unstructured":"Gaze RM, Keating MJ, Chung SH (1974) The evolution of the retinotectal map during development in Xenopus. Proc R Soc Lond B Biol Sci 185:301\u2013330","journal-title":"Proc R Soc Lond B Biol Sci"},{"issue":"4","key":"1571_CR99","first-page":"221","volume":"31","author":"E Geeraerts","year":"2016","unstructured":"Geeraerts E, Moons L, De Groef L (2016) Reaching for the brain: stimulating neural activity as the big leap in optic nerve regeneration. Eye Sci 31(4):221\u2013224","journal-title":"Eye Sci"},{"key":"1571_CR100","first-page":"57","volume":"18","author":"MG Ghinia","year":"2013","unstructured":"Ghinia MG (2013) Commonly used methods for purification of rare cell populations. Ann Romanian Soc Cell Biol 18:57\u201364","journal-title":"Ann Romanian Soc Cell Biol"},{"key":"1571_CR101","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1093\/hmg\/ddg249","volume":"12","author":"D Glynn","year":"2003","unstructured":"Glynn D, Bortnick RA, Morton AJ (2003) Complexin II is essential for normal neurological function in mice. Hum Mol Genet 12:2431\u20132448","journal-title":"Hum Mol Genet"},{"key":"1571_CR102","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1146\/annurev.neuro.23.1.579","volume":"23","author":"JL Goldberg","year":"2000","unstructured":"Goldberg JL, Barres BA (2000) The relationship between neuronal survival and regeneration. Annu Rev Neurosci 23:579\u2013612","journal-title":"Annu Rev Neurosci"},{"key":"1571_CR103","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1126\/science.1068428","volume":"296","author":"JL Goldberg","year":"2002","unstructured":"Goldberg JL, Klassen MP, Hua Y, Barres BA (2002) Amacrine-signaled loss of intrinsic axon growth ability by retinal ganglion cells. Science 296:1860\u20131864","journal-title":"Science"},{"key":"1571_CR104","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1023\/A:1008998832552","volume":"10","author":"D Goldman","year":"2001","unstructured":"Goldman D, Hankin M, Li Z, Dai X, Ding J (2001) Transgenic zebrafish for studying nervous system development and regeneration. Transgenic Res 10:21\u201333","journal-title":"Transgenic Res"},{"key":"1571_CR105","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1002\/glia.20531","volume":"55","author":"C Goritz","year":"2007","unstructured":"Goritz C, Thiebaut R, Tessier LH, Nieweg K, Moehle C, Buard I, Dupont JL, Schurgers LJ, Schmitz G, Pfrieger FW (2007) Glia-induced neuronal differentiation by transcriptional regulation. Glia 55:1108\u20131122","journal-title":"Glia"},{"key":"1571_CR106","doi-asserted-by":"crossref","first-page":"434","DOI":"10.2310\/7290.2011.00013","volume":"10","author":"M Gravel","year":"2011","unstructured":"Gravel M, Weng YC, Kriz J (2011) Model system for live imaging of neuronal responses to injury and repair. Mol Imaging 10:434\u2013445","journal-title":"Mol Imaging"},{"key":"1571_CR107","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s12031-012-9899-x","volume":"49","author":"VK Gupta","year":"2013","unstructured":"Gupta VK, You Y, Li JC, Klistorner A, Graham SL (2013) Protective effects of 7,8-dihydroxyflavone on retinal ganglion and RGC-5 cells against excitotoxic and oxidative stress. J Mol Neurosci 49:96\u2013104","journal-title":"J Mol Neurosci"},{"key":"1571_CR108","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.neuroimage.2011.07.069","volume":"59","author":"R Haenold","year":"2012","unstructured":"Haenold R, Herrmann KH, Schmidt S, Reichenbach JR, Schmidt KF, Lowel S, Witte OW, Weih F, Kretz A (2012) Magnetic resonance imaging of the mouse visual pathway for in vivo studies of degeneration and regeneration in the CNS. NeuroImage 59:363\u2013376","journal-title":"NeuroImage"},{"key":"1571_CR109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/exnr.2001.7693","volume":"171","author":"P Heiduschka","year":"2001","unstructured":"Heiduschka P, Romann I, Stieglitz T, Thanos S (2001) Perforated microelectrode arrays implanted in the regenerating adult central nervous system. Exp Neurol 171:1\u201310","journal-title":"Exp Neurol"},{"key":"1571_CR110","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1089\/neu.2011.1928","volume":"28","author":"M Hellstrom","year":"2011","unstructured":"Hellstrom M, Pollett MA, Harvey AR (2011) Post-injury delivery of rAAV2-CNTF combined with short-term pharmacotherapy is neuroprotective and promotes extensive axonal regeneration after optic nerve trauma. J Neurotrauma 28:2475\u20132483","journal-title":"J Neurotrauma"},{"key":"1571_CR111","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/(SICI)1097-4695(19981115)37:3<429::AID-NEU8>3.0.CO;2-N","volume":"37","author":"V Hieber","year":"1998","unstructured":"Hieber V, Dai X, Foreman M, Goldman D (1998) Induction of a1-tubulin gene expression during development and regeneration of the fish central nervous system. J Neurobiol 37:429\u2013440","journal-title":"J Neurobiol"},{"key":"1571_CR112","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S1385-299X(99)00024-0","volume":"4","author":"A Hoff","year":"1999","unstructured":"Hoff A, Hammerle H, Schlosshauer B (1999) Organotypic culture system of chicken retina. Brain Res Brain Res Protoc 4:237\u2013248","journal-title":"Brain Res Brain Res Protoc"},{"key":"1571_CR113","first-page":"2922","volume":"18","author":"S Hong","year":"2012","unstructured":"Hong S, Iizuka Y, Kim CY, Seong GJ (2012) Isolation of primary mouse retinal ganglion cells using immunopanning-magnetic separation. Mol Vis 18:2922\u20132930","journal-title":"Mol Vis"},{"key":"1571_CR114","first-page":"1456","volume":"20","author":"S Hong","year":"2014","unstructured":"Hong S, Iizuka Y, Lee T, Kim CY, Seong GJ (2014) Neuroprotective and neurite outgrowth effects of maltol on retinal ganglion cells under oxidative stress. Mol Vis 20:1456\u20131462","journal-title":"Mol Vis"},{"key":"1571_CR115","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.2741\/2810","volume":"13","author":"YY Huang","year":"2008","unstructured":"Huang YY, Neuhauss SC (2008) The optokinetic response in zebrafish and its applications. Front Biosci 13:1899\u20131916","journal-title":"Front Biosci"},{"key":"1571_CR116","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/cne.902360307","volume":"236","author":"MF Humphrey","year":"1985","unstructured":"Humphrey MF, Beazley LD (1985) Retinal ganglion cell death during optic nerve regeneration in the frog Hyla moorei. J Comp Neurol 236:382\u2013402","journal-title":"J Comp Neurol"},{"key":"1571_CR117","first-page":"1930","volume":"42","author":"M Inatani","year":"2001","unstructured":"Inatani M, Honjo M, Otori Y, Oohira A, Kido N, Tano Y, Honda Y, Tanihara H (2001) Inhibitory effects of neurocan and phosphacan on neurite outgrowth from retinal ganglion cells in culture. Investig Ophthalmol Vis Sci 42:1930\u20131938","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1571_CR118","first-page":"23","volume":"17","author":"T Inoue","year":"2000","unstructured":"Inoue T, Sasaki H, Hosokawa M, Fukuda Y (2000) Axonal regeneration of mouse retinal ganglion cells by peripheral nerve transplantation; a quantitative study. Restor Neurol Neurosci 17:23\u201329","journal-title":"Restor Neurol Neurosci"},{"key":"1571_CR119","doi-asserted-by":"crossref","first-page":"4468","DOI":"10.1523\/JNEUROSCI.22-11-04468.2002","volume":"22","author":"T Inoue","year":"2002","unstructured":"Inoue T, Hosokawa M, Morigiwa K, Ohashi Y, Fukuda Y (2002) Bcl-2 overexpression does not enhance in vivo axonal regeneration of retinal ganglion cells after peripheral nerve transplantation in adult mice. J Neurosci 22:4468\u20134477","journal-title":"J Neurosci"},{"key":"1571_CR120","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jneumeth.2008.06.016","volume":"174","author":"D Ivanov","year":"2008","unstructured":"Ivanov D, Dvoriantchikova G, Barakat DJ, Nathanson L, Shestopalov VI (2008) Differential gene expression profiling of large and small retinal ganglion cells. J Neurosci Methods 174:10\u201317","journal-title":"J Neurosci Methods"},{"key":"1571_CR121","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-1-60761-883-6_2","volume-title":"Animal models of behavioral analysis","author":"BG Jeffrey","year":"2011","unstructured":"Jeffrey BG, McGill TJ, Haley TL, Morgans CW, Duvoisin RM (2011) Anatomical, physiological, and behavioral analysis of rodent vision. In: Raber J (ed) Animal models of behavioral analysis. Humana Press, Totowa, pp\u00a029\u201354"},{"key":"1571_CR122","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1167\/iovs.15-17769","volume":"57","author":"TV Johnson","year":"2016","unstructured":"Johnson TV, Oglesby EN, Steinhart MR, Cone-Kimball E, Jefferys J, Quigley HA (2016) Time-lapse retinal ganglion cell dendritic field degeneration imaged in organotypic retinal explant culture. Investig Ophthalmol Vis Sci 57:253\u2013264","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1571_CR123","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1167\/iovs.12-9712","volume":"53","author":"G Kalesnykas","year":"2012","unstructured":"Kalesnykas G, Oglesby EN, Zack DJ, Cone FE, Steinhart MR, Tian J, Pease ME, Quigley HA (2012) Retinal ganglion cell morphology after optic nerve crush and experimental glaucoma. Investig Ophthalmol Vis Sci 53:3847\u20133857","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1571_CR124","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.neuroimage.2015.11.005","volume":"125","author":"A Kammen","year":"2016","unstructured":"Kammen A, Law M, Tjan BS, Toga AW, Shi Y (2016) Automated retinofugal visual pathway reconstruction with multi-shell HARDI and FOD-based analysis. NeuroImage 125:767\u2013779","journal-title":"NeuroImage"},{"key":"1571_CR125","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.neures.2008.03.008","volume":"61","author":"M Kaneda","year":"2008","unstructured":"Kaneda M, Nagashima M, Nunome T, Muramatsu T, Yamada Y, Kubo M, Muramoto K, Matsukawa T, Koriyama Y, Sugitani K, Vachkov IH, Mawatari K, Kato S (2008) Changes of phospho-growth-associated protein 43 (phospho-GAP43) in the zebrafish retina after optic nerve injury: a long-term observation. Neurosci Res 61:281\u2013288","journal-title":"Neurosci Res"},{"key":"1571_CR126","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.preteyeres.2013.07.004","volume":"37","author":"S Kato","year":"2013","unstructured":"Kato S, Matsukawa T, Koriyama Y, Sugitani K, Ogai K (2013) A molecular mechanism of optic nerve regeneration in fish: the retinoid signaling pathway. Prog Retin Eye Res 37:13\u201330","journal-title":"Prog Retin Eye Res"},{"key":"1571_CR127","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/nn.3447","volume":"16","author":"MT Ke","year":"2013","unstructured":"Ke MT, Fujimoto S, Imai T (2013) SeeDB: a simple and morphology-preserving optical clearing agent for neuronal circuit reconstruction. Nat Neurosci 16:1154\u20131161","journal-title":"Nat Neurosci"},{"key":"1571_CR128","first-page":"284","volume":"55","author":"MJ Keating","year":"1970","unstructured":"Keating MJ, Gaze RM (1970) The ipsilateral retinotectal pathway in the frog. Q J Exp Physiol Cogn Med Sci 55:284\u2013292","journal-title":"Q J Exp Physiol Cogn Med Sci"},{"key":"1571_CR129","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/nprot.2007.157","volume":"2","author":"B Knoll","year":"2007","unstructured":"Knoll B, Weinl C, Nordheim A, Bonhoeffer F (2007) Stripe assay to examine axonal guidance and cell migration. Nat Protoc 2:1216\u20131224","journal-title":"Nat Protoc"},{"key":"1571_CR130","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.jneumeth.2011.08.024","volume":"201","author":"T Koechling","year":"2011","unstructured":"Koechling T, Khalique H, Sundstrom E, Avila J, Lim F (2011) A culture model for neurite regeneration of human spinal cord neurons. J Neurosci Methods 201:346\u2013354","journal-title":"J Neurosci Methods"},{"key":"1571_CR131","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1111\/j.1471-4159.2011.07533.x","volume":"119","author":"Y Koriyama","year":"2011","unstructured":"Koriyama Y, Takagi Y, Chiba K, Yamazaki M, Arai K, Matsukawa T, Suzuki H, Sugitani K, Kagechika H, Kato S (2011) Neuritogenic activity of a genipin derivative in retinal ganglion cells is mediated by retinoic acid receptor beta expression through nitric oxide\/S-nitrosylation signaling. J Neurochem 119:1232\u20131242","journal-title":"J Neurochem"},{"key":"1571_CR132","doi-asserted-by":"crossref","first-page":"5712","DOI":"10.1167\/iovs.13-12085","volume":"54","author":"RR Krishnamoorthy","year":"2013","unstructured":"Krishnamoorthy RR, Clark AF, Daudt D, Vishwanatha JK, Yorio T (2013) A forensic path to RGC-5 cell line identification: lessons learned. Investig Ophthalmol Vis Sci 54:5712\u20135719","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1571_CR133","doi-asserted-by":"crossref","first-page":"15654","DOI":"10.1523\/JNEUROSCI.4340-10.2010","volume":"30","author":"T Kurimoto","year":"2010","unstructured":"Kurimoto T, Yin Y, Omura K, Gilbert HY, Kim D, Cen LP, Moko L, Kugler S, Benowitz LI (2010) Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion. J Neurosci 30:15654\u201315663","journal-title":"J Neurosci"},{"key":"1571_CR134","doi-asserted-by":"crossref","first-page":"14816","DOI":"10.1523\/JNEUROSCI.5511-12.2013","volume":"33","author":"T Kurimoto","year":"2013","unstructured":"Kurimoto T, Yin Y, Habboub G, Gilbert HY, Li Y, Nakao S, Hafezi-Moghadam A, Benowitz LI (2013) Neutrophils express oncomodulin and promote optic nerve regeneration. J Neurosci 33:14816\u201314824","journal-title":"J Neurosci"},{"key":"1571_CR135","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/dvdy.22190","volume":"239","author":"BW Kusik","year":"2010","unstructured":"Kusik BW, Hammond DR, Udvadia AJ (2010) Transcriptional regulatory regions of gap43 needed in developing and regenerating retinal ganglion cells. Dev Dyn 239:482\u2013495","journal-title":"Dev Dyn"},{"key":"1571_CR136","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1167\/iovs.04-0766","volume":"46","author":"WA Lagreze","year":"2005","unstructured":"Lagreze WA, Pielen A, Steingart R, Schlunck G, Hofmann HD, Gozes I, Kirsch M (2005) The peptides ADNF-9 and NAP increase survival and neurite outgrowth of rat retinal ganglion cells in vitro. Investig Ophthalmol Vis Sci 46:933\u2013938","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1571_CR137","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/jmri.1076","volume":"13","author":"D Bihan Le","year":"2001","unstructured":"Le Bihan D, Mangin JF, Poupon C, Clark CA, Pappata S, Molko N, Chabriat H (2001) Diffusion tensor imaging: concepts and applications. J Magn Reson Imaging 13:534\u2013546","journal-title":"J Magn Reson Imaging"},{"key":"1571_CR138","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.5213\/inj.1632630.315","volume":"20","author":"E Lee","year":"2016","unstructured":"Lee E, Kim HJ, Sun W (2016) See-through technology for biological tissue: 3-dimensional visualization of macromolecules. Int Neurourol J 20:S15\u2013S22","journal-title":"Int Neurourol J"},{"key":"1571_CR140","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1038\/mt.2016.102","volume":"24","author":"M Leibinger","year":"2016","unstructured":"Leibinger M, Andreadaki A, Gobrecht P, Levin E, Diekmann H, Fischer D (2016) Boosting central nervous system axon regeneration by circumventing limitations of natural cytokine signaling. Mol Ther 24:1712\u20131725","journal-title":"Mol Ther"},{"key":"1571_CR141","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1002\/cne.23920","volume":"524","author":"K Lemmens","year":"2015","unstructured":"Lemmens K, Bollaerts I, Bhumika S, De Groef L, Van houcke J, Darras VM, Van Hove I, Moons L (2015) Matrix metalloproteinases as promising regulators of axonal regrowth in the injured adult zebrafish retinotectal system. J Comp Neurol 524:1472\u20131493","journal-title":"J Comp Neurol"},{"key":"1571_CR142","doi-asserted-by":"crossref","first-page":"740","DOI":"10.4103\/1673-5374.182697","volume":"11","author":"K Lemmens","year":"2016","unstructured":"Lemmens K, Hove IV, Moons L (2016) Complementary research in mammals and fish indicates MMP-2 as a pleiotropic contributor to optic nerve regeneration. Neural Regener Res 11:740\u2013742","journal-title":"Neural Regener Res"},{"key":"1571_CR143","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1523\/JNEUROSCI.20-12-04615.2000","volume":"20","author":"S Leon","year":"2000","unstructured":"Leon S, Yin Y, Nguyen J, Irwin N, Benowitz LI (2000) Lens injury stimulates axon regeneration in the mature rat optic nerve. J Neurosci 20:4615\u20134626","journal-title":"J Neurosci"},{"key":"1571_CR144","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/dvdy.1159","volume":"221","author":"L Li","year":"2001","unstructured":"Li L (2001) Zebrafish mutants: behavioral genetic studies of visual system defects. Dev Dyn 221:365\u2013372","journal-title":"Dev Dyn"},{"key":"1571_CR145","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.nbd.2014.09.019","volume":"73","author":"S Li","year":"2015","unstructured":"Li S, He Q, Wang H, Tang X, Ho KW, Gao X, Zhang Q, Shen Y, Cheung A, Wong F, Wong YH, Ip NY, Jiang L, Yung WH, Liu K (2015) Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons. Neurobiol Dis 73:366\u2013376","journal-title":"Neurobiol Dis"},{"key":"1571_CR146","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/nn.4340","volume":"19","author":"JH Lim","year":"2016","unstructured":"Lim JH, Stafford BK, Nguyen PL, Lien BV, Wang C, Zukor K, He Z, Huberman AD (2016) Neural activity promotes long-distance, target-specific regeneration of adult retinal axons. Nat Neurosci 19:1073\u20131084","journal-title":"Nat Neurosci"},{"key":"1571_CR147","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1017\/S0952523806230207","volume":"24","author":"AE Lindsey","year":"2007","unstructured":"Lindsey AE, Powers MK (2007) Visual behavior of adult goldfish with regenerating retina. Vis Neurosci 24:247\u2013255","journal-title":"Vis Neurosci"},{"key":"1571_CR148","doi-asserted-by":"crossref","first-page":"e65966","DOI":"10.1371\/journal.pone.0065966","volume":"8","author":"JD Lindsey","year":"2013","unstructured":"Lindsey JD, Duong-Polk KX, Dai Y, Nguyen DH, Leung CK, Weinreb RN (2013) Protection by an oral disubstituted hydroxylamine derivative against loss of retinal ganglion cell differentiation following optic nerve crush. PLoS One 8:e65966","journal-title":"PLoS One"},{"key":"1571_CR149","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1523\/JNEUROSCI.4797-05.2006","volume":"26","author":"X Liu","year":"2006","unstructured":"Liu X, Hawkes E, Ishimaru T, Tran T, Sretavan DW (2006) EphB3: an endogenous mediator of adult axonal plasticity and regrowth after CNS injury. J Neurosci 26:3087\u20133101","journal-title":"J Neurosci"},{"key":"1571_CR150","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1523\/JNEUROSCI.5197-11.2012","volume":"32","author":"Y Liu","year":"2012","unstructured":"Liu Y, Yu H, Deaton SK, Szaro BG (2012) Heterogeneous nuclear ribonucleoprotein K, an RNA-binding protein, is required for optic axon regeneration in Xenopus laevis. J Neurosci 32:3563\u20133574","journal-title":"J Neurosci"},{"key":"1571_CR151","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/brain\/awh706","volume":"129","author":"A Logan","year":"2006","unstructured":"Logan A, Ahmed Z, Baird A, Gonzalez AM, Berry M (2006) Neurotrophic factor synergy is required for neuronal survival and disinhibited axon regeneration after CNS injury. Brain 129:490\u2013502","journal-title":"Brain"},{"key":"1571_CR152","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nrneurol.2012.227","volume":"9","author":"A London","year":"2013","unstructured":"London A, Benhar I, Schwartz M (2013) The retina as a window to the brain-from eye research to CNS disorders. Nat Rev Neurol 9:44\u201353","journal-title":"Nat Rev Neurol"},{"key":"1571_CR153","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1002\/jnr.22095","volume":"87","author":"B Lorber","year":"2009","unstructured":"Lorber B, Berry M, Douglas MR, Nakazawa T, Logan A (2009) Activated retinal glia promote neurite outgrowth of retinal ganglion cells via apolipoprotein E. J Neurosci Res 87:2645\u20132652","journal-title":"J Neurosci Res"},{"key":"1571_CR154","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.nbd.2011.08.008","volume":"45","author":"B Lorber","year":"2012","unstructured":"Lorber B, Guidi A, Fawcett JW, Martin KR (2012) Activated retinal glia mediated axon regeneration in experimental glaucoma. Neurobiol Dis 45:243\u2013252","journal-title":"Neurobiol Dis"},{"key":"1571_CR155","first-page":"1096","volume":"42","author":"X Luo","year":"2001","unstructured":"Luo X, Heidinger V, Picaud S, Lambrou G, Dreyfus H, Sahel J, Hicks D (2001) Selective excitotoxic degeneration of adult pig retinal ganglion cells in vitro. Investig Ophthalmol Vis Sci 42:1096\u20131106","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1571_CR156","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.expneurol.2013.03.001","volume":"247","author":"X Luo","year":"2013","unstructured":"Luo X, Salgueiro Y, Beckerman SR, Lemmon VP, Tsoulfas P, Park KK (2013) Three-dimensional evaluation of retinal ganglion cell axon regeneration and pathfinding in whole mouse tissue after injury. Exp Neurol 247:653\u2013662","journal-title":"Exp Neurol"},{"key":"1571_CR157","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/978-1-4939-0777-9_17","volume":"1162","author":"X Luo","year":"2014","unstructured":"Luo X, Yungher B, Park KK (2014) Application of tissue clearing and light sheet fluorescence microscopy to assess optic nerve regeneration in unsectioned tissues. Methods Mol Biol 1162:209\u2013217","journal-title":"Methods Mol Biol"},{"key":"1571_CR158","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0042-6989(02)00395-4","volume":"43","author":"H Maaswinkel","year":"2003","unstructured":"Maaswinkel H, Li L (2003) Spatio-temporal frequency characteristics of the optomotor response in zebrafish. Vis Res 43:21\u201330","journal-title":"Vis Res"},{"key":"1571_CR159","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1248\/bpb.27.445","volume":"27","author":"T Matsukawa","year":"2004","unstructured":"Matsukawa T, Arai K, Koriyama Y, Liu Z, Kato S (2004) Axonal regeneration of fish optic nerve after injury. Biol Pharm Bull 27:445\u2013451","journal-title":"Biol Pharm Bull"},{"key":"1571_CR160","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1126\/science.130.3390.1709","volume":"130","author":"HR Maturana","year":"1959","unstructured":"Maturana HR, Lettvin JY, McCulloch WS, Pitts WH (1959) Evidence that cut optic nerve fibers in a frog regenerate to their proper places in the tectum. Science 130:1709\u20131710","journal-title":"Science"},{"key":"1571_CR161","first-page":"17","volume":"2010","author":"AT McCurley","year":"2010","unstructured":"McCurley AT, Callard GV (2010) Time course analysis of gene expression patterns in zebrafish eye during optic nerve regeneration. J Exp Neurosci 2010:17\u201333","journal-title":"J Exp Neurosci"},{"key":"1571_CR162","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1017\/S0952523804043019","volume":"21","author":"AL McDowell","year":"2004","unstructured":"McDowell AL, Dixon LJ, Houchins JD, Bilotta J (2004) Visual processing of the zebrafish optic tectum before and after optic nerve damage. Vis Neurosci 21:97\u2013106","journal-title":"Vis Neurosci"},{"key":"1571_CR163","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/(SICI)1096-9861(19990628)409:2<299::AID-CNE10>3.0.CO;2-C","volume":"409","author":"RL Meyer","year":"1999","unstructured":"Meyer RL, Kageyama GH (1999) Large-scale synaptic errors during map formation by regeneration optic axons in the goldfish. J Comp Neurol 409:299\u2013312","journal-title":"J Comp Neurol"},{"key":"1571_CR164","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1167\/iovs.06-1329","volume":"48","author":"K Miyake","year":"2007","unstructured":"Miyake K, Yoshida M, Inoue Y, Hata Y (2007) Neuroprotective effect of transcorneal electrical stimulation on the acute phase of optic nerve injury. Investig Ophthalmol Vis Sci 48:2356\u20132361","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1571_CR165","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nature01041","volume":"419","author":"PP Monnier","year":"2002","unstructured":"Monnier PP, Sierra A, Macchi P, Deitinghoff L, Andersen JS, Mann M, Flad M, Hornberger MR, Stahl B, Bonhoeffer F, Mueller BK (2002) RGM is a repulsive guidance molecule for retinal axons. Nature 419:392\u2013395","journal-title":"Nature"},{"key":"1571_CR166","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1044-7431(02)00035-0","volume":"22","author":"PP Monnier","year":"2003","unstructured":"Monnier PP, Sierra A, Schwab JM, Henke-Fahle S, Mueller BK (2003) The Rho\/ROCK pathway mediates neurite growth-inhibitory activity associated with the chondroitin sulfate proteoglycans of the CNS glial scar. Mol Cell Neurosci 22:319\u2013330","journal-title":"Mol Cell Neurosci"},{"key":"1571_CR167","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1167\/iovs.15-17511","volume":"57","author":"PJ Morgan-Warren","year":"2016","unstructured":"Morgan-Warren PJ, O\u2019Neill J, de Cogan F, Spivak I, Ashush H, Kalinski H, Ahmed Z, Berry M, Feinstein E, Scott RA, Logan A (2016) siRNA-mediated knockdown of the mTOR inhibitor RTP801 promotes retinal ganglion cell survival and axon elongation by direct and indirect mechanisms. Investig Ophthalmol Vis Sci 57:429\u2013443","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1571_CR168","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jneumeth.2009.10.020","volume":"186","author":"KP Mueller","year":"2010","unstructured":"Mueller KP, Neuhauss SC (2010) Quantitative measurements of the optokinetic response in adult fish. J Neurosci Methods 186:29\u201334","journal-title":"J Neurosci Methods"},{"key":"1571_CR169","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1093\/brain\/awm257","volume":"130","author":"A Muller","year":"2007","unstructured":"Muller A, Hauk TG, Fischer D (2007) Astrocyte-derived CNTF switches mature RGCs to a regenerative state following inflammatory stimulation. Brain 130:3308\u20133320","journal-title":"Brain"},{"key":"1571_CR170","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s40478-014-0077-y","volume":"2","author":"EJ Munzel","year":"2014","unstructured":"Munzel EJ, Becker CG, Becker T, Williams A (2014) Zebrafish regenerate full thickness optic nerve myelin after demyelination, but this fails with increasing age. Acta Neuropathol Commun 2:77","journal-title":"Acta Neuropathol Commun"},{"key":"1571_CR171","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.exer.2014.12.005","volume":"131","author":"FM Nadal-Nicolas","year":"2015","unstructured":"Nadal-Nicolas FM, Salinas-Navarro M, Vidal-Sanz M, Agudo-Barriuso M (2015a) Two methods to trace retinal ganglion cells with fluorogold: from the intact optic nerve or by stereotactic injection into the optic tract. Exp Eye Res 131:12\u201319","journal-title":"Exp Eye Res"},{"key":"1571_CR172","doi-asserted-by":"crossref","first-page":"6095","DOI":"10.1167\/iovs.15-17195","volume":"56","author":"FM Nadal-Nicolas","year":"2015","unstructured":"Nadal-Nicolas FM, Sobrado-Calvo P, Jimenez-Lopez M, Vidal-Sanz M, Agudo-Barriuso M (2015b) Long-term effect of optic nerve axotomy on the retinal ganglion cell layer. Investig Ophthalmol Vis Sci 56:6095\u20136112","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1571_CR173","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0006-8993(90)91379-U","volume":"510","author":"K Narita","year":"1990","unstructured":"Narita K, Kawasaki F, Kita H (1990) Mn and Mg influxes through Ca channels of motor nerve terminals are prevented by verapamil in frogs. Brain Res 510:289\u2013295","journal-title":"Brain Res"},{"key":"1571_CR174","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1083\/jcb.107.3.1177","volume":"107","author":"KM Neugebauer","year":"1988","unstructured":"Neugebauer KM, Tomaselli KJ, Lilien J, Reichardt LF (1988) N-cadherin, NCAM, and integrins promote retinal neurite outgrowth on astrocytes in vitro. J Cell Biol 107:1177\u20131187","journal-title":"J Cell Biol"},{"key":"1571_CR175","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/neu.10165","volume":"54","author":"SC Neuhauss","year":"2003","unstructured":"Neuhauss SC (2003) Behavioral genetic approaches to visual system development and function in zebrafish. J Neurobiol 54:148\u2013160","journal-title":"J Neurobiol"},{"key":"1571_CR176","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/BF01179974","volume":"24","author":"TF Ng","year":"1995","unstructured":"Ng TF, So KF, Chung SK (1995) Influence of peripheral nerve grafts on the expression of GAP-43 in regenerating retinal ganglion cells in adult hamsters. J Neurocytol 24:487\u2013496","journal-title":"J Neurocytol"},{"key":"1571_CR177","volume-title":"Webvision: the organization of the retina and visual system","author":"S Nona","year":"1995","unstructured":"Nona S (1995) Regeneration in the goldfish visual System. In: Kolb H, Fernandez E, Nelson R (eds) Webvision: the organization of the retina and visual system. University of Utah, Salt Lake City"},{"key":"1571_CR178","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/0306-4522(89)90294-7","volume":"32","author":"DP Northmore","year":"1989","unstructured":"Northmore DP (1989a) Quantitative electrophysiological studies of regenerating visuotopic maps in goldfish\u2014I. Early recovery of dimming sensitivity in tectum and torus longitudinalis. Neuroscience 32:739\u2013747","journal-title":"Neuroscience"},{"key":"1571_CR179","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/0306-4522(89)90295-9","volume":"32","author":"DP Northmore","year":"1989","unstructured":"Northmore DP (1989b) Quantitative electrophysiological studies of regenerating visuotopic maps in goldfish\u2014II. Delayed recovery of sensitivity to small light flashes. Neuroscience 32:749\u2013757","journal-title":"Neuroscience"},{"key":"1571_CR180","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1007\/s11064-005-8825-9","volume":"30","author":"S Nusetti","year":"2005","unstructured":"Nusetti S, Obregon F, Quintal M, Benzo Z, Lima L (2005) Taurine and zinc modulate outgrowth from goldfish retinal explants. Neurochem Res 30:1483\u20131492","journal-title":"Neurochem Res"},{"key":"1571_CR181","doi-asserted-by":"crossref","first-page":"e106010","DOI":"10.1371\/journal.pone.0106010","volume":"9","author":"K Ogai","year":"2014","unstructured":"Ogai K, Kuwana A, Hisano S, Nagashima M, Koriyama Y, Sugitani K, Mawatari K, Nakashima H, Kato S (2014) Upregulation of leukemia inhibitory factor (LIF) during the early stage of optic nerve regeneration in zebrafish. PLoS One 9:e106010","journal-title":"PLoS One"},{"key":"1571_CR182","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.expneurol.2005.07.015","volume":"196","author":"T Okada","year":"2005","unstructured":"Okada T, Ichikawa M, Tokita Y, Horie H, Saito K, Yoshida J, Watanabe M (2005) Intravitreal macrophage activation enables cat retinal ganglion cells to regenerate injured axons into the mature optic nerve. Exp Neurol 196:153\u2013163","journal-title":"Exp Neurol"},{"key":"1571_CR183","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.brainres.2012.08.041","volume":"1480","author":"YT Ou","year":"2012","unstructured":"Ou YT, Lu MS, Chiao CC (2012) The effects of electrical stimulation on neurite outgrowth of goldfish retinal explants. Brain Res 1480:22\u201329","journal-title":"Brain Res"},{"key":"1571_CR184","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1126\/science.1161566","volume":"322","author":"KK Park","year":"2008","unstructured":"Park KK, Liu K, Hu Y, Smith PD, Wang C, Cai B, Xu B, Connolly L, Kramvis I, Sahin M, He Z (2008) Promoting axon regeneration in the adult CNS by modulation of the PTEN\/mTOR pathway. Science 322:963\u2013966","journal-title":"Science"},{"key":"1571_CR185","doi-asserted-by":"crossref","first-page":"e60486","DOI":"10.1371\/journal.pone.0060486","volume":"8","author":"V Paschon","year":"2013","unstructured":"Paschon V, Higa GS, Walter LT, Sousa E, Zuzarte FC, Weber VR, Resende RR, Kihara AH (2013) A new and reliable guide for studies of neuronal loss based on focal lesions and combinations of in vivo and in vitro approaches. PLoS One 8:e60486","journal-title":"PLoS One"},{"key":"1571_CR186","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.tins.2014.05.002","volume":"37","author":"V Pernet","year":"2014","unstructured":"Pernet V, Schwab ME (2014) Lost in the jungle: new hurdles for optic nerve axon regeneration. Trends Neurosci 37:381\u2013387","journal-title":"Trends Neurosci"},{"key":"1571_CR187","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.nbd.2012.11.011","volume":"51","author":"V Pernet","year":"2013","unstructured":"Pernet V, Joly S, Dalkara D, Jordi N, Schwarz O, Christ F, Schaffer DV, Flannery JG, Schwab ME (2013a) Long-distance axonal regeneration induced by CNTF gene transfer is impaired by axonal misguidance in the injured adult optic nerve. Neurobiol Dis 51:202\u2013213","journal-title":"Neurobiol Dis"},{"key":"1571_CR188","doi-asserted-by":"crossref","first-page":"e734","DOI":"10.1038\/cddis.2013.266","volume":"4","author":"V Pernet","year":"2013","unstructured":"Pernet V, Joly S, Jordi N, Dalkara D, Guzik-Kornacka A, Flannery JG, Schwab ME (2013b) Misguidance and modulation of axonal regeneration by Stat3 and Rho\/ROCK signaling in the transparent optic nerve. Cell Death Dis 4:e734","journal-title":"Cell Death Dis"},{"key":"1571_CR189","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s003350010102","volume":"11","author":"LH Pinto","year":"2000","unstructured":"Pinto LH, Enroth-Cugell C (2000) Tests of the mouse visual system. Mamm Genome 11:531\u2013536","journal-title":"Mamm Genome"},{"key":"1571_CR190","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1167\/iovs.04-0541","volume":"45","author":"GT Prusky","year":"2004","unstructured":"Prusky GT, Alam NM, Beekman S, Douglas RM (2004) Rapid quantification of adult and developing mouse spatial vision using a virtual optomotor system. Investig Ophthalmol Vis Sci 45:4611\u20134616","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1571_CR191","first-page":"774","volume":"36","author":"HA Quigley","year":"1995","unstructured":"Quigley HA, Nickells RW, Kerrigan LA, Pease ME, Thibault DJ, Zack DJ (1995) Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis. Invest Ophthalmol Vis Sci 36:774\u2013786","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1571_CR192","volume-title":"Degeneration and regeneration of the nervous system","author":"S Ram\u00f3nCajal","year":"1928","unstructured":"Ram\u00f3n y Cajal, S, May RM (1928) Degeneration and regeneration of the nervous system. Oxford University Press, Oxford"},{"key":"1571_CR193","unstructured":"Rasmussen JP, Sagasti A (2016) Learning to swim, again: axon regeneration in fish. Exp Neurol 318\u2013330"},{"key":"1571_CR194","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.cell.2014.10.010","volume":"159","author":"N Renier","year":"2014","unstructured":"Renier N, Wu Z, Simon DJ, Yang J, Ariel P, Tessier-Lavigne M (2014) iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging. Cell 159:896\u2013910","journal-title":"Cell"},{"key":"1571_CR195","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/284264a0","volume":"284","author":"PM Richardson","year":"1980","unstructured":"Richardson PM, McGuinness UM, Aguayo AJ (1980) Axons from CNS neurons regenerate into PNS grafts. Nature 284:264\u2013265","journal-title":"Nature"},{"key":"1571_CR196","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF01148324","volume":"13","author":"PM Richardson","year":"1984","unstructured":"Richardson PM, Issa VM, Aguayo AJ (1984) Regeneration of long spinal axons in the rat. J Neurocytol 13:165\u2013182","journal-title":"J Neurocytol"},{"key":"1571_CR197","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.oftal.2015.03.009","volume":"90","author":"N Ruzafa","year":"2015","unstructured":"Ruzafa N, Vecino E (2015) Effect of Muller cells on the survival and neuritogenesis in retinal ganglion cells. Archivos de la Sociedad Espanola de Oftalmologia 90:522\u2013526","journal-title":"Archivos de la Sociedad Espanola de Oftalmologia"},{"key":"1571_CR198","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1667\/0033-7587(2002)157[0500:NDORIO]2.0.CO;2","volume":"157","author":"S Ryu","year":"2002","unstructured":"Ryu S, Brown SL, Kolozsvary A, Ewing JR, Kim JH (2002) Noninvasive detection of radiation-induced optic neuropathy by manganese-enhanced MRI. Radiat Res 157:500\u2013505","journal-title":"Radiat Res"},{"key":"1571_CR199","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.expneurol.2007.02.002","volume":"205","author":"H Sagawa","year":"2007","unstructured":"Sagawa H, Terasaki H, Nakamura M, Ichikawa M, Yata T, Tokita Y, Watanabe M (2007) A novel ROCK inhibitor, Y-39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats. Exp Neurol 205:230\u2013240","journal-title":"Exp Neurol"},{"key":"1571_CR200","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/978-1-4939-0777-9_19","volume":"1162","author":"I Sandvig","year":"2014","unstructured":"Sandvig I, Sandvig A (2014) Using manganese-enhanced MRI to assess optic nerve regeneration. Methods Mol Biol 1162:233\u2013249","journal-title":"Methods Mol Biol"},{"key":"1571_CR201","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1002\/nbm.1778","volume":"25","author":"I Sandvig","year":"2012","unstructured":"Sandvig I, Thuen M, Hoang L, Olsen O, Sardella TC, Brekken C, Tvedt KE, Barnett SC, Haraldseth O, Berry M, Sandvig A (2012) In vivo MRI of olfactory ensheathing cell grafts and regenerating axons in transplant mediated repair of the adult rat optic nerve. NMR Biomed 25:620\u2013631","journal-title":"NMR Biomed"},{"key":"1571_CR202","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/S1044-7431(03)00228-8","volume":"24","author":"PS Sapieha","year":"2003","unstructured":"Sapieha PS, Peltier M, Rendahl KG, Manning WC, Di Polo A (2003) Fibroblast growth factor-2 gene delivery stimulates axon growth by adult retinal ganglion cells after acute optic nerve injury. Mol Cell Neurosci 24:656\u2013672","journal-title":"Mol Cell Neurosci"},{"key":"1571_CR203","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0006-8993(91)91732-G","volume":"565","author":"J Sautter","year":"1991","unstructured":"Sautter J, Schwartz M, Duvdevani R, Sabel BA (1991) GM1 ganglioside treatment reduces visual deficits after graded crush of the rat optic nerve. Brain Res 565:23\u201333","journal-title":"Brain Res"},{"key":"1571_CR204","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1523\/JNEUROSCI.15-01-00665.1995","volume":"15","author":"Y Sauve","year":"1995","unstructured":"Sauve Y, Sawai H, Rasminsky M (1995) Functional synaptic connections made by regenerated retinal ganglion cell axons in the superior colliculus of adult hamsters. J Neurosci 15:665\u2013675","journal-title":"J Neurosci"},{"key":"1571_CR205","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1523\/JNEUROSCI.08-07-02381.1988","volume":"8","author":"ME Schwab","year":"1988","unstructured":"Schwab ME, Caroni P (1988) Oligodendrocytes and CNS myelin are nonpermissive substrates for neurite growth and fibroblast spreading in vitro. J Neurosci 8:2381\u20132393","journal-title":"J Neurosci"},{"key":"1571_CR206","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1523\/JNEUROSCI.05-09-02415.1985","volume":"5","author":"ME Schwab","year":"1985","unstructured":"Schwab ME, Thoenen H (1985) Dissociated neurons regenerate into sciatic but not optic nerve explants in culture irrespective of neurotrophic factors. J Neurosci 5:2415\u20132423","journal-title":"J Neurosci"},{"key":"1571_CR207","doi-asserted-by":"crossref","first-page":"5514","DOI":"10.1523\/JNEUROSCI.15-08-05514.1995","volume":"15","author":"JM Schwalb","year":"1995","unstructured":"Schwalb JM, Boulis NM, Gu MF, Winickoff J, Jackson PS, Irwin N, Benowitz LI (1995) Two factors secreted by the goldfish optic nerve induce retinal ganglion cells to regenerate axons in culture. J Neurosci 15:5514\u20135525","journal-title":"J Neurosci"},{"key":"1571_CR208","first-page":"301","volume":"20","author":"GM Seigel","year":"2014","unstructured":"Seigel GM (2014) Review: R28 retinal precursor cells: the first 20\u00a0years. Mol Vis 20:301\u2013306","journal-title":"Mol Vis"},{"key":"1571_CR209","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1126\/science.aaa8694","volume":"348","author":"C Shang","year":"2015","unstructured":"Shang C, Liu Z, Chen Z, Shi Y, Wang Q, Liu S, Li D, Cao P (2015) A parvalbumin-positive excitatory visual pathway to trigger fear responses in mice. Science 348:1472\u20131477","journal-title":"Science"},{"key":"1571_CR210","doi-asserted-by":"crossref","first-page":"e1661","DOI":"10.1038\/cddis.2015.22","volume":"6","author":"TP Sharma","year":"2015","unstructured":"Sharma TP, Liu Y, Wordinger RJ, Pang IH, Clark AF (2015) Neuritin 1 promotes retinal ganglion cell survival and axonal regeneration following optic nerve crush. Cell Death Dis 6:e1661","journal-title":"Cell Death Dis"},{"key":"1571_CR211","first-page":"53202","volume":"103","author":"S Shirazi Fard","year":"2015","unstructured":"Shirazi Fard S, Blixt M, Hallbook F (2015) Whole retinal explants from chicken embryos for electroporation and chemical reagent treatments. J Vis Exp 103:53202","journal-title":"J Vis Exp"},{"key":"1571_CR212","doi-asserted-by":"crossref","first-page":"32","DOI":"10.4103\/1673-5374.175038","volume":"11","author":"JW Shum","year":"2016","unstructured":"Shum JW, Liu K, So KF (2016) The progress in optic nerve regeneration, where are we? Neural Regener Res 11:32\u201336","journal-title":"Neural Regener Res"},{"key":"1571_CR213","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nrn1326","volume":"5","author":"J Silver","year":"2004","unstructured":"Silver J, Miller JH (2004) Regeneration beyond the glial scar. Nat Rev Neurosci 5:146\u2013156","journal-title":"Nat Rev Neurosci"},{"key":"1571_CR214","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/cne.903070302","volume":"307","author":"EL Singman","year":"1991","unstructured":"Singman EL, Scalia F (1991) Quantitative study of the tectally projecting retinal ganglion cells in the adult frog. II. Cell survival and functional recovery after optic nerve transection. J Comp Neurol 307:351\u2013369","journal-title":"J Comp Neurol"},{"key":"1571_CR215","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-1-4614-3209-8_19","volume":"801","author":"C Sippl","year":"2014","unstructured":"Sippl C, Tamm ER (2014) What is the nature of the RGC-5 cell line? Adv Exp Med Biol 801:145\u2013154","journal-title":"Adv Exp Med Biol"},{"key":"1571_CR216","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.neuron.2009.11.021","volume":"64","author":"PD Smith","year":"2009","unstructured":"Smith PD, Sun F, Park KK, Cai B, Wang C, Kuwako K, Martinez-Carrasco I, Connolly L, He Z (2009) SOCS3 deletion promotes optic nerve regeneration in vivo. Neuron 64:617\u2013623","journal-title":"Neuron"},{"key":"1571_CR217","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0006-8993(85)91047-9","volume":"328","author":"KF So","year":"1985","unstructured":"So KF, Aguayo AJ (1985) Lengthy regrowth of cut axons from ganglion cells after peripheral nerve transplantation into the retina of adult rats. Brain Res 328:349\u2013354","journal-title":"Brain Res"},{"key":"1571_CR218","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/jnr.10673","volume":"73","author":"I Soto","year":"2003","unstructured":"Soto I, Marie B, Baro DJ, Blanco RE (2003) FGF-2 modulates expression and distribution of GAP-43 in frog retinal ganglion cells after optic nerve injury. J Neurosci Res 73:507\u2013517","journal-title":"J Neurosci Res"},{"key":"1571_CR219","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1086\/physzool.21.4.30152014","volume":"21","author":"RW Sperry","year":"1948","unstructured":"Sperry RW (1948) Patterning of central synapses in regeneration of the optic nerve in teleosts. Physiol Zool 21:351\u2013361","journal-title":"Physiol Zool"},{"key":"1571_CR220","doi-asserted-by":"crossref","first-page":"4369","DOI":"10.1167\/iovs.14-13882","volume":"55","author":"MB Steketee","year":"2014","unstructured":"Steketee MB, Oboudiyat C, Daneman R, Trakhtenberg E, Lamoureux P, Weinstein JE, Heidemann S, Barres BA, Goldberg JL (2014) Regulation of intrinsic axon growth ability at retinal ganglion cell growth cones. Investig Ophthalmol Vis Sci 55:4369\u20134377","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1571_CR221","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0165-0270(98)00020-X","volume":"81","author":"RV Stirling","year":"1998","unstructured":"Stirling RV, Dunlop SA, Beazley LD (1998) An in vitro technique for electrophysiological mapping of reptilian retinotectal projections. J Neurosci Methods 81:85\u201389","journal-title":"J Neurosci Methods"},{"key":"1571_CR222","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1017\/S0952523899164083","volume":"16","author":"RV Stirling","year":"1999","unstructured":"Stirling RV, Dunlop SA, Beazley LD (1999) Electrophysiological evidence for transient topographic organization of retinotectal projections during optic nerve regeneration in the lizard, Ctenophorus ornatus. Vis Neurosci 16:681\u2013693","journal-title":"Vis Neurosci"},{"key":"1571_CR223","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/978-3-319-17121-0_89","volume":"854","author":"K Sugitani","year":"2016","unstructured":"Sugitani K, Koriyama Y, Ogai K, Wakasugi K, Kato S (2016) A possible role of neuroglobin in the retina after optic nerve injury: a comparative study of zebrafish and mouse retina. Adv Exp Med Biol 854:671\u2013675","journal-title":"Adv Exp Med Biol"},{"key":"1571_CR224","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.conb.2010.03.013","volume":"20","author":"F Sun","year":"2010","unstructured":"Sun F, He Z (2010) Neuronal intrinsic barriers for axon regeneration in the adult CNS. Curr Opin Neurobiol 20:510\u2013518","journal-title":"Curr Opin Neurobiol"},{"key":"1571_CR225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroimage.2007.11.049","volume":"40","author":"SW Sun","year":"2008","unstructured":"Sun SW, Liang HF, Cross AH, Song SK (2008) Evolving Wallerian degeneration after transient retinal ischemia in mice characterized by diffusion tensor imaging. NeuroImage 40:1\u201310","journal-title":"NeuroImage"},{"key":"1571_CR226","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature10594","volume":"480","author":"F Sun","year":"2011","unstructured":"Sun F, Park KK, Belin S, Wang D, Lu T, Chen G, Zhang K, Yeung C, Feng G, Yankner BA, He Z (2011) Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature 480:372\u2013375","journal-title":"Nature"},{"key":"1571_CR227","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.neuron.2015.03.064","volume":"86","author":"LO Sun","year":"2015","unstructured":"Sun LO, Brady CM, Cahill H, Al-Khindi T, Sakuta H, Dhande OS, Noda M, Huberman AD, Nathans J, Kolodkin AL (2015) Functional assembly of accessory optic system circuitry critical for compensatory eye movements. Neuron 86:971\u2013984","journal-title":"Neuron"},{"key":"1571_CR228","first-page":"1540","volume":"14","author":"I Surgucheva","year":"2008","unstructured":"Surgucheva I, Weisman AD, Goldberg JL, Shnyra A, Surguchov A (2008) Gamma-synuclein as a marker of retinal ganglion cells. Mol Vis 14:1540\u20131548","journal-title":"Mol Vis"},{"key":"1571_CR229","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1742-9994-9-10","volume":"9","author":"C Tappeiner","year":"2012","unstructured":"Tappeiner C, Gerber S, Enzmann V, Balmer J, Jazwinska A, Tschopp M (2012) Visual acuity and contrast sensitivity of adult zebrafish. Front Zool 9:10","journal-title":"Front Zool"},{"key":"1571_CR230","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1167\/iovs.13-13535","volume":"55","author":"L Taylor","year":"2014","unstructured":"Taylor L, Arner K, Taylor IH, Ghosh F (2014) Feet on the ground: physical support of the inner retina is a strong determinant for cell survival and structural preservation in vitro. Investig Ophthalmol Vis Sci 55:2200\u20132213","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1571_CR231","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.exer.2011.07.011","volume":"93","author":"G Thangaraj","year":"2011","unstructured":"Thangaraj G, Greif A, Layer PG (2011) Simple explant culture of the embryonic chicken retina with long-term preservation of photoreceptors. Exp Eye Res 93:556\u2013564","journal-title":"Exp Eye Res"},{"key":"1571_CR232","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0006-8993(87)90799-2","volume":"406","author":"S Thanos","year":"1987","unstructured":"Thanos S, Vidal-Sanz M, Aguayo AJ (1987) The use of rhodamine-B-isothiocyanate (RITC) as an anterograde and retrograde tracer in the adult rat visual system. Brain Res 406:317\u2013321","journal-title":"Brain Res"},{"key":"1571_CR233","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0014-4835(92)90050-3","volume":"54","author":"S Thanos","year":"1992","unstructured":"Thanos S, Vanselow J, Mey J (1992) Ganglion cells in the juvenile chick retina and their ability to regenerate axons in vitro. Exp Eye Res 54:377\u2013391","journal-title":"Exp Eye Res"},{"key":"1571_CR234","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/PL00005657","volume":"114","author":"S Thanos","year":"1997","unstructured":"Thanos S, Naskar R, Heiduschka P (1997) Regenerating ganglion cell axons in the adult rat establish retinofugal topography and restore visual function. Exp Brain Res 114:483\u2013491","journal-title":"Exp Brain Res"},{"key":"1571_CR235","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/jmri.20400","volume":"22","author":"M Thuen","year":"2005","unstructured":"Thuen M, Singstad TE, Pedersen TB, Haraldseth O, Berry M, Sandvig A, Brekken C (2005) Manganese-enhanced MRI of the optic visual pathway and optic nerve injury in adult rats. J Magn Reson Imaging 22:492\u2013500","journal-title":"J Magn Reson Imaging"},{"key":"1571_CR236","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/jmri.21504","volume":"28","author":"M Thuen","year":"2008","unstructured":"Thuen M, Berry M, Pedersen TB, Goa PE, Summerfield M, Haraldseth O, Sandvig A, Brekken C (2008) Manganese-enhanced MRI of the rat visual pathway: acute neural toxicity, contrast enhancement, axon resolution, axonal transport, and clearance of Mn(2+). J Magn Reson Imaging 28:855\u2013865","journal-title":"J Magn Reson Imaging"},{"key":"1571_CR237","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/jmri.21606","volume":"29","author":"M Thuen","year":"2009","unstructured":"Thuen M, Olsen O, Berry M, Pedersen TB, Kristoffersen A, Haraldseth O, Sandvig A, Brekken C (2009) Combination of Mn(2+)-enhanced and diffusion tensor MR imaging gives complementary information about injury and regeneration in the adult rat optic nerve. J Magn Reson Imaging 29:39\u201351","journal-title":"J Magn Reson Imaging"},{"key":"1571_CR238","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1186\/1756-0500-5-693","volume":"5","author":"KA Toops","year":"2012","unstructured":"Toops KA, Hagemann TL, Messing A, Nickells RW (2012) The effect of glial fibrillary acidic protein expression on neurite outgrowth from retinal explants in a permissive environment. BMC Res Notes 5:693","journal-title":"BMC Res Notes"},{"key":"1571_CR239","first-page":"274","volume":"14","author":"RK Tsai","year":"1998","unstructured":"Tsai RK, Wang HZ, Sheu MM (1998) Capability of neurite regeneration of retinal explant from adult rat after optic nerve injury. Kaohsiung J Med Sci 14:274\u2013279","journal-title":"Kaohsiung J Med Sci"},{"key":"1571_CR240","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.gep.2008.05.002","volume":"8","author":"AJ Udvadia","year":"2008","unstructured":"Udvadia AJ (2008) 3.6\u00a0kb genomic sequence from Takifugu capable of promoting axon growth-associated gene expression in developing and regenerating zebrafish neurons. Gene Express Patterns 8:382\u2013388","journal-title":"Gene Express Patterns"},{"key":"1571_CR241","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev-pharmtox-010814-124803","volume":"55","author":"DJ Urban","year":"2015","unstructured":"Urban DJ, Roth BL (2015) DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility. Annu Rev Pharmacol Toxicol 55:399\u2013417","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"1571_CR242","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.4103\/1673-5374.172311","volume":"10","author":"I Hove Van","year":"2015","unstructured":"Van Hove I, Lefevere E, Moons L (2015) ROCK inhibition as a novel potential strategy for axonal regeneration in optic neuropathies. Neural Regener Res 10:1949\u20131950","journal-title":"Neural Regener Res"},{"key":"1571_CR243","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2017.08.013","volume":"60","author":"J Van houcke","year":"2017","unstructured":"Van houcke J, Bollaerts I, Geeraerts E, Davis B, Beckers A, Van Hove I, Lemmens K, De Groef L, Moons L (2017) Successful optic nerve regeneration in the senescent zebrafish despite age-related decline of cell intrinsic and extrinsic response processes. Neurobiol Aging 60:1\u201310","journal-title":"Neurobiol Aging"},{"key":"1571_CR244","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.pneurobio.2015.06.002","volume":"131","author":"S Velde Van de","year":"2015","unstructured":"Van de Velde S, De Groef L, Stalmans I, Moons L, Van Hove I (2015) Towards axonal regeneration and neuroprotection in glaucoma: rho kinase inhibitors as promising therapeutics. Prog Neurobiol 131:105\u2013119","journal-title":"Prog Neurobiol"},{"key":"1571_CR245","doi-asserted-by":"crossref","first-page":"e0125250","DOI":"10.1371\/journal.pone.0125250","volume":"10","author":"E Vecino","year":"2015","unstructured":"Vecino E, Heller JP, Veiga-Crespo P, Martin KR, Fawcett JW (2015) Influence of extracellular matrix components on the expression of integrins and regeneration of adult retinal ganglion cells. PLoS One 10:e0125250","journal-title":"PLoS One"},{"key":"1571_CR246","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.ydbio.2007.09.019","volume":"312","author":"MB Veldman","year":"2007","unstructured":"Veldman MB, Bemben MA, Thompson RC, Goldman D (2007) Gene expression analysis of zebrafish retinal ganglion cells during optic nerve regeneration identifies KLF6a and KLF7a as important regulators of axon regeneration. Dev Biol 312:596\u2013612","journal-title":"Dev Biol"},{"key":"1571_CR247","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.mcn.2010.01.004","volume":"43","author":"MB Veldman","year":"2010","unstructured":"Veldman MB, Bemben MA, Goldman D (2010) Tuba1a gene expression is regulated by KLF6\/7 and is necessary for CNS development and regeneration in zebrafish. Mol Cell Neurosci 43:370\u2013383","journal-title":"Mol Cell Neurosci"},{"key":"1571_CR248","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1523\/JNEUROSCI.07-09-02894.1987","volume":"7","author":"M Vidal-Sanz","year":"1987","unstructured":"Vidal-Sanz M, Bray GM, Villegas-Perez MP, Thanos S, Aguayo AJ (1987) Axonal regeneration and synapse formation in the superior colliculus by retinal ganglion cells in the adult rat. J Neurosci 7:2894\u20132909","journal-title":"J Neurosci"},{"key":"1571_CR249","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1007\/BF01190471","volume":"20","author":"M Vidal-Sanz","year":"1991","unstructured":"Vidal-Sanz M, Bray GM, Aguayo AJ (1991) Regenerated synapses persist in the superior colliculus after the regrowth of retinal ganglion cell axons. J Neurocytol 20:940\u2013952","journal-title":"J Neurocytol"},{"key":"1571_CR250","doi-asserted-by":"crossref","unstructured":"Wang J, Kolomeyer AM, Zarbin MA, Townes-Anderson E (2011) Organotypic culture of full-thickness adult porcine retina. J Vis Exp","DOI":"10.3791\/2655"},{"key":"1571_CR251","first-page":"233","volume":"4","author":"M Watanabe","year":"1997","unstructured":"Watanabe M, Sawai H, Fukuda Y (1997) Survival of axotomized retinal ganglion cells in adult mammals. Clin Neurosci 4:233\u2013239","journal-title":"Clin Neurosci"},{"key":"1571_CR252","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1167\/iovs.03-0406","volume":"45","author":"E Wehrwein","year":"2004","unstructured":"Wehrwein E, Thompson SA, Coulibaly SF, Linn DM, Linn CL (2004) Acetylcholine protection of adult pig retinal ganglion cells from glutamate-induced excitotoxicity. Investig Ophthalmol Vis Sci 45:1531\u20131543","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1571_CR253","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13064-015-0034-x","volume":"10","author":"C Welte","year":"2015","unstructured":"Welte C, Engel S, Stuermer CA (2015) Upregulation of the zebrafish Nogo-A homologue, Rtn4b, in retinal ganglion cells is functionally involved in axon regeneration. Neural Dev 10:6","journal-title":"Neural Dev"},{"key":"1571_CR254","doi-asserted-by":"crossref","first-page":"e0118918","DOI":"10.1371\/journal.pone.0118918","volume":"10","author":"RR Williams","year":"2015","unstructured":"Williams RR, Venkatesh I, Pearse DD, Udvadia AJ, Bunge MB (2015) MASH1\/Ascl1a leads to GAP43 expression and axon regeneration in the adult CNS. PLoS One 10:e0118918","journal-title":"PLoS One"},{"key":"1571_CR255","first-page":"29","volume":"74","author":"DJ Willshaw","year":"1983","unstructured":"Willshaw DJ, Fawcett JW, Gaze RM (1983) The visuotectal projections made by Xenopus \u2018pie slice\u2019 compound eyes. J Embryol Exp Morphol 74:29\u201345","journal-title":"J Embryol Exp Morphol"},{"key":"1571_CR256","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1167\/iovs.02-0715","volume":"44","author":"DY Wu","year":"2003","unstructured":"Wu DY, Zheng JQ, McDonald MA, Chang B, Twiss JL (2003) PKC isozymes in the enhanced regrowth of retinal neurites after optic nerve injury. Investig Ophthalmol Vis Sci 44:2783\u20132790","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1571_CR257","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s11596-011-0389-0","volume":"31","author":"Z Xu","year":"2011","unstructured":"Xu Z, Jiang F, Zeng Y, Alkhodari HT, Chen F (2011) Culture of rat retinal ganglion cells. J Huazhong Univ Sci Technol Med Sci 31:400\u2013403","journal-title":"J Huazhong Univ Sci Technol Med Sci"},{"key":"1571_CR258","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nature10567","volume":"479","author":"T Xue","year":"2011","unstructured":"Xue T, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, Yau KW (2011) Melanopsin signalling in mammalian iris and retina. Nature 479:67\u201373","journal-title":"Nature"},{"key":"1571_CR259","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0168-0102(93)90006-C","volume":"16","author":"D Yanagihara","year":"1993","unstructured":"Yanagihara D, Watanabe S, Takagi S, Mitarai G (1993) Neuroanatomical substrate for the dorsal light response. II. Effects of kainic acid-induced lesions of the valvula cerebelli on the goldfish dorsal light response. Neurosci Res 16:33\u201337","journal-title":"Neurosci Res"},{"key":"1571_CR260","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s11604-016-0533-7","volume":"34","author":"J Yang","year":"2016","unstructured":"Yang J, Li Q, Wang M, Cao X, Ding Y, Wang G, Liao C (2016) Semiquantitative assessment of optic nerve injury using manganese-enhanced MRI. Jpn J Radiol 34:356\u2013365","journal-title":"Jpn J Radiol"},{"key":"1571_CR261","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1017\/S0952523800003746","volume":"10","author":"B Yazejian","year":"1993","unstructured":"Yazejian B, Fain GL (1993) Whole-cell currents activated at nicotinic acetylcholine receptors on ganglion cells isolated from goldfish retina. Vis Neurosci 10:353\u2013361","journal-title":"Vis Neurosci"},{"key":"1571_CR262","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1016\/j.cub.2013.08.015","volume":"23","author":"M Yilmaz","year":"2013","unstructured":"Yilmaz M, Meister M (2013) Rapid innate defensive responses of mice to looming visual stimuli. Curr Biol 23:2011\u20132015","journal-title":"Curr Biol"},{"key":"1571_CR263","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1089\/neu.1996.13.49","volume":"13","author":"E Yoles","year":"1996","unstructured":"Yoles E, Belkin M, Schwartz M (1996) HU-211, a nonpsychotropic cannabinoid, produces short- and long-term neuroprotection after optic nerve axotomy. J Neurotrauma 13:49\u201357","journal-title":"J Neurotrauma"},{"key":"1571_CR264","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF00365930","volume":"7","author":"T Yoshida","year":"1991","unstructured":"Yoshida T, Takeuchi M (1991) Expression of fibronectin and laminin by different types of mouse glial cells cultured in a serum-free medium. Cytotechnology 7:187\u2013196","journal-title":"Cytotechnology"},{"key":"1571_CR265","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s10633-014-9478-2","volume":"130","author":"M Yukita","year":"2015","unstructured":"Yukita M, Machida S, Nishiguchi KM, Tsuda S, Yokoyama Y, Yasuda M, Maruyama K, Nakazawa T (2015) Molecular, anatomical and functional changes in the retinal ganglion cells after optic nerve crush in mice. Doc Ophthalmol Adv Ophthalmol 130:149\u2013156","journal-title":"Doc Ophthalmol Adv Ophthalmol"},{"key":"1571_CR266","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/gt.2015.51","volume":"22","author":"BJ Yungher","year":"2015","unstructured":"Yungher BJ, Luo X, Salgueiro Y, Blackmore MG, Park KK (2015) Viral vector-based improvement of optic nerve regeneration: characterization of individual axons\u2019 growth patterns and synaptogenesis in a visual target. Gene Ther 22:811\u2013821","journal-title":"Gene Ther"},{"key":"1571_CR267","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S1046-2023(02)00263-3","volume":"28","author":"SS Zhang","year":"2002","unstructured":"Zhang SS, Fu XY, Barnstable CJ (2002) Tissue culture studies of retinal development. Methods 28:439\u2013447","journal-title":"Methods"},{"key":"1571_CR268","first-page":"2867","volume":"16","author":"XM Zhang","year":"2010","unstructured":"Zhang XM, Li Liu DT, Chiang SW, Choy KW, Pang CP, Lam DS, Yam GH (2010) Immunopanning purification and long-term culture of human retinal ganglion cells. Mol Vis 16:2867\u20132872","journal-title":"Mol Vis"},{"key":"1571_CR269","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.neuron.2014.08.037","volume":"84","author":"X Zhao","year":"2014","unstructured":"Zhao X, Liu M, Cang J (2014) Visual cortex modulates the magnitude but not the selectivity of looming-evoked responses in the superior colliculus of awake mice. Neuron 84:202\u2013213","journal-title":"Neuron"},{"key":"1571_CR270","doi-asserted-by":"crossref","first-page":"e57280","DOI":"10.1371\/journal.pone.0057280","volume":"8","author":"S Zou","year":"2013","unstructured":"Zou S, Tian C, Ge S, Hu B (2013) Neurogenesis of retinal ganglion cells is not essential to visual functional recovery after optic nerve injury in adult zebrafish. PLoS One 8:e57280","journal-title":"PLoS One"},{"key":"1571_CR271","doi-asserted-by":"crossref","unstructured":"Zou SQ, Tian C, Du ST, Hu B (2014) Retrograde labeling of retinal ganglion cells in adult zebrafish with fluorescent dyes. J Vis Exp","DOI":"10.3791\/50987"}],"container-title":["Brain Structure and Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00429-017-1571-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-017-1571-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-017-1571-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T17:58:36Z","timestamp":1660067916000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00429-017-1571-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,30]]},"references-count":265,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["1571"],"URL":"https:\/\/doi.org\/10.1007\/s00429-017-1571-3","relation":{},"ISSN":["1863-2653","1863-2661"],"issn-type":[{"value":"1863-2653","type":"print"},{"value":"1863-2661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,30]]}}}