{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:19:45Z","timestamp":1792531185100,"version":"4.5.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T00:00:00Z","timestamp":1519776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T00:00:00Z","timestamp":1519776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2R01NSO41489"],"award-info":[{"award-number":["2R01NSO41489"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["5R01DA023999-07 subcontract"],"award-info":[{"award-number":["5R01DA023999-07 subcontract"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Brain Struct Funct"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s00429-018-1621-5","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T06:54:06Z","timestamp":1519800846000},"page":"2361-2375","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Multiple roles of Sonic Hedgehog in the developing human cortex are suggested by its widespread distribution"],"prefix":"10.1007","volume":"223","author":[{"given":"Fani","family":"Memi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Zecevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevena","family":"Radonji\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,28]]},"reference":[{"issue":"10","key":"1621_CR1","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1101\/gad.1543607","volume":"21","author":"BL Allen","year":"2007","unstructured":"Allen BL, Tenzen T, McMahon AP (2007) The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development. Genes Dev 21(10):1244\u20131257. https:\/\/doi.org\/10.1101\/gad.1543607","journal-title":"Genes Dev"},{"issue":"6063","key":"1621_CR2","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1126\/science.1206936","volume":"334","author":"JI Alvarez","year":"2011","unstructured":"Alvarez JI, Dodelet-Devillers A, Kebir H, Ifergan I, Fabre PJ, Terouz S, Sabbagh M, Wosik K, Bourbonniere L, Bernard M, van Horssen J, de Vries HE, Charron F, Prat A (2011) The Hedgehog pathway promotes blood\u2013brain barrier integrity and CNS immune quiescence. Science 334(6063):1727\u20131731. https:\/\/doi.org\/10.1126\/science.1206936","journal-title":"Science"},{"issue":"5","key":"1621_CR700","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1007\/s00429-016-1343-5","volume":"222","author":"A Alzu'bi","year":"2017","unstructured":"Alzu'bi A, Lindsay S, Kerwin J, Looi SJ, Khalil F, Clowry GJ (2017) Distinct cortical and sub-cortical neurogenic domains for GABAergic interneuron precursor transcription factors NKX2.1, OLIG2 and COUP-TFII in early fetal human telencephalon. Brain struct funct 222(5):2309\u20132328. https:\/\/doi.org\/10.1007\/s00429-016-1343-5","journal-title":"Brain struct funct"},{"issue":"2","key":"1621_CR3","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.ajhg.2011.07.001","volume":"89","author":"GU Bae","year":"2011","unstructured":"Bae GU, Domene S, Roessler E, Schachter K, Kang JS, Muenke M, Krauss RS (2011) Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors. Am J Hum Genet 89(2):231\u2013240. https:\/\/doi.org\/10.1016\/j.ajhg.2011.07.001","journal-title":"Am J Hum Genet"},{"issue":"1","key":"1621_CR4","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S1534-5807(03)00394-0","volume":"6","author":"CB Bai","year":"2004","unstructured":"Bai CB, Stephen D, Joyner AL (2004) All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Dev cell 6(1):103\u2013115","journal-title":"Dev cell"},{"issue":"6","key":"1621_CR5","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1016\/j.neuron.2012.10.027","volume":"76","author":"JP Baudoin","year":"2012","unstructured":"Baudoin JP, Viou L, Launay PS, Luccardini C, Espeso Gil S, Kiyasova V, Irinopoulou T, Alvarez C, Rio JP, Boudier T, Lechaire JP, Kessaris N, Spassky N, Metin C (2012) Tangentially migrating neurons assemble a primary cilium that promotes their reorientation to the cortical plate. Neuron 76(6):1108\u20131122. https:\/\/doi.org\/10.1016\/j.neuron.2012.10.027","journal-title":"Neuron"},{"issue":"3","key":"1621_CR6","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/ng1196-353","volume":"14","author":"E Belloni","year":"1996","unstructured":"Belloni E, Muenke M, Roessler E, Traverso G, Siegel-Bartelt J, Frumkin A, Mitchell HF, Donis-Keller H, Helms C, Hing AV, Heng HH, Koop B, Martindale D, Rommens JM, Tsui LC, Scherer SW (1996) Identification of sonic hedgehog as a candidate gene responsible for holoprosencephaly. Nat Genet 14(3):353\u2013356. https:\/\/doi.org\/10.1038\/ng1196-353","journal-title":"Nat Genet"},{"issue":"1","key":"1621_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0893-133X(01)00225-1","volume":"25","author":"FM Benes","year":"2001","unstructured":"Benes FM, Berretta S (2001) GABAergic interneurons: implications for understanding schizophrenia and bipolar disorder. Neuropsychopharmacology 25(1):1\u201327. https:\/\/doi.org\/10.1016\/s0893-133x(01)00225-1","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"1621_CR8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1097\/YPG.0b013e3283586343","volume":"23","author":"ET Betcheva","year":"2013","unstructured":"Betcheva ET, Yosifova AG, Mushiroda T, Kubo M, Takahashi A, Karachanak SK, Zaharieva IT, Hadjidekova SP, Dimova II, Vazharova RV, Stoyanov DS, Milanova VK, Tolev T, Kirov G, Kamatani N, Toncheva DI, Nakamura Y (2013) Whole-genome-wide association study in the Bulgarian population reveals HHAT as schizophrenia susceptibility gene. Psychiatr Genet 23(1):11\u201319. https:\/\/doi.org\/10.1097\/YPG.0b013e3283586343","journal-title":"Psychiatr Genet"},{"issue":"3","key":"1621_CR9","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/nn1396","volume":"8","author":"D Bourikas","year":"2005","unstructured":"Bourikas D, Pekarik V, Baeriswyl T, Grunditz A, Sadhu R, Nardo M, Stoeckli ET (2005) Sonic hedgehog guides commissural axons along the longitudinal axis of the spinal cord. Nat Neurosci 8(3):297\u2013304. https:\/\/doi.org\/10.1038\/nn1396","journal-title":"Nat Neurosci"},{"issue":"1","key":"1621_CR10","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S0092-8674(03)00199-5","volume":"113","author":"F Charron","year":"2003","unstructured":"Charron F, Stein E, Jeong J, McMahon AP, Tessier-Lavigne M (2003) The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell 113(1):11\u201323","journal-title":"Cell"},{"issue":"6599","key":"1621_CR11","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/383407a0","volume":"383","author":"C Chiang","year":"1996","unstructured":"Chiang C, Litingtung Y, Lee E, Young KE, Corden JL, Westphal H, Beachy PA (1996) Cyclopia and defective axial patterning in mice lacking sonic hedgehog gene function. Nature 383(6599):407\u2013413. https:\/\/doi.org\/10.1038\/383407a0","journal-title":"Nature"},{"issue":"2","key":"1621_CR12","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.cub.2006.11.033","volume":"17","author":"V Clement","year":"2007","unstructured":"Clement V, Sanchez P, de Tribolet N, Radovanovic I, Ruiz i Altaba A (2007) HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr Biol 17(2):165\u2013172. https:\/\/doi.org\/10.1016\/j.cub.2006.11.033","journal-title":"Curr Biol"},{"issue":"4","key":"1621_CR900","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1111\/j.1469-7580.2010.01281.x","volume":"27","author":"G Clowry","year":"2010","unstructured":"Clowry G, Molnar Z, Rakic P (2010) Renewed focus on the developing human neocortex. J Anat 217(4):276\u2013288. https:\/\/doi.org\/10.1111\/j.1469-7580.2010.01281.x","journal-title":"J Anat"},{"key":"1621_CR13","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/B978-0-444-54299-1.00011-X","volume":"197","author":"DG Currier","year":"2012","unstructured":"Currier DG, Polk RC, Reeves RH (2012) A sonic hedgehog (Shh) response deficit in trisomic cells may be a common denominator for multiple features of Down syndrome. Prog Brain Res 197:223\u2013236. https:\/\/doi.org\/10.1016\/b978-0-444-54299-1.00011-x","journal-title":"Prog Brain Res"},{"issue":"24","key":"1621_CR14","doi-asserted-by":"crossref","first-page":"5201","DOI":"10.1242\/dev.128.24.5201","volume":"128","author":"N Dahmane","year":"2001","unstructured":"Dahmane N, Sanchez P, Gitton Y, Palma V, Sun T, Beyna M, Weiner H, Ruiz i Altaba A (2001) The sonic hedgehog\u2013Gli pathway regulates dorsal brain growth and tumorigenesis. Development 128(24):5201\u20135212","journal-title":"Development"},{"issue":"2","key":"1621_CR15","doi-asserted-by":"publisher","first-page":"e14680","DOI":"10.1371\/journal.pone.0014680","volume":"6","author":"RK Dave","year":"2011","unstructured":"Dave RK, Ellis T, Toumpas MC, Robson JP, Julian E, Adolphe C, Bartlett PF, Cooper HM, Reynolds BA, Wainwright BJ (2011) Sonic hedgehog and notch signaling can cooperate to regulate neurogenic divisions of neocortical progenitors. PLoS One 6(2):e14680. https:\/\/doi.org\/10.1371\/journal.pone.0014680","journal-title":"PLoS One"},{"issue":"7","key":"1621_CR16","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1016\/0092-8674(93)90627-3","volume":"75","author":"Y Echelard","year":"1993","unstructured":"Echelard Y, Epstein DJ, St-Jacques B, Shen L, Mohler J, McMahon JA, McMahon AP (1993) Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75(7):1417\u20131430","journal-title":"Cell"},{"issue":"5","key":"1621_CR17","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/0092-8674(95)90536-7","volume":"81","author":"J Ericson","year":"1995","unstructured":"Ericson J, Muhr J, Placzek M, Lints T, Jessell TM, Edlund T (1995) Sonic hedgehog induces the differentiation of ventral forebrain neurons: a common signal for ventral patterning within the neural tube. Cell 81(5):747\u2013756","journal-title":"Cell"},{"issue":"7321","key":"1621_CR18","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/nature09612","volume":"468","author":"C Eroglu","year":"2010","unstructured":"Eroglu C, Barres BA (2010) Regulation of synaptic connectivity by glia. Nature 468(7321):223\u2013231. https:\/\/doi.org\/10.1038\/nature09612","journal-title":"Nature"},{"issue":"6275","key":"1621_CR19","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1126\/science.aab3103","volume":"351","author":"WT Farmer","year":"2016","unstructured":"Farmer WT, Abrahamsson T, Chierzi S, Lui C, Zaelzer C, Jones EV, Bally BP, Chen GG, Theroux JF, Peng J, Bourque CW, Charron F, Ernst C, Sjostrom PJ, Murai KK (2016) Neurons diversify astrocytes in the adult brain through sonic hedgehog signaling. Science 351(6275):849\u2013854. https:\/\/doi.org\/10.1126\/science.aab3103","journal-title":"Science"},{"issue":"20","key":"1621_CR20","doi-asserted-by":"publisher","first-page":"5031","DOI":"10.1242\/dev.01349","volume":"131","author":"M Fuccillo","year":"2004","unstructured":"Fuccillo M, Rallu M, McMahon AP, Fishell G (2004) Temporal requirement for hedgehog signaling in ventral telencephalic patterning. Development 131(20):5031\u20135040. https:\/\/doi.org\/10.1242\/dev.01349","journal-title":"Development"},{"issue":"10","key":"1621_CR21","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1038\/nrn1990","volume":"7","author":"M Fuccillo","year":"2006","unstructured":"Fuccillo M, Joyner AL, Fishell G (2006) Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development. Nat Rev Neurosci 7(10):772\u2013783. https:\/\/doi.org\/10.1038\/nrn1990","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"1621_CR22","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.neuron.2013.10.045","volume":"80","author":"DH Geschwind","year":"2013","unstructured":"Geschwind DH, Rakic P (2013) Cortical evolution: judge the brain by its cover. Neuron 80(3):633\u2013647. https:\/\/doi.org\/10.1016\/j.neuron.2013.10.045","journal-title":"Neuron"},{"issue":"2","key":"1621_CR23","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s00213-005-2212-8","volume":"180","author":"A Guidotti","year":"2005","unstructured":"Guidotti A, Auta J, Davis JM, Dong E, Grayson DR, Veldic M, Zhang X, Costa E (2005) GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon. Psychopharmacology 180(2):191\u2013205. https:\/\/doi.org\/10.1007\/s00213-005-2212-8","journal-title":"Psychopharmacology"},{"issue":"24","key":"1621_CR24","doi-asserted-by":"publisher","first-page":"7981","DOI":"10.1523\/JNEUROSCI.16-24-07981.1996","volume":"16","author":"M Hajihosseini","year":"1996","unstructured":"Hajihosseini M, Tham TN, Dubois-Dalcq M (1996) Origin of oligodendrocytes within the human spinal cord. J Neurosci 16(24):7981\u20137994","journal-title":"J Neurosci"},{"issue":"6","key":"1621_CR25","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.neuron.2012.02.009","volume":"73","author":"CC Harwell","year":"2012","unstructured":"Harwell CC, Parker PR, Gee SM, Okada A, McConnell SK, Kreitzer AC, Kriegstein AR (2012) Sonic hedgehog expression in corticofugal projection neurons directs cortical microcircuit formation. Neuron 73(6):1116\u20131126. https:\/\/doi.org\/10.1016\/j.neuron.2012.02.009","journal-title":"Neuron"},{"issue":"4","key":"1621_CR26","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1136\/adc.86.4.293","volume":"86","author":"HS Heussler","year":"2002","unstructured":"Heussler HS, Suri M, Young ID, Muenke M (2002) Extreme variability of expression of a sonic hedgehog mutation: attention difficulties and holoprosencephaly. Arch Dis Child 86(4):293\u2013296","journal-title":"Arch Dis Child"},{"issue":"23","key":"1621_CR27","doi-asserted-by":"publisher","first-page":"3059","DOI":"10.1101\/gad.938601","volume":"15","author":"PW Ingham","year":"2001","unstructured":"Ingham PW, McMahon AP (2001) Hedgehog signaling in animal development: paradigms and principles. Genes Dev 15(23):3059\u20133087. https:\/\/doi.org\/10.1101\/gad.938601","journal-title":"Genes Dev"},{"issue":"6","key":"1621_CR28","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.devcel.2011.04.017","volume":"20","author":"L Izzi","year":"2011","unstructured":"Izzi L, Levesque M, Morin S, Laniel D, Wilkes BC, Mille F, Krauss RS, McMahon AP, Allen BL, Charron F (2011) Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation. Dev Cell 20(6):788\u2013801. https:\/\/doi.org\/10.1016\/j.devcel.2011.04.017","journal-title":"Dev Cell"},{"issue":"2","key":"1621_CR29","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/j.1741-4520.2012.00368.x","volume":"52","author":"M Komada","year":"2012","unstructured":"Komada M (2012) Sonic hedgehog signaling coordinates the proliferation and differentiation of neural stem\/progenitor cells by regulating cell cycle kinetics during development of the neocortex. Congenit Anom (Kyoto) 52(2):72\u201377. https:\/\/doi.org\/10.1111\/j.1741-4520.2012.00368.x","journal-title":"Congenit Anom (Kyoto)"},{"issue":"16","key":"1621_CR30","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.1242\/dev.015891","volume":"135","author":"M Komada","year":"2008","unstructured":"Komada M, Saitsu H, Kinboshi M, Miura T, Shiota K, Ishibashi M (2008) Hedgehog signaling is involved in development of the neocortex. Development 135(16):2717\u20132727. https:\/\/doi.org\/10.1242\/dev.015891","journal-title":"Development"},{"issue":"4","key":"1621_CR31","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1038\/nrn1648","volume":"6","author":"DA Lewis","year":"2005","unstructured":"Lewis DA, Hashimoto T, Volk DW (2005) Cortical inhibitory neurons and schizophrenia. Nat Rev Neurosci 6(4):312\u2013324. https:\/\/doi.org\/10.1038\/nrn1648","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"1621_CR32","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1006\/dbio.2000.0146","volume":"236","author":"Y Liu","year":"2001","unstructured":"Liu Y, May NR, Fan CM (2001) Growth arrest specific gene 1 is a positive growth regulator for the cerebellum. Dev Biol 236(1):30\u201345. https:\/\/doi.org\/10.1006\/dbio.2000.0146","journal-title":"Dev Biol"},{"issue":"6","key":"1621_CR33","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/S0896-6273(03)00561-0","volume":"39","author":"R Machold","year":"2003","unstructured":"Machold R, Hayashi S, Rutlin M, Muzumdar MD, Nery S, Corbin JG, Gritli-Linde A, Dellovade T, Porter JA, Rubin LL, Dudek H, McMahon AP, Fishell G (2003) Sonic hedgehog Is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron 39(6):937\u2013950. https:\/\/doi.org\/10.1016\/S0896-6273(03)00561-0","journal-title":"Neuron"},{"issue":"2","key":"1621_CR34","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1523\/JNEUROSCI.4445-12.2013","volume":"33","author":"S Malik","year":"2013","unstructured":"Malik S, Vinukonda G, Vose LR, Diamond D, Bhimavarapu BB, Hu F, Zia MT, Hevner R, Zecevic N, Ballabh P (2013) Neurogenesis continues in the third trimester of pregnancy and is suppressed by premature birth. J Neurosci 33(2):411\u2013423. https:\/\/doi.org\/10.1523\/jneurosci.4445-12.2013","journal-title":"J Neurosci"},{"issue":"1","key":"1621_CR62","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1006\/geno.1995.1104","volume":"28","author":"V Marigo","year":"1995","unstructured":"Marigo V, Roberts DJ, Lee SM, Tsukurov O, Levi T, Gastier JM, Epstein DJ, Gilbert DJ, Copeland NG, Seidman CE et al (1995) Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog. Genomics 28(1):44\u201351","journal-title":"Genomics"},{"issue":"5","key":"1621_CR35","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.stem.2013.04.008","volume":"12","author":"AM Maroof","year":"2013","unstructured":"Maroof AM, Keros S, Tyson JA, Ying SW, Ganat YM, Merkle FT, Liu B, Goulburn A, Stanley EG, Elefanty AG, Widmer HR, Eggan K, Goldstein PA, Anderson SA, Studer L (2013) Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells. Cell Stem Cell 12(5):559\u2013572. https:\/\/doi.org\/10.1016\/j.stem.2013.04.008","journal-title":"Cell Stem Cell"},{"issue":"10","key":"1621_CR36","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1101\/gad.1546307","volume":"21","author":"DC Martinelli","year":"2007","unstructured":"Martinelli DC, Fan CM (2007) Gas1 extends the range of Hedgehog action by facilitating its signaling. Genes Dev 21(10):1231\u20131243. https:\/\/doi.org\/10.1101\/gad.1546307","journal-title":"Genes Dev"},{"issue":"7215","key":"1621_CR37","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1038\/nature07358","volume":"455","author":"JS McLellan","year":"2008","unstructured":"McLellan JS, Zheng X, Hauk G, Ghirlando R, Beachy PA, Leahy DJ (2008) The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. Nature 455(7215):979\u2013983. https:\/\/doi.org\/10.1038\/nature07358","journal-title":"Nature"},{"issue":"7495","key":"1621_CR38","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/nature13185","volume":"508","author":"JA Miller","year":"2014","unstructured":"Miller JA, Ding SL, Sunkin SM, Smith KA, Ng L, Szafer A, Ebbert A, Riley ZL, Royall JJ, Aiona K, Arnold JM, Bennet C, Bertagnolli D, Brouner K, Butler S, Caldejon S, Carey A, Cuhaciyan C, Dalley RA, Dee N, Dolbeare TA, Facer BA, Feng D, Fliss TP, Gee G, Goldy J, Gourley L, Gregor BW, Gu G, Howard RE, Jochim JM, Kuan CL, Lau C, Lee CK, Lee F, Lemon TA, Lesnar P, McMurray B, Mastan N, Mosqueda N, Naluai-Cecchini T, Ngo NK, Nyhus J, Oldre A, Olson E, Parente J, Parker PD, Parry SE, Stevens A, Pletikos M, Reding M, Roll K, Sandman D, Sarreal M, Shapouri S, Shapovalova NV, Shen EH, Sjoquist N, Slaughterbeck CR, Smith M, Sodt AJ, Williams D, Zollei L, Fischl B, Gerstein MB, Geschwind DH, Glass IA, Hawrylycz MJ, Hevner RF, Huang H, Jones AR, Knowles JA, Levitt P, Phillips JW, Sestan N, Wohnoutka P, Dang C, Bernard A, Hohmann JG, Lein ES (2014) Transcriptional landscape of the prenatal human brain. Nature 508(7495):199\u2013206. https:\/\/doi.org\/10.1038\/nature13185","journal-title":"Nature"},{"issue":"13","key":"1621_CR39","doi-asserted-by":"publisher","first-page":"2479","DOI":"10.1093\/hmg\/8.13.2479","volume":"8","author":"L Nanni","year":"1999","unstructured":"Nanni L, Ming JE, Bocian M, Steinhaus K, Bianchi DW, Die-Smulders C, Giannotti A, Imaizumi K, Jones KL, Campo MD, Martin RA, Meinecke P, Pierpont ME, Robin NH, Young ID, Roessler E, Muenke M (1999) The mutational spectrum of the sonic hedgehog gene in holoprosencephaly: SHH mutations cause a significant proportion of autosomal dominant holoprosencephaly. Hum Mol Genet 8(13):2479\u20132488","journal-title":"Hum Mol Genet"},{"issue":"9","key":"1621_CR40","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1093\/hmg\/8.9.1683","volume":"8","author":"S Odent","year":"1999","unstructured":"Odent S, Atti-Bitach T, Blayau M, Mathieu M, Aug J, Delezo de AL, Gall JY, Le Marec B, Munnich A, David V, Vekemans M (1999) Expression of the sonic hedgehog (SHH) gene during early human development and phenotypic expression of new mutations causing holoprosencephaly. Hum Mol Genet 8(9):1683\u20131689","journal-title":"Hum Mol Genet"},{"issue":"7117","key":"1621_CR41","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/nature05246","volume":"444","author":"A Okada","year":"2006","unstructured":"Okada A, Charron F, Morin S, Shin DS, Wong K, Fabre PJ, Tessier-Lavigne M, McConnell SK (2006) Boc is a receptor for sonic hedgehog in the guidance of commissural axons. Nature 444(7117):369\u2013373. https:\/\/doi.org\/10.1038\/nature05246","journal-title":"Nature"},{"key":"1621_CR42","doi-asserted-by":"publisher","first-page":"254","DOI":"10.3389\/fncel.2013.00254","volume":"7","author":"JA Ortega","year":"2013","unstructured":"Ortega JA, Radonjic NV, Zecevic N (2013) Sonic hedgehog promotes generation and maintenance of human forebrain Olig2 progenitors. Front Cell Neurosci 7:254. https:\/\/doi.org\/10.3389\/fncel.2013.00254","journal-title":"Front Cell Neurosci"},{"issue":"2","key":"1621_CR43","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s00439-011-1078-6","volume":"131","author":"DE Pineda-Alvarez","year":"2012","unstructured":"Pineda-Alvarez DE, Roessler E, Hu P, Srivastava K, Solomon BD, Siple CE, Fan CM, Muenke M (2012) Missense substitutions in the GAS1 protein present in holoprosencephaly patients reduce the affinity for its ligand, SHH. Hum Genet 131(2):301\u2013310. https:\/\/doi.org\/10.1007\/s00439-011-1078-6","journal-title":"Hum Genet"},{"issue":"1","key":"1621_CR44","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.cell.2015.09.004","volume":"163","author":"AA Pollen","year":"2015","unstructured":"Pollen AA, Nowakowski Tomasz J, Chen J, Retallack H, Sandoval-Espinosa C, Nicholas Cory R, Shuga J, Liu Siyuan J, Oldham Michael C, Diaz A, Lim Daniel A, Leyrat Anne A, West Jay A, Kriegstein Arnold R (2015) Molecular Identity of human outer radial glia during cortical development. Cell 163(1):55\u201367. https:\/\/doi.org\/10.1016\/j.cell.2015.09.004","journal-title":"Cell"},{"issue":"6","key":"1621_CR45","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.1016\/j.celrep.2014.11.026","volume":"9","author":"NV Radonjic","year":"2014","unstructured":"Radonjic NV, Ayoub AE, Memi F, Yu X, Maroof A, Jakovcevski I, Anderson SA, Rakic P, Zecevic N (2014) Diversity of cortical interneurons in primates: the role of the dorsal proliferative niche. Cell Rep 9(6):2139\u20132151. https:\/\/doi.org\/10.1016\/j.celrep.2014.11.026","journal-title":"Cell Rep"},{"issue":"1","key":"1621_CR46","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1093\/cercor\/bhu183","volume":"26","author":"NV Radonjic","year":"2016","unstructured":"Radonjic NV, Memi F, Ortega JA, Glidden N, Zhan H, Zecevic N (2016) The role of sonic hedgehog in the specification of human cortical progenitors in vitro. Cereb cortex 26(1):131\u2013143. https:\/\/doi.org\/10.1093\/cercor\/bhu183","journal-title":"Cereb cortex"},{"issue":"6226","key":"1621_CR47","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1126\/science.1260943","volume":"347","author":"SK Reilly","year":"2015","unstructured":"Reilly SK, Yin J, Ayoub AE, Emera D, Leng J, Cotney J, Sarro R, Rakic P, Noonan JP (2015) Evolutionary genomics. Evolutionary changes in promoter and enhancer activity during human corticogenesis. Science 347(6226):1155\u20131159. https:\/\/doi.org\/10.1126\/science.1260943","journal-title":"Science"},{"issue":"7","key":"1621_CR48","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1002\/ajmg.a.33466","volume":"152a","author":"LA Ribeiro","year":"2010","unstructured":"Ribeiro LA, Quiezi RG, Nascimento A, Bertolacini CP, Richieri-Costa A (2010) Holoprosencephaly and holoprosencephaly-like phenotype and GAS1 DNA sequence changes: report of four Brazilian patients. Am J Med Genet A 152a(7):1688\u20131694. https:\/\/doi.org\/10.1002\/ajmg.a.33466","journal-title":"Am J Med Genet A"},{"issue":"19","key":"1621_CR49","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1002\/ajmg.a.31311","volume":"140","author":"G Santiago","year":"2006","unstructured":"Santiago G, Abramides DV, De-Vitto LP, Ribeiro LA, Meira SG Jr, Richieri-Costa A (2006) Language skills and neuropsychological performance in patients with SHH mutations and a holoprosencephaly-like phenotype. Am J Med Genet A 140(19):2085\u20132090. https:\/\/doi.org\/10.1002\/ajmg.a.31311","journal-title":"Am J Med Genet A"},{"key":"1621_CR50","doi-asserted-by":"publisher","first-page":"e623","DOI":"10.1038\/tp.2015.115","volume":"5","author":"LD Selemon","year":"2015","unstructured":"Selemon LD, Zecevic N (2015) Schizophrenia: a tale of two critical periods for prefrontal cortical development. Transl Psychiatry 5:e623. https:\/\/doi.org\/10.1038\/tp.2015.115","journal-title":"Transl Psychiatry"},{"issue":"6","key":"1621_CR51","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1172\/JCI32032","volume":"117","author":"M Seppala","year":"2007","unstructured":"Seppala M, Depew MJ, Martinelli DC, Fan CM, Sharpe PT, Cobourne MT (2007) Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog. J Clin Invest 117(6):1575\u20131584. https:\/\/doi.org\/10.1172\/jci32032","journal-title":"J Clin Invest"},{"issue":"2","key":"1621_CR53","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.neuron.2015.12.008","volume":"89","author":"JC Silbereis","year":"2016","unstructured":"Silbereis JC, Pochareddy S, Zhu Y, Li M, Sestan N (2016) The cellular and molecular landscapes of the developing human central nervous system. Neuron 89(2):248\u2013268. https:\/\/doi.org\/10.1016\/j.neuron.2015.12.008","journal-title":"Neuron"},{"issue":"13","key":"1621_CR54","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1242\/dev.128.13.2545","volume":"128","author":"N Tekki-Kessaris","year":"2001","unstructured":"Tekki-Kessaris N, Woodruff R, Hall AC, Gaffield W, Kimura S, Stiles CD, Rowitch DH, Richardson WD (2001) Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon. Development 128(13):2545\u20132554","journal-title":"Development"},{"issue":"5","key":"1621_CR55","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.devcel.2006.04.004","volume":"10","author":"T Tenzen","year":"2006","unstructured":"Tenzen T, Allen BL, Cole F, Kang JS, Krauss RS, McMahon AP (2006) The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev Cell 10(5):647\u2013656. https:\/\/doi.org\/10.1016\/j.devcel.2006.04.004","journal-title":"Dev Cell"},{"issue":"7","key":"1621_CR56","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1242\/dev.111526","volume":"142","author":"JA Tyson","year":"2015","unstructured":"Tyson JA, Goldberg EM, Maroof AM, Xu Q, Petros TJ, Anderson SA (2015) Duration of culture and sonic hedgehog signaling differentially specify PV versus SST cortical interneuron fates from embryonic stem cells. Development 142(7):1267\u20131278. https:\/\/doi.org\/10.1242\/dev.111526","journal-title":"Development"},{"issue":"7","key":"1621_CR57","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1038\/nn.4307","volume":"19","author":"L Wang","year":"2016","unstructured":"Wang L, Hou S, Han YG (2016a) Hedgehog signaling promotes basal progenitor expansion and the growth and folding of the neocortex. Nat Neurosci 19(7):888\u2013896 https:\/\/doi.org\/10.1038\/nn.4307","journal-title":"Nat Neurosci"},{"key":"1621_CR58","doi-asserted-by":"publisher","first-page":"10481","DOI":"10.1038\/ncomms10481","volume":"7","author":"Y Wang","year":"2016","unstructured":"Wang Y, Wu Q, Yang P, Wang C, Liu J, Ding W, Liu W, Bai Y, Yang Y, Wang H, Gao S, Wang X (2016b) LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain. Nat Commun 7:10481. https:\/\/doi.org\/10.1038\/ncomms10481","journal-title":"Nat Commun"},{"issue":"22","key":"1621_CR59","doi-asserted-by":"publisher","first-page":"4987","DOI":"10.1242\/dev.02090","volume":"132","author":"Q Xu","year":"2005","unstructured":"Xu Q, Wonders CP, Anderson SA (2005) Sonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon. Development 132(22):4987\u20134998. https:\/\/doi.org\/10.1242\/dev.02090","journal-title":"Development"},{"issue":"3","key":"1621_CR60","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.neuron.2009.03.022","volume":"62","author":"PT Yam","year":"2009","unstructured":"Yam PT, Langlois SD, Morin S, Charron F (2009) Sonic hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathway. Neuron 62(3):349\u2013362. https:\/\/doi.org\/10.1016\/j.neuron.2009.03.022","journal-title":"Neuron"},{"issue":"5","key":"1621_CR61","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.devcel.2006.04.005","volume":"10","author":"W Zhang","year":"2006","unstructured":"Zhang W, Kang JS, Cole F, Yi MJ, Krauss RS (2006) Cdo functions at multiple points in the sonic hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly. Dev cell 10(5):657\u2013665. https:\/\/doi.org\/10.1016\/j.devcel.2006.04.005","journal-title":"Dev cell"}],"container-title":["Brain Structure and Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00429-018-1621-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-018-1621-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-018-1621-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:09:27Z","timestamp":1660522167000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00429-018-1621-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,28]]},"references-count":63,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["1621"],"URL":"https:\/\/doi.org\/10.1007\/s00429-018-1621-5","relation":{},"ISSN":["1863-2653","1863-2661"],"issn-type":[{"value":"1863-2653","type":"print"},{"value":"1863-2661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,28]]},"assertion":[{"value":"29 September 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Tissue was obtained from the Human Fetal Tissue Repository at the Albert Einstein College of Medicine (Bronx), Advanced Bioscience Resources (Alameda, CA), StemEx (Diamond Springs, CA, USA) and the joint MRC\/Wellcome Trust-funded Human Developmental Biology Resource () after legal abortions with informed maternal written consent and approval from the Ethics Committees of the participating institutions. All human material was handled with special care and in accordance with the ethical standards set by the Ethics Committee of the University of Connecticut and the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This work was funded by NIH Grants 2R01NSO41489 and Subcontract 5R01DA023999-07(NZ).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}