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To address this issue, we investigated male mice haplodeficient for GAD67 (<jats:italic>GAD67<\/jats:italic><jats:sup>+<jats:italic>\/GFP<\/jats:italic><\/jats:sup> mice), which showed a reduced social interaction, social dominance and increased immobility in the forced swim test. No differences were found in rotarod performance and sensorimotor gating. We also addressed potential effects of social deprivation, which is known, during early life, to affect GABAergic function and induces behavioral abnormalities similar to the symptoms found in psychiatric disorders. Indeed, social isolation of <jats:italic>GAD67<\/jats:italic><jats:sup>+<jats:italic>\/GFP<\/jats:italic><\/jats:sup> mice provoked increased rearing activity in the social interaction test and hyperlocomotion on elevated plus maze. Since GABA closely interacts with the dopaminergic, serotonergic and cholinergic neurotransmitter systems, we investigated <jats:italic>GAD67<\/jats:italic><jats:sup>+<jats:italic>\/GFP<\/jats:italic><\/jats:sup> and <jats:italic>GAD67<\/jats:italic><jats:sup>+<jats:italic>\/<\/jats:italic>+<\/jats:sup> mice for morphological markers of the latter systems and found increased tyrosine hydroxylase (TH)-IR fiber densities in CA1 of dorsal hippocampus. By contrast, no differences in numbers and densities of TH-positive neurons of the midbrain dopamine regions, serotonin (5-HT) neurons of the raphe nuclei, or choline acetyltransferase (ChAT)-expressing neurons of basal forebrain and their respective terminal fields were observed. Our results indicate that GAD67 haplodeficiency impairs sociability and increases vulnerability to social stress, provokes depressive-like behavior and alters the catecholaminergic innervation in brain areas associated with schizophrenia. <jats:italic>GAD67<\/jats:italic><jats:sup>+<jats:italic>\/GFP<\/jats:italic><\/jats:sup> mice may provide a useful model for studying the impact of GABAergic dysfunction as related to neuropsychiatric disorders.<\/jats:p>","DOI":"10.1007\/s00429-020-02087-6","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T12:05:40Z","timestamp":1591617940000},"page":"1719-1742","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Glutamic acid decarboxylase 67 haplodeficiency in mice: consequences of postweaning social isolation on behavior and changes in brain neurochemical systems"],"prefix":"10.1007","volume":"225","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2162-116X","authenticated-orcid":false,"given":"Sven","family":"Nullmeier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Elmers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"D\u2019Hanis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran Veer Kaur","family":"Sandhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Stork","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchio","family":"Yanagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Panther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Schwegler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,8]]},"reference":[{"issue":"8","key":"2087_CR1","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1016\/j.euroneuro.2015.04.025","volume":"25","author":"CG Abdallah","year":"2015","unstructured":"Abdallah CG, Jackowski A, Sato JR, Mao X, Kang G, Cheema R, Coplan JD, Mathew SJ, Shungu DC (2015) Prefrontal cortical GABA abnormalities are associated with reduced hippocampal volume in major depressive disorder. 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