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Proper development of inhibitory interneurons is crucial for sensory function. Here we report a timeline of Parvalbumin-positive (PV<jats:sup>+<\/jats:sup>) interneuron development in the three most important sensory cortical areas in the <jats:italic>Ehmt1<\/jats:italic><jats:sup>+<jats:italic>\/<\/jats:italic>\u2212<\/jats:sup> mouse. We find a hitherto unreported delay of PV<jats:sup>+<\/jats:sup> neuron maturation early in sensory development, with layer- and region-specific variability later in development. The delayed PV<jats:sup>+<\/jats:sup> maturation is also reflected in a delayed maturation of GABAergic transmission in <jats:italic>Ehmt1<\/jats:italic><jats:sup>+<jats:italic>\/<\/jats:italic>\u2212<\/jats:sup> auditory cortex, where we find a reduced GABA release probability specifically in putative PV<jats:sup>+<\/jats:sup> synapses. Together with earlier reports of excitatory impairments in <jats:italic>Ehmt1<\/jats:italic><jats:sup>+<jats:italic>\/<\/jats:italic>\u2212<\/jats:sup> neurons, we propose a shift in excitatory-inhibitory balance towards overexcitability in <jats:italic>Ehmt1<\/jats:italic><jats:sup>+<jats:italic>\/<\/jats:italic>\u2212<\/jats:sup> sensory cortices as a consequence of early deficits in inhibitory maturation.<\/jats:p>","DOI":"10.1007\/s00429-020-02149-9","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T05:02:22Z","timestamp":1601010142000},"page":"2701-2716","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["EHMT1 regulates Parvalbumin-positive interneuron development and GABAergic input in sensory cortical areas"],"prefix":"10.1007","volume":"225","author":[{"given":"Moritz","family":"Negwer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karol","family":"Piera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"Hesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"L\u00fctje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Aarts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Schubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7448-9289","authenticated-orcid":false,"given":"Nael","family":"Nadif Kasri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"2149_CR1","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.neuron.2018.12.026","volume":"101","author":"MW Antoine","year":"2019","unstructured":"Antoine MW, Langberg T, Schnepel P, Feldman DE (2019) Increased excitation-inhibition ratio stabilizes synapse and circuit excitability in four autism mouse models. 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