{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:49:38Z","timestamp":1740145778649,"version":"3.37.3"},"reference-count":99,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Brain Struct Funct"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s00429-020-02159-7","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T18:03:07Z","timestamp":1604080987000},"page":"2799-2813","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intravenous infusion of bone marrow mononuclear cells promotes functional recovery and improves impaired cognitive function via inhibition of Rho guanine nucleotide triphosphatases and inflammatory signals in a model of chronic epilepsy"],"prefix":"10.1007","volume":"225","author":[{"given":"Zaquer Suzana Munhoz","family":"Costa-Ferro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gutierre Neves","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele Vieira","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Rodrigo","family":"Marinowic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise Cantarelli","family":"Machado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz Monteiro","family":"Longo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6776-1515","authenticated-orcid":false,"given":"Jaderson Costa","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"key":"2159_CR1","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1002\/stem.2029","volume":"33","author":"S Agadi","year":"2015","unstructured":"Agadi S, Shetty AK (2015) Concise review: prospects of bone marrow mononuclear cells and mesenchymal stem cells for treating status epilepticus and chronic epilepsy. Stem Cells 33:2093\u20132103. https:\/\/doi.org\/10.1002\/stem.2029","journal-title":"Stem Cells"},{"key":"2159_CR2","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nrn.2017.45","volume":"18","author":"C Anacker","year":"2017","unstructured":"Anacker C, Hen R (2017) Adult hippocampal neurogenesis and cognitive flexibility\u2014linking memory and mood. Nat Rev Neurosci 18:335\u2013346. https:\/\/doi.org\/10.1038\/nrn.2017.45","journal-title":"Nat Rev Neurosci"},{"key":"2159_CR3","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/scrt93","volume":"3","author":"S Arnous","year":"2012","unstructured":"Arnous S, Mozid A, Martin J, Mathur A (2012) Bone marrow mononuclear cells and acute myocardial infarction. Stem Cell Res Ther 3:2. https:\/\/doi.org\/10.1186\/scrt93","journal-title":"Stem Cell Res Ther"},{"key":"2159_CR4","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1002\/glia.22312","volume":"60","author":"E Aronica","year":"2012","unstructured":"Aronica E, Ravizza T, Zurolo E, Vezzani A (2012) Astrocyte immune responses in epilepsy. Glia 60:1258\u20131268. https:\/\/doi.org\/10.1002\/glia.22312","journal-title":"Glia"},{"key":"2159_CR5","doi-asserted-by":"publisher","unstructured":"Autieri MV (1996) cDNA cloning of human allograft inflammatory factor-1: tissue distribution, cytokine induction, and mRNA expression in injured rat carotid arteries. Biochem Biophys Res Commun 228:29\u201337 https:\/\/doi.org\/10.1006\/bbrc.1996.1612","DOI":"10.1006\/bbrc.1996.1612"},{"key":"2159_CR6","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.yebeh.2019.05.036","volume":"97","author":"E Bartolini","year":"2019","unstructured":"Bartolini E, Sander JW (2019) Dealing with the storm: an overview of seizure precipitants and spontaneous seizure worsening in drug-resistant epilepsy. Epilepsy Behav 97:212\u2013218. https:\/\/doi.org\/10.1016\/j.yebeh.2019.05.036","journal-title":"Epilepsy Behav"},{"key":"2159_CR7","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1002\/stem.1510","volume":"31","author":"IS Behbahan","year":"2013","unstructured":"Behbahan IS, Keating A, Gale RP (2013) Concise review: bone marrow autotransplants for liver disease? Stem Cells 31:2313\u20132329. https:\/\/doi.org\/10.1002\/stem.1510","journal-title":"Stem Cells"},{"key":"2159_CR8","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/361031a0","volume":"361","author":"TV Bliss","year":"1993","unstructured":"Bliss TV, Collingridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31\u201339. https:\/\/doi.org\/10.1038\/361031a0","journal-title":"Nature"},{"key":"2159_CR9","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1113\/jphysiol.1973.sp010273","volume":"232","author":"TV Bliss","year":"1973","unstructured":"Bliss TV, Lomo T (1973) Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol 232:331\u2013356. https:\/\/doi.org\/10.1113\/jphysiol.1973.sp010273","journal-title":"J Physiol"},{"key":"2159_CR10","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3389\/fncel.2013.00109","volume":"7","author":"D Boison","year":"2013","unstructured":"Boison D, Sandau US, Ruskin DN, Kawamura M Jr, Masino SA (2013) Homeostatic control of brain function\u2014new approaches to understand epileptogenesis. Front Cell Neurosci 7:109. https:\/\/doi.org\/10.3389\/fncel.2013.00109","journal-title":"Front Cell Neurosci"},{"key":"2159_CR11","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/978-94-017-8914-1_13","volume":"813","author":"PS Buckmaster","year":"2014","unstructured":"Buckmaster PS (2014) Does mossy fiber sprouting give rise to the epileptic state? Adv Exp Med Biol 813:161\u2013168. https:\/\/doi.org\/10.1007\/978-94-017-8914-1_13","journal-title":"Adv Exp Med Biol"},{"key":"2159_CR12","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1111\/j.1528-1157.1991.tb05533.x","volume":"32","author":"EA Cavalheiro","year":"1991","unstructured":"Cavalheiro EA, Leite JP, Bortolotto ZA, Turski WA, Ikonomidou C, Turski L (1991) Long-term effects of pilocarpine in rats: structural damage of the brain triggers kindling and spontaneous I recurrent seizures. Epilepsia 32:778\u2013782. https:\/\/doi.org\/10.1111\/j.1528-1157.1991.tb05533.x","journal-title":"Epilepsia"},{"key":"2159_CR13","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/0165-3806(87)90227-6","volume":"37","author":"EA Cavalheiro","year":"1987","unstructured":"Cavalheiro EA, Silva DF, Turski WA, Calderazzo-Filho LS, Bortolotto ZA, Turski L (1987) The susceptibility of rats to pilocarpine-induced seizures is age-dependent. Dev Brain Res 37:43\u201358. https:\/\/doi.org\/10.1016\/0165-3806(87)90227-6","journal-title":"Dev Brain Res"},{"key":"2159_CR14","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.3389\/fneur.2018.01023","volume":"9","author":"CF Cavarsan","year":"2018","unstructured":"Cavarsan CF, Malheiros J, Hamani C, Najm I, Covolan L (2018) Is mossy fiber sprouting a potential therapeutic target for epilepsy? Front Neurol 9:1023. https:\/\/doi.org\/10.3389\/fneur.2018.01023","journal-title":"Front Neurol"},{"key":"2159_CR15","doi-asserted-by":"publisher","unstructured":"Choi EK et al. (2017) Regulation of RhoA GTPase and novel target proteins for ROCK Small GTPases. https:\/\/doi.org\/10.1080\/21541248.2017.1364831","DOI":"10.1080\/21541248.2017.1364831"},{"key":"2159_CR16","doi-asserted-by":"publisher","unstructured":"Costa-Ferro ZS et al. (2012) Transplantation of bone marrow mononuclear cells decreases seizure incidence, mitigates neuronal loss and modulates pro-inflammatory cytokine production in epileptic rats. Neurobiol Dis 46:302\u2013313. https:\/\/doi.org\/10.1016\/j.nbd.2011.12.001","DOI":"10.1016\/j.nbd.2011.12.001"},{"key":"2159_CR17","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.seizure.2009.12.003","volume":"19","author":"ZS Costa-Ferro","year":"2010","unstructured":"Costa-Ferro ZS et al (2010) Prevention of seizures and reorganization of hippocampal functions by transplantation of bone marrow cells in the acute phase of experimental epilepsy. Seizure 19:84\u201392. https:\/\/doi.org\/10.1016\/j.seizure.2009.12.003","journal-title":"Seizure"},{"key":"2159_CR18","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s10616-013-9557-3","volume":"66","author":"ZSM Costa-Ferro","year":"2014","unstructured":"Costa-Ferro ZSM et al (2014) Antiepileptic and neuroprotective effects of human umbilical cord blood mononuclear cells in a pilocarpine-induced epilepsy model. Cytotechnology 66:193\u2013199. https:\/\/doi.org\/10.1007\/s10616-013-9557-3","journal-title":"Cytotechnology"},{"key":"2159_CR19","doi-asserted-by":"publisher","unstructured":"Council NR (2011) Guide for the care and use of laboratory animals: eighth edition. The National Academies Press, Washington, DC. https:\/\/doi.org\/10.17226\/12910","DOI":"10.17226\/12910"},{"key":"2159_CR20","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/s0920-1211(99)00119-9","volume":"39","author":"L Covolan","year":"2000","unstructured":"Covolan L, Mello LEAM (2000) Temporal profile of neuronal injury following pilocarpine or kainic acid-induced status epilepticus. Epilepsy Res 39:133\u2013152. https:\/\/doi.org\/10.1016\/s0920-1211(99)00119-9","journal-title":"Epilepsy Res"},{"key":"2159_CR21","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.jneumeth.2008.04.019","volume":"172","author":"G Curia","year":"2008","unstructured":"Curia G, Longo D, Biagini G, Jones RS, Avoli M (2008) The pilocarpine model of temporal lobe epilepsy. J Neurosci Methods 172:143\u2013157. https:\/\/doi.org\/10.1016\/j.jneumeth.2008.04.019","journal-title":"J Neurosci Methods"},{"key":"2159_CR22","doi-asserted-by":"publisher","first-page":"e648","DOI":"10.1002\/term.2334","volume":"12","author":"JC DaCosta","year":"2018","unstructured":"DaCosta JC et al (2018) Safety and seizure control in patients with mesial temporal lobe epilepsy treated with regional superselective intra-arterial injection of autologous bone marrow mononuclear cells. J Tissue Eng Regen Med 12:e648\u2013e656. https:\/\/doi.org\/10.1002\/term.2334","journal-title":"J Tissue Eng Regen Med"},{"key":"2159_CR23","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.bbrc.2004.08.004","volume":"322","author":"PK Dash","year":"2004","unstructured":"Dash PK, Orsi SA, Moody M, Moore AN (2004) A role for hippocampal Rho-ROCK pathway in long-term spatial memory. Biochem Biophys Res Commun 322:893\u2013898. https:\/\/doi.org\/10.1016\/j.bbrc.2004.08.004","journal-title":"Biochem Biophys Res Commun"},{"key":"2159_CR24","doi-asserted-by":"publisher","unstructured":"de Oliveira DL et al. (2008) Effects of early-life LiCl-pilocarpine-induced status epilepticus on memory and anxiety in adult rats are associated with mossy fiber sprouting and elevated CSF S100B protein Epilepsia 49:842\u2013852. https:\/\/doi.org\/10.1111\/j.1528-1167.2007.01484.x","DOI":"10.1111\/j.1528-1167.2007.01484.x"},{"key":"2159_CR25","doi-asserted-by":"publisher","unstructured":"de Vargas LDS et al. (2017) Methylprednisolone as a memory enhancer in rats: Effects on aversive memory, long-term potentiation and calcium influx Brain Res 1670:44\u201351 https:\/\/doi.org\/10.1016\/j.brainres.2017.06.007","DOI":"10.1016\/j.brainres.2017.06.007"},{"key":"2159_CR26","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.neubiorev.2016.02.007","volume":"63","author":"EE de Vries","year":"2016","unstructured":"de Vries EE, van den Munckhof B, Braun KP, van Royen-Kerkhof A, de Jager W, Jansen FE (2016) Inflammatory mediators in human epilepsy: a systematic review and meta-analysis. Neurosci Biobehav Rev 63:177\u2013190. https:\/\/doi.org\/10.1016\/j.neubiorev.2016.02.007","journal-title":"Neurosci Biobehav Rev"},{"key":"2159_CR27","doi-asserted-by":"publisher","unstructured":"do Prado-Lima PAS et al. (2019) The antidepressant effect of bone marrow mononuclear cell transplantation in chronic stress. J Psychopharmacol 33:632\u2013639 doi:https:\/\/doi.org\/10.1177\/0269881119841562","DOI":"10.1177\/0269881119841562"},{"key":"2159_CR28","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.eplepsyres.2018.02.008","volume":"141","author":"S Fukumura","year":"2018","unstructured":"Fukumura S et al (2018) Intravenous infusion of mesenchymal stem cells reduces epileptogenesis in a rat model of status epilepticus. Epilepsy Res 141:56\u201363. https:\/\/doi.org\/10.1016\/j.eplepsyres.2018.02.008","journal-title":"Epilepsy Res"},{"key":"2159_CR29","doi-asserted-by":"publisher","unstructured":"Furini CR, Myskiw JC, Schmidt BE, Marcondes LA, Izquierdo I (2014) D1 and D5 dopamine receptors participate on the consolidation of two different memories. Behav Brain Res 271:212\u2013217 doi:https:\/\/doi.org\/10.1016\/j.bbr.2014.06.027","DOI":"10.1016\/j.bbr.2014.06.027"},{"key":"2159_CR30","doi-asserted-by":"publisher","first-page":"700","DOI":"10.2174\/1389201019666181017161752","volume":"19","author":"G Guerra","year":"2018","unstructured":"Guerra G, Perrotta F, Testa G (2018) Circulating endothelial progenitor cells biology and regenerative medicine in pulmonary vascular diseases. Curr Pharm Biotechnol 19:700\u2013707. https:\/\/doi.org\/10.2174\/1389201019666181017161752","journal-title":"Curr Pharm Biotechnol"},{"key":"2159_CR31","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1126\/science.279.5350.509","volume":"279","author":"A Hall","year":"1998","unstructured":"Hall A (1998) Rho GTPases and the actin cytoskeleton. Science 279:509\u2013514. https:\/\/doi.org\/10.1126\/science.279.5350.509","journal-title":"Science"},{"key":"2159_CR32","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1042\/BST20120103","volume":"40","author":"A Hall","year":"2012","unstructured":"Hall A (2012) Rho family GTPases. Biochem Soc Trans 40:1378\u20131382. https:\/\/doi.org\/10.1042\/BST20120103","journal-title":"Biochem Soc Trans"},{"key":"2159_CR33","doi-asserted-by":"publisher","unstructured":"Harney SM et al. (2008) Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis Rheumatology (Oxford) 47:1761\u20131767. https:\/\/doi.org\/10.1093\/rheumatology\/ken376","DOI":"10.1093\/rheumatology\/ken376"},{"key":"2159_CR34","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1038\/nrm2476","volume":"9","author":"SJ Heasman","year":"2008","unstructured":"Heasman SJ, Ridley AJ (2008) Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol 9:690\u2013701. https:\/\/doi.org\/10.1038\/nrm2476","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2159_CR35","doi-asserted-by":"publisher","unstructured":"Herman JP, Watson SJ (1987) The rat brain in stereotaxic coordinates (2nd edn) vol 10. Trends Neurosci. https:\/\/doi.org\/10.1016\/0166-2236(87)90017-8","DOI":"10.1016\/0166-2236(87)90017-8"},{"key":"2159_CR36","doi-asserted-by":"publisher","first-page":"8926","DOI":"10.1523\/JNEUROSCI.5161-12.2013","volume":"33","author":"MS Hester","year":"2013","unstructured":"Hester MS, Danzer SC (2013) Accumulation of abnormal adult-generated hippocampal granule cells predicts seizure frequency and severity. J Neurosci 33:8926\u20138936. https:\/\/doi.org\/10.1523\/JNEUROSCI.5161-12.2013","journal-title":"J Neurosci"},{"key":"2159_CR37","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1038\/nrm.2016.67","volume":"17","author":"RG Hodge","year":"2016","unstructured":"Hodge RG, Ridley AJ (2016) Regulating Rho GTPases and their regulators. Nat Rev Mol Cell Biol 17:496\u2013510. https:\/\/doi.org\/10.1038\/nrm.2016.67","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2159_CR38","doi-asserted-by":"publisher","first-page":"525","DOI":"10.4103\/1673-5374.205080","volume":"12","author":"J Hu","year":"2017","unstructured":"Hu J, Selzer ME (2017) RhoA as a target to promote neuronal survival and axon regeneration. Neural Regen Res 12:525\u2013528. https:\/\/doi.org\/10.4103\/1673-5374.205080","journal-title":"Neural Regen Res"},{"key":"2159_CR39","doi-asserted-by":"publisher","unstructured":"Iris FJ et al. (1993) Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment. Nat Genet 3:137\u2013145. https:\/\/doi.org\/10.1038\/ng0293-137","DOI":"10.1038\/ng0293-137"},{"issue":"Suppl 1","key":"2159_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1528-1167.2010.02904.x","volume":"52","author":"FE Jensen","year":"2011","unstructured":"Jensen FE (2011) Epilepsy as a spectrum disorder: Implications from novel clinical and basic neuroscience. Epilepsia 52(Suppl 1):1\u20136. https:\/\/doi.org\/10.1111\/j.1528-1167.2010.02904.x","journal-title":"Epilepsia"},{"key":"2159_CR41","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1073\/pnas.0912931107","volume":"107","author":"C Katche","year":"2010","unstructured":"Katche C, Bekinschtein P, Slipczuk L, Goldin A, Izquierdo IA, Cammarota M, Medina JH (2010) Delayed wave of c-Fos expression in the dorsal hippocampus involved specifically in persistence of long-term memory storage. Proc Natl Acad Sci USA 107:349\u2013354. https:\/\/doi.org\/10.1073\/pnas.0912931107","journal-title":"Proc Natl Acad Sci USA"},{"key":"2159_CR42","doi-asserted-by":"publisher","unstructured":"Kim IH, Wang H, Soderling SH, Yasuda R (2014) Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall. Elife. https:\/\/doi.org\/10.7554\/eLife.02839","DOI":"10.7554\/eLife.02839"},{"key":"2159_CR43","doi-asserted-by":"publisher","unstructured":"Kocher AA et al. (2001) Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 7:430\u2013436 https:\/\/doi.org\/10.1038\/86498","DOI":"10.1038\/86498"},{"key":"2159_CR44","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s11064-013-1217-7","volume":"39","author":"MM Leal","year":"2014","unstructured":"Leal MM et al (2014) Early transplantation of bone marrow mononuclear cells promotes neuroprotection and modulation of inflammation after status epilepticus in mice by paracrine mechanisms. Neurochem Res 39:259\u2013268. https:\/\/doi.org\/10.1007\/s11064-013-1217-7","journal-title":"Neurochem Res"},{"key":"2159_CR45","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/s0149-7634(05)80076-4","volume":"14","author":"JP Leite","year":"1990","unstructured":"Leite JP, Bortolotto ZA, Cavalheiro EA (1990) Spontaneous recurrent seizures in rats: an experimental model of partial epilepsy. Neurosci Biobehav Rev 14:511\u2013517. https:\/\/doi.org\/10.1016\/s0149-7634(05)80076-4","journal-title":"Neurosci Biobehav Rev"},{"key":"2159_CR46","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/s0920-1211(02)00072-4","volume":"50","author":"JP Leite","year":"2002","unstructured":"Leite JP, Garcia-Cairasco N, Cavalheiro EA (2002) New insights from the use of pilocarpine and kainate models. Epilepsy Res 50:93\u2013103. https:\/\/doi.org\/10.1016\/s0920-1211(02)00072-4","journal-title":"Epilepsy Res"},{"key":"2159_CR47","doi-asserted-by":"publisher","first-page":"5053","DOI":"10.1523\/JNEUROSCI.5024-07.2008","volume":"28","author":"PP Lenck-Santini","year":"2008","unstructured":"Lenck-Santini PP, Holmes GL (2008) Altered phase precession and compression of temporal sequences by place cells in epileptic rats. J Neurosci 28:5053\u20135062. https:\/\/doi.org\/10.1523\/JNEUROSCI.5024-07.2008","journal-title":"J Neurosci"},{"key":"2159_CR48","doi-asserted-by":"publisher","unstructured":"Li J, Xing H, Jiang G, Su Z, Wu Y, Zhang Y, Guo S (2016) Increased expression of Rac1 in epilepsy patients and animal models. Neurochem Res 41:836\u2013843. https:\/\/doi.org\/10.1007\/s11064-015-1759-y","DOI":"10.1007\/s11064-015-1759-y"},{"key":"2159_CR49","doi-asserted-by":"publisher","unstructured":"Liu Y et al. (2016) Hippocampal activation of Rac1 regulates the forgetting of object. Recogn Mem Curr Biol 26:2351\u20132357 doi:https:\/\/doi.org\/10.1016\/j.cub.2016.06.056","DOI":"10.1016\/j.cub.2016.06.056"},{"key":"2159_CR50","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1046\/j.1460-9568.2000.00117.x","volume":"12","author":"M Lynch","year":"2000","unstructured":"Lynch M, Sayin \u00dc, Bownds J, Janumpalli S, Sutula T (2000) Long-term consequences of early postnatal seizures on hippocampal learning and plasticity. Eur J Neurosci 12:2252\u20132264. https:\/\/doi.org\/10.1046\/j.1460-9568.2000.00117.x","journal-title":"Eur J Neurosci"},{"key":"2159_CR51","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1152\/physrev.00014.2003","volume":"84","author":"MA Lynch","year":"2004","unstructured":"Lynch MA (2004) Long-term potentiation and memory. Physiol Rev 84:87\u2013136. https:\/\/doi.org\/10.1152\/physrev.00014.2003","journal-title":"Physiol Rev"},{"key":"2159_CR52","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1126\/science.285.5435.1870","volume":"285","author":"RC Malenka","year":"1999","unstructured":"Malenka RC, Nicoll RA (1999) Long-term potentiation\u2013a decade of progress? Science 285:1870\u20131874. https:\/\/doi.org\/10.1126\/science.285.5435.1870","journal-title":"Science"},{"key":"2159_CR53","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1111\/j.1528-1167.2012.03521.x","volume":"53","author":"JM Malheiros","year":"2012","unstructured":"Malheiros JM et al (2012) Manganese-enhanced magnetic resonance imaging detects mossy fiber sprouting in the pilocarpine model of epilepsy. Epilepsia 53:1225\u20131232. https:\/\/doi.org\/10.1111\/j.1528-1167.2012.03521.x","journal-title":"Epilepsia"},{"key":"2159_CR54","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.yebeh.2005.11.003","volume":"8","author":"R Mameniskiene","year":"2006","unstructured":"Mameniskiene R, Jatuzis D, Kaubrys G, Budrys V (2006) The decay of memory between delayed and long-term recall in patients with temporal lobe epilepsy. Epilepsy Behav 8:278\u2013288. https:\/\/doi.org\/10.1016\/j.yebeh.2005.11.003","journal-title":"Epilepsy Behav"},{"key":"2159_CR55","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/nature02617","volume":"429","author":"M Matsuzaki","year":"2004","unstructured":"Matsuzaki M, Honkura N, Ellis-Davies GC, Kasai H (2004) Structural basis of long-term potentiation in single dendritic spines. Nature 429:761\u2013766. https:\/\/doi.org\/10.1038\/nature02617","journal-title":"Nature"},{"key":"2159_CR56","doi-asserted-by":"publisher","unstructured":"Mazumder AG, Sharma P, Patial V, Singh D (2017) Ginkgo biloba L. attenuates spontaneous recurrent seizures and associated neurological conditions in lithium-pilocarpine rat model of temporal lobe epilepsy through inhibition of mammalian target of rapamycin pathway hyperactivation. J Ethnopharmacol 204:8\u201317. https:\/\/doi.org\/10.1016\/j.jep.2017.03.060","DOI":"10.1016\/j.jep.2017.03.060"},{"key":"2159_CR57","doi-asserted-by":"publisher","unstructured":"Mello LE, Longo B (2009) PLASTICITY|Synaptic reorganization in the hippocampal dentate gyrus. In. pp 1210\u20131215. https:\/\/doi.org\/10.1016\/b978-012373961-2.00333-7","DOI":"10.1016\/b978-012373961-2.00333-7"},{"key":"2159_CR58","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1111\/j.1528-1157.1993.tb02123.x","volume":"34","author":"LEAM Mello","year":"1993","unstructured":"Mello LEAM, Cavalheiro EA, Tan AM, Kupfer WR, Pretorius JK, Babb TL, Finch DM (1993) Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: cell loss and mossy fiber sprouting. Epilepsia 34:985\u2013995. https:\/\/doi.org\/10.1111\/j.1528-1157.1993.tb02123.x","journal-title":"Epilepsia"},{"key":"2159_CR59","doi-asserted-by":"publisher","unstructured":"Milczarek O, Jarocha D, Starowicz-Filip A, Kwiatkowski S, Badyra B, Majka M (2018) Multiple autologous bone marrow-derived CD271(+) mesenchymal stem cell transplantation overcomes drug-resistant epilepsy in children. Stem Cells Transl Med 7:20\u201333 https:\/\/doi.org\/10.1002\/sctm.17-0041","DOI":"10.1002\/sctm.17-0041"},{"key":"2159_CR60","doi-asserted-by":"publisher","unstructured":"Morris RG, Anderson E, Lynch GS, Baudry M (1986) Selective impairment of learning and blockade of long-term potentiation by an N-methyl-d-aspartate receptor antagonist. AP5 Nat 319:774\u2013776 https:\/\/doi.org\/10.1038\/319774a0","DOI":"10.1038\/319774a0"},{"key":"2159_CR61","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1126\/science.281.5385.2038","volume":"281","author":"EI Moser","year":"1998","unstructured":"Moser EI, Krobert KA, Moser MB, Morris RG (1998) Impaired spatial learning after saturation of long-term potentiation. Science 281:2038\u20132042. https:\/\/doi.org\/10.1126\/science.281.5385.2038","journal-title":"Science"},{"key":"2159_CR62","doi-asserted-by":"publisher","unstructured":"Muller L, Tokay T, Porath K, Kohling R, Kirschstein T (2013) Enhanced NMDA receptor-dependent LTP in the epileptic CA1 area via upregulation of NR2B. Neurobiol Dis 54:183\u2013193 https:\/\/doi.org\/10.1016\/j.nbd.2012.12.011","DOI":"10.1016\/j.nbd.2012.12.011"},{"key":"2159_CR63","doi-asserted-by":"publisher","unstructured":"Murakoshi H, Wang H, Yasuda R (2011) Local, persistent activation of Rho GTPases during plasticity of single dendritic spines. Nature 472:100\u2013104 doi:https:\/\/doi.org\/10.1038\/nature09823","DOI":"10.1038\/nature09823"},{"key":"2159_CR64","unstructured":"Organization WOH (2019) Epilepsy: a public health imperative. Geneva"},{"key":"2159_CR65","doi-asserted-by":"publisher","first-page":"3727","DOI":"10.1523\/jneurosci.17-10-03727.1997","volume":"17","author":"JM Parent","year":"1997","unstructured":"Parent JM, Yu TW, Leibowitz RT, Geschwind DH, Sloviter RS, Lowenstein DH (1997) Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. J Neurosci 17:3727\u20133738. https:\/\/doi.org\/10.1523\/jneurosci.17-10-03727.1997","journal-title":"J Neurosci"},{"key":"2159_CR66","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.neuron.2006.09.040","volume":"52","author":"M Park","year":"2006","unstructured":"Park M, Salgado JM, Ostroff L, Helton TD, Robinson CG, Harris KM, Ehlers MD (2006) Plasticity-induced growth of dendritic spines by exocytic trafficking from recycling endosomes. Neuron 52:817\u2013830. https:\/\/doi.org\/10.1016\/j.neuron.2006.09.040","journal-title":"Neuron"},{"key":"2159_CR67","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1016\/j.eplepsyres.2014.04.003","volume":"108","author":"JN Pearson","year":"2014","unstructured":"Pearson JN, Schulz KM, Patel M (2014) Specific alterations in the performance of learning and memory tasks in models of chemoconvulsant-induced status epilepticus. Epilepsy Res 108:1032\u20131040. https:\/\/doi.org\/10.1016\/j.eplepsyres.2014.04.003","journal-title":"Epilepsy Res"},{"key":"2159_CR68","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.phrs.2005.03.003","volume":"52","author":"P Pereira","year":"2005","unstructured":"Pereira P, Tysca D, Oliveira P, da Silva Brum LF, Picada JN, Ardenghi P (2005) Neurobehavioral and genotoxic aspects of rosmarinic acid. Pharmacol Res 52:199\u2013203. https:\/\/doi.org\/10.1016\/j.phrs.2005.03.003","journal-title":"Pharmacol Res"},{"key":"2159_CR69","doi-asserted-by":"publisher","unstructured":"Queiroz CM, Mello LE (2007) Synaptic plasticity of the CA3 commissural projection in epileptic rats: an in vivo electrophysiological study. Eur J Neurosci 25:3071\u20133079. https:\/\/doi.org\/10.1111\/j.1460-9568.2007.05573.x","DOI":"10.1111\/j.1460-9568.2007.05573.x"},{"key":"2159_CR70","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","volume":"32","author":"RJ Racine","year":"1972","unstructured":"Racine RJ (1972) Modification of seizure activity by electrical stimulation: II Motor seizure. Electroencephalogr Clin Neurophysiol 32:281\u2013294. https:\/\/doi.org\/10.1016\/0013-4694(72)90177-0","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"2159_CR71","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1016\/j.clineuro.2013.09.035","volume":"115","author":"WL Ramey","year":"2013","unstructured":"Ramey WL, Martirosyan NL, Lieu CM, Hasham HA, Lemole GM Jr, Weinand ME (2013) Current management and surgical outcomes of medically intractable epilepsy. Clin Neurol Neurosurg 115:2411\u20132418. https:\/\/doi.org\/10.1016\/j.clineuro.2013.09.035","journal-title":"Clin Neurol Neurosurg"},{"issue":"Suppl 5","key":"2159_CR72","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/j.1528-1167.2005.01006.x","volume":"46","author":"T Ravizza","year":"2005","unstructured":"Ravizza T et al (2005) Inflammatory response and glia activation in developing rat hippocampus after status epilepticus. Epilepsia 46(Suppl 5):113\u2013117. https:\/\/doi.org\/10.1111\/j.1528-1167.2005.01006.x","journal-title":"Epilepsia"},{"key":"2159_CR73","doi-asserted-by":"publisher","unstructured":"Reid IC, Stewart CA (1997) Seizures, memory and synaptic plasticity. Seizure 6:351\u2013359 https:\/\/doi.org\/10.1016\/s1059-1311(97)80034-9","DOI":"10.1016\/s1059-1311(97)80034-9"},{"key":"2159_CR74","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/s0962-8924(01)02153-5","volume":"11","author":"AJ Ridley","year":"2001","unstructured":"Ridley AJ (2001) Rho family proteins: coordinating cell responses. Trends Cell Biol 11:471\u2013477. https:\/\/doi.org\/10.1016\/s0962-8924(01)02153-5","journal-title":"Trends Cell Biol"},{"issue":"1199\u20131210","key":"2159_CR75","doi-asserted-by":"publisher","first-page":"e1196","DOI":"10.1016\/j.neuron.2019.04.012","volume":"102","author":"T Saneyoshi","year":"2019","unstructured":"Saneyoshi T et al (2019) Reciprocal activation within a kinase-effector complex underlying persistence of structural LTP. Neuron 102(1199\u20131210):e1196. https:\/\/doi.org\/10.1016\/j.neuron.2019.04.012","journal-title":"Neuron"},{"key":"2159_CR76","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1038\/nrn.2016.87","volume":"17","author":"HE Scharfman","year":"2016","unstructured":"Scharfman HE (2016) The enigmatic mossy cell of the dentate gyrus. Nat Rev Neurosci 17:562\u2013575. https:\/\/doi.org\/10.1038\/nrn.2016.87","journal-title":"Nat Rev Neurosci"},{"key":"2159_CR77","doi-asserted-by":"publisher","unstructured":"Schluesener HJ, Seid K, Kretzschmar J, Meyermann R (1998) Allograft-inflammatory factor-1 in rat experimental autoimmune encephalomyelitis, neuritis, and uveitis: expression by activated macrophages and microglial cells. Glia 24:244\u2013251. https:\/\/doi.org\/10.1002\/(sici)1098-1136(199810)24:2<244::aid-glia9>3.0.co;2-3","DOI":"10.1002\/(sici)1098-1136(199810)24:2<244::aid-glia9>3.0.co;2-3"},{"key":"2159_CR78","doi-asserted-by":"publisher","unstructured":"Sharma AK et al. (2009) Kainic acid-induced F-344 rat model of mesial temporal lobe epilepsy: gene expression and canonical pathways Toxicol Pathol 37:776\u2013789 https:\/\/doi.org\/10.1177\/0192623309344202","DOI":"10.1177\/0192623309344202"},{"key":"2159_CR79","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1242\/jcs.064964","volume":"124","author":"ST Sit","year":"2011","unstructured":"Sit ST, Manser E (2011) Rho GTPases and their role in organizing the actin cytoskeleton. J Cell Sci 124:679\u2013683. https:\/\/doi.org\/10.1242\/jcs.064964","journal-title":"J Cell Sci"},{"key":"2159_CR80","doi-asserted-by":"publisher","first-page":"112044","DOI":"10.1016\/j.bbr.2019.112044","volume":"372","author":"IV Smolensky","year":"2019","unstructured":"Smolensky IV, Zubareva OE, Kalemenev SV, Lavrentyeva VV, Dyomina AV, Karepanov AA, Zaitsev AV (2019) Impairments in cognitive functions and emotional and social behaviors in a rat lithium-pilocarpine model of temporal lobe epilepsy. Behav Brain Res 372:112044. https:\/\/doi.org\/10.1016\/j.bbr.2019.112044","journal-title":"Behav Brain Res"},{"key":"2159_CR81","doi-asserted-by":"publisher","first-page":"e48128","DOI":"10.1371\/journal.pone.0048128","volume":"7","author":"LM Suarez","year":"2012","unstructured":"Suarez LM et al (2012) Systemic injection of kainic acid differently affects LTP magnitude depending on its epileptogenic efficiency. PLoS One 7:e48128. https:\/\/doi.org\/10.1371\/journal.pone.0048128","journal-title":"PLoS One"},{"key":"2159_CR82","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1002\/ana.410260303","volume":"26","author":"T Sutula","year":"1989","unstructured":"Sutula T, Cascino G, Cavazos J, Parada I, Ramirez L (1989) Mossy fiber synaptic reorganization in the epileptic human temporal lobe. Ann Neurol 26:321\u2013330. https:\/\/doi.org\/10.1002\/ana.410260303","journal-title":"Ann Neurol"},{"key":"2159_CR83","doi-asserted-by":"publisher","unstructured":"Tai XY, Bernhardt B, Thom M, Thompson P, Baxendale S, Koepp M, Bernasconi N (2018) Review: Neurodegenerative processes in temporal lobe epilepsy with hippocampal sclerosis: clinical, pathological and neuroimaging evidence. Neuropathol Appl Neurobiol 44:70\u201390. https:\/\/doi.org\/10.1111\/nan.12458","DOI":"10.1111\/nan.12458"},{"key":"2159_CR84","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1152\/physrev.2001.81.1.153","volume":"81","author":"Y Takai","year":"2001","unstructured":"Takai Y, Sasaki T, Matozaki T (2001) Small GTP-binding proteins. Physiol Rev 81:153\u2013208. https:\/\/doi.org\/10.1152\/physrev.2001.81.1.153","journal-title":"Physiol Rev"},{"key":"2159_CR85","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1523\/jneurosci.05-04-01016.1985","volume":"5","author":"DL Tauck","year":"1985","unstructured":"Tauck DL, Nadler JV (1985) Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats. J Neurosci 5:1016\u20131022. https:\/\/doi.org\/10.1523\/jneurosci.05-04-01016.1985","journal-title":"J Neurosci"},{"key":"2159_CR86","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780195100273.003.0010","volume-title":"Synaptic Plasticity in the Hippocampus","author":"B Tim","year":"2006","unstructured":"Tim B, Graham C, Richard M (2006) Synaptic Plasticity in the Hippocampus. Oxford University Press, New York. https:\/\/doi.org\/10.1093\/acprof:oso\/9780195100273.003.0010"},{"key":"2159_CR87","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/46574","volume":"402","author":"N Toni","year":"1999","unstructured":"Toni N, Buchs PA, Nikonenko I, Bron CR, Muller D (1999) LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite. Nature 402:421\u2013425. https:\/\/doi.org\/10.1038\/46574","journal-title":"Nature"},{"key":"2159_CR88","doi-asserted-by":"publisher","unstructured":"Turski WA, Cavalheiro EA, Bortolotto ZA, Mello LM, Schwarz M, Turski L (1984) Seizures produced by pilocarpine in mice: a behavioral, electroencephalographic and morphological analysis Brain Res 321:237\u2013253 https:\/\/doi.org\/10.1016\/0006-8993(84)90177-x","DOI":"10.1016\/0006-8993(84)90177-x"},{"key":"2159_CR89","doi-asserted-by":"publisher","unstructured":"Turski WA, Cavalheiro EA, Schwarz M, Czuczwar SJ, Kleinrok Z, Turski L (1983) Limbic seizures produced by pilocarpine in rats: Behavioural, electroencephalographic and neuropathological study. Behav Brain Res 9:315\u2013335 https:\/\/doi.org\/10.1016\/0166-4328(83)90136-5","DOI":"10.1016\/0166-4328(83)90136-5"},{"key":"2159_CR90","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1161\/STROKEAHA.116.012701","volume":"47","author":"FS Vahidy","year":"2016","unstructured":"Vahidy FS, Rahbar MH, Zhu H, Rowan PJ, Bambhroliya AB, Savitz SI (2016) Systematic review and meta-analysis of bone marrow-derived mononuclear cells in animal models of ischemic stroke. Stroke 47:1632\u20131639. https:\/\/doi.org\/10.1161\/STROKEAHA.116.012701","journal-title":"Stroke"},{"key":"2159_CR91","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.lfs.2011.06.006","volume":"89","author":"GT Venturin","year":"2011","unstructured":"Venturin GT, Greggio S, Marinowic DR, Zanirati G, Cammarota M, Machado DC, DaCosta JC (2011) Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats. Life Sci 89:229\u2013234. https:\/\/doi.org\/10.1016\/j.lfs.2011.06.006","journal-title":"Life Sci"},{"key":"2159_CR92","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.expneurol.2011.09.033","volume":"244","author":"A Vezzani","year":"2013","unstructured":"Vezzani A, Aronica E, Mazarati A, Pittman QJ (2013) Epilepsy and brain inflammation. Exp Neurol 244:11\u201321. https:\/\/doi.org\/10.1016\/j.expneurol.2011.09.033","journal-title":"Exp Neurol"},{"key":"2159_CR93","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ijdevneu.2019.03.005","volume":"75","author":"LE Wearick-Silva","year":"2019","unstructured":"Wearick-Silva LE, Sebben AD, Costa-Ferro ZSM, Marinowic DR, Nunes ML (2019) Undernourishment and recurrent seizures early in life impair long-term potentiation and alter NMDAR and AMPAR expression in rat hippocampus. Int J Dev Neurosci 75:13\u201318. https:\/\/doi.org\/10.1016\/j.ijdevneu.2019.03.005","journal-title":"Int J Dev Neurosci"},{"key":"2159_CR94","doi-asserted-by":"publisher","unstructured":"Wiens KM, Lin H, Liao D (2005) Rac1 induces the clustering of AMPA receptors during spinogenesis. J Neurosci 25:10627\u201310636 https:\/\/doi.org\/10.1523\/JNEUROSCI.1947-05.2005","DOI":"10.1523\/JNEUROSCI.1947-05.2005"},{"key":"2159_CR95","unstructured":"Xiao-Lan Ai FY, Xiao-Jing Wang, Dong-Bei Duan, Ke Li, Zi-You Hu, Guo Yin, Mei Wang, Bing-Yi Wu (2018) Role of allograft inflammatory factor-1 in regulating the proliferation, migration and apoptosis of colorectal cancer cells Nan Fang yi ke da xue xue bao. J Southern Med Univ 38:511\u2013519"},{"key":"2159_CR96","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1111\/cns.12382","volume":"21","author":"G Zanirati","year":"2015","unstructured":"Zanirati G et al (2015) Transplantation of bone marrow mononuclear cells modulates hippocampal expression of growth factors in chronically epileptic animals. CNS Neurosci Ther 21:463\u2013471. https:\/\/doi.org\/10.1111\/cns.12382","journal-title":"CNS Neurosci Ther"},{"key":"2159_CR97","doi-asserted-by":"publisher","unstructured":"Zhao YY, Yan DJ, Chen ZW (2013) Role of AIF-1 in the regulation of inflammatory activation and diverse disease processes. Cell Immunol 284:75\u201383 https:\/\/doi.org\/10.1016\/j.cellimm.2013.07.008","DOI":"10.1016\/j.cellimm.2013.07.008"},{"key":"2159_CR98","doi-asserted-by":"publisher","unstructured":"Zhou C, Lippman JJ, Sun H, Jensen FE (2011) Hypoxia-induced neonatal seizures diminish silent synapses and long-term potentiation in hippocampal CA1 neurons. J Neurosci 31:18211\u201318222. https:\/\/doi.org\/10.1523\/JNEUROSCI.4838-11.2011","DOI":"10.1523\/JNEUROSCI.4838-11.2011"},{"key":"2159_CR99","doi-asserted-by":"publisher","first-page":"3667","DOI":"10.1111\/j.1460-9568.2007.05598.x","volume":"25","author":"JL Zhou","year":"2007","unstructured":"Zhou JL, Shatskikh TN, Liu X, Holmes GL (2007) Impaired single cell firing and long-term potentiation parallels memory impairment following recurrent seizures. Eur J Neurosci 25:3667\u20133677. https:\/\/doi.org\/10.1111\/j.1460-9568.2007.05598.x","journal-title":"Eur J Neurosci"}],"container-title":["Brain Structure and Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-020-02159-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00429-020-02159-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-020-02159-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T11:05:28Z","timestamp":1605697528000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00429-020-02159-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,30]]},"references-count":99,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["2159"],"URL":"https:\/\/doi.org\/10.1007\/s00429-020-02159-7","relation":{},"ISSN":["1863-2653","1863-2661"],"issn-type":[{"type":"print","value":"1863-2653"},{"type":"electronic","value":"1863-2661"}],"subject":[],"published":{"date-parts":[[2020,10,30]]},"assertion":[{"value":"18 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All experimental procedures were performed in accordance with guidelines of the USA National Institutes of Health Guide for the Care and Use of Laboratory Animals (Council ) and were approved by the Animal Care and Use Committees of the Pontifical Catholic University of Rio Grande do Sul (CEUA 7839-PUCRS).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}