{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:45:24Z","timestamp":1784069124356,"version":"3.55.0"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T00:00:00Z","timestamp":1613174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T00:00:00Z","timestamp":1613174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"NWG Macintosh Memorial Grant"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Brain Struct Funct"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1007\/s00429-021-02235-6","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T08:43:58Z","timestamp":1613292238000},"page":"1209-1227","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Nerve injury alters restraint-induced activation of the basolateral amygdala in male rats"],"prefix":"10.1007","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8517-5656","authenticated-orcid":false,"given":"James W. M.","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3934-4380","authenticated-orcid":false,"given":"Kevin A.","family":"Keay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,13]]},"reference":[{"key":"2235_CR1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.neuron.2009.12.002","volume":"65","author":"A Adhikari","year":"2010","unstructured":"Adhikari A, Topiwala MA, Gordon JA (2010) Synchronized activity between the ventral hippocampus and the medial prefrontal cortex during anxiety. Neuron 65:257\u2013269","journal-title":"Neuron"},{"key":"2235_CR2","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.neuron.2011.07.027","volume":"71","author":"A Adhikari","year":"2011","unstructured":"Adhikari A, Topiwala MA, Gordon JA (2011) Single units in the medial prefrontal cortex with anxiety-related firing patterns are preferentially influenced by ventral hippocampal activity. Neuron 71:898\u2013910","journal-title":"Neuron"},{"key":"2235_CR4","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.pain.2003.12.015","volume":"108","author":"VA Apkarian","year":"2004","unstructured":"Apkarian VA, Sosa Y, Krauss BR, Thomas SP, Fredrickson BE, Levy RE, Harden NR, Chialvo DR (2004) Chronic pain patients are impaired on an emotional decision-making task. Pain 108:129\u2013136","journal-title":"Pain"},{"key":"2235_CR6","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/nrn875","volume":"3","author":"MG Baxter","year":"2002","unstructured":"Baxter MG, Murray EA (2002) The amygdala and reward. Nat Rev Neurosci 3:563\u2013573","journal-title":"Nat Rev Neurosci"},{"key":"2235_CR7","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","volume":"33","author":"GJ Bennett","year":"1988","unstructured":"Bennett GJ, Xie YK (1988) A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33:87\u2013107","journal-title":"Pain"},{"key":"2235_CR11","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.neulet.2013.02.005","volume":"541","author":"J Chen","year":"2013","unstructured":"Chen J, Song Y, Yang J, Zhang Y, Zhao P, Zhu XJ, Su HC (2013) The contribution of Tnf-alpha in the amygdala to anxiety in mice with persistent inflammatory pain. Neurosci Lett 541:275\u2013280","journal-title":"Neurosci Lett"},{"key":"2235_CR12","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/S0306-4522(99)00028-7","volume":"92","author":"KK Chung","year":"1999","unstructured":"Chung KK, Martinez M, Herbert J (1999) Central serotonin depletion modulates the behavioural, endocrine and physiological responses to repeated social stress and subsequent c-Fos expression in the brains of male rats. Neuroscience 92:613\u2013625","journal-title":"Neuroscience"},{"issue":"3","key":"2235_CR13","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1002\/(SICI)1096-9861(19960311)366:3<495::AID-CNE9>3.0.CO;2-#","volume":"366","author":"CI Clement","year":"1996","unstructured":"Clement CI, Keay KA, Owler BK, Bandler R (1996) Common patterns of increased and decreased fos expression in midbrain and pons evoked by noxious deep somatic and noxious visceral manipulations in the rat. J Comp Neurol 366(3):495\u2013515","journal-title":"J Comp Neurol"},{"key":"2235_CR14","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/0306-4522(94)00355-9","volume":"64","author":"WE Cullinan","year":"1995","unstructured":"Cullinan WE, Herman JP, Battaglia DF, Akil H, Watson SJ (1995) Pattern and time course of immediate early gene expression in rat brain following acute stress. Neuroscience 64:477\u2013505","journal-title":"Neuroscience"},{"key":"2235_CR15","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1146\/annurev.ne.15.030192.002033","volume":"15","author":"M Davis","year":"1992","unstructured":"Davis M (1992) The role of the amygdala in fear and anxiety. Annu Rev Neurosci 15:353\u2013375","journal-title":"Annu Rev Neurosci"},{"key":"2235_CR16","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/npp.2009.109","volume":"35","author":"M Davis","year":"2010","unstructured":"Davis M, Walker DL, Miles L, Grillon C (2010) Phasic vs sustained fear in rats and humans: role of the extended amygdala in fear vs anxiety. Neuropsychopharmacology 35:105\u2013135","journal-title":"Neuropsychopharmacology"},{"key":"2235_CR17","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1046\/j.1460-9568.1999.00645.x","volume":"11","author":"CV Dayas","year":"1999","unstructured":"Dayas CV, Buller KM, Day TA (1999) Neuroendocrine responses to an emotional stressor: evidence for involvement of the medial but not the central amygdala. Eur J Neurosci 11:2312\u20132322","journal-title":"Eur J Neurosci"},{"key":"2235_CR18","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1046\/j.0953-816x.2001.01733.x","volume":"14","author":"CV Dayas","year":"2001","unstructured":"Dayas CV, Buller KM, Crane JW, Xu Y, Day TA (2001a) Stressor categorization: acute physical and psychological stressors elicit distinctive recruitment patterns in the amygdala and in medullary noradrenergic cell groups. Eur J Neurosci 14:1143\u20131152","journal-title":"Eur J Neurosci"},{"key":"2235_CR19","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/S0306-4522(01)00213-5","volume":"105","author":"CV Dayas","year":"2001","unstructured":"Dayas CV, Buller KM, Day TA (2001b) Medullary neurones regulate hypothalamic corticotropin-releasing factor cell responses to an emotional stressor. Neuroscience 105:707\u2013719","journal-title":"Neuroscience"},{"key":"2235_CR20","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1002\/cne.20259","volume":"478","author":"CV Dayas","year":"2004","unstructured":"Dayas CV, Buller KM, Day TA (2004) Hypothalamic paraventricular nucleus neurons regulate medullary catecholamine cell responses to restraint stress. J Comp Neurol 478:22\u201334","journal-title":"J Comp Neurol"},{"key":"2235_CR21","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.bbr.2006.10.021","volume":"176","author":"S Deyama","year":"2007","unstructured":"Deyama S, Nakagawa T, Kaneko S, Uehara T, Minami M (2007) Involvement of the bed nucleus of the stria terminalis in the negative affective component of visceral and somatic pain in rats. Behav Brain Res 176:367\u2013371","journal-title":"Behav Brain Res"},{"key":"2235_CR22","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/S0165-0173(01)00079-0","volume":"38","author":"H-W Dong","year":"2001","unstructured":"Dong H-W, Petrovich GD, Swanson LW (2001) Topography of projections from amygdala to bed nuclei of the stria terminalis. Brain Res Rev 38:192\u2013246","journal-title":"Brain Res Rev"},{"key":"2235_CR23","doi-asserted-by":"publisher","first-page":"10357","DOI":"10.1523\/JNEUROSCI.2119-09.2009","volume":"29","author":"S Duvarci","year":"2009","unstructured":"Duvarci S, Bauer EP, Pare D (2009) The bed nucleus of the stria terminalis mediates inter-individual variations in anxiety and fear. J Neurosci 29:10357\u201310361","journal-title":"J Neurosci"},{"key":"2235_CR25","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0006-8993(09)90005-1","volume":"658","author":"S Feldman","year":"1994","unstructured":"Feldman S, Conforti N, Itzik A, Weidenfeld J (1994) Differential effect of amygdaloid lesions on CRF-41, ACTH and corticosterone responses following neural stimuli. Brain Res 658:21\u201326","journal-title":"Brain Res"},{"key":"2235_CR26","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1523\/JNEUROSCI.4257-13.2014","volume":"34","author":"AC Felix-Ortiz","year":"2014","unstructured":"Felix-Ortiz AC, Tye KM (2014) Amygdala inputs to the ventral hippocampus bidirectionally modulate social behavior. J Neurosci 34:586\u2013595","journal-title":"J Neurosci"},{"key":"2235_CR27","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/j.neuron.2013.06.016","volume":"79","author":"AC Felix-Ortiz","year":"2013","unstructured":"Felix-Ortiz AC, Beyeler A, Seo C, Leppla CA, Wildes CP, Tye KM (2013) BLA To vHPC inputs modulate anxiety-related behaviors. Neuron 79:658\u2013664","journal-title":"Neuron"},{"key":"2235_CR29","doi-asserted-by":"publisher","first-page":"6370","DOI":"10.1523\/JNEUROSCI.21-16-06370.2001","volume":"21","author":"SB Floresco","year":"2001","unstructured":"Floresco SB, Blaha CD, Yang CR, Phillips AG (2001) Dopamine D1 and NMDA receptors mediate potentiation of basolateral amygdala-evoked firing of nucleus accumbens neurons. J Neurosci 21:6370\u20136376","journal-title":"J Neurosci"},{"key":"2235_CR30","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.neuroscience.2012.09.048","volume":"227","author":"EA Fortaleza","year":"2012","unstructured":"Fortaleza EA, Scopinho AA, Correa FM (2012a) Beta-adrenoceptors in the medial amygdaloid nucleus modulate the tachycardiac response to restraint stress in rats. Neuroscience 227:170\u2013179","journal-title":"Neuroscience"},{"key":"2235_CR31","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.phrs.2012.04.004","volume":"66","author":"EA Fortaleza","year":"2012","unstructured":"Fortaleza EA, Scopinho AA, De Aguiar Correa FM (2012b) Alpha1 and alpha2-adrenoceptors in the medial amygdaloid nucleus modulate differently the cardiovascular responses to restraint stress in rats. Pharmacol Res 66:154\u2013162","journal-title":"Pharmacol Res"},{"key":"2235_CR32","doi-asserted-by":"publisher","first-page":"E2570","DOI":"10.1371\/journal.pone.0002570","volume":"3","author":"AS Fox","year":"2008","unstructured":"Fox AS, Shelton SE, Oakes TR, Davidson RJ, Kalin NH (2008) Trait-like brain activity during adolescence predicts anxious temperament in primates. PLoS ONE 3:E2570","journal-title":"PLoS ONE"},{"key":"2235_CR33","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1016\/j.neuroscience.2006.01.026","volume":"139","author":"PL Gabbott","year":"2006","unstructured":"Gabbott PL, Warner TA, Busby SJ (2006) Amygdala input monosynaptically innervates parvalbumin immunoreactive local circuit neurons in rat medial prefrontal cortex. Neuroscience 139:1039\u20131048","journal-title":"Neuroscience"},{"key":"2235_CR34","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1113\/eph8702357","volume":"87","author":"C Gauriau","year":"2002","unstructured":"Gauriau C, Bernard JF (2002) Pain pathways and parabrachial circuits in the rat. Exp Physiol 87:251\u2013258","journal-title":"Exp Physiol"},{"key":"2235_CR35","doi-asserted-by":"publisher","first-page":"3204","DOI":"10.1111\/j.1460-9568.2012.08235.x","volume":"36","author":"L Goncalves","year":"2012","unstructured":"Goncalves L, Dickenson AH (2012) Asymmetric time-dependent activation of right central amygdala neurones in rats with peripheral neuropathy and pregabalin modulation. Eur J Neurosci 36:3204\u20133213","journal-title":"Eur J Neurosci"},{"key":"2235_CR36","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.expneurol.2008.04.043","volume":"213","author":"L Goncalves","year":"2008","unstructured":"Goncalves L, Silva R, Pinto-Ribeiro F, Pego JM, Bessa JM, Pertovaara A, Sousa N, Almeida A (2008) Neuropathic pain is associated with depressive behaviour and induces neuroplasticity in the amygdala of the rat. Exp Neurol 213:48\u201356","journal-title":"Exp Neurol"},{"key":"2235_CR37","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.neuroscience.2010.12.049","volume":"178","author":"NM Grissom","year":"2011","unstructured":"Grissom NM, Bhatnagar S (2011) The basolateral amygdala regulates adaptation to stress via beta-adrenergic receptor-mediated reductions in phosphorylated extracellular signal-regulated kinase. Neuroscience 178:108\u2013122","journal-title":"Neuroscience"},{"key":"2235_CR38","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s00429-007-0150-4","volume":"212","author":"W Hoover","year":"2007","unstructured":"Hoover W, Vertes R (2007) Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat. Brain Struct Funct 212:149\u2013179","journal-title":"Brain Struct Funct"},{"key":"2235_CR39","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1523\/JNEUROSCI.22-03-01137.2002","volume":"22","author":"JG Howland","year":"2002","unstructured":"Howland JG, Taepavarapruk P, Phillips AG (2002) Glutamate receptor-dependent modulation of dopamine efflux in the nucleus accumbens by basolateral, but not central, nucleus of the amygdala in rats. J Neurosci 22:1137\u20131145","journal-title":"J Neurosci"},{"key":"2235_CR40","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.pain.2006.09.003","volume":"127","author":"R Ikeda","year":"2007","unstructured":"Ikeda R, Takahashi Y, Inoue K, Kato F (2007) NMDA receptor-independent synaptic plasticity in the central amygdala in the rat model of neuropathic pain. Pain 127:161\u2013172","journal-title":"Pain"},{"issue":"3","key":"2235_CR41","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/0304-3959(91)90216-K","volume":"47","author":"MP Jensen","year":"1991","unstructured":"Jensen MP, Turner JA, Romano JM, Karoly P (1991) Coping with chronic pain: a critical review of the literature. Pain 47(3):249\u2013283","journal-title":"Pain"},{"key":"2235_CR42","doi-asserted-by":"publisher","first-page":"2642","DOI":"10.1152\/jn.00461.2011","volume":"106","author":"G Ji","year":"2011","unstructured":"Ji G, Neugebauer V (2011) Pain-related deactivation of medial prefrontal cortical neurons involves mGluR1 and GABA(A) receptors. J Neurophysiol 106:2642\u20132652","journal-title":"J Neurophysiol"},{"key":"2235_CR43","doi-asserted-by":"publisher","first-page":"5451","DOI":"10.1523\/JNEUROSCI.0225-10.2010","volume":"30","author":"G Ji","year":"2010","unstructured":"Ji G, Sun H, Fu Y, Li Z, Pais-Vieira M, Galhardo V, Neugebauer V (2010) Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation. J Neurosci 30:5451","journal-title":"J Neurosci"},{"key":"2235_CR44","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s13041-014-0072-z","volume":"7","author":"H Jiang","year":"2014","unstructured":"Jiang H, Fang D, Kong LY, Jin ZR, Cai J, Kang XJ, Wan Y, Xing GG (2014) Sensitization of neurons in the central nucleus of the amygdala via the decreased gabaergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats. Mol Brain 7:72","journal-title":"Mol Brain"},{"key":"2235_CR45","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/0306-4522(94)90408-1","volume":"61","author":"LR Johnson","year":"1994","unstructured":"Johnson LR, Aylward RL, Hussain Z, Totterdell S (1994) Input from the amygdala to the rat nucleus accumbens: its relationship with tyrosine hydroxylase immunoreactivity and identified neurons. Neuroscience 61:851\u2013865","journal-title":"Neuroscience"},{"key":"2235_CR46","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1002\/cne.21848","volume":"511","author":"NJ Justice","year":"2008","unstructured":"Justice NJ, Yuan ZF, Sawchenko PE, Vale W (2008) Type 1 corticotropin-releasing factor receptor expression reported in BAC transgenic mice: implications for reconciling ligand-receptor mismatch in the central corticotropin-releasing factor system. J Comp Neurol 511:479\u2013496","journal-title":"J Comp Neurol"},{"key":"2235_CR47","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1111\/joa.12238","volume":"225","author":"E Kalman","year":"2014","unstructured":"Kalman E, Keay KA (2014) Different patterns of morphological changes in the hippocampus and dentate gyrus accompany the differential expression of disability following nerve injury. J Anat 225:591\u2013603","journal-title":"J Anat"},{"key":"2235_CR48","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.bbr.2014.01.045","volume":"264","author":"S Karimi","year":"2014","unstructured":"Karimi S, Attarzadeh-Yazdi G, Yazdi-Ravandi S, Hesam S, Azizi P, Razavi Y, Haghparast A (2014) Forced swim stress but not exogenous corticosterone could induce the reinstatement of extinguished morphine conditioned place preference in rats: involvement of glucocorticoid receptors in the basolateral amygdala. Behav Brain Res 264:43\u201350","journal-title":"Behav Brain Res"},{"key":"2235_CR49","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.neulet.2003.12.010","volume":"361","author":"KA Keay","year":"2004","unstructured":"Keay KA, Monassi CR, Levison DB, Bandler R (2004) Peripheral nerve injury evokes disabilities and sensory dysfunction in a subpopulation of rats: a closer model to human chronic neuropathic pain? Neurosci Lett 361:188\u2013191","journal-title":"Neurosci Lett"},{"key":"2235_CR50","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1002\/cne.902980104","volume":"298","author":"H Kita","year":"1990","unstructured":"Kita H, Kitai ST (1990) Amygdaloid projections to the frontal cortex and the striatum in the rat. J Comp Neurol 298:40\u201349","journal-title":"J Comp Neurol"},{"key":"2235_CR51","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.pain.2010.12.029","volume":"152","author":"D Kodama","year":"2011","unstructured":"Kodama D, Ono H, Tanabe M (2011) Increased hippocampal glycine uptake and cognitive dysfunction after peripheral nerve injury. Pain 152:809\u2013817","journal-title":"Pain"},{"key":"2235_CR52","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1002\/cne.901720408","volume":"172","author":"JE Krettek","year":"1977","unstructured":"Krettek JE, Price JL (1977) Projections from the amygdaloid complex to the cerebral cortex and thalamus in the rat and cat. J Comp Neurol 172:687\u2013722","journal-title":"J Comp Neurol"},{"key":"2235_CR53","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1002\/cne.901780204","volume":"178","author":"JE Krettek","year":"1978","unstructured":"Krettek JE, Price JL (1978a) Amygdaloid projections to subcortical structures within the basal forebrain and brainstem in the rat and cat. J Comp Neurol 178:225\u2013254","journal-title":"J Comp Neurol"},{"key":"2235_CR54","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1002\/cne.901780205","volume":"178","author":"JE Krettek","year":"1978","unstructured":"Krettek JE, Price JL (1978b) A description of the amygdaloid complex in the rat and cat with observations on intra-amygdaloid axonal connections. J Comp Neurol 178:255\u2013280","journal-title":"J Comp Neurol"},{"key":"2235_CR55","first-page":"863","volume":"26","author":"D Lakens","year":"2013","unstructured":"Lakens D (2013) Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and anovas. Front Psychol 26:863","journal-title":"Front Psychol"},{"key":"2235_CR56","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1146\/annurev.neuro.23.1.155","volume":"23","author":"J Ledoux","year":"2000","unstructured":"Ledoux J (2000) Emotion circuits in the brain. Annu Rev Neurosci 23:155\u2013184","journal-title":"Annu Rev Neurosci"},{"key":"2235_CR57","doi-asserted-by":"publisher","first-page":"6434","DOI":"10.1523\/JNEUROSCI.17-16-06434.1997","volume":"17","author":"Y Lee","year":"1997","unstructured":"Lee Y, Davis M (1997) Role of the hippocampus, the bed nucleus of the stria terminalis, and the amygdala in the excitatory effect of corticotropin-releasing hormone on the acoustic startle reflex. J Neurosci 17:6434\u20136446","journal-title":"J Neurosci"},{"key":"2235_CR58","doi-asserted-by":"publisher","first-page":"2218","DOI":"10.1016\/j.pain.2012.07.007","volume":"153","author":"H Leite-Almeida","year":"2012","unstructured":"Leite-Almeida H, Cerqueira JJ, Wei H, Ribeiro-Costa N, Anjos-Martins H, Sousa N, Pertovaara A, Almeida A (2012) Differential effects of left\/right neuropathy on rats\u2019 anxiety and cognitive behavior. Pain 153:2218\u20132225","journal-title":"Pain"},{"key":"2235_CR59","doi-asserted-by":"publisher","first-page":"E70921","DOI":"10.1371\/journal.pone.0070921","volume":"8","author":"Z Li","year":"2013","unstructured":"Li Z, Wang J, Chen L, Zhang M, Wan Y (2013) Basolateral amygdala lesion inhibits the development of pain chronicity in neuropathic pain rats. PLoS ONE 8:E70921","journal-title":"PLoS ONE"},{"key":"2235_CR60","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1017\/S146114571100174X","volume":"16","author":"J Liu","year":"2013","unstructured":"Liu J, Garza JC, Li W, Lu XY (2013) Melanocortin-4 receptor in the medial amygdala regulates emotional stress-induced anxiety-like behaviour, anorexia and corticosterone secretion. Int J Neuropsychopharmacol 16:105\u2013120","journal-title":"Int J Neuropsychopharmacol"},{"key":"2235_CR61","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.physbeh.2016.08.009","volume":"165","author":"CC Long","year":"2016","unstructured":"Long CC, Sadler KE, Kolber BJ (2016) Hormonal and molecular effects of restrain stress on formalin-induced pain-like behaviour in male and female mice. Physiol Behav 165:278\u2013285","journal-title":"Physiol Behav"},{"key":"2235_CR62","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.neuropharm.2012.05.047","volume":"66","author":"L Luongo","year":"2013","unstructured":"Luongo L, De Novellis V, Gatta L, Palazzo E, Vita D, Guida F, Giordano C, Siniscalco D, Marabese I, De Chiaro M, Boccella S, Rossi F, Maione S (2013) Role of metabotropic glutamate receptor 1 in the basolateral amygdala-driven prefrontal cortical deactivation in inflammatory pain in the rat. Neuropharmacology 66:317\u2013329","journal-title":"Neuropharmacology"},{"key":"2235_CR63","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/j.1365-2826.2005.01279.x","volume":"17","author":"S Ma","year":"2005","unstructured":"Ma S, Morilak DA (2005) Norepinephrine release in medial amygdala facilitates activation of the hypothalamic-pituitary-adrenal axis in response to acute immobilisation stress. J Neuroendocrinol 17:22\u201328","journal-title":"J Neuroendocrinol"},{"key":"2235_CR64","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.pnpbp.2017.06.032","volume":"87","author":"MO Martel","year":"2017","unstructured":"Martel MO, Shir Y, Ware MA (2017) Substance-related disorders: a review of prevalence and correlates among patients with chronic pain. Prog Neuropsychopharmacol Biol Psychiatry 87:245\u2013254","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"2235_CR65","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/0306-4522(91)90248-M","volume":"44","author":"AJ Mcdonald","year":"1991","unstructured":"Mcdonald AJ (1991) Topographical organization of amygdaloid projections to the caudatoputamen, nucleus accumbens, and related striatal-like areas of the rat brain. Neuroscience 44:15\u201333","journal-title":"Neuroscience"},{"key":"2235_CR66","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/S0006-8993(99)01926-5","volume":"843","author":"S Miyahara","year":"1999","unstructured":"Miyahara S, Komori T, Fujiwara R, Shizuya K, Yamamoto M, Ohmori M, Okazaki Y (1999) Effects of restraint stress on alpha(1) adrenoceptor mRNA expression in the hypothalamus and midbrain of the rat. Brain Res 843:130\u2013135","journal-title":"Brain Res"},{"key":"2235_CR67","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/s41583-020-0310-6","volume":"21","author":"JS Mogil","year":"2020","unstructured":"Mogil JS (2020) Qualitative sex differences in pain processing: emerging evidence of a biased literature. Nat Rev Neurosci 21:353\u2013365","journal-title":"Nat Rev Neurosci"},{"key":"2235_CR68","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1046\/j.1460-9568.2003.02627.x","volume":"17","author":"CR Monassi","year":"2003","unstructured":"Monassi CR, Bandler R, Keay KA (2003) A Subpopulation of rats show social and sleep-waking changes typical of chronic neuropathic pain following peripheral nerve injury. Eur J Neurosci 17:1907\u20131920","journal-title":"Eur J Neurosci"},{"key":"2235_CR69","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.pnpbp.2007.11.003","volume":"32","author":"TJ Morano","year":"2008","unstructured":"Morano TJ, Bailey NJ, Cahill CM, Dumont EC (2008) Nuclei-and condition-specific responses to pain in the bed nucleus of the stria terminalis. Prog Neuropsychopharmacol Biol Psychiatry 32:643\u2013650","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"2235_CR70","doi-asserted-by":"publisher","first-page":"5747","DOI":"10.1523\/JNEUROSCI.0587-12.2012","volume":"32","author":"AA Mutso","year":"2012","unstructured":"Mutso AA, Radzicki D, Baliki MN, Huang L, Banisadr G, Centeno MV, Radulovic J, Martina M, Miller RJ, Apkarian AV (2012) Abnormalities in hippocampal functioning with persistent pain. J Neurosci 32:5747\u20135756","journal-title":"J Neurosci"},{"key":"2235_CR71","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/S0006-8993(98)01191-3","volume":"835","author":"EJ Nestler","year":"1999","unstructured":"Nestler EJ, Kelz MB, Chen J (1999) \u0394FosB: a molecular mediator of long-term neural and behavioral plasticity. Brain Res 835:10\u201317","journal-title":"Brain Res"},{"issue":"20","key":"2235_CR72","doi-asserted-by":"publisher","first-page":"11042","DOI":"10.1073\/pnas.191352698","volume":"98","author":"EJ Nestler","year":"2001","unstructured":"Nestler EJ, Barrot M, Self DW (2001) \u0394FosB: a sustained molecular switch for addiction. Proc Natl Acad Sci (USA) 98(20):11042\u201311046","journal-title":"Proc Natl Acad Sci (USA)"},{"key":"2235_CR73","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/978-3-662-46450-2_13","volume":"227","author":"V Neugebauer","year":"2015","unstructured":"Neugebauer V (2015) Amygdala pain mechanisms. Handb Exp Pharmacol 227:261\u2013284","journal-title":"Handb Exp Pharmacol"},{"key":"2235_CR74","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.neuroscience.2003.10.029","volume":"123","author":"EM Nikulina","year":"2004","unstructured":"Nikulina EM, Covington HE 3rd, Ganschow L, Hammer RP Jr, Miczek KA (2004) Long-term behavioral and neuronal cross-sensitization to amphetamine induced by repeated brief social defeat stress: Fos in the ventral tegmental area and amygdala. Neuroscience 123:857\u2013865","journal-title":"Neuroscience"},{"key":"2235_CR75","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0893-133X(95)00177-F","volume":"15","author":"P O\u2019donnell","year":"1996","unstructured":"O\u2019donnell P, Grace AA (1996) Dopaminergic reduction of excitability in nucleus accumbens neurons recorded in vitro. Neuropsychopharmacology 15:87\u201397","journal-title":"Neuropsychopharmacology"},{"key":"2235_CR76","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.neures.2010.12.007","volume":"69","author":"H Okuno","year":"2011","unstructured":"Okuno H (2011) Regulation and function of immediate-early genes in the brain: beyound neuronal activity markers. Neurosci Res 69:175\u2013186","journal-title":"Neurosci Res"},{"key":"2235_CR77","doi-asserted-by":"publisher","first-page":"9961","DOI":"10.1523\/JNEUROSCI.0795-09.2009","volume":"29","author":"JA Oler","year":"2009","unstructured":"Oler JA, Fox AS, Shelton SE, Christian BT, Murali D, Oakes TR, Davidson RJ, Kalin NH (2009) Serotonin transporter availability in the amygdala and bed nucleus of the stria terminalis predicts anxious temperament and brain glucose metabolic activity. J Neurosci 29:9961\u20139966","journal-title":"J Neurosci"},{"issue":"6","key":"2235_CR106","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1097\/j.pain.0000000000000150","volume":"156","author":"E Palazzo","year":"2015","unstructured":"Palazzo E, Romano R, Luongo L, Boccella S, De Gregorio D, Giordano ME, Rossi F, Marabese I, Scafuro MA, de Novellis V, Maione S (2015) MMPIP, an mGluR7-selective negative allosteric modulator, alleviates pain and normalizes affective and cognitive behavior in neuropathic mice. Pain 156(6):1060\u20131073","journal-title":"Pain"},{"key":"2235_CR78","volume-title":"The rat brain in stereotaxic coordinates","author":"G Paxinos","year":"2005","unstructured":"Paxinos G, Watson C (2005) The rat brain in stereotaxic coordinates. Academic Press, Boston"},{"key":"2235_CR80","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1111\/ejn.12781","volume":"41","author":"DJ Rademacher","year":"2015","unstructured":"Rademacher DJ, Mendoza-Elias N, Meredith GE (2015) Effects of context-drug learning on synaptic connectivity in the basolateral nucleus of the amygdala in rats. Eur J Neurosci 41:205\u2013215","journal-title":"Eur J Neurosci"},{"key":"2235_CR81","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1038\/npp.2010.236","volume":"36","author":"WJ Ren","year":"2011","unstructured":"Ren WJ, Liu Y, Zhou LJ, Li W, Zhong Y, Pang RP, Xin WJ, Wei XH, Wang J, Zhu HQ, Wu CY, Qin ZH, Liu G, Liu XG (2011) Peripheral nerve injury leads to working memory deficits and dysfunction of the hippocampus by upregulation of TNF-alpha in rodents. Neuropsychopharmacology 36:979\u2013992","journal-title":"Neuropsychopharmacology"},{"key":"2235_CR82","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/S0006-8993(98)00294-7","volume":"796","author":"JB Rosen","year":"1998","unstructured":"Rosen JB, Fanselow MS, Young SL, Sitcoske M, Maren S (1998) Immediate-early gene expression in the amygdala following footshock stress and contextual fear conditioning. Brain Res 796:132\u2013142","journal-title":"Brain Res"},{"key":"2235_CR83","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.expneurol.2008.04.002","volume":"212","author":"C Rouillon","year":"2008","unstructured":"Rouillon C, Abraini JH, David HN (2008) Prefrontal cortex and basolateral amygdala modulation of dopamine-mediated locomotion in the nucleus accumbens core. Exp Neurol 212:213\u2013217","journal-title":"Exp Neurol"},{"key":"2235_CR84","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.ejpain.2011.05.016","volume":"16","author":"T Rouwette","year":"2012","unstructured":"Rouwette T, Vanelderen P, De Reus M, Loohuis NO, Giele J, Van Egmond J, Scheenen W, Scheffer GJ, Roubos E, Vissers K, Kozicz T (2012) Experimental neuropathy increases limbic forebrain CRF. Eur J Pain 16:61\u201371","journal-title":"Eur J Pain"},{"key":"2235_CR86","doi-asserted-by":"publisher","first-page":"E1194","DOI":"10.1038\/tp.2017.161","volume":"7","author":"BM Sharp","year":"2017","unstructured":"Sharp BM (2017) Basolateral amygdala and stress-induced hyperexcitability affect motivated behaviors and addiction. Transl Psychiatry 7:E1194","journal-title":"Transl Psychiatry"},{"key":"2235_CR87","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/S0959-4388(97)80008-6","volume":"7","author":"P Shizgal","year":"1997","unstructured":"Shizgal P (1997) Neural basis of utility estimation. Curr Opin Neurobiol 7:198\u2013208","journal-title":"Curr Opin Neurobiol"},{"key":"2235_CR88","doi-asserted-by":"publisher","first-page":"7737","DOI":"10.1523\/JNEUROSCI.20-20-07737.2000","volume":"20","author":"SL Smith-Roe","year":"2000","unstructured":"Smith-Roe SL, Kelley AE (2000) Coincident activation of NMDA and dopamine D1 receptors within the nucleus accumbens core is required for appetitive instrumental learning. J Neurosci 20:7737\u20137742","journal-title":"J Neurosci"},{"key":"2235_CR89","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1159\/000123454","volume":"36","author":"LW Swanson","year":"1983","unstructured":"Swanson LW, Sawchenko PE, Rivier J, Vale WW (1983) Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study. Neuroendocrinology 36:165\u2013186","journal-title":"Neuroendocrinology"},{"key":"2235_CR90","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1097\/ALN.0000000000000403","volume":"121","author":"M Tajerian","year":"2014","unstructured":"Tajerian M, Leu D, Zou Y, Sahbaie P, Li W, Khan H, Hsu V, Kingery W, Huang TT, Becerra L, Clark JD (2014) Brain neuroplastic changes accompany anxiety and memory deficits in a model of complex regional pain syndrome. Anesthesiology 121:852\u2013865","journal-title":"Anesthesiology"},{"key":"2235_CR91","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1002\/jnr.23883","volume":"95","author":"AM Taylor","year":"2017","unstructured":"Taylor AM, Mehrabani S, Liu S, Taylor AJ, Cahill CM (2017) Topography of microglial activation in sensory- and affect-related brain regions in chronic pain. J Neurosci Res 95:1330\u20131335","journal-title":"J Neurosci Res"},{"key":"2235_CR92","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nrn2647","volume":"10","author":"YM Ulrich-Lai","year":"2009","unstructured":"Ulrich-Lai YM, Herman JP (2009) Neural regulation of endocrine and autonomic stress responses. Nat Rev Neurosci 10:397\u2013409","journal-title":"Nat Rev Neurosci"},{"key":"2235_CR93","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.physbeh.2006.03.012","volume":"88","author":"YM Ulrich-Lai","year":"2006","unstructured":"Ulrich-Lai YM, Xie W, Meij JT, Dolgas CM, Yu L, Herman JP (2006) Limbic and HPA axis function in an animal model of chronic neuropathic pain. Physiol Behav 88:67\u201376","journal-title":"Physiol Behav"},{"key":"2235_CR94","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1177\/1073858416633104","volume":"22","author":"TB Usdin","year":"2016","unstructured":"Usdin TB, Dimitrov EL (2016) The effects of extended pain on behavior. Neuroscientist 22:521\u2013533","journal-title":"Neuroscientist"},{"issue":"4","key":"2235_CR95","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/j.neuroscience.2007.10.070","volume":"152","author":"DJ Vagg","year":"2008","unstructured":"Vagg DJ, Bandler R, Keay KA (2008) Hypovolemic shock: critical involvement of a projection from the ventrolateral periaqueductal gray to the caudal midline medulla. Neuroscience 152(4):1099\u20131109","journal-title":"Neuroscience"},{"key":"2235_CR96","doi-asserted-by":"publisher","first-page":"9375","DOI":"10.1523\/JNEUROSCI.17-23-09375.1997","volume":"17","author":"DL Walker","year":"1997","unstructured":"Walker DL, Davis M (1997) Double dissociation between the involvement of the bed nucleus of the stria terminalis and the central nucleus of the amygdala in startle increases produced by conditioned versus unconditioned fear. J Neurosci 17:9375","journal-title":"J Neurosci"},{"key":"2235_CR97","doi-asserted-by":"publisher","first-page":"E18739","DOI":"10.1371\/journal.pone.0018739","volume":"6","author":"DV Wang","year":"2011","unstructured":"Wang DV, Wang F, Liu J, Zhang L, Wang Z, Lin L (2011) Neurons in the amygdala with response-selectivity for anxiety in two ethologically based tests. PLoS ONE 6:E18739","journal-title":"PLoS ONE"},{"key":"2235_CR98","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.neubiorev.2015.08.017","volume":"57","author":"KM Wassum","year":"2015","unstructured":"Wassum KM, Izquierdo A (2015) The basolateral amygdala in reward learning and addiction. Neurosci Biobehav Rev 57:271\u2013283","journal-title":"Neurosci Biobehav Rev"},{"key":"2235_CR99","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/0006-8993(82)90272-4","volume":"232","author":"KL Weller","year":"1982","unstructured":"Weller KL, Smith DA (1982) Afferent connections to the bed nucleus of the stria terminalis. Brain Res 232:255\u2013270","journal-title":"Brain Res"},{"key":"2235_CR101","doi-asserted-by":"publisher","first-page":"11935","DOI":"10.1038\/ncomms11935","volume":"7","author":"Y Yang","year":"2016","unstructured":"Yang Y, Wang ZH, Jin S, Gao D, Liu N, Chen SP, Zhang S, Liu Q, Liu E, Wang X, Liang X, Wei P, Li X, Li Y, Yue C, Li HL, Wang YL, Wang Q, Ke D, Xie Q, Xu F, Wang L, Wang JZ (2016) Opposite monosynaptic scaling of BLP-VCA1 inputs governs hopefulness- and helplessness-modulated spatial learning and memory. Nat Commun 7:11935","journal-title":"Nat Commun"},{"key":"2235_CR102","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.neuron.2018.10.013","volume":"100","author":"EY Yap","year":"2018","unstructured":"Yap EY, Greenberg ME (2018) Activity-regulated transcription: bridging the gap between neural activity and behaviour. Neuron 100:330\u2013348","journal-title":"Neuron"},{"key":"2235_CR103","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/0006-8993(82)90518-2","volume":"239","author":"CY Yim","year":"1982","unstructured":"Yim CY, Mogenson GJ (1982) Response of nucleus accumbens neurons to amygdala stimulation and its modification by dopamine. Brain Res 239:401\u2013415","journal-title":"Brain Res"},{"key":"2235_CR104","doi-asserted-by":"publisher","first-page":"2741","DOI":"10.1007\/s00213-015-3911-4","volume":"232","author":"G Yu","year":"2015","unstructured":"Yu G, Sharp BM (2015) Basolateral amygdala and ventral hippocampus in stress-induced amplification of nicotine self-administration during reacquisition in rat. Psychopharmacology 232:2741\u20132749","journal-title":"Psychopharmacology"},{"key":"2235_CR105","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","volume":"16","author":"M Zimmermann","year":"1983","unstructured":"Zimmermann M (1983) Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16:109\u2013110","journal-title":"Pain"}],"container-title":["Brain Structure and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-021-02235-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00429-021-02235-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-021-02235-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T03:07:53Z","timestamp":1674961673000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00429-021-02235-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,13]]},"references-count":96,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["2235"],"URL":"https:\/\/doi.org\/10.1007\/s00429-021-02235-6","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-178751\/v1","asserted-by":"object"}]},"ISSN":["1863-2653","1863-2661"],"issn-type":[{"value":"1863-2653","type":"print"},{"value":"1863-2661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,13]]},"assertion":[{"value":"9 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}