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Deafness can be caused by particular mutations in the neuroplastin (<jats:italic>Nptn<\/jats:italic>) gene, which encodes a transmembrane recognition molecule of the immunoglobulin (Ig) superfamily and plasma membrane Calcium ATPase (PMCA) accessory subunit. This study investigates whether the complete absence of neuroplastin or the loss of neuroplastin in the adult after normal development lead to hearing impairment in mice analyzed by behavioral, electrophysiological, and in vivo imaging measurements. Auditory brainstem recordings from adult neuroplastin-deficient mice (<jats:italic>Nptn<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup>) show that these mice are deaf. With age, hair cells and spiral ganglion cells degenerate in <jats:italic>Nptn<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> mice. Adult <jats:italic>Nptn<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> mice fail to behaviorally respond to white noise and show reduced baseline blood flow in the auditory cortex (AC) as revealed by single-photon emission computed tomography (SPECT). In adult <jats:italic>Nptn<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> mice, tone-evoked cortical activity was not detectable within the primary auditory field (A1) of the AC, although we observed non-persistent tone-like evoked activities in electrophysiological recordings of some young <jats:italic>Nptn<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> mice. Conditional ablation of neuroplastin in <jats:italic>Nptn<\/jats:italic><jats:sup><jats:italic>lox\/loxEmx1Cre<\/jats:italic><\/jats:sup> mice reveals that behavioral responses to simple tones or white noise do not require neuroplastin expression by central glutamatergic neurons. Loss of neuroplastin from hair cells in adult <jats:italic>Nptn<\/jats:italic><jats:sup><jats:italic>\u0394lox\/loxPrCreERT<\/jats:italic><\/jats:sup> mice after normal development is correlated with increased hearing thresholds and only high prepulse intensities result in effective prepulse inhibition (PPI) of the startle response. Furthermore, we show that neuroplastin is required for the expression of PMCA 2 in outer hair cells. This suggests that altered Ca<jats:sup>2+<\/jats:sup> homeostasis underlies the observed hearing impairments and leads to hair cell degeneration. Our results underline the importance of neuroplastin for the development and the maintenance of the auditory system.<\/jats:p>","DOI":"10.1007\/s00429-021-02269-w","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T12:03:12Z","timestamp":1618228992000},"page":"1533-1551","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Neuroplastin expression is essential for hearing and hair cell PMCA expression"],"prefix":"10.1007","volume":"226","author":[{"given":"Xiao","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5854-1545","authenticated-orcid":false,"given":"Michael G. 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