{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:19:09Z","timestamp":1792783149892,"version":"4.5.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T00:00:00Z","timestamp":1659830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T00:00:00Z","timestamp":1659830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Dr. Gerald J. and Dorothy R. Friedman New York Foundation for Medical Research Grant","id":[{"id":"https:\/\/ror.org\/02yxc8q04","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG050663"],"award-info":[{"award-number":["AG050663"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["265087"],"award-info":[{"award-number":["265087"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009347","name":"INPRFM","doi-asserted-by":"crossref","award":["NC19110.0"],"award-info":[{"award-number":["NC19110.0"]}],"id":[{"id":"10.13039\/501100009347","id-type":"DOI","asserted-by":"crossref"}]},{"name":"DGAPA-UNAM PAPITT","award":["IN208515"],"award-info":[{"award-number":["IN208515"]}]},{"name":"DGAPA-UNAM PAPITT","award":["IN209018"],"award-info":[{"award-number":["IN209018"]}]},{"DOI":"10.13039\/501100009347","name":"INPRFM","doi-asserted-by":"crossref","award":["NC143290.0"],"award-info":[{"award-number":["NC143290.0"]}],"id":[{"id":"10.13039\/501100009347","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Brain Struct Funct"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hypophysiotropic thyrotropin-releasing hormone (TRH) neurons function as metabolic sensors that regulate the thyroid axis and energy homeostasis. Less is known about the role of other hypothalamic TRH neurons. As central administration of TRH decreases food intake and increases histamine in the tuberomammillary nuclei (TMN), and TMN histamine neurons are densely innervated by TRH fibers from an unknown origin, we mapped the location of TRH neurons that project to the TMN. The retrograde tracer, cholera toxin B subunit (CTB), was injected into the TMN E1\u2013E2, E4\u2013E5 subdivisions of adult Sprague\u2013Dawley male rats. TMN projecting neurons were observed in the septum, preoptic area, bed nucleus of the stria terminalis (BNST), perifornical area, anterior paraventricular nucleus, peduncular and tuberal lateral hypothalamus (TuLH), suprachiasmatic nucleus and medial amygdala. However, CTB\/pro-TRH178-199 double-labeled cells were only found in the TuLH. The specificity of the retrograde tract-tracing result was confirmed by administering the anterograde tracer,\n                    <jats:italic>Phaseolus vulgaris<\/jats:italic>\n                    leuco-agglutinin (PHAL) into the TuLH. Double-labeled PHAL-pro-TRH boutons were identified in all subdivisions of the TMN. TMN neurons double-labeled for histidine decarboxylase (\n                    <jats:italic>Hdc<\/jats:italic>\n                    )\/PHAL,\n                    <jats:italic>Hdc<\/jats:italic>\n                    \/\n                    <jats:italic>Trh receptor<\/jats:italic>\n                    (\n                    <jats:italic>Trhr<\/jats:italic>\n                    ), and\n                    <jats:italic>Hdc<\/jats:italic>\n                    \/\n                    <jats:italic>Trh<\/jats:italic>\n                    . Further confirmation of a TuLH-TRH neuronal projection to the TMN was established in a transgenic mouse that expresses Cre recombinase in TRH-producing cells following microinjection of a Cre recombinase-dependent AAV that expresses mCherry into the TuLH. We conclude that, in rodents, the TRH innervation of TMN originates in part from TRH neurons in the TuLH, and that this TRH population may contribute to regulate energy homeostasis through histamine\n                    <jats:italic>Trhr-<\/jats:italic>\n                    positive neurons of the TMN.\n                  <\/jats:p>","DOI":"10.1007\/s00429-022-02527-5","type":"journal-article","created":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T12:02:32Z","timestamp":1659873752000},"page":"2329-2347","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Origin of thyrotropin-releasing hormone neurons that innervate the tuberomammillary nuclei"],"prefix":"10.1007","volume":"227","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5560-2645","authenticated-orcid":false,"given":"Edith","family":"S\u00e1nchez-Jaramillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Wittmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Menyh\u00e9rt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praful","family":"Singru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela B.","family":"G\u00f3mez-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"S\u00e1nchez-Islas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nashiely","family":"Y\u00e1\u00f1ez-Recendis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime Arturo","family":"Pimentel-Cabrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Le\u00f3n-Olea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"Gereben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csaba","family":"Fekete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Charli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald M.","family":"Lechan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,7]]},"reference":[{"issue":"2","key":"2527_CR1","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.neuint.2006.09.009","volume":"50","author":"A Aguilar-Valles","year":"2007","unstructured":"Aguilar-Valles A, Sanchez E, de Gortari P, Garcia-Vazquez AI, Ramirez-Amaya V, Bermudez-Rattoni F, Joseph-Bravo P (2007) The expression of TRH, its receptors and degrading enzyme is differentially modulated in the rat limbic system during training in the Morris water maze. Neurochem Int 50(2):404\u2013417. https:\/\/doi.org\/10.1016\/j.neuint.2006.09.009","journal-title":"Neurochem Int"},{"issue":"1","key":"2527_CR2","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/cne.903230109","volume":"323","author":"MS Airaksinen","year":"1992","unstructured":"Airaksinen MS, Alanen S, Szaba E, Visser TJ, Panula P (1992) Multiple neurotransmitters in the tuberomammillary nucleus: comparison of rat, mouse, and guinea pig. J Comp Neurol 323(1):103\u2013116. https:\/\/doi.org\/10.1002\/cne.903230109","journal-title":"J Comp Neurol"},{"issue":"2","key":"2527_CR3","doi-asserted-by":"publisher","first-page":"323","DOI":"10.3181\/00379727-77-18766","volume":"77","author":"BK Anand","year":"1951","unstructured":"Anand BK, Brobeck JR (1951) Localization of a \u201cfeeding center\u201d in the hypothalamus of the rat. Proc Soc Exp Biol Med 77(2):323\u2013324. https:\/\/doi.org\/10.3181\/00379727-77-18766","journal-title":"Proc Soc Exp Biol Med"},{"issue":"2","key":"2527_CR4","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0149-7634(95)00015-1","volume":"20","author":"LL Bernardis","year":"1996","unstructured":"Bernardis LL, Bellinger LL (1996) The lateral hypothalamic area revisited: ingestive behavior. Neurosci Biobehav Rev 20(2):189\u2013287. https:\/\/doi.org\/10.1016\/0149-7634(95)00015-1","journal-title":"Neurosci Biobehav Rev"},{"issue":"3","key":"2527_CR5","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1111\/j.1476-5381.1989.tb12012.x","volume":"97","author":"LJ Bristow","year":"1989","unstructured":"Bristow LJ, Bennett GW (1989) Effect of chronic intra-accumbens administration of the TRH analogue CG3509 on histamine-induced behaviour in the rat. Br J Pharmacol 97(3):745\u2013752. https:\/\/doi.org\/10.1111\/j.1476-5381.1989.tb12012.x","journal-title":"Br J Pharmacol"},{"issue":"1","key":"2527_CR6","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/cne.903110105","volume":"311","author":"H Ericson","year":"1991","unstructured":"Ericson H, Blomqvist A, Kohler C (1991) Origin of neuronal inputs to the region of the tuberomammillary nucleus of the rat brain. J Comp Neurol 311(1):45\u201364. https:\/\/doi.org\/10.1002\/cne.903110105","journal-title":"J Comp Neurol"},{"issue":"2","key":"2527_CR7","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1210\/er.2013-1087","volume":"35","author":"C Fekete","year":"2014","unstructured":"Fekete C, Lechan RM (2014) Central regulation of hypothalamic-pituitary-thyroid axis under physiological and pathophysiological conditions. Endocr Rev 35(2):159\u2013194. https:\/\/doi.org\/10.1210\/er.2013-1087","journal-title":"Endocr Rev"},{"issue":"24","key":"2527_CR8","doi-asserted-by":"publisher","first-page":"9224","DOI":"10.1523\/JNEUROSCI.20-24-09224.2000","volume":"20","author":"C Fekete","year":"2000","unstructured":"Fekete C, Mih\u00e1ly E, Luo LG, Kelly J, Clausen JT, Mao Q, Rand WM, Moss LG, Kuhar M, Emerson CH, Jackson IM, Lechan RM (2000) Association of cocaine- and amphetamine-regulated transcript-immunoreactive elements with thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and its role in the regulation of the hypothalamic-pituitary-thyroid axis during fasting. J Neurosci 20(24):9224\u20139234. https:\/\/doi.org\/10.1523\/JNEUROSCI.20-24-09224.2000","journal-title":"J Neurosci"},{"issue":"2","key":"2527_CR9","doi-asserted-by":"publisher","first-page":"I","DOI":"10.1016\/j.orcp.2007.01.002","volume":"1","author":"T Fukagawa","year":"2007","unstructured":"Fukagawa T, Fukagawa K, Gotoh K, Noguchi H, Yoshimatsu H (2007) Prepro-TRH 178\u2013199 inhibits histamine- or restraint stress-induced activation of corticotropin releasing hormone production in rat hypothalamus. Obes Res Clin Pract 1(2):I\u2013II. https:\/\/doi.org\/10.1016\/j.orcp.2007.01.002","journal-title":"Obes Res Clin Pract"},{"issue":"4","key":"2527_CR10","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1002\/cne.902940404","volume":"294","author":"LM Geeraedts","year":"1990","unstructured":"Geeraedts LM, Nieuwenhuys R, Veening JG (1990) Medial forebrain bundle of the rat: IV. Cytoarchitecture of the caudal (lateral hypothalamic) part of the medial forebrain bundle bed nucleus. J Comp Neurol 294(4):537\u2013568. https:\/\/doi.org\/10.1002\/cne.902940404","journal-title":"J Comp Neurol"},{"issue":"3","key":"2527_CR11","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1111\/j.1471-4159.2007.04802.x","volume":"103","author":"K Gotoh","year":"2007","unstructured":"Gotoh K, Fukagawa K, Fukagawa T, Noguchi H, Kakuma T, Sakata T, Yoshimatsu H (2007) Hypothalamic neuronal histamine mediates the thyrotropin-releasing hormone-induced suppression of food intake. J Neurochem 103(3):1102\u20131110. https:\/\/doi.org\/10.1111\/j.1471-4159.2007.04802.x","journal-title":"J Neurochem"},{"issue":"2","key":"2527_CR12","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nrn1034","volume":"4","author":"H Haas","year":"2003","unstructured":"Haas H, Panula P (2003) The role of histamine and the tuberomamillary nucleus in the nervous system. Nat Rev Neurosci 4(2):121\u2013130. https:\/\/doi.org\/10.1038\/nrn1034","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"2527_CR13","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1152\/physrev.00043.2007","volume":"88","author":"HL Haas","year":"2008","unstructured":"Haas HL, Sergeeva OA, Selbach O (2008) Histamine in the nervous system. Physiol Rev 88(3):1183\u20131241. https:\/\/doi.org\/10.1152\/physrev.00043.2007","journal-title":"Physiol Rev"},{"issue":"1","key":"2527_CR14","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.brainresrev.2010.02.002","volume":"64","author":"JD Hahn","year":"2010","unstructured":"Hahn JD, Swanson LW (2010) Distinct patterns of neuronal inputs and outputs of the juxtaparaventricular and suprafornical regions of the lateral hypothalamic area in the male rat. Brain Res Rev 64(1):14\u2013103. https:\/\/doi.org\/10.1016\/j.brainresrev.2010.02.002","journal-title":"Brain Res Rev"},{"issue":"2","key":"2527_CR15","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1002\/1096-9861(20001211)428:2<319::AID-CNE10>3.0.CO;2-9","volume":"428","author":"H Heuer","year":"2000","unstructured":"Heuer H, Sch\u00e4fer MK, O\u2019Donnell D, Walker P, Bauer K (2000) Expression of thyrotropin releasing hormone receptor 2 (TRH-R2) in the central nervous system of rats. J Comp Neurol 428(2):319\u2013336","journal-title":"J Comp Neurol"},{"issue":"17\u201318","key":"2527_CR16","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1016\/s0024-3205(98)00087-3","volume":"62","author":"A Horita","year":"1998","unstructured":"Horita A (1998) An update on the CNS actions of TRH and its analogs. Life Sci 62(17\u201318):1443\u20131448. https:\/\/doi.org\/10.1016\/s0024-3205(98)00087-3","journal-title":"Life Sci"},{"key":"2527_CR17","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.neuroscience.2014.06.043","volume":"277","author":"E Horjales-Araujo","year":"2014","unstructured":"Horjales-Araujo E, Hellysaz A, Broberger C (2014) Lateral hypothalamic thyrotropin-releasing hormone neurons: distribution and relationship to histochemically defined cell populations in the rat. Neuroscience 277:87\u2013102. https:\/\/doi.org\/10.1016\/j.neuroscience.2014.06.043","journal-title":"Neuroscience"},{"issue":"5","key":"2527_CR18","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1159\/000124943","volume":"47","author":"K Ishikawa","year":"1988","unstructured":"Ishikawa K, Taniguchi Y, Inoue K, Kurosumi K, Suzuki M (1988) Immunocytochemical delineation of thyrotrophic area: origin of thyrotropin-releasing hormone in the median eminence. Neuroendocrinology 47(5):384\u2013388. https:\/\/doi.org\/10.1159\/000124943","journal-title":"Neuroendocrinology"},{"key":"2527_CR19","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.neulet.2014.07.022","volume":"579","author":"IS Jang","year":"2014","unstructured":"Jang IS (2014) Metabotropic glutamate receptors inhibit GABA release in rat histamine neurons. Neurosci Lett 579:106\u2013109. https:\/\/doi.org\/10.1016\/j.neulet.2014.07.022","journal-title":"Neurosci Lett"},{"issue":"2","key":"2527_CR20","doi-asserted-by":"publisher","first-page":"e0400-18","DOI":"10.1523\/ENEURO.0400-18.2019","volume":"6","author":"GL Jones","year":"2019","unstructured":"Jones GL, Wittmann G, Yokosawa EB, Yu H, Mercer AJ, Lechan RM, Low MJ (2019) Selective restoration of pomc expression in glutamatergic POMC neurons: evidence for a dynamic hypothalamic neurotransmitter network. eNeuro 6(2):e0400-18. https:\/\/doi.org\/10.1523\/ENEURO.0400-18.2019","journal-title":"eNeuro"},{"issue":"19","key":"2527_CR21","doi-asserted-by":"publisher","first-page":"3948","DOI":"10.1002\/cne.22432","volume":"518","author":"A K\u00e1d\u00e1r","year":"2010","unstructured":"K\u00e1d\u00e1r A, S\u00e1nchez E, Wittmann G, Singru PS, F\u00fczesi T, Marsili A, Larsen PR, Liposits Z, Lechan RM, Fekete C (2010) Distribution of hypophysiotropic thyrotropin-releasing hormone (TRH)-synthesizing neurons in the hypothalamic paraventricular nucleus of the mouse. J Comp Neurol 518(19):3948\u20133961. https:\/\/doi.org\/10.1002\/cne.22432","journal-title":"J Comp Neurol"},{"issue":"4","key":"2527_CR22","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1002\/cne.903070402","volume":"307","author":"H Kawano","year":"1991","unstructured":"Kawano H, Tsuruo Y, Bando H, Daikoku S (1991) Hypophysiotrophic TRH-producing neurons identified by combining immunohistochemistry for pro-TRH and retrograde tracing. J Comp Neurol 307(4):531\u2013538. https:\/\/doi.org\/10.1002\/cne.903070402","journal-title":"J Comp Neurol"},{"issue":"7","key":"2527_CR23","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.1210\/en.2014-1885","volume":"156","author":"I Lazcano","year":"2015","unstructured":"Lazcano I, Cabral A, Uribe RM, Jaimes-Hoy L, Perello M, Joseph-Bravo P, S\u00e1nchez-Jaramillo E, Charli JL (2015) Fasting enhances pyroglutamyl peptidase II activity in tanycytes of the mediobasal hypothalamus of male adult rats. Endocrinology 156(7):2713\u20132723. https:\/\/doi.org\/10.1210\/en.2014-1885","journal-title":"Endocrinology"},{"issue":"5","key":"2527_CR24","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1111\/j.1460-9568.2006.04644.x","volume":"23","author":"J Mahia","year":"2006","unstructured":"Mahia J, Puerto A (2006) Lesions of tuberomammillary nuclei induce differential polydipsic and hyperphagic effects. Eur J Neurosci 23(5):1321\u20131331. https:\/\/doi.org\/10.1111\/j.1460-9568.2006.04644.x","journal-title":"Eur J Neurosci"},{"key":"2527_CR25","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1111\/j.1365-2818.1993.tb03313.x","volume":"169","author":"EMM Manders","year":"1993","unstructured":"Manders EMM, Verbeek FJ, Aten JA (1993) Measurement colocalization of objects in dual-colours confocal images. J Microsc 169:375\u2013382","journal-title":"J Microsc"},{"issue":"3","key":"2527_CR26","doi-asserted-by":"publisher","first-page":"212","DOI":"10.2174\/157339907781369002","volume":"3","author":"T Masaki","year":"2007","unstructured":"Masaki T, Yoshimatsu H (2007) Neuronal histamine and its receptors in obesity and diabetes. Curr Diabetes Rev 3(3):212\u2013216. https:\/\/doi.org\/10.2174\/157339907781369002","journal-title":"Curr Diabetes Rev"},{"issue":"2","key":"2527_CR27","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1210\/endo.142.2.7954","volume":"142","author":"EA Nillni","year":"2001","unstructured":"Nillni EA, Aird F, Seidah NG, Todd RB, Koenig JI (2001) PreproTRH(178\u2013199) and two novel peptides (pFQ7 and pSE14) derived from its processing, which are produced in the paraventricular nucleus of the rat hypothalamus, are regulated during suckling. Endocrinology 142(2):896\u2013906. https:\/\/doi.org\/10.1210\/endo.142.2.7954","journal-title":"Endocrinology"},{"issue":"1\u20132","key":"2527_CR28","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/0006-8993(86)90319-7","volume":"373","author":"T Ono","year":"1986","unstructured":"Ono T, Sasaki K, Nishino H, Fukuda M, Shibata R (1986) Feeding and diurnal related activity of lateral hypothalamic neurons in freely behaving rats. Brain Res 373(1\u20132):92\u2013102. https:\/\/doi.org\/10.1016\/0006-8993(86)90319-7","journal-title":"Brain Res"},{"issue":"2","key":"2527_CR29","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/0006-8993(89)90244-8","volume":"490","author":"K Ookuma","year":"1989","unstructured":"Ookuma K, Yoshimatsu H, Sakata T, Fujimoto K, Fukagawa F (1989) Hypothalamic sites of neuronal histamine action on food intake by rats. Brain Res 490(2):268\u2013275. https:\/\/doi.org\/10.1016\/0006-8993(89)90244-8","journal-title":"Brain Res"},{"issue":"1","key":"2527_CR30","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1109\/TSMC.1979.4310076","volume":"9","author":"NA Otsu","year":"1979","unstructured":"Otsu NA (1979) Threshold selection method from gray-level histograms. IEEE Trans Syst Man Cybern 9(1):62\u201366. https:\/\/doi.org\/10.1109\/TSMC.1979.4310076","journal-title":"IEEE Trans Syst Man Cybern"},{"issue":"7","key":"2527_CR31","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1038\/nrn3526","volume":"14","author":"P Panula","year":"2013","unstructured":"Panula P, Nuutinen S (2013) The histaminergic network in the brain: basic organization and role in disease. Nat Rev Neurosci 14(7):472\u2013487. https:\/\/doi.org\/10.1038\/nrn3526","journal-title":"Nat Rev Neurosci"},{"issue":"14","key":"2527_CR32","doi-asserted-by":"publisher","first-page":"4471","DOI":"10.1523\/JNEUROSCI.2976-08.2009","volume":"29","author":"R Parmentier","year":"2009","unstructured":"Parmentier R, Kolbaev S, Klyuch BP, Vandael D, Lin JS, Selbach O et al (2009) Excitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone. J Neurosci 29(14):4471\u20134483. https:\/\/doi.org\/10.1523\/JNEUROSCI.2976-08.2009","journal-title":"J Neurosci"},{"key":"2527_CR33","volume-title":"The mouse brain in stereotaxic coordinates","author":"G Paxinos","year":"2001","unstructured":"Paxinos G, Franklin KBJ (2001) The mouse brain in stereotaxic coordinates, 2nd edn. Academic Press, San Diego","edition":"2"},{"key":"2527_CR34","volume-title":"The rat brain in stereotaxic coordinates","author":"G Paxinos","year":"2009","unstructured":"Paxinos G, Watson C (2009) The rat brain in stereotaxic coordinates, 6th edn. Academic Press, China","edition":"6"},{"issue":"3","key":"2527_CR35","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1007\/s00429-017-1553-5","volume":"223","author":"Z P\u00e9terfi","year":"2018","unstructured":"P\u00e9terfi Z, Farkas E, Nagyunyomi-S\u00e9nyi K, K\u00e1d\u00e1r A, Ott\u00f3 S, Horv\u00e1th A, F\u00fczesi T, Lechan RM, Fekete C (2018) Role of TRH\/UCN3 neurons of the perifornical area\/bed nucleus of stria terminalis region in the regulation of the anorexigenic POMC neurons of the arcuate nucleus in male mice and rats. Brain Struct Funct 223(3):1329\u20131341. https:\/\/doi.org\/10.1007\/s00429-017-1553-5","journal-title":"Brain Struct Funct"},{"issue":"4","key":"2527_CR36","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1002\/cne.901830402","volume":"183","author":"CB Saper","year":"1979","unstructured":"Saper CB, Swanson LW, Cowan WM (1979) An autoradiographic study of the efferent connections of the lateral hypothalamic area in the rat. J Comp Neurol 183(4):689\u2013706. https:\/\/doi.org\/10.1002\/cne.901830402","journal-title":"J Comp Neurol"},{"key":"2527_CR37","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.brainres.2012.10.010","volume":"1488","author":"A Sarvari","year":"2012","unstructured":"Sarvari A, Farkas E, Kadar A, Zseli G, Fuzesi T, Lechan RM, Fekete C (2012) Thyrotropin-releasing hormone-containing axons innervate histaminergic neurons in the tuberomammillary nucleus. Brain Res 1488:72\u201380. https:\/\/doi.org\/10.1016\/j.brainres.2012.10.010","journal-title":"Brain Res"},{"issue":"7","key":"2527_CR38","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","volume":"9","author":"J Schindelin","year":"2012","unstructured":"Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, Preibisch S, Rueden C, Saalfeld S, Schmid B, Tinevez JY, White DJ, Hartenstein V, Eliceiri K, Tomancak P, Cardona A (2012) Fiji: an open-source platform for biological-image analysis. Nat Methods 9(7):676\u2013682. https:\/\/doi.org\/10.1038\/nmeth.2019","journal-title":"Nat Methods"},{"issue":"2","key":"2527_CR39","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/nn.4220","volume":"19","author":"GD Stuber","year":"2016","unstructured":"Stuber GD, Wise RA (2016) Lateral hypothalamic circuits for feeding and reward. Nat Neurosci 19(2):198\u2013205. https:\/\/doi.org\/10.1038\/nn.4220","journal-title":"Nat Neurosci"},{"issue":"2","key":"2527_CR40","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/0091-3057(82)90078-8","volume":"17","author":"T Suzuki","year":"1982","unstructured":"Suzuki T, Kohno H, Sakurada T, Tadano T, Kisara K (1982) Intracranial injection of thyrotropin releasing hormone (TRH) suppresses starvation-induced feeding and drinking in rats. Pharmacol Biochem Behav 17(2):249\u2013253. https:\/\/doi.org\/10.1016\/0091-3057(82)90078-8","journal-title":"Pharmacol Biochem Behav"},{"issue":"2","key":"2527_CR41","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/s0006-8993(01)02853-0","volume":"913","author":"S Suzuki","year":"2001","unstructured":"Suzuki S, Solberg LC, Redei EE, Handa RJ (2001) Prepro-thyrotropin releasing hormone 178\u2013199 immunoreactivity is altered in the hypothalamus of the Wistar-Kyoto strain of rat. Brain Res 913(2):224\u2013233. https:\/\/doi.org\/10.1016\/s0006-8993(01)02853-0","journal-title":"Brain Res"},{"issue":"3","key":"2527_CR42","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/cne.22017","volume":"515","author":"G Wittmann","year":"2009","unstructured":"Wittmann G, Fuzesi T, Singru PS, Liposits Z, Lechan RM, Fekete C (2009) Efferent projections of thyrotropin-releasing hormone-synthesizing neurons residing in the anterior parvocellular subdivision of the hypothalamic paraventricular nucleus. J Comp Neurol 515(3):313\u2013330. https:\/\/doi.org\/10.1002\/cne.22017","journal-title":"J Comp Neurol"},{"key":"2527_CR43","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.neuroscience.2019.05.032","volume":"413","author":"D Yin","year":"2019","unstructured":"Yin D, Dong H, Wang TX, Hu ZZ, Cheng NN, Qu WM, Huang ZL (2019) Glutamate activates the histaminergic tuberomammillary nucleus and increases wakefulness in rats. Neuroscience 413:86\u201398. https:\/\/doi.org\/10.1016\/j.neuroscience.2019.05.032","journal-title":"Neuroscience"},{"issue":"5","key":"2527_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/sleep\/zsz031","volume":"42","author":"X Yu","year":"2019","unstructured":"Yu X, Ma Y, Harding EC, Yustos R, Vyssotski AL, Franks NP, Wisden W (2019) Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness. Sleep 42(5):1\u201313. https:\/\/doi.org\/10.1093\/sleep\/zsz031","journal-title":"Sleep"},{"issue":"3","key":"2527_CR45","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1002\/cne.10257","volume":"448","author":"DR Ziegler","year":"2002","unstructured":"Ziegler DR, Cullinan WE, Herman JP (2002) Distribution of vesicular glutamate transporter mRNA in rat hypothalamus. J Comp Neurol 448(3):217\u2013229. https:\/\/doi.org\/10.1002\/cne.10257","journal-title":"J Comp Neurol"}],"container-title":["Brain Structure and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-022-02527-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00429-022-02527-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-022-02527-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T05:10:08Z","timestamp":1661490608000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00429-022-02527-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,7]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["2527"],"URL":"https:\/\/doi.org\/10.1007\/s00429-022-02527-5","relation":{},"ISSN":["1863-2653","1863-2661"],"issn-type":[{"value":"1863-2653","type":"print"},{"value":"1863-2661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,7]]},"assertion":[{"value":"22 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have nothing to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Protocols followed the NIH guide for the care and use of laboratory animals (8th ed.), and the Official Mexican Norm for production, care and use of laboratory animals NOM-062-ZOO-1999. All experimental protocols were reviewed and approved by the Institutional Animal Care and Use Committee at Tufts Medical Center and Tufts University School of Medicine and the institutional bioethics committees at Instituto de Biotecnolog\u00eda-UNAM and Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}