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Elife 7:e32510","journal-title":"Elife"}],"container-title":["Brain Structure and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-022-02604-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00429-022-02604-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-022-02604-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T16:00:40Z","timestamp":1676995240000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00429-022-02604-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,18]]},"references-count":71,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["2604"],"URL":"https:\/\/doi.org\/10.1007\/s00429-022-02604-9","relation":{},"ISSN":["1863-2661"],"issn-type":[{"value":"1863-2661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,18]]},"assertion":[{"value":"28 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No original experimental data were involved in this study. Codes used for model simulations will be made publicly available at ModelDB (https:\/\/senselab.med.yale.edu\/ModelDB\/) upon acceptance of this work for publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"The authors declare no competing financial interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Despite a growing recognition that striatal cholinergic interneurons, also known as tonically active neurons (TANs), can significantly impact synaptic plasticity and firing patterns of projection neurons in the striatum, there has been relatively little computational work to simulate and analyze their properties. We address this gap by developing a computational model of TANs, fit to match a large collection of experimental results. Simulations of the computational model allow us to analyze the roles of various transmembrane currents in producing TAN responses and the contribution of acetylcholine released by TANs in sculpting their activity in response to excitatory inputs, which could have implications for reinforcement learning and for motor tics in conditions such as Tourette\u2019s syndrome.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Significance statement"}}]}}