{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:19:08Z","timestamp":1792783148892,"version":"4.5.0"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:00:00Z","timestamp":1690156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:00:00Z","timestamp":1690156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Istanbul University Research Projects Unit","award":["TSA-2022-39128"],"award-info":[{"award-number":["TSA-2022-39128"]}],"id":[{"id":"https:\/\/ror.org\/03a5qrr21","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Brain Struct Funct"],"DOI":"10.1007\/s00429-023-02683-2","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T04:02:32Z","timestamp":1690171352000},"page":"1885-1899","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Morphometric analysis of medial temporal lobe subregions in Alzheimer's disease using high-resolution MRI"],"prefix":"10.1007","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8329-5507","authenticated-orcid":false,"given":"Emre","family":"Hari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1956-575X","authenticated-orcid":false,"given":"Elif","family":"Kurt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1849-0055","authenticated-orcid":false,"given":"Cigdem","family":"Ulasoglu-Yildiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6588-3479","authenticated-orcid":false,"given":"Ali","family":"Bayram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6032-0856","authenticated-orcid":false,"given":"Ba\u015far","family":"Bilgic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6803-734X","authenticated-orcid":false,"given":"Tamer","family":"Demiralp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2908-8475","authenticated-orcid":false,"given":"Hakan","family":"Gurvit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,24]]},"reference":[{"issue":"3","key":"2683_CR1","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1212\/WNL.42.3.631","volume":"42","author":"PV Arriagada","year":"1992","unstructured":"Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT (1992) Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42(3):631. https:\/\/doi.org\/10.1212\/WNL.42.3.631","journal-title":"Neurology"},{"issue":"4","key":"2683_CR2","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1017\/S0033291708004054","volume":"39","author":"F Beacher","year":"2009","unstructured":"Beacher F, Daly E, Simmons A, Prasher V, Morris R, Robinson C, Murphy DGM (2009) Alzheimer\u2019s disease and down\u2019s syndrome: an in vivo MRI study. Psychol Med 39(4):675\u2013684. https:\/\/doi.org\/10.1017\/S0033291708004054","journal-title":"Psychol Med"},{"issue":"1","key":"2683_CR3","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1093\/brain\/awz378","volume":"143","author":"TJ Betthauser","year":"2020","unstructured":"Betthauser TJ, Koscik RL, Jonaitis EM, Allison SL, Cody KA, Erickson CM, Clark LR (2020) Amyloid and tau imaging biomarkers explain cognitive decline from late middle-age. Brain 143(1):320\u2013335. https:\/\/doi.org\/10.1093\/brain\/awz378","journal-title":"Brain"},{"issue":"4","key":"2683_CR4","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/BF00308809","volume":"82","author":"H Braak","year":"1991","unstructured":"Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82(4):239\u2013259. https:\/\/doi.org\/10.1007\/BF00308809","journal-title":"Acta Neuropathol"},{"issue":"3","key":"2683_CR5","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0197-4580(95)00021-6","volume":"16","author":"H Braak","year":"1995","unstructured":"Braak H, Braak E (1995) Staging of Alzheimer\u2019s disease-related neurofibrillary changes. Neurobiol Aging 16(3):271\u2013284. https:\/\/doi.org\/10.1016\/0197-4580(95)00021-6","journal-title":"Neurobiol Aging"},{"issue":"4","key":"2683_CR6","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1080\/01688638408401233","volume":"6","author":"H Buschke","year":"1984","unstructured":"Buschke H (1984) Cued recall in amnesia. J Clin Neuropsychol 6(4):433\u2013440. https:\/\/doi.org\/10.1080\/01688638408401233","journal-title":"J Clin Neuropsychol"},{"issue":"4","key":"2683_CR7","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.3233\/JAD-2010-091186","volume":"19","author":"A Cherubini","year":"2010","unstructured":"Cherubini A, P\u00e9ran P, Spoletini I, Di Paola M, Di Iulio F, Hagberg GE, Caltagirone C (2010) Combined volumetry and DTI in subcortical structures of mild cognitive impairment and Alzheimer\u2019s disease patients. J Alzheimer\u2019s Dis 19(4):1273\u20131282. https:\/\/doi.org\/10.3233\/JAD-2010-091186","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"9","key":"2683_CR8","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1001\/archneur.1993.00540090046009","volume":"50","author":"C-A Cu\u00e9nod","year":"1993","unstructured":"Cu\u00e9nod C-A, Denys A, Michot J-L, Jehenson P, Forette F, Kaplan D, Boller F (1993) Amygdala atrophy in Alzheimer\u2019s disease: an in vivo magnetic resonance imaging study. Archiv Neurol 50(9):941\u2013945. https:\/\/doi.org\/10.1001\/archneur.1993.00540090046009","journal-title":"Archiv Neurol"},{"issue":"2","key":"2683_CR9","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1006\/nimg.1998.0395","volume":"9","author":"AM Dale","year":"1999","unstructured":"Dale AM, Fischl B, Sereno MI (1999) Cortical surface-based analysis I segmentation and surface reconstruction. Neuroimage 9(2):179\u2013194. https:\/\/doi.org\/10.1006\/nimg.1998.0395","journal-title":"Neuroimage"},{"key":"2683_CR10","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.neuroscience.2015.08.033","volume":"309","author":"R De Flores","year":"2015","unstructured":"De Flores R, La Joie R, Ch\u00e9telat G (2015) Structural imaging of hippocampal subfields in healthy aging and Alzheimer\u2019s disease. Neuroscience 309:29\u201350. https:\/\/doi.org\/10.1016\/j.neuroscience.2015.08.033","journal-title":"Neuroscience"},{"issue":"6","key":"2683_CR11","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1590\/S1807-59322011000600021","volume":"66","author":"LG de Vasconcelos","year":"2011","unstructured":"de Vasconcelos LG, Jackowski AP, de Oliveira MO, Flor YMR, Bueno OFA, Brucki SMD (2011) Voxel-based morphometry findings in Alzheimer\u2019s disease: neuropsychiatric symptoms and disability correlations-preliminary results. Clinics 66(6):1045\u20131050. https:\/\/doi.org\/10.1590\/S1807-59322011000600021","journal-title":"Clinics"},{"issue":"3","key":"2683_CR12","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","volume":"31","author":"RS Desikan","year":"2006","unstructured":"Desikan RS, S\u00e9gonne F, Fischl B, Quinn BT, Dickerson BC, Blacker D, Hyman BT (2006) An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage 31(3):968\u2013980. https:\/\/doi.org\/10.1016\/j.neuroimage.2006.01.021","journal-title":"Neuroimage"},{"issue":"1","key":"2683_CR13","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s13024-019-0333-5","volume":"14","author":"MA DeTure","year":"2019","unstructured":"DeTure MA, Dickson DW (2019) The neuropathological diagnosis of Alzheimer\u2019s disease. Mol Neurodegener 14(1):32. https:\/\/doi.org\/10.1186\/s13024-019-0333-5","journal-title":"Mol Neurodegener"},{"issue":"3","key":"2683_CR14","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/s0896-6273(02)00569-x","volume":"33","author":"B Fischl","year":"2002","unstructured":"Fischl B, Salat DH, Busa E, Albert M, Dieterich M, Haselgrove C, Dale AM (2002) Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 33(3):341\u2013355. https:\/\/doi.org\/10.1016\/s0896-6273(02)00569-x","journal-title":"Neuron"},{"issue":"3","key":"2683_CR15","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","volume":"12","author":"MF Folstein","year":"1975","unstructured":"Folstein MF, Folstein SE, McHugh PR (1975) \u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician. J Psychiatric Res 12(3):189\u2013198. https:\/\/doi.org\/10.1016\/0022-3956(75)90026-6","journal-title":"J Psychiatric Res"},{"issue":"2","key":"2683_CR16","doi-asserted-by":"publisher","first-page":"581","DOI":"10.3233\/JAD-2010-091549","volume":"22","author":"S F\u00f6rster","year":"2010","unstructured":"F\u00f6rster S, Vaitl A, Teipel SJ, Yakushev I, Mustafa M, la Foug\u00e8re C, Hampel H (2010) Functional representation of olfactory impairment in early Alzheimer\u2019s disease. J Alzheimer\u2019s Dis 22(2):581\u2013591. https:\/\/doi.org\/10.3233\/JAD-2010-091549","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"6","key":"2683_CR17","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1093\/brain\/119.6.2001","volume":"119","author":"NC Fox","year":"1996","unstructured":"Fox NC, Warrington EK, Freeborough PA, Hartikainen P, Kennedy AM, Stevens JM, Rossor MN (1996) Presymptomatic hippocampal atrophy in Alzheimer\u2019s disease: a longitudinal MRI study. Brain 119(6):2001\u20132007. https:\/\/doi.org\/10.1093\/brain\/119.6.2001","journal-title":"Brain"},{"issue":"4","key":"2683_CR18","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.neubiorev.2005.04.021","volume":"30","author":"RG Giaccio","year":"2006","unstructured":"Giaccio RG (2006) The dual origin hypothesis: An evolutionary brain-behavior framework for analyzing psychiatric disorders. Neurosci Biobehav Rev 30(4):526\u2013550. https:\/\/doi.org\/10.1016\/j.neubiorev.2005.04.021","journal-title":"Neurosci Biobehav Rev"},{"issue":"4","key":"2683_CR19","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1159\/000017133","volume":"10","author":"M Golebiowski","year":"1999","unstructured":"Golebiowski M, Barcikowska M, Pfeffer A (1999) Magnetic resonance imaging-based hippocampal volumetry in patients with dementia of the Alzheimer type. Dement Geriatr Cogn Disord 10(4):284\u2013288. https:\/\/doi.org\/10.1159\/000017133","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"3","key":"2683_CR20","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1097\/WAD.0b013e3181cfc78b","volume":"24","author":"E Grober","year":"2010","unstructured":"Grober E, Sanders AE, Hall C, Lipton RB (2010) Free and cued selective reminding identifies very mild dementia in primary care. Alzheimer Dis Assoc Disord 24(3):284\u2013290. https:\/\/doi.org\/10.1097\/WAD.0b013e3181cfc78b","journal-title":"Alzheimer Dis Assoc Disord"},{"issue":"10","key":"2683_CR21","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1001\/archneur.1980.00500590049006","volume":"37","author":"AG Herzog","year":"1980","unstructured":"Herzog AG, Kemper TL (1980) Amygdaloid changes in aging and dementia. Arch Neurol 37(10):625\u2013629. https:\/\/doi.org\/10.1001\/archneur.1980.00500590049006","journal-title":"Arch Neurol"},{"issue":"6","key":"2683_CR22","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1159\/000106651","volume":"8","author":"R Heun","year":"1997","unstructured":"Heun R, Mazanek M, Atzor K-R, Tintera J, Gawehn J, Burkart M, Stoeter P (1997) Amygdala-hippocampal atrophy and memory performance in dementia of Alzheimer type. Dementia Geriatric Cognit Disord 8(6):329\u2013336. https:\/\/doi.org\/10.1159\/000106651","journal-title":"Dementia Geriatric Cognit Disord"},{"issue":"3","key":"2683_CR23","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1097\/YCO.0b013e3280ebb613","volume":"20","author":"D Hor\u00ednek","year":"2007","unstructured":"Hor\u00ednek D, Varjassyov\u00e1 A, Hort J (2007) Magnetic resonance analysis of amygdalar volume in Alzheimer\u2019s disease. Curr Opin Psychiatry 20(3):273\u2013277. https:\/\/doi.org\/10.1097\/YCO.0b013e3280ebb613","journal-title":"Curr Opin Psychiatry"},{"key":"2683_CR24","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.neuroimage.2015.04.042","volume":"115","author":"JE Iglesias","year":"2015","unstructured":"Iglesias JE, Augustinack JC, Nguyen K, Player CM, Player A, Wright M, Van Leemput K (2015) A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: application to adaptive segmentation of in vivo MRI. Neuroimage 115:117\u2013137. https:\/\/doi.org\/10.1016\/j.neuroimage.2015.04.042","journal-title":"Neuroimage"},{"issue":"2","key":"2683_CR65","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1093\/brain\/awac299","volume":"146","author":"PS Insel","year":"2023","unstructured":"Insel PS, Young CB, Johnson KA, Sperling RA, Mormino EC, Donohue MC (2023) Tau positron emission tomography in preclinical Alzheimer\u2019s disease. Brain 146(2):700\u2013711. https:\/\/doi.org\/10.1093\/brain\/awac299","journal-title":"Brain"},{"issue":"5","key":"2683_CR25","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1080\/01688639708403753","volume":"19","author":"RJ Ivnik","year":"1997","unstructured":"Ivnik RJ, Smith GE, Lucas JA, Tangalos EG, Kokmen E, Petersen RC (1997) Free and cued selective reminding test: MOANS norms. J Clin Exp Neuropsychol 19(5):676\u2013691. https:\/\/doi.org\/10.1080\/01688639708403753","journal-title":"J Clin Exp Neuropsychol"},{"issue":"1","key":"2683_CR26","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S1474-4422(09)70299-6","volume":"9","author":"CRJ Jack","year":"2010","unstructured":"Jack CRJ, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, Trojanowski JQ (2010) Hypothetical model of dynamic biomarkers of the Alzheimer\u2019s pathological cascade. Lancet Neurol 9(1):119\u2013128. https:\/\/doi.org\/10.1016\/S1474-4422(09)70299-6","journal-title":"Lancet Neurol"},{"issue":"4","key":"2683_CR27","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.jalz.2011.04.007","volume":"7","author":"CR Jack","year":"2011","unstructured":"Jack CR, Barkhof F, Bernstein MA, Cantillon M, Cole PE, DeCarli C, Frisoni GB (2011) Steps to standardization and validation of hippocampal volumetry as a biomarker in clinical trials and diagnostic criterion for Alzheimer\u2019s disease. Alzheimer Dementia 7(4):474\u2013485. https:\/\/doi.org\/10.1016\/j.jalz.2011.04.007","journal-title":"Alzheimer Dementia"},{"issue":"1","key":"2683_CR28","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jalz.2012.09.017","volume":"10","author":"F Jessen","year":"2014","unstructured":"Jessen F, Wolfsgruber S, Wiese B, Bickel H, M\u00f6sch E, Kaduszkiewicz H, Wagner M (2014) AD dementia risk in late MCI, in early MCI, and in subjective memory impairment Alzheimer\u2019s & Dementia. J Alzheimer\u2019s Assoc 10(1):76\u201383. https:\/\/doi.org\/10.1016\/j.jalz.2012.09.017","journal-title":"J Alzheimer\u2019s Assoc"},{"issue":"2","key":"2683_CR29","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3390\/bios8020041","volume":"8","author":"AM Kotecha","year":"2018","unstructured":"Kotecha AM, Corr\u00eaa ADC, Fisher KM, Rushworth JV (2018) Olfactory dysfunction as a global biomarker for sniffing out Alzheimer\u2019s disease: a meta-analysis. Biosensors 8(2):41. https:\/\/doi.org\/10.3390\/bios8020041","journal-title":"Biosensors"},{"issue":"3","key":"2683_CR30","doi-asserted-by":"publisher","first-page":"2264","DOI":"10.1016\/j.neuroimage.2009.10.056","volume":"49","author":"M Lehmann","year":"2010","unstructured":"Lehmann M, Douiri A, Kim LG, Modat M, Chan D, Ourselin S, Fox NC (2010) Atrophy patterns in Alzheimer\u2019s disease and semantic dementia: a comparison of FreeSurfer and manual volumetric measurements. Neuroimage 49(3):2264\u20132274. https:\/\/doi.org\/10.1016\/j.neuroimage.2009.10.056","journal-title":"Neuroimage"},{"issue":"8","key":"2683_CR31","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1016\/j.neurobiolaging.2010.01.022","volume":"31","author":"Y Liu","year":"2010","unstructured":"Liu Y, Paajanen T, Zhang Y, Westman E, Wahlund L-O, Simmons A, Tsolaki M (2010) Analysis of regional MRI volumes and thicknesses as predictors of conversion from mild cognitive impairment to Alzheimer\u2019s disease. Neurobiol Aging 31(8):1375\u20131385. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2010.01.022","journal-title":"Neurobiol Aging"},{"key":"2683_CR32","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.neuroimage.2017.02.051","volume":"150","author":"SN Lockhart","year":"2017","unstructured":"Lockhart SN, Sch\u00f6ll M, Baker SL, Ayakta N, Swinnerton KN, Bell RK, Janabi M (2017) Amyloid and tau PET demonstrate region-specific associations in normal older people. Neuroimage 150:191\u2013199. https:\/\/doi.org\/10.1016\/j.neuroimage.2017.02.051","journal-title":"Neuroimage"},{"key":"2683_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/C2009-0-02721-4","author":"JK Mai","year":"2011","unstructured":"Mai JK, Paxinos G (2011) The human nervous system. Academic Press. https:\/\/doi.org\/10.1016\/C2009-0-02721-4","journal-title":"Academic Press"},{"issue":"3","key":"2683_CR34","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","volume":"7","author":"GM McKhann","year":"2011","unstructured":"McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CRJ, Kawas CH, Phelps CH (2011) The diagnosis of dementia due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease Alzheimer\u2019s & dementia. J Alzheimer\u2019s Assoc 7(3):263\u2013269. https:\/\/doi.org\/10.1016\/j.jalz.2011.03.005","journal-title":"J Alzheimer\u2019s Assoc"},{"issue":"3","key":"2683_CR35","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.jalz.2016.09.012","volume":"13","author":"JL Molinuevo","year":"2017","unstructured":"Molinuevo JL, Rabin LA, Amariglio R, Buckley R, Dubois B, Ellis KA, Group, S. C. D. I. (SCD-I. W) (2017) Implementation of subjective cognitive decline criteria in research studies Alzheimer\u2019s and dementia. J Alzheimer\u2019s Assoc 13(3):296\u2013311. https:\/\/doi.org\/10.1016\/j.jalz.2016.09.012","journal-title":"J Alzheimer\u2019s Assoc"},{"key":"2683_CR36","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1212\/WNL.43.11.2412-a","volume":"41","author":"JC Morris","year":"1991","unstructured":"Morris JC (1991) The clinical dementia rating (cdr): current version and. Young 41:1588\u20131592. https:\/\/doi.org\/10.1212\/WNL.43.11.2412-a","journal-title":"Young"},{"key":"2683_CR37","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780195385151.001.0001","author":"D Pandya","year":"2015","unstructured":"Pandya D, Petrides M, Cipolloni PB (2015) Cerebral cortex: architecture, connections, and the dual origin concept. Oxford University Press. https:\/\/doi.org\/10.1093\/med\/9780195385151.001.0001","journal-title":"Oxford University Press"},{"issue":"3","key":"2683_CR38","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.1365-2796.2004.01388.x","volume":"256","author":"RC Petersen","year":"2004","unstructured":"Petersen RC (2004) Mild cognitive impairment as a diagnostic entity. J Intern Med 256(3):183\u2013194. https:\/\/doi.org\/10.1111\/j.1365-2796.2004.01388.x","journal-title":"J Intern Med"},{"issue":"1","key":"2683_CR39","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.pscychresns.2011.06.014","volume":"194","author":"SP Poulin","year":"2011","unstructured":"Poulin SP, Dautoff R, Morris JC, Barrett LF, Dickerson BC, Initiative ADN (2011) Amygdala atrophy is prominent in early Alzheimer\u2019s disease and relates to symptom severity. Psychiatry Res Neuroimaging 194(1):7\u201313. https:\/\/doi.org\/10.1016\/j.pscychresns.2011.06.014","journal-title":"Psychiatry Res Neuroimaging"},{"issue":"3","key":"2683_CR40","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1002\/1531-8249(199903)45:3<358::AID-ANA12>3.0.CO;2-X","volume":"45","author":"JL Price","year":"1999","unstructured":"Price JL, Morris JC (1999) Tangles and plaques in nondemented aging and \u201cpreclinical\u201d Alzheimer\u2019s disease. Ann Neurol 45(3):358\u2013368. https:\/\/doi.org\/10.1002\/1531-8249(199903)45:3%3c358::AID-ANA12%3e3.0.CO;2-X","journal-title":"Ann Neurol"},{"issue":"4","key":"2683_CR41","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/0197-4580(91)90006-6","volume":"12","author":"JL Price","year":"1991","unstructured":"Price JL, Davis PB, Morris JC, White DL (1991) The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer\u2019s disease. Neurobiol Aging 12(4):295\u2013312. https:\/\/doi.org\/10.1016\/0197-4580(91)90006-6","journal-title":"Neurobiol Aging"},{"issue":"4","key":"2683_CR42","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.3233\/JAD-160842","volume":"55","author":"M Quarmley","year":"2017","unstructured":"Quarmley M, Moberg PJ, Mechanic-Hamilton D, Kabadi S, Arnold SE, Wolk DA, Roalf DR (2017) Odor identification screening improves diagnostic classification in incipient Alzheimer\u2019s disease. J Alzheimer\u2019s Dis 55(4):1497\u20131507. https:\/\/doi.org\/10.3233\/JAD-160842","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"1","key":"2683_CR43","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1159\/000115751","volume":"30","author":"RO Roberts","year":"2008","unstructured":"Roberts RO, Geda YE, Knopman DS, Cha RH, Pankratz VS, Boeve BF, Rocca WA (2008) The mayo clinic study of aging: design and sampling, participation, baseline measures and sample characteristics. Neuroepidemiology 30(1):58\u201369. https:\/\/doi.org\/10.1159\/000115751","journal-title":"Neuroepidemiology"},{"issue":"1","key":"2683_CR44","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1159\/000464422","volume":"24","author":"A Sanabria-Castro","year":"2017","unstructured":"Sanabria-Castro A, Alvarado-Echeverr\u00eda I, Monge-Bonilla C (2017) Molecular pathogenesis of Alzheimer\u2019s disease: an update. Ann Neurosci 24(1):46\u201354. https:\/\/doi.org\/10.1159\/000464422","journal-title":"Ann Neurosci"},{"key":"2683_CR45","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.neuroimage.2017.04.046","volume":"155","author":"ZM Saygin","year":"2017","unstructured":"Saygin ZM, Kliemann D, Iglesias JE, van der Kouwe AJW, Boyd E, Reuter M, Frosch MP (2017) High-resolution magnetic resonance imaging reveals nuclei of the human amygdala: manual segmentation to automatic atlas. Neuroimage 155:370\u2013382. https:\/\/doi.org\/10.1016\/j.neuroimage.2017.04.046","journal-title":"Neuroimage"},{"issue":"10","key":"2683_CR46","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1136\/jnnp.55.10.967","volume":"55","author":"P Scheltens","year":"1992","unstructured":"Scheltens P, Leys D, Barkhof F, Huglo D, Weinstein HC, Vermersch P, Valk J (1992) Atrophy of medial temporal lobes on MRI in \u201cprobable\u201d Alzheimer\u2019s disease and normal ageing: diagnostic value and neuropsychological correlates. J Neurol Neurosurg Psychiatry 55(10):967\u2013972. https:\/\/doi.org\/10.1136\/jnnp.55.10.967","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"5","key":"2683_CR47","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.neuron.2016.01.028","volume":"89","author":"M Sch\u00f6ll","year":"2016","unstructured":"Sch\u00f6ll M, Lockhart SN, Schonhaut DR, O\u2019Neil JP, Janabi M, Ossenkoppele R, Schwimmer HD (2016) PET imaging of tau deposition in the aging human brain. Neuron 89(5):971\u2013982. https:\/\/doi.org\/10.1016\/j.neuron.2016.01.028","journal-title":"Neuron"},{"key":"2683_CR48","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1159\/000360925","volume":"34","author":"C Schultz","year":"2014","unstructured":"Schultz C, Engelhardt M (2014) Anatomy of the hippocampal formation. Front Neurol Neurosci 34:6\u201317. https:\/\/doi.org\/10.1159\/000360925","journal-title":"Front Neurol Neurosci"},{"issue":"4","key":"2683_CR49","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1002\/ana.410320412","volume":"32","author":"SA Scott","year":"1992","unstructured":"Scott SA, Sparks DL, Scheff SW, Dekosky ST, Knox CA (1992) Amygdala cell loss and atrophy in Alzheimer\u2019s disease. Ann Neurol 32(4):555\u2013563. https:\/\/doi.org\/10.1002\/ana.410320412","journal-title":"Ann Neurol"},{"issue":"5","key":"2683_CR50","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1080\/13607863.2013.768208","volume":"17","author":"SC Seligman","year":"2013","unstructured":"Seligman SC, Kamath V, Giovannetti T, Arnold SE, Moberg PJ (2013) Olfaction and apathy in Alzheimer\u2019s disease, mild cognitive impairment, and healthy older adults. Aging Ment Health 17(5):564\u2013570. https:\/\/doi.org\/10.1080\/13607863.2013.768208","journal-title":"Aging Ment Health"},{"issue":"10","key":"2683_CR51","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/nrn3085","volume":"12","author":"SA Small","year":"2011","unstructured":"Small SA, Schobel SA, Buxton RB, Witter MP, Barnes CA (2011) A pathophysiological framework of hippocampal dysfunction in ageing and disease. Nat Rev Neurosci 12(10):585\u2013601. https:\/\/doi.org\/10.1038\/nrn3085","journal-title":"Nat Rev Neurosci"},{"issue":"2","key":"2683_CR52","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1002\/ana.25395","volume":"85","author":"RA Sperling","year":"2019","unstructured":"Sperling RA, Mormino EC, Schultz AP, Betensky RA, Papp KV, Amariglio RE, Hedden T (2019) The impact of amyloid-beta and tau on prospective cognitive decline in older individuals. Ann Neurol 85(2):181\u2013193. https:\/\/doi.org\/10.1002\/ana.25395","journal-title":"Ann Neurol"},{"key":"2683_CR53","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1146\/annurev.neuro.27.070203.144130","volume":"27","author":"LR Squire","year":"2004","unstructured":"Squire LR, Stark CEL, Clark RE (2004) The medial temporal lobe. Annu Rev Neurosci 27:279\u2013306. https:\/\/doi.org\/10.1146\/annurev.neuro.27.070203.144130","journal-title":"Annu Rev Neurosci"},{"issue":"4","key":"2683_CR54","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/nrn2614","volume":"10","author":"NM van Strien","year":"2009","unstructured":"van Strien NM, Cappaert NLM, Witter MP (2009) The anatomy of memory: an interactive overview of the parahippocampal-hippocampal network. Nat Rev Neurosci 10(4):272\u2013282. https:\/\/doi.org\/10.1038\/nrn2614","journal-title":"Nat Rev Neurosci"},{"issue":"2","key":"2683_CR55","doi-asserted-by":"publisher","first-page":"381","DOI":"10.3233\/JAD-142838","volume":"46","author":"L Velayudhan","year":"2015","unstructured":"Velayudhan L, Gasper A, Pritchard M, Baillon S, Messer C, Proitsi P (2015) Pattern of smell identification impairment in Alzheimer\u2019s disease. J Alzheimer\u2019s Dis 46(2):381\u2013387. https:\/\/doi.org\/10.3233\/JAD-142838","journal-title":"J Alzheimer\u2019s Dis"},{"key":"2683_CR56","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.dadm.2016.12.010","volume":"6","author":"P Vemuri","year":"2017","unstructured":"Vemuri P, Lowe VJ, Knopman DS, Senjem ML, Kemp BJ, Schwarz CG, Jack CR Jr (2017) Tau-PET uptake: regional variation in average SUVR and impact of amyloid deposition. Alzheimer\u2019s Dement 6:21\u201330. https:\/\/doi.org\/10.1016\/j.dadm.2016.12.010","journal-title":"Alzheimer\u2019s Dement"},{"issue":"2","key":"2683_CR57","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/0306-4522(90)90408-V","volume":"37","author":"LJK Vogt","year":"1990","unstructured":"Vogt LJK, Hyman BT, Van Hoesen GW, Damasio AR (1990) Pathological alterations in the amygdala in Alzheimer\u2019s disease. Neuroscience 37(2):377\u2013385. https:\/\/doi.org\/10.1016\/0306-4522(90)90408-V","journal-title":"Neuroscience"},{"key":"2683_CR58","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.brainres.2010.08.018","volume":"1357","author":"J Wang","year":"2010","unstructured":"Wang J, Eslinger PJ, Doty RL, Zimmerman EK, Grunfeld R, Sun X, Smith MB (2010) Olfactory deficit detected by fMRI in early Alzheimer\u2019s disease. Brain Res 1357:184\u2013194. https:\/\/doi.org\/10.1016\/j.brainres.2010.08.018","journal-title":"Brain Res"},{"issue":"7","key":"2683_CR59","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1080\/13803395.2016.1253667","volume":"39","author":"AM Ward","year":"2017","unstructured":"Ward AM, Calamia M, Thiemann E, Dunlap J, Tranel D (2017) Association between olfaction and higher cortical functions in Alzheimer\u2019s disease, mild cognitive impairment, and healthy older adults. J Clin Exp Neuropsychol 39(7):646\u2013658. https:\/\/doi.org\/10.1080\/13803395.2016.1253667","journal-title":"J Clin Exp Neuropsychol"},{"issue":"4","key":"2683_CR60","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1002\/gps.1472","volume":"21","author":"RS Wilson","year":"2006","unstructured":"Wilson RS, Li Y, Aggarwal NT, McCann JJ, Gilley DW, Bienias JL, Evans DA (2006) Cognitive decline and survival in Alzheimer\u2019s disease. Int J Geriatr Psychiatry 21(4):356\u2013362. https:\/\/doi.org\/10.1002\/gps.1472","journal-title":"Int J Geriatr Psychiatry"},{"key":"2683_CR61","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.neurobiolaging.2016.09.011","volume":"49","author":"DA Wolk","year":"2017","unstructured":"Wolk DA, Das SR, Mueller SG, Weiner MW, Yushkevich PA, Initiative ADN (2017) Medial temporal lobe subregional morphometry using high resolution MRI in Alzheimer\u2019s disease. Neurobiol Aging 49:204\u2013213. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2016.09.011","journal-title":"Neurobiol Aging"},{"key":"2683_CR62","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/B978-0-12-374236-0.10022-7","volume-title":"Third E. Paxinos","author":"DM Yilmazer-Hanke","year":"2012","unstructured":"Yilmazer-Hanke DM (2012) Amygdala. In: Mai JK (ed) Third E. Paxinos. Academic Press, San Diego, pp 759\u2013834. https:\/\/doi.org\/10.1016\/B978-0-12-374236-0.10022-7"},{"issue":"1","key":"2683_CR63","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1002\/hbm.22627","volume":"36","author":"PA Yushkevich","year":"2015","unstructured":"Yushkevich PA, Pluta JB, Wang H, Xie L, Ding S, Gertje EC, Wolk DA (2015) Automated volumetry and regional thickness analysis of hippocampal subfields and medial temporal cortical structures in mild cognitive impairment. Hum Brain Mapp 36(1):258\u2013287. https:\/\/doi.org\/10.1002\/hbm.22627","journal-title":"Hum Brain Mapp"},{"issue":"9","key":"2683_CR64","doi-asserted-by":"publisher","first-page":"2784","DOI":"10.1093\/brain\/awab262","volume":"144","author":"PA Yushkevich","year":"2021","unstructured":"Yushkevich PA, Mu\u00f1oz L\u00f3pez M, de Onzo\u00f1o I, Martin MM, Ittyerah R, Lim S, Ravikumar S, Wang J (2021) Three-dimensional mapping of neurofibrillary tangle burden in the human medial temporal lobe. Brain 144(9):2784\u20132797. https:\/\/doi.org\/10.1093\/brain\/awab262","journal-title":"Brain"}],"container-title":["Brain Structure and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-023-02683-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00429-023-02683-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-023-02683-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T01:02:53Z","timestamp":1695344573000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00429-023-02683-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,24]]},"references-count":65,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["2683"],"URL":"https:\/\/doi.org\/10.1007\/s00429-023-02683-2","relation":{},"ISSN":["1863-2661"],"issn-type":[{"value":"1863-2661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,24]]},"assertion":[{"value":"16 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Clinical Research Ethics Committee of Istanbul University, Istanbul Faculty of Medicine. This study was performed in accordance with the ethical principles of the latest version of the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was provided by all participants.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}