{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:27:33Z","timestamp":1791084453388,"version":"4.1.0"},"reference-count":93,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"National Institute of health","award":["DA50558"],"award-info":[{"award-number":["DA50558"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH132680"],"award-info":[{"award-number":["MH132680"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH132680"],"award-info":[{"award-number":["MH132680"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH112768"],"award-info":[{"award-number":["R01MH112768"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Brain Struct Funct"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Corticotropin-releasing hormone (CRH) signaling through its cognate receptors, CRHR1 and CRHR2, contributes to diverse stress-related functions in the mammalian brain. Whereas CRHR2 is predominantly expressed in choroid plexus and blood vessels, CRHR1 is abundantly expressed in neurons in discrete brain regions, including the neocortex, hippocampus and nucleus accumbens. Activation of CRHR1 influences motivated behaviors, emotional states, and learning and memory. However, it is unknown whether alterations in CRHR1 signaling contribute to aberrant motivated behaviors observed, for example, in stressful contexts. These questions require tools to manipulate CRHR1 selectively. Here we describe and validate a novel\n                    <jats:italic>Crhr1<\/jats:italic>\n                    -FlpO mouse. Using bacterial artificial chromosome (BAC) transgenesis, we engineered a transgenic mouse that expresses FlpO recombinase in CRHR1-expressing cells. We used two independent methods to assess the specificity of FlpO to CRHR1-expressing cells. First, we injected\n                    <jats:italic>Crhr1<\/jats:italic>\n                    -FlpO mice with Flp-dependent viruses expressing fluorescent reporter molecules. Additionally, we crossed the\n                    <jats:italic>Crhr1<\/jats:italic>\n                    -FlpO mouse with a transgenic Flp-dependent reporter mouse. CRHR1 and reporter molecules were identified using immunocytochemistry and visualized via confocal microscopy in several brain regions in which CRHR1 expression and function is established. Expression of Flp-dependent viral constructs was highly specific to CRHR1-expressing cells in all regions examined (over 90% co-localization). In accord, robust and specific expression of the Flp-dependent transgenic reporter was observed in a reporter mouse, recapitulating endogenous CRHR1 expression. The\n                    <jats:italic>Crhr1<\/jats:italic>\n                    -FlpO mouse enables selective genetic access to CRHR1-expressing cells within the mouse brain. When combined with Cre-lox or site-specific recombinases, the mouse facilitates intersectional manipulations of CRHR1-expressing neurons.\n                  <\/jats:p>","DOI":"10.1007\/s00429-024-02879-0","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T06:49:13Z","timestamp":1734504553000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Targeting corticotropin-releasing hormone receptor type 1 (Crhr1) neurons: validating the specificity of a novel transgenic Crhr1-FlpO mouse"],"prefix":"10.1007","volume":"230","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6774-5902","authenticated-orcid":false,"given":"Mason","family":"Hardy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4862-3704","authenticated-orcid":false,"given":"Yuncai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0771-8616","authenticated-orcid":false,"given":"Tallie Z.","family":"Baram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4673-390X","authenticated-orcid":false,"given":"Nicholas J.","family":"Justice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"issue":"43","key":"2879_CR1","doi-asserted-by":"publisher","first-page":"16945","DOI":"10.1523\/JNEUROSCI.1445-13.2013","volume":"33","author":"AL Andres","year":"2013","unstructured":"Andres AL, Regev L, Phi L, Seese RR, Chen Y, Gall CM, Baram TZ (2013) NMDA receptor activation and calpain contribute to disruption of dendritic spines by the stress neuropeptide CRH. J Neurosci 33(43):16945\u201316960. https:\/\/doi.org\/10.1523\/JNEUROSCI.1445-13.2013","journal-title":"J Neurosci"},{"issue":"5","key":"2879_CR2","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1111\/jnc.13195","volume":"134","author":"D Baglietto-Vargas","year":"2015","unstructured":"Baglietto-Vargas D, Chen Y, Suh D, Ager RR, Rodriguez-Ortiz CJ, Medeiros R, Myczek K, Green KN, Baram TZ, LaFerla FM (2015) Short-term modern life-like stress exacerbates A\u03b2-pathology and synapse loss in 3xTg-AD mice. J Neurochem 134(5):915\u2013926. https:\/\/doi.org\/10.1111\/jnc.13195","journal-title":"J Neurochem"},{"key":"2879_CR3","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1146\/annurev.pharmtox.44.101802.121410","volume":"44","author":"TL Bale","year":"2004","unstructured":"Bale TL, Vale WW (2004) CRF and CRF receptors: role in stress responsivity and other behaviors. Annu Rev Pharmacol Toxicol 44:525\u2013557. https:\/\/doi.org\/10.1146\/annurev.pharmtox.44.101802.121410","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"4","key":"2879_CR4","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.biopsych.2010.05.028","volume":"68","author":"TL Bale","year":"2010","unstructured":"Bale TL, Baram TZ, Brown AS, Goldstein JM, Insel TR, McCarthy MM, Nemeroff CB, Reyes TM, Simerly RB, Susser ES, Nestler EJ (2010) Early life programming and neurodevelopmental disorders. Biol Psychiatry 68(4):314\u2013319. https:\/\/doi.org\/10.1016\/j.biopsych.2010.05.028","journal-title":"Biol Psychiatry"},{"issue":"12","key":"2879_CR5","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1016\/j.biopsych.2021.01.007","volume":"89","author":"HM Baumgartner","year":"2021","unstructured":"Baumgartner HM, Schulkin J, Berridge KC (2021) Activating corticotropin-releasing factor systems in the nucleus accumbens, amygdala, and bed nucleus of stria terminalis: incentive motivation or aversive motivation? Biol Psychiatry 89(12):1162\u20131175. https:\/\/doi.org\/10.1016\/j.biopsych.2021.01.007","journal-title":"Biol Psychiatry"},{"issue":"6","key":"2879_CR6","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1038\/mp.2009.141","volume":"15","author":"EB Binder","year":"2010","unstructured":"Binder EB, Nemeroff CB (2010) The CRF system, stress, depression and anxiety\u2014insights from human genetic studies. Mol Psychiatry 15(6):574\u2013588. https:\/\/doi.org\/10.1038\/mp.2009.141","journal-title":"Mol Psychiatry"},{"issue":"1","key":"2879_CR7","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/s41467-023-36780-x","volume":"14","author":"MT Birnie","year":"2023","unstructured":"Birnie MT, Short AK, de Carvalho GB, Taniguchi L, Gunn BG, Pham AL, Itoga CA, Xu X, Chen LY, Mahler SV, Chen Y, Baram TZ (2023) Stress-induced plasticity of a CRH\/GABA projection disrupts reward behaviors in mice. Nat Commun 14(1):1088. https:\/\/doi.org\/10.1038\/s41467-023-36780-x","journal-title":"Nat Commun"},{"issue":"9","key":"2879_CR8","doi-asserted-by":"publisher","first-page":"3788","DOI":"10.1523\/JNEUROSCI.22-09-03788.2002","volume":"22","author":"T Blank","year":"2002","unstructured":"Blank T, Nijholt I, Eckart K, Spiess J (2002) Priming of long-term potentiation in mouse hippocampus by corticotropin-releasing factor and acute stress: implications for hippocampus-dependent learning. J Neurosci 22(9):3788\u20133794. https:\/\/doi.org\/10.1523\/JNEUROSCI.22-09-03788.2002","journal-title":"J Neurosci"},{"issue":"2","key":"2879_CR9","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/0006-8993(85)91048-0","volume":"328","author":"MR Brown","year":"1985","unstructured":"Brown MR, Fisher LA, Webb V, Vale WW, Rivier JE (1985) Corticotropin-releasing factor: a physiologic regulator of adrenal epinephrine secretion. Brain Res 328(2):355\u2013357. https:\/\/doi.org\/10.1016\/0006-8993(85)91048-0","journal-title":"Brain Res"},{"issue":"6","key":"2879_CR10","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/0896-6273(93)90230-o","volume":"11","author":"CP Chang","year":"1993","unstructured":"Chang CP, Pearse II, O\u2019Connell RV, S., Rosenfeld MG (1993) Identification of a seven transmembrane helix receptor for corticotropin-releasing factor and sauvagine in mammalian brain. Neuron 11(6):1187\u20131195. https:\/\/doi.org\/10.1016\/0896-6273(93)90230-o","journal-title":"Neuron"},{"issue":"19","key":"2879_CR11","doi-asserted-by":"publisher","first-page":"8967","DOI":"10.1073\/pnas.90.19.8967","volume":"90","author":"R Chen","year":"1993","unstructured":"Chen R, Lewis KA, Perrin MH, Vale WW (1993) Expression cloning of a human corticotropin-releasing-factor receptor. Proc Natl Acad Sci 90(19):8967\u20138971. https:\/\/doi.org\/10.1073\/pnas.90.19.8967","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"2879_CR12","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1002\/(SICI)1096-9861","volume":"420","author":"Y Chen","year":"2000","unstructured":"Chen Y, Brunson KL, M\u00fcller MB, Cariaga W, Baram TZ (2000) Immuno-cytochemical distribution of corticotropin-releasing hormone receptor type\u20101 (CRF1)\u2010like immunoreactivity in the mouse brain: light microscopy analysis using an antibody directed against the C\u2010terminus. J Comp Neurol 420(3):305\u2013323. https:\/\/doi.org\/10.1002\/(SICI)1096-9861)420:3%3C305::AID-CNE3%3E3.0.CO;2-8","journal-title":"J Comp Neurol"},{"issue":"18","key":"2879_CR13","doi-asserted-by":"publisher","first-page":"7171","DOI":"10.1523\/JNEUROSCI.21-18-07171.2001","volume":"21","author":"Y Chen","year":"2001","unstructured":"Chen Y, Bender RA, Frotscher M, Baram TZ (2001) Novel and transient populations of corticotropin-releasing hormone-expressing neurons in developing hippocampus suggest unique functional roles: a quantitative spatiotemporal analysis. J Neurosci 21(18):7171\u20137181. https:\/\/doi.org\/10.1523\/JNEUROSCI.21-18-07171.2001","journal-title":"J Neurosci"},{"issue":"3","key":"2879_CR14","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.neuroscience.2004.03.036","volume":"126","author":"Y Chen","year":"2004","unstructured":"Chen Y, Brunson KL, Adelmann G, Bender RA, Frotscher M, Baram TZ (2004) Hippocampal corticotropin releasing hormone: pre-and postsynaptic location and release by stress. Neuroscience 126(3):533\u2013540. https:\/\/doi.org\/10.1016\/j.neuroscience.2004.03.036","journal-title":"Neuroscience"},{"issue":"11","key":"2879_CR15","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1038\/sj.mp.4001863","volume":"11","author":"Y Chen","year":"2006","unstructured":"Chen Y, Fenoglio KA, Dub\u00e9 CM, Grigoriadis DE, Baram TZ (2006) Cellular and molecular mechanisms of hippocampal activation by acute stress are age-dependent. Mol Psychiatry 11(11):992\u20131002. https:\/\/doi.org\/10.1038\/sj.mp.4001863","journal-title":"Mol Psychiatry"},{"issue":"29","key":"2879_CR16","doi-asserted-by":"publisher","first-page":"13123","DOI":"10.1073\/pnas.1003825107","volume":"107","author":"Y Chen","year":"2010","unstructured":"Chen Y, Rex CS, Rice CJ, Dub\u00e9 CM, Gall CM, Lynch G, Baram TZ (2010) Correlated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signaling. Proc Natl Acad Sci 107(29):13123\u201313128. https:\/\/doi.org\/10.1073\/pnas.1003825107","journal-title":"Proc Natl Acad Sci"},{"issue":"12","key":"2879_CR17","doi-asserted-by":"publisher","first-page":"4769","DOI":"10.1210\/en.2015-1673","volume":"156","author":"Y Chen","year":"2015","unstructured":"Chen Y, Molet J, Gunn BG, Ressler K, Baram TZ (2015) Diversity of reporter expression patterns in transgenic mouse lines targeting corticotropin-releasing hormone-expressing neurons. Endocrinology 156(12):4769\u20134780. https:\/\/doi.org\/10.1210\/en.2015-1673","journal-title":"Endocrinology"},{"issue":"44","key":"2879_CR18","doi-asserted-by":"publisher","first-page":"11295","DOI":"10.1523\/JNEUROSCI.2542-16.2016","volume":"36","author":"Y Chen","year":"2016","unstructured":"Chen Y, Molet J, Lauterborn JC, Trieu BH, Bolton JL, Patterson KP, Gall CM, Lynch G, Baram TZ (2016) Converging, synergistic actions of multiple stress hormones mediate Enduring Memory impairments after Acute Simultaneous stresses. J Neurosci 36(44):11295\u201311307. https:\/\/doi.org\/10.1523\/JNEUROSCI.2542-16.2016","journal-title":"J Neurosci"},{"key":"2879_CR19","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.neuropharm.2012.09.022","volume":"67","author":"C Cui","year":"2013","unstructured":"Cui C, Noronha A, Morikawa H, Alvarez VA, Stuber GD, Szumlinski KK, Kash TL, Roberto M, Wilcox MV (2013) New insights on neurobiological mechanisms underlying alcohol addiction. Neuropharmacology 67:223\u2013232. https:\/\/doi.org\/10.1016\/j.neuropharm.2012.09.022","journal-title":"Neuropharmacology"},{"issue":"18","key":"2879_CR20","doi-asserted-by":"publisher","first-page":"4036","DOI":"10.1523\/JNEUROSCI.2210-20.2021","volume":"41","author":"Q Cui","year":"2021","unstructured":"Cui Q, Pamukcu A, Cherian S, Chang IYM, Berceau BL, Xenias HS, Higgs MH, Rajamanickam S, Chen Y, Du X, Zhang Y, McMorrow H, Abecassis ZA, Boca SM, Justice NJ, Wilson CJ, Chan CS (2021) Dissociable roles of Pallidal Neuron subtypes in Regulating Motor patterns. J Neurosci 41(18):4036\u20134059. https:\/\/doi.org\/10.1523\/JNEUROSCI.2210-20.2021","journal-title":"J Neurosci"},{"issue":"6","key":"2879_CR21","doi-asserted-by":"publisher","first-page":"e0180311","DOI":"10.1371\/journal.pone.0180311","volume":"12","author":"MM Curran","year":"2017","unstructured":"Curran MM, Sandman CA, Poggi Davis E, Glynn LM, Baram TZ (2017) Abnormal dendritic maturation of developing cortical neurons exposed to corticotropin releasing hormone (CRH): insights into effects of prenatal adversity? PLoS ONE 12(6):e0180311. https:\/\/doi.org\/10.1371\/journal.pone.0180311","journal-title":"PLoS ONE"},{"issue":"8","key":"2879_CR22","doi-asserted-by":"publisher","first-page":"3778","DOI":"10.1038\/s41380-020-0659-y","volume":"26","author":"S Cursano","year":"2021","unstructured":"Cursano S, Battaglia CR, Urrutia-Ruiz C, Grabrucker S, Sch\u00f6n M, Bockmann J, Braum\u00fcller S, Radermacher P, Roselli F, Huber-Lang M, Boeckers TM (2021) A CRHR1 antagonist prevents synaptic loss and memory deficits in a trauma-induced delirium-like syndrome. Mol Psychiatry 26(8):3778\u20133794. https:\/\/doi.org\/10.1038\/s41380-020-0659-y","journal-title":"Mol Psychiatry"},{"issue":"6","key":"2879_CR23","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1038\/s41593-018-0151-z","volume":"21","author":"N Dedic","year":"2018","unstructured":"Dedic N, K\u00fchne C, Jakovcevski M, Hartmann J, Genewsky AJ, Gomes KS, Anderzhanova E, P\u00f6hlmann ML, Chang S, Kolarz A, Vogl AM, Dine J, Metzger MW, Schmid B, Almada RC, Ressler KJ, Wotjak CT, Grinevich V, Chen A, Schmidt MV, Wurst W, Refojo D, Deussing JM (2018) Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety. Nat Neurosci 21(6):803\u2013807. https:\/\/doi.org\/10.1038\/s41593-018-0151-z","journal-title":"Nat Neurosci"},{"key":"2879_CR24","doi-asserted-by":"publisher","first-page":"170593","DOI":"10.1016\/j.peptides.2021.170593","volume":"143","author":"L Demarchi","year":"2021","unstructured":"Demarchi L, Pawluski JL, Bosch OJ (2021) The brain oxytocin and corticotropin-releasing factor systems in grieving mothers: what we know and what we need to learn. Peptides 143:170593. https:\/\/doi.org\/10.1016\/j.peptides.2021.170593","journal-title":"Peptides"},{"issue":"4","key":"2879_CR25","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1152\/physrev.00042.2017","volume":"98","author":"JM Deussing","year":"2018","unstructured":"Deussing JM, Chen A (2018) The corticotropin-releasing factor family: physiology of the stress response. Physiol Rev 98(4):2225\u20132286. https:\/\/doi.org\/10.1152\/physrev.00042.2017","journal-title":"Physiol Rev"},{"issue":"5","key":"2879_CR26","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.neuron.2020.06.003","volume":"107","author":"LE Fenno","year":"2020","unstructured":"Fenno LE, Ramakrishnan C, Kim YS, Evans KE, Lo M, Vesuna S, Inoue M, Cheung KYM, Yuen E, Pichamoorthy N, Hong ASO, Deisseroth K (2020) Comprehensive Dual- and triple-feature intersectional single-vector delivery of Diverse Functional payloads to cells of behaving mammals. Neuron 107(5):836\u2013853e11. https:\/\/doi.org\/10.1016\/j.neuron.2020.06.003","journal-title":"Neuron"},{"key":"2879_CR27","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.psyneuen.2014.12.005","volume":"53","author":"E Flandreau","year":"2015","unstructured":"Flandreau E, Risbrough V, Lu A, Ableitner M, Geyer MA, Holsboer F, Deussing JM (2015) Cell type-specific modifications of corticotropin-releasing factor (CRF) and its type 1 receptor (CRF1) on startle behavior and sensorimotor gating. Psychoneuroendocrinology 53:16\u201328. https:\/\/doi.org\/10.1016\/j.psyneuen.2014.12.005","journal-title":"Psychoneuroendocrinology"},{"issue":"6","key":"2879_CR28","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.devcel.2014.07.001","volume":"30","author":"I Garcia","year":"2014","unstructured":"Garcia I, Quast KB, Huang L, Herman AM, Selever J, Deussing JM, Justice NJ, Arenkiel BR (2014) Local CRH signaling promotes synaptogenesis and circuit integration of adult-born neurons. Dev Cell 30(6):645\u2013659. https:\/\/doi.org\/10.1016\/j.devcel.2014.07.001","journal-title":"Dev Cell"},{"issue":"44","key":"2879_CR29","doi-asserted-by":"publisher","first-page":"18156","DOI":"10.1073\/pnas.1116523109","volume":"109","author":"O George","year":"2012","unstructured":"George O, Sanders C, Freiling J, Grigoryan E, Vu S, Allen CD, Crawford E, Mandyam CD, Koob GF (2012) Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking. Proc Natl Acad Sci USA 109(44):18156\u201318161. https:\/\/doi.org\/10.1073\/pnas.1116523109","journal-title":"Proc Natl Acad Sci USA"},{"key":"2879_CR30","doi-asserted-by":"publisher","unstructured":"Gilpin NW, Yu W, Kash TL (2021) Forebrain-midbrain circuits and peptides involved in hyperalgesia after chronic alcohol exposure. Alcohol Research: Curr Reviews 41(1). https:\/\/doi.org\/10.35946\/arcr.v41.1.13","DOI":"10.35946\/arcr.v41.1.13"},{"issue":"5","key":"2879_CR31","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1111\/j.1365-2826.2009.01865.x","volume":"21","author":"M Greetfeld","year":"2009","unstructured":"Greetfeld M, Schmidt MV, Ganea K, Sterlemann V, Liebl C, M\u00fcller MB (2009) A single episode of restraint stress regulates central corticotrophin-releasing hormone receptor expression and binding in specific areas of the mouse brain. J Neuroendocrinol 21(5):473\u2013480. https:\/\/doi.org\/10.1111\/j.1365-2826.2009.01865.x","journal-title":"J Neuroendocrinol"},{"issue":"11","key":"2879_CR32","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.tins.2017.08.004","volume":"40","author":"BG Gunn","year":"2017","unstructured":"Gunn BG, Baram TZ (2017) Stress and seizures: space, time and hippocampal circuits. Trends Neurosci 40(11):667\u2013679. https:\/\/doi.org\/10.1016\/j.tins.2017.08.004","journal-title":"Trends Neurosci"},{"issue":"8","key":"2879_CR33","doi-asserted-by":"publisher","first-page":"4182","DOI":"10.1093\/cercor\/bhx103","volume":"27","author":"BG Gunn","year":"2017","unstructured":"Gunn BG, Cox CD, Chen Y, Frotscher M, Gall CM, Baram TZ, Lynch G (2017) The endogenous stress hormone CRH modulates excitatory transmission and network physiology in hippocampus. Cereb Cortex 27(8):4182\u20134198. https:\/\/doi.org\/10.1093\/cercor\/bhx103","journal-title":"Cereb Cortex"},{"key":"2879_CR34","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s00429-018-1793-z","volume":"224","author":"BG Gunn","year":"2019","unstructured":"Gunn BG, Sanchez GA, Lynch G, Baram TZ, Chen Y (2019) Hyper-diversity of CRH interneurons in mouse hippocampus. Brain Struct Function 224:583\u2013598. https:\/\/doi.org\/10.1007\/s00429-018-1793-z","journal-title":"Brain Struct Function"},{"issue":"1","key":"2879_CR35","doi-asserted-by":"publisher","first-page":"e0191363","DOI":"10.1371\/journal.pone.0191363","volume":"13","author":"A Hooper","year":"2018","unstructured":"Hooper A, Fuller PM, Maguire J (2018) Hippocampal corticotropin-releasing hormone neurons support recognition memory and modulate hippocampal excitability. PLoS ONE 13(1):e0191363. https:\/\/doi.org\/10.1371\/journal.pone.0191363","journal-title":"PLoS ONE"},{"issue":"11","key":"2879_CR36","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.biopsych.2013.10.013","volume":"75","author":"AR Howerton","year":"2014","unstructured":"Howerton AR, Roland AV, Fluharty JM, Marshall A, Chen A, Daniels D, Beck SG, Bale TL (2014) Sex differences in corticotropin-releasing factor receptor-1 action within the dorsal raphe nucleus in stress responsivity. Biol Psychiatry 75(11):873\u2013883. https:\/\/doi.org\/10.1016\/j.biopsych.2013.10.013","journal-title":"Biol Psychiatry"},{"key":"2879_CR37","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.neubiorev.2019.06.010","volume":"103","author":"S Hupalo","year":"2019","unstructured":"Hupalo S, Bryce CA, Bangasser DA, Berridge CW, Valentino RJ, Floresco SB (2019) Corticotropin-releasing factor (CRF) circuit modulation of cognition and motivation. Neurosci Biobehavioral Reviews 103:50\u201359. https:\/\/doi.org\/10.1016\/j.neubiorev.2019.06.010","journal-title":"Neurosci Biobehavioral Reviews"},{"issue":"15","key":"2879_CR38","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.1002\/cne.24676","volume":"527","author":"CA Itoga","year":"2019","unstructured":"Itoga CA, Chen Y, Fateri C, Echeverry PA, Lai JM, Delgado J, Badhon S, Short A, Baram TZ, Xu X (2019) New viral-genetic mapping uncovers an enrichment of corticotropin-releasing hormone-expressing neuronal inputs to the nucleus accumbens from stress-related brain regions. J Comp Neurol 527(15):2474\u20132487. https:\/\/doi.org\/10.1002\/cne.24676","journal-title":"J Comp Neurol"},{"issue":"39","key":"2879_CR39","doi-asserted-by":"publisher","first-page":"13005","DOI":"10.1523\/JNEUROSCI.1784-10.2010","volume":"30","author":"AS Ivy","year":"2010","unstructured":"Ivy AS, Rex CS, Chen Y, Dub\u00e9 C, Maras PM, Grigoriadis DE, Gall CM, Lynch G, Baram TZ (2010) Hippocampal dysfunction and cognitive impairments provoked by chronic early-life stress involve excessive activation of CRH receptors. J Neurosci 30(39):13005\u201313015. https:\/\/doi.org\/10.1523\/JNEUROSCI.1784-10.2010","journal-title":"J Neurosci"},{"issue":"8","key":"2879_CR40","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1523\/JNEUROSCI.1492-17.2017","volume":"38","author":"Z Jiang","year":"2018","unstructured":"Jiang Z, Rajamanickam S, Justice NJ (2018) Local corticotropin-releasing factor signaling in the hypothalamic paraventricular nucleus. J Neurosci 38(8):1874\u20131890. https:\/\/doi.org\/10.1523\/JNEUROSCI.1492-17.2017","journal-title":"J Neurosci"},{"issue":"6","key":"2879_CR41","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/nrn2632","volume":"10","author":"M Jo\u00ebls","year":"2009","unstructured":"Jo\u00ebls M, Baram TZ (2009) The neuro-symphony of stress. Nat Rev Neurosci 10(6):459\u2013466. https:\/\/doi.org\/10.1038\/nrn2632","journal-title":"Nat Rev Neurosci"},{"issue":"4","key":"2879_CR42","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1002\/cne.21848","volume":"511","author":"NJ Justice","year":"2008","unstructured":"Justice NJ, Yuan ZF, Sawchenko PE, Vale W (2008) Type 1 corticotropin-releasing factor receptor expression reported in BAC transgenic mice: implications for reconciling ligand\u2010receptor mismatch in the central corticotropin\u2010releasing factor system. J Comp Neurol 511(4):479\u2013496. https:\/\/doi.org\/10.1002\/cne.21848","journal-title":"J Comp Neurol"},{"issue":"11","key":"2879_CR43","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.1111\/acer.13484","volume":"41","author":"A Kimbrough","year":"2017","unstructured":"Kimbrough A, de Guglielmo G, Kononoff J, Kallupi M, Zorrilla EP, George O (2017) CRF 1 receptor-dependent increases in Irritability\u2010like Behavior during abstinence from chronic intermittent ethanol vapor exposure. Alcoholism: Clin Experimental Res 41(11):1886\u20131895. https:\/\/doi.org\/10.1111\/acer.13484","journal-title":"Alcoholism: Clin Experimental Res"},{"key":"2879_CR44","doi-asserted-by":"publisher","unstructured":"Kishimoto T, Pearse RV 2, Lin CR, Rosenfeld MG (1995) A sauvagine\/corticotropin-releasing factor receptor expressed in heart and skeletal muscle. Proceedings of the National Academy of Sciences, 92(4), 1108\u20131112. https:\/\/doi.org\/10.1073\/pnas.92.4.1108","DOI":"10.1073\/pnas.92.4.1108"},{"key":"2879_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsgos.2023.01.002","author":"CL Kooiker","year":"2023","unstructured":"Kooiker CL, Chen Y, Birnie MT, Baram TZ (2023) Genetic tagging uncovers a robust, selective activation of the thalamic paraventricular nucleus by adverse experiences early in life. Biol Psychiatry Global Open Sci. https:\/\/doi.org\/10.1016\/j.bpsgos.2023.01.002","journal-title":"Biol Psychiatry Global Open Sci"},{"issue":"2\u20133","key":"2879_CR46","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.ejphar.2007.11.066","volume":"583","author":"A Korosi","year":"2008","unstructured":"Korosi A, Baram TZ (2008) The central corticotropin releasing factor system during development and adulthood. Eur J Pharmacol 583(2\u20133):204\u2013214. https:\/\/doi.org\/10.1016\/j.ejphar.2007.11.066","journal-title":"Eur J Pharmacol"},{"issue":"8","key":"2879_CR47","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1002\/dvg.20641","volume":"48","author":"A Kranz","year":"2010","unstructured":"Kranz A, Fu J, Duerschke K, Weidlich S, Naumann R, Stewart AF, Anastassiadis K (2010) An improved flp deleter mouse in C57Bl\/6 based on Flpo recombinase. Genesis 48(8):512\u2013520. https:\/\/doi.org\/10.1002\/dvg.20641","journal-title":"Genesis"},{"key":"2879_CR48","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3389\/fncel.2013.00091","volume":"7","author":"S Kratzer","year":"2013","unstructured":"Kratzer S, Mattusch C, Metzger MW, Dedic N, Noll-Hussong M, Kafitz KW, Eder M, Deussing JM, Holsboer F, Kochs E, Rammes G (2013) Activation of CRH receptor type 1 expressed on glutamatergic neurons increases excitability of CA1 pyramidal neurons by the modulation of voltage-gated ion channels. Front Cell Neurosci 7:91. https:\/\/doi.org\/10.3389\/fncel.2013.00091","journal-title":"Front Cell Neurosci"},{"issue":"8","key":"2879_CR49","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1093\/cercor\/bhq252","volume":"21","author":"Y Kubota","year":"2011","unstructured":"Kubota Y, Shigematsu N, Karube F, Sekigawa A, Kato S, Yamaguchi N, Hirai Y, Morishima M, Kawaguchi Y (2011) Selective coexpression of multiple chemical markers defines discrete populations of neocortical GABAergic neurons. Cereb Cortex (New York N Y: 1991) 21(8):1803\u20131817. https:\/\/doi.org\/10.1093\/cercor\/bhq252","journal-title":"Cereb Cortex (New York N Y: 1991)"},{"key":"2879_CR50","doi-asserted-by":"publisher","unstructured":"Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe,A. F., Boguski, M. S., Brockway, K. S., Byrnes, E. J., Chen, L., Chen, L., Chen, T.M., Chin, M. C., Chong, J., Crook, B. E., Czaplinska, A., Dang, C. N., Datta, S.,Dee, N. R.,\u2026 Jones, A. R. (2007). Genome-wide atlas of gene expression in the adult mouse brain. Nature, 445(7124), 168\u2013176. https:\/\/doi.org\/10.1038\/nature05453","DOI":"10.1038\/nature05453"},{"issue":"7420","key":"2879_CR51","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/nature11436","volume":"490","author":"JC Lemos","year":"2012","unstructured":"Lemos JC, Wanat MJ, Smith JS, Reyes BA, Hollon NG, Van Bockstaele EJ, Chavkin C, Phillips PE (2012) Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive. Nature 490(7420):402\u2013406. https:\/\/doi.org\/10.1038\/nature11436","journal-title":"Nature"},{"issue":"29","key":"2879_CR52","doi-asserted-by":"publisher","first-page":"5647","DOI":"10.1523\/JNEUROSCI.0479-19.2019","volume":"39","author":"JC Lemos","year":"2019","unstructured":"Lemos JC, Shin JH, Alvarez VA (2019) Striatal cholinergic interneurons are a novel target of corticotropin releasing factor. J Neurosci 39(29):5647\u20135661. https:\/\/doi.org\/10.1523\/JNEUROSCI.0479-19.2019","journal-title":"J Neurosci"},{"key":"2879_CR53","doi-asserted-by":"publisher","unstructured":"Lovenberg TW, Liaw CW, Grigoriadis DE, Clevenger W, Chalmers DT, De Souza EB, Oltersdorf T (1995) Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain. Proceedings of the National Academy of Sciences, 92(3), 836\u2013840. https:\/\/doi.org\/10.1073\/pnas.92.3.836","DOI":"10.1073\/pnas.92.3.836"},{"issue":"1","key":"2879_CR54","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s12915-022-01227-0","volume":"20","author":"SJ Lusk","year":"2022","unstructured":"Lusk SJ, McKinney A, Hunt PJ, Fahey PG, Patel J, Chang A, Sun JJ, Martinez VK, Zhu PJ, Egbert JR, Allen G, Jiang X, Arenkiel BR, Tolias AS, Costa-Mattioli M, Ray RS (2022) A CRISPR toolbox for generating intersectional genetic mouse models for functional, molecular, and anatomical circuit mapping. BMC Biol 20(1):28. https:\/\/doi.org\/10.1186\/s12915-022-01227-0","journal-title":"BMC Biol"},{"issue":"5","key":"2879_CR55","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/nn.2529","volume":"13","author":"AC Magalhaes","year":"2010","unstructured":"Magalhaes AC, Holmes KD, Dale LB, Comps-Agrar L, Lee D, Yadav PN, Drysdale L, Poulter MO, Roth BL, Pin JP, Anisman H, Ferguson SS (2010) CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling. Nat Neurosci 13(5):622\u2013629. https:\/\/doi.org\/10.1038\/nn.2529","journal-title":"Nat Neurosci"},{"issue":"1","key":"2879_CR56","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/npp.2015.142","volume":"41","author":"JR Mantsch","year":"2016","unstructured":"Mantsch JR, Baker DA, Funk D, L\u00ea AD, Shaham Y (2016) Stress-induced reinstatement of drug seeking: 20 years of progress. Neuropsychopharmacology 41(1):335\u2013356. https:\/\/doi.org\/10.1038\/npp.2015.142","journal-title":"Neuropsychopharmacology"},{"issue":"1\u20132","key":"2879_CR57","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.mce.2011.05.035","volume":"342","author":"QY Meng","year":"2011","unstructured":"Meng QY, Chen XN, Tong DL, Zhou JN (2011) Stress and glucocorticoids regulated corticotropin releasing factor in rat prefrontal cortex. Mol Cell Endocrinol 342(1\u20132):54\u201363. https:\/\/doi.org\/10.1016\/j.mce.2011.05.035","journal-title":"Mol Cell Endocrinol"},{"issue":"10","key":"2879_CR58","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1038\/nn1123","volume":"6","author":"MB M\u00fcller","year":"2003","unstructured":"M\u00fcller MB, Zimmermann S, Sillaber I, Hagemeyer TP, Deussing JM, Timpl P, Kormann MS, Droste SK, K\u00fchn R, Reul JM, Holsboer F, Wurst W (2003) Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. Nat Neurosci 6(10):1100\u20131107. https:\/\/doi.org\/10.1038\/nn1123","journal-title":"Nat Neurosci"},{"issue":"2","key":"2879_CR59","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/84397","volume":"19","author":"J Nakai","year":"2001","unstructured":"Nakai J, Ohkura M, Imoto K (2001) A high signal-to-noise Ca2\u2009+\u2009probe composed of a single green fluorescent protein. Nat Biotechnol 19(2):137\u2013141. https:\/\/doi.org\/10.1038\/84397","journal-title":"Nat Biotechnol"},{"key":"2879_CR60","doi-asserted-by":"publisher","unstructured":"Navabpour S, Kwapis JL, Jarome TJ (2020) A neuroscientist\u2019s guide to transgenic mice and other genetic tools. Neuroscience & Biobehavioral Reviews, 108, 732\u2013748.https:\/\/doi.org\/10.1016\/j.neubiorev.2019.12.013","DOI":"10.1016\/j.neubiorev.2019.12.013"},{"issue":"17","key":"2879_CR61","doi-asserted-by":"publisher","first-page":"3666","DOI":"10.1002\/cne.24295","volume":"525","author":"MG Oyola","year":"2017","unstructured":"Oyola MG, Thompson MK, Handa AZ, Handa RJ (2017) Distribution and chemical composition of estrogen receptor \u03b2 neurons in the paraventricular nucleus of the female and male mouse hypothalamus. J Comp Neurol 525(17):3666\u20133682. https:\/\/doi.org\/10.1002\/cne.24295","journal-title":"J Comp Neurol"},{"key":"2879_CR62","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-024-01233-y","author":"G Pan","year":"2024","unstructured":"Pan G, Zhao B, Zhang M, Guo Y, Yan Y, Dai D, Zhang X, Yang H, Ni J, Huang Z, Li X, Duan S (2024) Nucleus Accumbens Corticotropin-releasing hormone neurons projecting to the Bed Nucleus of the stria Terminalis Promote Wakefulness and positive affective state. Neurosci Bull. https:\/\/doi.org\/10.1007\/s12264-024-01233-yAdvance online publication","journal-title":"Neurosci Bull"},{"issue":"7","key":"2879_CR63","doi-asserted-by":"publisher","first-page":"2969","DOI":"10.1073\/pnas.92.7.2969","volume":"92","author":"M Perrin","year":"1995","unstructured":"Perrin M, Donaldson C, Chen R, Blount A, Berggren T, Bilezikjian L, Sawchenko P, Vale W (1995) Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart. Proc Natl Acad Sci 92(7):2969\u20132973. https:\/\/doi.org\/10.1073\/pnas.92.7.2969","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"2879_CR64","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1196\/annals.1317.065","volume":"1070","author":"MH Perrin","year":"2006","unstructured":"Perrin MH, Grace CR, Riek R, Vale WW (2006) The three-Dimensional structure of the N\u2010Terminal domain of Corticotropin\u2010releasing factor receptors: Sushi domains and the B1 family of G protein\u2013coupled receptors. Ann N Y Acad Sci 1070(1):105\u2013119. https:\/\/doi.org\/10.1196\/annals.1317.065","journal-title":"Ann N Y Acad Sci"},{"key":"2879_CR65","doi-asserted-by":"publisher","first-page":"100400","DOI":"10.1016\/j.coemr.2022.100400","volume":"26","author":"S Rajamanickam","year":"2022","unstructured":"Rajamanickam S, Justice NJ (2022) Hypothalamic corticotropin-releasing factor neurons modulate behavior, endocrine, and autonomic stress responses via direct synaptic projections. Curr Opin Endocr Metabolic Res 26:100400. https:\/\/doi.org\/10.1016\/j.coemr.2022.100400","journal-title":"Curr Opin Endocr Metabolic Res"},{"issue":"6042","key":"2879_CR66","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1126\/science.1205295","volume":"333","author":"RS Ray","year":"2011","unstructured":"Ray RS, Corcoran AE, Brust RD, Kim JC, Richerson GB, Nattie E, Dymecki SM (2011) Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition. Science 333(6042):637\u2013642. https:\/\/doi.org\/10.1126\/science.1205295","journal-title":"Science"},{"issue":"1","key":"2879_CR67","doi-asserted-by":"publisher","first-page":"e162","DOI":"10.1371\/journal.pone.0000162","volume":"2","author":"CS Raymond","year":"2007","unstructured":"Raymond CS, Soriano P (2007) High-efficiency FLP and \u03a6C31 site-specific recombination in mammalian cells. PLoS ONE 2(1):e162. https:\/\/doi.org\/10.1371\/journal.pone.0000162","journal-title":"PLoS ONE"},{"issue":"6051","key":"2879_CR68","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1126\/science.1202107","volume":"333","author":"D Refojo","year":"2011","unstructured":"Refojo D, Schweizer M, Kuehne C, Ehrenberg S, Thoeringer C, Vogl AM, Dedic N, Schumacher M, von Wolff G, Avrabos C, Touma C, Engblom D, Sch\u00fctz G, Nave KA, Eder M, Wotjak CT, Sillaber I, Holsboer F, Wurst W, Deussing JM (2011) Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1. Science 333(6051):1903\u20131907. https:\/\/doi.org\/10.1126\/science.1202107","journal-title":"Science"},{"issue":"2","key":"2879_CR69","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1006\/jmbi.1998.2149","volume":"284","author":"L Ringrose","year":"1998","unstructured":"Ringrose L, Lounnas V, Ehrlich L, Buchholz F, Wade R, Stewart AF (1998) Comparative kinetic analysis of FLP and cre recombinases: mathematical models for DNA binding and recombination. J Mol Biol 284(2):363\u2013384. https:\/\/doi.org\/10.1006\/jmbi.1998.2149","journal-title":"J Mol Biol"},{"issue":"9","key":"2879_CR70","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/s41574-019-0228-0","volume":"15","author":"G Russell","year":"2019","unstructured":"Russell G, Lightman S (2019) The human stress response. Nat Reviews Endocrinol 15(9):525\u2013534. https:\/\/doi.org\/10.1038\/s41574-019-0228-0","journal-title":"Nat Reviews Endocrinol"},{"issue":"1","key":"2879_CR71","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.neulet.2007.01.047","volume":"416","author":"A Schierloh","year":"2007","unstructured":"Schierloh A, Deussing J, Wurst W, Zieglg\u00e4nsberger W, Rammes G (2007) Corticotropin-releasing factor (CRF) receptor type 1-dependent modulation of synaptic plasticity. Neurosci Lett 416(1):82\u201386. https:\/\/doi.org\/10.1016\/j.neulet.2007.01.047","journal-title":"Neurosci Lett"},{"key":"2879_CR72","doi-asserted-by":"publisher","first-page":"146850","DOI":"10.1016\/j.brainres.2020.146850","volume":"1740","author":"S Simpson","year":"2020","unstructured":"Simpson S, Shankar K, Kimbrough A, George O (2020) Role of corticotropin-releasing factor in alcohol and nicotine addiction. Brain Res 1740:146850. https:\/\/doi.org\/10.1016\/j.brainres.2020.146850","journal-title":"Brain Res"},{"issue":"4","key":"2879_CR73","doi-asserted-by":"publisher","first-page":"383","DOI":"10.31887\/DCNS.2006.8.4\/ssmith","volume":"8","author":"SM Smith","year":"2006","unstructured":"Smith SM, Vale WW (2006) The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress. Dialog Clin Neurosci 8(4):383\u2013395. https:\/\/doi.org\/10.31887\/DCNS.2006.8.4\/ssmith","journal-title":"Dialog Clin Neurosci"},{"issue":"4","key":"2879_CR74","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.tins.2014.02.006","volume":"37","author":"R Spanagel","year":"2014","unstructured":"Spanagel R, Noori HR, Heilig M (2014) Stress and alcohol interactions: animal studies and clinical significance. Trends Neurosci 37(4):219\u2013227. https:\/\/doi.org\/10.1016\/j.tins.2014.02.006","journal-title":"Trends Neurosci"},{"issue":"4","key":"2879_CR75","doi-asserted-by":"publisher","first-page":"e13268","DOI":"10.1111\/jne.13268","volume":"35","author":"LM Stanton","year":"2023","unstructured":"Stanton LM, Price AJ, Manning EE (2023) Hypothalamic corticotrophin releasing hormone neurons in stress-induced psychopathology: revaluation of synaptic contributions. J Neuroendocrinol 35(4):e13268. https:\/\/doi.org\/10.1111\/jne.13268","journal-title":"J Neuroendocrinol"},{"key":"2879_CR94","unstructured":"Statements & Declarations"},{"issue":"11","key":"2879_CR76","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1038\/s41592-020-00981-9","volume":"17","author":"F Sun","year":"2020","unstructured":"Sun F, Zhou J, Dai B, Qian T, Zeng J, Li X, Zhuo Y, Zhang Y, Wang Y, Qian C, Tan K, Feng J, Dong H, Lin D, Cui G, Li Y (2020) Next-generation GRAB sensors for monitoring dopaminergic activity in vivo. Nat Methods 17(11):1156\u20131166. https:\/\/doi.org\/10.1038\/s41592-020-00981-9","journal-title":"Nat Methods"},{"issue":"48","key":"2879_CR77","doi-asserted-by":"publisher","first-page":"17416","DOI":"10.1523\/JNEUROSCI.3087-11.2011","volume":"31","author":"Y Sztainberg","year":"2011","unstructured":"Sztainberg Y, Kuperman Y, Justice N, Chen A (2011) An anxiolytic role for CRF receptor type 1 in the Globus Pallidus. J Neurosci 31(48):17416\u201317424. https:\/\/doi.org\/10.1523\/JNEUROSCI.3087-11.2011","journal-title":"J Neurosci"},{"key":"2879_CR79","doi-asserted-by":"publisher","unstructured":"Taniguchi, H., He, M., Wu, P., Kim, S., Paik, R., Sugino, K.,\u2026 Huang, Z. J. (2011).A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex. Neuron, 71(6), 995\u20131013. https:\/\/doi.org\/10.1016\/j.neuron.2011.07.026","DOI":"10.1016\/j.neuron.2011.07.026"},{"issue":"10","key":"2879_CR80","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.biopsych.2016.03.2106","volume":"80","author":"A Uribe-Mari\u00f1o","year":"2016","unstructured":"Uribe-Mari\u00f1o A, Gassen NC, Wiesbeck MF, Balsevich G, Santarelli S, Solfrank B, Dournes C, Fries GR, Masana M, Labermeier C, Wang XD, Hafner K, Schmid B, Rein T, Chen A, Deussing JM, Schmidt MV (2016) Prefrontal Cortex Corticotropin-Releasing Factor Receptor 1 conveys acute stress-Induced Executive Dysfunction. Biol Psychiatry 80(10):743\u2013753. https:\/\/doi.org\/10.1016\/j.biopsych.2016.03.2106","journal-title":"Biol Psychiatry"},{"issue":"4514","key":"2879_CR81","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1126\/science.6267699","volume":"213","author":"W Vale","year":"1981","unstructured":"Vale W, Spiess J, Rivier C, Rivier J (1981) Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and \u03b2-endorphin. Science 213(4514):1394\u20131397. https:\/\/doi.org\/10.1126\/science.6267699","journal-title":"Science"},{"key":"2879_CR82","doi-asserted-by":"publisher","unstructured":"Van Pett K, Viau V, Bittencourt JC, Chan RK, Li HY, Arias C, Prins GS, Perrin M, Vale W, Sawchenko PE (2000) Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse. J Comp Neurol 428(2):191\u2013212. https:\/\/doi.org\/10.1002\/1096-9861(20001211)428:2%3C191::aid-cne1%3E3.0.co;2-u","DOI":"10.1002\/1096-9861(20001211)428:2%3C191::aid-cne1%3E3.0.co;2-u"},{"issue":"1","key":"2879_CR83","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1038\/s41398-021-01497-2","volume":"11","author":"D Vandael","year":"2021","unstructured":"Vandael D, Wierda K, Vints K, Baatsen P, De Groef L, Moons L, Rybakin V, Gounko NV (2021) Corticotropin-releasing factor induces functional and structural synaptic remodelling in acute stress. Translational Psychiatry 11(1):378. https:\/\/doi.org\/10.1038\/s41398-021-01497-2","journal-title":"Translational Psychiatry"},{"issue":"1","key":"2879_CR84","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0014-5793(93)80427-v","volume":"335","author":"N Vita","year":"1993","unstructured":"Vita N, Laurent P, Lefort S, Chalon P, Lelias JM, Kaghad M, Le Fur G, Caput D, Ferrara P (1993) Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors. FEBS Lett 335(1):1\u20135. https:\/\/doi.org\/10.1016\/0014-5793(93)80427-v","journal-title":"FEBS Lett"},{"issue":"1","key":"2879_CR85","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/nn.3591","volume":"17","author":"JJ Walsh","year":"2014","unstructured":"Walsh JJ, Friedman AK, Sun H, Heller EA, Ku SM, Juarez B, Burnham VL, Mazei-Robison MS, Ferguson D, Golden SA, Koo JW, Chaudhury D, Christoffel DJ, Pomeranz L, Friedman JM, Russo SJ, Nestler EJ, Han MH (2014) Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway. Nat Neurosci 17(1):27\u201329. https:\/\/doi.org\/10.1038\/nn.3591","journal-title":"Nat Neurosci"},{"issue":"38","key":"2879_CR86","doi-asserted-by":"publisher","first-page":"13625","DOI":"10.1523\/JNEUROSCI.2259-11.2011","volume":"31","author":"XD Wang","year":"2011","unstructured":"Wang XD, Rammes G, Kraev I, Wolf M, Liebl C, Scharf SH, Rice CJ, Wurst W, Holsboer F, Deussing JM, Baram TZ, Stewart MG, M\u00fcller MB, Schmidt MV (2011) Forebrain CRF\u2081 modulates early-life stress-programmed cognitive deficits. J Neurosci 31(38):13625\u201313634. https:\/\/doi.org\/10.1523\/JNEUROSCI.2259-11.2011","journal-title":"J Neurosci"},{"key":"2879_CR87","doi-asserted-by":"publisher","unstructured":"Weera MM, Gilpin NW (2019) Biobehavioral interactions between stress and alcohol. Alcohol Research: Curr Reviews 40(1). https:\/\/doi.org\/10.35946\/arcr.v40.1.04","DOI":"10.35946\/arcr.v40.1.04"},{"key":"2879_CR88","doi-asserted-by":"publisher","first-page":"e67822","DOI":"10.7554\/eLife.67822","volume":"11","author":"MM Weera","year":"2022","unstructured":"Weera MM, Agoglia AE, Douglass E, Jiang Z, Rajamanickam S, Shackett RS, Herman MA, Justice NJ, Gilpin NW (2022) Generation of a CRF1-Cre transgenic rat and the role of central amygdala CRF1 cells in nociception and anxiety-like behavior. eLife 11:e67822. https:\/\/doi.org\/10.7554\/eLife.67822","journal-title":"eLife"},{"issue":"1","key":"2879_CR89","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1046\/j.1471-4159.1999.0720388.x","volume":"72","author":"S Wille","year":"1999","unstructured":"Wille S, Sydow S, Palchaudhuri MR, Spiess J, Dautzenberg FM (1999) Identification of amino acids in the N-terminal domain of corticotropin\u2010releasing factor receptor 1 that are important determinants of high\u2010affinity ligand binding. J Neurochem 72(1):388\u2013395. https:\/\/doi.org\/10.1046\/j.1471-4159.1999.0720388.x","journal-title":"J Neurochem"},{"key":"2879_CR90","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1007\/s002210050576","volume":"123","author":"XX Yan","year":"1998","unstructured":"Yan XX, Baram TZ, Gerth A, Schultz L, Ribak CE (1998) Co-localization of corticotropin-releasing hormone with glutamate decarboxylase and calcium-binding proteins in infant rat neocortical interneurons. Exp Brain Res 123:334\u2013340. https:\/\/doi.org\/10.1007\/s002210050576","journal-title":"Exp Brain Res"},{"issue":"6","key":"2879_CR91","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1016\/j.neuron.2018.08.015","volume":"99","author":"X Yu","year":"2018","unstructured":"Yu X, Taylor AM, Nagai J, Golshani P, Evans CJ, Coppola G, Khakh BS (2018) Reducing astrocyte calcium signaling in vivo alters striatal microcircuits and causes repetitive behavior. Neuron 99(6):1170\u20131187. https:\/\/doi.org\/10.1016\/j.neuron.2018.08.015","journal-title":"Neuron"},{"issue":"1","key":"2879_CR92","doi-asserted-by":"publisher","first-page":"8201","DOI":"10.1038\/s41467-023-44015-2","volume":"14","author":"W Zhang","year":"2023","unstructured":"Zhang W, Fu Y, Peng L, Ogawa Y, Ding X, Rasband A, Zhou X, Shelly M, Rasband MN, Zou P (2023) Immunoproximity biotinylation reveals the axon initial segment proteome. Nat Commun 14(1):8201. https:\/\/doi.org\/10.1038\/s41467-023-44015-2","journal-title":"Nat Commun"},{"key":"2879_CR93","doi-asserted-by":"publisher","first-page":"1163462","DOI":"10.3389\/fnins.2023.1163462","volume":"17","author":"C Zhao","year":"2023","unstructured":"Zhao C, Ries C, Du Y, Zhang J, Sakimura K, Itoi K, Deussing JM (2023) Differential CRH expression level determines efficiency of cre- and flp-dependent recombination. Front NeuroSci 17:1163462. https:\/\/doi.org\/10.3389\/fnins.2023.1163462","journal-title":"Front NeuroSci"}],"container-title":["Brain Structure and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-024-02879-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00429-024-02879-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-024-02879-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:33Z","timestamp":1737936033000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00429-024-02879-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,18]]},"references-count":93,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["2879"],"URL":"https:\/\/doi.org\/10.1007\/s00429-024-02879-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.11.08.622735","asserted-by":"object"}]},"ISSN":["1863-2661"],"issn-type":[{"value":"1863-2661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,18]]},"assertion":[{"value":"23 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All housing and experimental procedures were performed in accordance with the National Institute of Health (NIH) guidelines and approved by the University of California-Irvine Institutional Animal Care and Use Committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"12"}}