{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:23:09Z","timestamp":1786980189515,"version":"build-2736575974"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002332","name":"Semmelweis University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002332","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Brain Struct Funct"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The human brain exhibits intricate hemispheric asymmetries at both structural and functional levels. Recent research highlights the significance of these asymmetries in various neurological diseases, with left-sided pathologies often associated with worse clinical outcomes. This study aims to unravel the lateralisation of resting-state network connectivity in the human brain using rs-fMRI, exploring its implications for the pathophysiology of neurological disorders. In this study, we utilized a multifaceted analytical approach with seven graph-theoretical measures, three voxel-based metrics, and the laterality index. The study was conducted on two independent datasets: a Local cohort comprising 102 right-handed healthy control participants, and a comparative cohort of 86 right-handed healthy control participants from the ADNI database.Our results reveal significant lateralisation of resting-state functional network connectivity in several brain regions across both datasets. The following regions exhibited consistent significant left-sided lateralisation in both cohorts, even when using different metrics: Cerebellum (10, Crus2, 6), Frontal (Orbital, Inferior Triangular, Superior), Supramarginal (posterior), Lateral Occipital, Inferior Temporal (posterior). Right lateralisation: Cerebellum 7b, Frontal Pole, Supracalcarine, Juxtapositional Lobule. The consistency of lateralisation patterns across multiple analytical methods and independent cohorts underscores the importance of our findings. The observed lateralisation phenomena might have important implications for the pathophysiology of various neurological diseases, potentially offering insights into disease progression and prognosis.<\/jats:p>","DOI":"10.1007\/s00429-025-03039-8","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T08:41:09Z","timestamp":1762764069000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hemispheric asymmetries in resting-state connectivity: insights from healthy controls and implications for neurological disorders"],"prefix":"10.1007","volume":"230","author":[{"given":"Gergo","family":"Bolla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalida Borbala","family":"Berente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orsolya","family":"Szalmas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tunde","family":"Mangel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Kamondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andras Attila","family":"Horvath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"3039_CR1","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.neuroimage.2014.09.001","volume":"104","author":"O Agcaoglu","year":"2015","unstructured":"Agcaoglu O, Miller R, Mayer AR, Hugdahl K, Calhoun VD (2015) Lateralization of resting state networks and relationship to age and gender. Neuroimage 104:310\u201325. https:\/\/doi.org\/10.1016\/j.neuroimage.2014.09.001","journal-title":"Neuroimage"},{"issue":"1","key":"3039_CR2","doi-asserted-by":"publisher","DOI":"10.1140\/epjp\/s13360-023-03687-x","volume":"138","author":"F Ahmad","year":"2023","unstructured":"Ahmad F, Ahmad I, Guerrero-S\u00e1nchez Y (2023) Classification of schizophrenia-associated brain regions in resting-state fMRI. Eur Phys J Plus 138(1):58. https:\/\/doi.org\/10.1140\/epjp\/s13360-023-03687-x","journal-title":"Eur Phys J Plus"},{"issue":"50","key":"3039_CR3","doi-asserted-by":"publisher","first-page":"e0166242024","DOI":"10.1523\/JNEUROSCI.0166-24.2024","volume":"44","author":"I Andrulyte","year":"2024","unstructured":"Andrulyte I, De Bezenac C, Branzi F, Forkel SJ, Taylor PN, Keller SS (2024) The relationship between white matter architecture and Language lateralization in the healthy brain. J Neurosci Off J Soc Neurosci 44(50):e0166242024. https:\/\/doi.org\/10.1523\/JNEUROSCI.0166-24.2024","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"3039_CR4","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.copsyc.2018.12.023","volume":"29","author":"P Bartolomeo","year":"2019","unstructured":"Bartolomeo P, Malkinson TS (2019) Hemispheric lateralization of attention processes in the human brain. Curr Opin Psychol 29:90\u201396. https:\/\/doi.org\/10.1016\/j.copsyc.2018.12.023","journal-title":"Curr Opin Psychol"},{"issue":"3","key":"3039_CR5","doi-asserted-by":"publisher","first-page":"e0230129","DOI":"10.1371\/journal.pone.0230129","volume":"15","author":"I Brumer","year":"2020","unstructured":"Brumer I, Vita ED, Ashmore J, Jarosz J, Borri M (2020) Implementation of clinically relevant and robust fMRI-Based Language lateralization: choosing the laterality index calculation method. PLoS ONE 15(3):e0230129. https:\/\/doi.org\/10.1371\/journal.pone.0230129","journal-title":"PLoS ONE"},{"key":"3039_CR6","doi-asserted-by":"publisher","first-page":"110006","DOI":"10.1016\/j.yebeh.2024.110006","volume":"159","author":"B Clemens","year":"2024","unstructured":"Clemens B, Emri M, D\u00f6m\u00f6t\u00f6r J, Fekete I, Fekete K (2024) Left hemispheric epilepsy is more frequent and has worse clinical course that right hemispheric epilepsy. Epilepsy Behav 159:110006. https:\/\/doi.org\/10.1016\/j.yebeh.2024.110006","journal-title":"Epilepsy Behav"},{"issue":"9","key":"3039_CR7","doi-asserted-by":"publisher","first-page":"4944","DOI":"10.1002\/hbm.22524","volume":"35","author":"K Caeyenberghs","year":"2014","unstructured":"Caeyenberghs K, Leemans A (2014) Hemispheric lateralization of topological organization in structural brain networks. Hum Brain Mapp 35(9):4944\u20134957. https:\/\/doi.org\/10.1002\/hbm.22524","journal-title":"Hum Brain Mapp"},{"key":"3039_CR65","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/907464","author":"Cha","year":"2015","unstructured":"Cha J, Hwang JM, Jo HJ, Seo SW, Na DL, Lee JM (2015) Assessment of Functional Characteristics of Amnestic Mild Cognitive Impairment and Alzheimer\u2019s Disease Using Various Methods of Resting-State FMRI Analysis. BioMed Res Int 2015(1):907464. https:\/\/doi.org\/10.1155\/2015\/907464","journal-title":"BioMed Research International"},{"issue":"3","key":"3039_CR8","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s00221-006-0794-y","volume":"179","author":"P Chlebus","year":"2007","unstructured":"Chlebus P, Mikl M, Br\u00e1zdil M, Pa\u017eourkov\u00e1 M, Krupa P, and Ivan Rektor (2007) fMRI evaluation of hemispheric Language dominance using various methods of laterality index calculation. Exp Brain Res 179(3):365\u2013374. https:\/\/doi.org\/10.1007\/s00221-006-0794-y","journal-title":"Exp Brain Res"},{"issue":"4","key":"3039_CR9","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3892\/or.2024.8798","volume":"52","author":"NT Cini","year":"2024","unstructured":"Cini NT, Pennisi M, Genc S et al (2024) Glioma lateralization: focus on the anatomical localization and the distribution of molecular alterations (Review). Oncol Rep 52(4):139. https:\/\/doi.org\/10.3892\/or.2024.8798","journal-title":"Oncol Rep"},{"issue":"1","key":"3039_CR10","doi-asserted-by":"publisher","first-page":"bhad437","DOI":"10.1093\/cercor\/bhad437","volume":"34","author":"Z Dai","year":"2024","unstructured":"Dai Z, Song L, Luo C, Liu D, Li M, Han Z (2024) Hemispheric lateralization of language processing: insights from network-based symptom mapping and patient subgroups. Cerebral Cortex\u00a0(New York, N.Y.: 1991) 34(1):bhad437. https:\/\/doi.org\/10.1093\/cercor\/bhad437","journal-title":"Cerebral Cortex\u00a0(New York, N.Y.: 1991)"},{"issue":"4","key":"3039_CR11","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1089\/brain.2012.0137","volume":"3","author":"M Daianu","year":"2013","unstructured":"Daianu M, Jahanshad N, Nir TM et al (2013) Breakdown of brain connectivity between normal aging and Alzheimer\u2019s disease: a structural k-core network analysis. Brain Connect 3(4):407\u2013422. https:\/\/doi.org\/10.1089\/brain.2012.0137","journal-title":"Brain Connect"},{"key":"3039_CR12","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.neuroimage.2017.11.025","volume":"167","author":"F de Vos","year":"2018","unstructured":"de Vos F, Koini M, Schouten TM et al (2018) A comprehensive analysis of resting state fMRI measures to classify individual patients with Alzheimer\u2019s disease. Neuroimage 167:62\u201372. https:\/\/doi.org\/10.1016\/j.neuroimage.2017.11.025","journal-title":"Neuroimage"},{"issue":"4","key":"3039_CR13","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1111\/j.1528-1157.1997.tb01743.x","volume":"38","author":"AC Dean","year":"1997","unstructured":"Dean AC, Solomon G, Harden C, Papakostas G, Labar DR (1997) Left hemispheric dominance of epileptiform discharges. Epilepsia 38(4):503\u2013505. https:\/\/doi.org\/10.1111\/j.1528-1157.1997.tb01743.x","journal-title":"Epilepsia"},{"issue":"1","key":"3039_CR14","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1002\/hbm.20482","volume":"30","author":"G Deshpande","year":"2009","unstructured":"Deshpande G, LaConte S, Peltier S, Xiaoping H (2009) Integrated local correlation: a new measure of local coherence in fMRI data. Hum Brain Mapp 30(1):13\u201323. https:\/\/doi.org\/10.1002\/hbm.20482","journal-title":"Hum Brain Mapp"},{"issue":"12","key":"3039_CR15","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1046\/j.1528-1157.2002.24002.x","volume":"43","author":"MJ Doherty","year":"2002","unstructured":"Doherty MJ, Walting PJ, Morita DC et al (2002) Do nonspecific focal EEG slowing and epileptiform abnormalities favor one hemisphere? Epilepsia 43(12):1593\u201395. https:\/\/doi.org\/10.1046\/j.1528-1157.2002.24002.x","journal-title":"Epilepsia"},{"issue":"9","key":"3039_CR16","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1111\/j.1528-1167.2012.03533.x","volume":"53","author":"F Fahoum","year":"2012","unstructured":"Fahoum F, Lopes R, Pittau F, Dubeau F, Gotman J (2012) Widespread epileptic networks in focal epilepsies: EEG-fMRI study. Epilepsia 53(9):1618\u20131627. https:\/\/doi.org\/10.1111\/j.1528-1167.2012.03533.x","journal-title":"Epilepsia"},{"key":"3039_CR17","doi-asserted-by":"publisher","first-page":"110102","DOI":"10.1016\/j.jtbi.2019.110102","volume":"486","author":"S Fornari","year":"2020","unstructured":"Fornari S, Sch\u00e4fer A, Kuhl E (2020) Spatially-extended nucleation-aggregation-fragmentation models for the dynamics of Prion-like neurodegenerative protein-spreading in the brain and its connectome. J Theor Biol 486:110102. https:\/\/doi.org\/10.1016\/j.jtbi.2019.110102","journal-title":"J Theor Biol"},{"issue":"10","key":"3039_CR18","doi-asserted-by":"publisher","first-page":"3089","DOI":"10.1093\/brain\/awv229","volume":"138","author":"L Frings","year":"2015","unstructured":"Frings L, Hellwig S, Spehl TS et al (2015) Asymmetries of amyloid-\u03b2 burden and neuronal dysfunction are positively correlated in alzheimer\u2019s disease. Brain 138(10):3089\u20133099. https:\/\/doi.org\/10.1093\/brain\/awv229","journal-title":"Brain"},{"issue":"October","key":"3039_CR19","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.nbd.2013.06.005","volume":"58","author":"AM Garc\u00eda-Cabrero","year":"2013","unstructured":"Garc\u00eda-Cabrero AM, Guerrero-L\u00f3pez R, Gir\u00e1ldez BG et al (2013) Hyperexcitability and epileptic seizures in a model of frontotemporal dementia. Neurobiol Dis 58(October):200\u2013208. https:\/\/doi.org\/10.1016\/j.nbd.2013.06.005","journal-title":"Neurobiol Dis"},{"issue":"5","key":"3039_CR20","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1007\/s11682-016-9629-z","volume":"11","author":"T Guadalupe","year":"2017","unstructured":"Guadalupe T, Mathias SR, Vanerp GMT, et al (2017) Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex. Brain Imaging Behav 11(5):1497\u20131514. https:\/\/doi.org\/10.1007\/s11682-016-9629-z","journal-title":"Brain Imaging Behav"},{"issue":"4","key":"3039_CR21","doi-asserted-by":"publisher","first-page":"3597","DOI":"10.3390\/ijms24043597","volume":"24","author":"M Guardiola-Ripoll","year":"2023","unstructured":"Guardiola-Ripoll M, Fatj\u00f3-Vilas M (2023) A systematic review of the human accelerated regions in schizophrenia and related disorders: where the evolutionary and neurodevelopmental hypotheses converge. Int J Mol Sci 24(4):3597. https:\/\/doi.org\/10.3390\/ijms24043597","journal-title":"Int J Mol Sci"},{"issue":"2","key":"3039_CR22","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.neuroimage.2009.12.051","volume":"50","author":"S Hayasaka","year":"2010","unstructured":"Hayasaka S, Laurienti PJ (2010) Comparison of characteristics between region-and voxel-based network analyses in resting-state fMRI data. Neuroimage 50(2):499\u2013508. https:\/\/doi.org\/10.1016\/j.neuroimage.2009.12.051","journal-title":"Neuroimage"},{"key":"3039_CR64","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2012.12.004","author":"Herv\u00e9","year":"2012","unstructured":"Herv\u00e9 PY, Zago L, Petit L, Mazoyer B, Tzourio-Mazoyer N (2013) Revisiting Human Hemispheric Specialization with Neuroimaging. Trends Cogn Sci 17(2):69\u201380. https:\/\/doi.org\/10.1016\/j.tics.2012.12.004","journal-title":". Trends in Cognitive Sciences"},{"issue":"3","key":"3039_CR23","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1684\/j.1950-6945.2001.tb00384.x","volume":"3","author":"MD Holmes","year":"2001","unstructured":"Holmes MD, Dodrill CB, Kutsy RL, Ojemann GA, Miller JW (2001) Is the left cerebral hemisphere more prone to epileptogenesis than the right? Epileptic Disord 3(3):137\u2013141","journal-title":"Epileptic Disord"},{"issue":"1","key":"3039_CR24","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.neuroimage.2009.08.004","volume":"49","author":"MD Holmes","year":"2010","unstructured":"Holmes MD, Quiring J, Tucker DM (2010) Evidence that juvenile myoclonic epilepsy is a disorder of frontotemporal corticothalamic networks. Neuroimage 49(1):80\u201393. https:\/\/doi.org\/10.1016\/j.neuroimage.2009.08.004","journal-title":"Neuroimage"},{"issue":"21","key":"3039_CR25","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1212\/WNL.0b013e3181c34b47","volume":"73","author":"S Hoops","year":"2009","unstructured":"Hoops S, Nazem S, Siderowf AD et al (2009) Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson disease. Neurology 73(21):1738. https:\/\/doi.org\/10.1212\/WNL.0b013e3181c34b47","journal-title":"Neurology"},{"key":"3039_CR26","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.psychres.2016.03.001","volume":"244","author":"A Horv\u00e1th","year":"2016","unstructured":"Horv\u00e1th A, Montana X, Lanquart J-P et al (2016) Effects of state and trait anxiety on sleep structure: a polysomnographic study in 1083 subjects. Psychiatry Res 244:279\u2013283. https:\/\/doi.org\/10.1016\/j.psychres.2016.03.001","journal-title":"Psychiatry Res"},{"issue":"8","key":"3039_CR27","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1016\/j.clinph.2021.03.050","volume":"132","author":"AA Horvath","year":"2021","unstructured":"Horvath AA, Papp A, Zsuffa J et al (2021) Subclinical epileptiform activity accelerates the progression of alzheimer\u2019s disease: A Long-Term EEG study. Clin Neurophysiol Off J Int Federation Clin Neurophysiol 132(8):1982\u20131989. https:\/\/doi.org\/10.1016\/j.clinph.2021.03.050","journal-title":"Clin Neurophysiol Off J Int Federation Clin Neurophysiol"},{"key":"3039_CR69","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.130220","author":"Hou","year":"2014","unstructured":"Hou JM, Zhao M, Zhang W et al (2014) Resting-State Functional Connectivity Abnormalities in Patients with Obsessive\u2013Compulsive Disorder and Their Healthy First-Degree Relatives. Research Papers. J Psychiatry Neurosci 39(5):304\u201311. https:\/\/doi.org\/10.1503\/jpn.130220","journal-title":"Journal of Psychiatry and Neuroscience"},{"issue":"1","key":"3039_CR28","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1093\/brain\/awx319","volume":"141","author":"DJ Irwin","year":"2017","unstructured":"Irwin DJ, McMillan CT, Xie SX et al (2017) Asymmetry of Post-Mortem neuropathology in Behavioural-Variant frontotemporal dementia. Brain 141(1):288. https:\/\/doi.org\/10.1093\/brain\/awx319","journal-title":"Brain"},{"issue":"4","key":"3039_CR29","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1002\/mrm.1243","volume":"46","author":"AL Janke","year":"2001","unstructured":"Janke AL, de Zubicaray G, Rose SE, Griffin M, Chalk JB, Galloway GJ (2001) 4D deformation modeling of cortical disease progression in Alzheimer\u2019s dementia. Magn Reson Med 46(4):661\u2013666. https:\/\/doi.org\/10.1002\/mrm.1243","journal-title":"Magn Reson Med"},{"issue":"3","key":"3039_CR30","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/s41582-024-00932-4","volume":"20","author":"A Kamondi","year":"2024","unstructured":"Kamondi A, Grigg-Damberger M, L\u00f6scher W, Tanila H, Andras Attila H (2024) Epilepsy and epileptiform activity in Late-Onset alzheimer disease: clinical and pathophysiological Advances, gaps and conundrums. Nat Reviews Neurol 20(3):162\u2013182. https:\/\/doi.org\/10.1038\/s41582-024-00932-4","journal-title":"Nat Reviews Neurol"},{"key":"3039_CR31","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.bbr.2016.06.043","volume":"322","author":"A Khazaee","year":"2017","unstructured":"Khazaee A, Ebrahimzadeh A, Babajani-Feremi A (2017) Classification of Patients with MCI and AD from Healthy Controls Using Directed Graph Measures of Resting-State fMRI. Behav Brain Res Mech Aging Alzheimer\u2019s Disease Memory Impairments 322:339\u201350. https:\/\/doi.org\/10.1016\/j.bbr.2016.06.043","journal-title":"Behav Brain Res Mech Aging Alzheimer\u2019s Disease Memory Impairments"},{"issue":"7","key":"3039_CR32","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1212\/WNL.0000000000002375","volume":"86","author":"G Kim","year":"2016","unstructured":"Kim G, Ahmadian SS, Peterson M et al (2016) Asymmetric pathology in primary progressive aphasia with progranulin mutations and TDP inclusions. Neurology 86(7):627. https:\/\/doi.org\/10.1212\/WNL.0000000000002375","journal-title":"Neurology"},{"key":"3039_CR66","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25033","author":"Kong","year":"2020","unstructured":"Kong XZ, Postema MC, Guadalupe T et al (2022) Mapping Brain Asymmetry in Health and Disease through the ENIGMA Consortium. Hum Brain Mapp 43(1):167\u201381. https:\/\/doi.org\/10.1002\/hbm.25033","journal-title":"Human Brain Mapping"},{"issue":"4","key":"3039_CR33","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1177\/1073858411422754","volume":"18","author":"MA Kramer","year":"2012","unstructured":"Kramer MA, Cash SS (2012) Epilepsy as a disorder of cortical network organization. Neuroscientist: Rev J Bringing Neurobiol Neurol Psychiatry 18(4):360\u2013372. https:\/\/doi.org\/10.1177\/1073858411422754","journal-title":"Neuroscientist: Rev J Bringing Neurobiol Neurol Psychiatry"},{"key":"3039_CR34","doi-asserted-by":"publisher","DOI":"10.1002\/alz.079245","author":"A Lam","year":"2023","unstructured":"Lam A, Jacobs H, Thibault E et al (2023) Association of focal epilepsy in Alzheimer\u2019s disease with Tau, amyloid, and neurodegeneration. Alzheimers Dement. https:\/\/doi.org\/10.1002\/alz.079245","journal-title":"Alzheimers Dement"},{"issue":"9","key":"3039_CR35","doi-asserted-by":"publisher","first-page":"e209920","DOI":"10.1212\/WNL.0000000000209920","volume":"103","author":"AD Lam","year":"2024","unstructured":"Lam AD, Thibault EG, Mayblyum DV et al (2024) Association of seizure foci and location of Tau and amyloid deposition and brain atrophy in patients with alzheimer disease and seizures. Neurology 103(9):e209920. https:\/\/doi.org\/10.1212\/WNL.0000000000209920","journal-title":"Neurology"},{"key":"3039_CR67","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.742973","author":"Li","year":"2021","unstructured":"Li MT, Zhang SX, Li X et al (2021) Amplitude of Low-Frequency Fluctuation in Multiple Frequency Bands in Tension-Type Headache Patients: A Resting-State Functional Magnetic Resonance Imaging Study. Front Neurosci 15:742973. https:\/\/doi.org\/10.3389\/fnins.2021.742973","journal-title":"Frontiers in Neuroscience"},{"issue":"3","key":"3039_CR36","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1111\/j.1528-1167.2007.00982.x","volume":"48","author":"T Loddenkemper","year":"2007","unstructured":"Loddenkemper T, Morris HH, Lineweaver TT, Kellinghaus C (2007) Repeated intracarotid amobarbital tests. Epilepsia 48(3):553\u2013558. https:\/\/doi.org\/10.1111\/j.1528-1167.2007.00982.x","journal-title":"Epilepsia"},{"issue":"8","key":"3039_CR37","doi-asserted-by":"publisher","first-page":"e1005637","DOI":"10.1371\/journal.pcbi.1005637","volume":"13","author":"MA Lopes","year":"2017","unstructured":"Lopes MA, Richardson MP, Abela E et al (2017) An optimal strategy for epilepsy surgery: disruption of the Rich-Club? PLoS Comput Biol 13(8):e1005637. https:\/\/doi.org\/10.1371\/journal.pcbi.1005637","journal-title":"PLoS Comput Biol"},{"issue":"3","key":"3039_CR38","doi-asserted-by":"publisher","first-page":"fcab211","DOI":"10.1093\/braincomms\/fcab211","volume":"3","author":"N Lubben","year":"2021","unstructured":"Lubben N, Ensink E, Coetzee GA, and Viviane Labrie (2021) The enigma and implications of brain hemispheric asymmetry in neurodegenerative diseases. Brain Commun 3(3):fcab211. https:\/\/doi.org\/10.1093\/braincomms\/fcab211","journal-title":"Brain Commun"},{"issue":"4","key":"3039_CR39","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/j.neuroimage.2011.06.075","volume":"58","author":"R Martuzzi","year":"2011","unstructured":"Martuzzi R, Ramani R, Qiu M, Shen X, Papademetris X, Todd Constable R (2011) A whole-brain voxel based measure of intrinsic connectivity contrast reveals local changes in tissue connectivity with anesthetic without a priori assumptions on thresholds or regions of interest. Neuroimage 58(4):1044\u201350. https:\/\/doi.org\/10.1016\/j.neuroimage.2011.06.075","journal-title":"Neuroimage"},{"issue":"8","key":"3039_CR40","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1001\/archneur.1986.00520080014012","volume":"43","author":"MF Mendez","year":"1986","unstructured":"Mendez MF, Cummings JL, Benson DF (1986) Depression in Epilepsy. Significance and phenomenology. Arch Neurol 43(8):766\u2013770. https:\/\/doi.org\/10.1001\/archneur.1986.00520080014012","journal-title":"Arch Neurol"},{"key":"3039_CR41","doi-asserted-by":"publisher","first-page":"1092125","DOI":"10.3389\/fnins.2023.1092125","volume":"17","author":"F Morfini","year":"2023","unstructured":"Morfini F, Whitfield-Gabrieli S, Nieto-Casta\u00f1\u00f3n A (2023) Functional connectivity MRI quality control procedures in CONN. Front NeuroSci 17:1092125. https:\/\/doi.org\/10.3389\/fnins.2023.1092125","journal-title":"Front NeuroSci"},{"key":"3039_CR42","doi-asserted-by":"crossref","unstructured":"Nieto-Castanon A (2020) Handbook of functional connectivity magnetic resonance imaging methods in CONN. Hilbert","DOI":"10.56441\/hilbertpress.2207.6598"},{"issue":"8","key":"3039_CR43","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1016\/j.neuron.2024.02.010","volume":"112","author":"S Ocklenburg","year":"2024","unstructured":"Ocklenburg S, Guo ZV (2024) Cross-hemispheric communication: insights on lateralized brain functions. Neuron 112(8):1222\u20131234. https:\/\/doi.org\/10.1016\/j.neuron.2024.02.010","journal-title":"Neuron"},{"key":"3039_CR44","doi-asserted-by":"publisher","first-page":"e50830","DOI":"10.7554\/eLife.50830","volume":"8","author":"JB Pereira","year":"2019","unstructured":"Pereira JB, Ossenkoppele R, Palmqvist S et al (2019) Amyloid and Tau accumulate across distinct Spatial networks and are differentially associated with brain connectivity. eLife 8:e50830. https:\/\/doi.org\/10.7554\/eLife.50830","journal-title":"eLife"},{"key":"3039_CR45","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.neuroimage.2013.08.048","volume":"84","author":"JD Power","year":"2014","unstructured":"Power JD, Mitra A, Laumann TO, Snyder AZ, Schlaggar BL, Petersen SE (2014) Methods to detect, characterize, and remove motion artifact in resting state fMRI. Neuroimage 84:320\u201341. https:\/\/doi.org\/10.1016\/j.neuroimage.2013.08.048","journal-title":"Neuroimage"},{"issue":"3","key":"3039_CR46","doi-asserted-by":"publisher","first-page":"747","DOI":"10.3233\/JAD-170798","volume":"65","author":"F Powell","year":"2018","unstructured":"Powell F, Tosun D, Sadeghi R, Weiner M, Raj A, Alzheimer\u2019s Disease Neuroimaging Initiative (2018) Preserved structural network organization mediates pathology spread in Alzheimer\u2019s disease spectrum despite loss of white matter tract integrity. J Alzheimers Dis 65(3):747\u2013764. https:\/\/doi.org\/10.3233\/JAD-170798","journal-title":"J Alzheimers Dis"},{"issue":"8","key":"3039_CR47","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.3174\/ajnr.A0584","volume":"28","author":"S Rodrigo","year":"2007","unstructured":"Rodrigo S, Naggara O, Oppenheim C et al (2007) Human subinsular asymmetry studied by diffusion tensor imaging and fiber tracking. AJNR Am J Neuroradiol 28(8):1526. https:\/\/doi.org\/10.3174\/ajnr.A0584","journal-title":"AJNR Am J Neuroradiol"},{"issue":"1","key":"3039_CR48","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/geriatrics8010012","volume":"8","author":"F Salis","year":"2023","unstructured":"Salis F, Costaggiu D, and Antonella Mandas (2023) Mini-Mental state examination: optimal Cut-Off levels for mild and severe cognitive impairment. Geriatrics 8(1):12. https:\/\/doi.org\/10.3390\/geriatrics8010012","journal-title":"Geriatrics"},{"issue":"11","key":"3039_CR49","doi-asserted-by":"publisher","first-page":"e13788","DOI":"10.1371\/journal.pone.0013788","volume":"5","author":"EJ Sanz-Arigita","year":"2010","unstructured":"Sanz-Arigita EJ, Schoonheim MM, Damoiseaux JS et al (2010) Loss of Small-World networks in alzheimer\u2019s disease: graph analysis of fMRI Resting-State functional connectivity. PLoS ONE 5(11):e13788. https:\/\/doi.org\/10.1371\/journal.pone.0013788","journal-title":"PLoS ONE"},{"issue":"10284","key":"3039_CR50","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","volume":"397","author":"P Scheltens","year":"2021","unstructured":"Scheltens P, Strooper BD, Kivipelto M et al (2021) Alzheimer\u2019s disease. Lancet 397(10284):1577\u20131590. https:\/\/doi.org\/10.1016\/S0140-6736(20)32205-4","journal-title":"Lancet"},{"key":"3039_CR51","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.neuroimage.2019.01.079","volume":"189","author":"J Schmitz","year":"2019","unstructured":"Schmitz J, Fraenz C, Schl\u00fcter C et al (2019) Hemispheric asymmetries in cortical gray matter microstructure identified by neurite orientation dispersion and density imaging. Neuroimage 189:667\u201375. https:\/\/doi.org\/10.1016\/j.neuroimage.2019.01.079","journal-title":"Neuroimage"},{"issue":"2","key":"3039_CR52","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.neuroimage.2011.06.078","volume":"58","author":"R Sladky","year":"2011","unstructured":"Sladky R, Friston KJ, Tr\u00f6stl J, Cunnington R, Moser E, Windischberger C (2011) Slice-timing effects and their correction in functional MRI. Neuroimage 58(2):588\u201394. https:\/\/doi.org\/10.1016\/j.neuroimage.2011.06.078","journal-title":"Neuroimage"},{"key":"3039_CR53","doi-asserted-by":"publisher","unstructured":"Smith SM (2001) \u2018Preparing fMRI Data for Statistical Analysis\u2019. In Functional Magnetic Resonance Imaging: An Introduction to Methods, edited by Peter Jezzard, Paul M Matthews, and Stephen M Smith. Oxford University Press. https:\/\/doi.org\/10.1093\/acprof:oso\/9780192630711.003.0012","DOI":"10.1093\/acprof:oso\/9780192630711.003.0012"},{"key":"3039_CR68","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2006.07.002","author":"Fink Gereion R.","year":"2007","unstructured":"Stephan KE, Fink GR, Marshall JC (2007) Mechanisms of Hemispheric Specialization: Insights from Analyses of Connectivity. Neuropsychologia 45(2\u20134):209. https:\/\/doi.org\/10.1016\/j.neuropsychologia.2006.07.002","journal-title":"Neuropsychologia"},{"key":"3039_CR54","doi-asserted-by":"publisher","unstructured":"Telesford QK, Ashley R, Morgan S, Hayasaka et al (2010) Reproducibility of graph metrics in fMRI networks. Front Neuroinformatics 4. https:\/\/doi.org\/10.3389\/fninf.2010.00117","DOI":"10.3389\/fninf.2010.00117"},{"issue":"1","key":"3039_CR55","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/nrn1009","volume":"4","author":"AW Toga","year":"2003","unstructured":"Toga AW, Thompson PM (2003) Mapping brain asymmetry. Nat Rev Neurosci 4(1):37\u201348. https:\/\/doi.org\/10.1038\/nrn1009","journal-title":"Nat Rev Neurosci"},{"issue":"2","key":"3039_CR56","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1111\/neup.12348","volume":"37","author":"T Uchihara","year":"2017","unstructured":"Uchihara T (2017) An order in lewy body disorders: retrograde degeneration in hyperbranching axons as a fundamental structural template accounting for focal\/multifocal lewy body disease. Neuropathology: Official J Japanese Soc Neuropathology 37(2):129\u2013149. https:\/\/doi.org\/10.1111\/neup.12348","journal-title":"Neuropathology: Official J Japanese Soc Neuropathology"},{"issue":"3","key":"3039_CR57","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1080\/00207454.2022.2098736","volume":"134","author":"AO Varoglu","year":"2024","unstructured":"Varoglu AO (2024) Is the left hemisphere more prone to epilepsy and poor prognosis than the right hemisphere? Int J Neurosci 134(3):224\u2013228. https:\/\/doi.org\/10.1080\/00207454.2022.2098736","journal-title":"Int J Neurosci"},{"issue":"3","key":"3039_CR58","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1089\/brain.2012.0073","volume":"2","author":"S Whitfield-Gabrieli","year":"2012","unstructured":"Whitfield-Gabrieli S, Nieto-Castanon A (2012) Conn: A functional connectivity toolbox for correlated and anticorrelated brain networks. Brain Connect 2(3):125\u2013141. https:\/\/doi.org\/10.1089\/brain.2012.0073","journal-title":"Brain Connect"},{"issue":"3","key":"3039_CR59","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001560","volume":"20","author":"X Wu","year":"2022","unstructured":"Wu X, Kong X, Vatansever D et al (2022) Dynamic changes in brain lateralization correlate with human cognitive performance. PLoS Biol 20(3):e3001560. https:\/\/doi.org\/10.1371\/journal.pbio.3001560","journal-title":"PLoS Biol"},{"issue":"2","key":"3039_CR60","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.clinph.2014.09.009","volume":"126","author":"RB Yaffe","year":"2015","unstructured":"Yaffe RB, Borger P, Megevand P et al (2015) Physiology of functional and effective networks in epilepsy. Clin Neurophysiology: Official J Int Federation Clin Neurophysiol 126(2):227\u2013236. https:\/\/doi.org\/10.1016\/j.clinph.2014.09.009","journal-title":"Clin Neurophysiology: Official J Int Federation Clin Neurophysiol"},{"key":"3039_CR61","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3389\/fnagi.2017.00261","volume":"9","author":"C Yang","year":"2017","unstructured":"Yang C, Zhong S, Zhou X, Wei L, Wang L, and Shengdong Nie (2017) The abnormality of topological asymmetry between hemispheric brain white matter networks in alzheimer\u2019s disease and mild cognitive impairment. Front Aging Neurosci 9:261. https:\/\/doi.org\/10.3389\/fnagi.2017.00261","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"3039_CR62","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.jneumeth.2008.04.012","volume":"172","author":"Q-H Zou","year":"2008","unstructured":"Zou Q-H, Zhu C-Z, Yang Y et al (2008) An improved approach to detection of amplitude of Low-Frequency fluctuation (ALFF) for Resting-State fMRI: fractional ALFF. J Neurosci Methods 172(1):137\u2013141","journal-title":"J Neurosci Methods"},{"issue":"45","key":"3039_CR63","doi-asserted-by":"publisher","first-page":"15034","DOI":"10.1523\/JNEUROSCI.2612-10.2010","volume":"30","author":"X-N Zuo","year":"2010","unstructured":"Zuo X-N, Kelly C, Martino AD et al (2010) Growing together and growing apart: regional and sex differences in the lifespan developmental trajectories of functional homotopy. J Neurosci 30(45):15034\u201315043. https:\/\/doi.org\/10.1523\/JNEUROSCI.2612-10.2010","journal-title":"J Neurosci"}],"container-title":["Brain Structure and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-025-03039-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00429-025-03039-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-025-03039-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:25:51Z","timestamp":1781612751000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00429-025-03039-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,10]]},"references-count":69,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3039"],"URL":"https:\/\/doi.org\/10.1007\/s00429-025-03039-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7233697\/v1","asserted-by":"object"}]},"ISSN":["1863-2661"],"issn-type":[{"value":"1863-2661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,10]]},"assertion":[{"value":"28 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Every participant gave their written informed consent. The Hungarian Medical Research Council authorized our research (reference number: IV\/5831 3\/2021\/EKU).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and patient consent"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Permission to reproduce material from other sources"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial registration"}}],"article-number":"174"}}