{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:24:45Z","timestamp":1787667885621,"version":"build-2736575974"},"reference-count":83,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Ph.D. fellowship from the Chinese Scholarship Council"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Brain Struct Funct"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The hippocampus and amygdala play essential roles in human cognition and emotion, through their extensive connectivity with other brain regions and close interaction between them. Uncovering the functional organization of the hippocampus\u2013amygdala complex and its relationship with neurotransmitter distribution can enhance our understanding of their biological functionality, and provide a basis for further exploration of the clinical relevance. An emerging functional connectivity analysis method termed connectopic mapping, may offer a novel approach to characterize this functional organization. In this study, we applied connectopic mapping to the hippocampus-amygdala complex, testing its utility with resting-state functional magnetic resonance imaging (fMRI) scans of two independent datasets: one comprising healthy individuals (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009410) and another comprising a psychiatric cohort (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009367). The spatial organization of derived gradient maps was compared to 18 positron emission tomography (PET) or single photon emission computed tomography (SPECT) scan templates for different neurotransmitter systems. Individual gradient\u2013neurotransmitter similarity indices were correlated with mental health outcomes. Our analyses identified six distinct gradient maps in both datasets. The third-order gradients showed stable similarity with 5-HT1A receptor maps across various resting-state scans. Similarities were also observed between gradient maps and the distribution patterns of neurotransmitters within the dopaminergic system. Individual gradient-to-5-HT1A similarity was positively correlated with depressive severity and anxiety sensitivity, highlighting the psychopathological relevance. These findings demonstrate that across the psychiatric continuum, connectopic mapping is a powerful tool for exploring the relationship between functional connectivity organization and neurotransmitter distribution, showing potential as a comprehensive transdiagnostic biomarker.\n                  <\/jats:p>","DOI":"10.1007\/s00429-026-03134-4","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:34:01Z","timestamp":1780464841000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characterizing functional connectivity gradients for the hippocampus\u2013amygdala complex in healthy and psychiatric cohorts"],"prefix":"10.1007","volume":"231","author":[{"given":"Xiang-Shen","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janna N.","family":"Vrijsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen V.","family":"Haak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose M.","family":"Collard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip F. P.","family":"van Eijndhoven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian F.","family":"Beckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guill\u00e9n","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indira","family":"Tendolkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Kohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"3134_CR1","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3389\/fnbeh.2014.00199","volume":"8","author":"PR Albert","year":"2014","unstructured":"Albert PR, Vahid-Ansari F, Luckhart C (2014) Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre-and post-synaptic 5-HT1A receptor expression. Front Behav Neurosci 8:199. https:\/\/doi.org\/10.3389\/fnbeh.2014.00199","journal-title":"Front Behav Neurosci"},{"key":"3134_CR2","doi-asserted-by":"publisher","first-page":"2","DOI":"10.4172\/2471-271X.1000120","volume":"2","author":"G Ayano","year":"2016","unstructured":"Ayano G (2016) Dopamine: receptors, functions, synthesis, pathways, locations and mental disorders: review of literatures. J Ment Disord Treat 2:2. https:\/\/doi.org\/10.4172\/2471-271X.1000120","journal-title":"J Ment Disord Treat"},{"key":"3134_CR3","doi-asserted-by":"publisher","first-page":"10721","DOI":"10.1523\/JNEUROSCI.6413-10.2011","volume":"31","author":"GR Barker","year":"2011","unstructured":"Barker GR, Warburton EC (2011) When is the hippocampus involved in recognition memory? J Neurosci 31:10721\u201310731. https:\/\/doi.org\/10.1523\/JNEUROSCI.6413-10.2011","journal-title":"J Neurosci"},{"key":"3134_CR4","doi-asserted-by":"publisher","first-page":"e17","DOI":"10.1192\/j.eurpsy.2023.4","volume":"66","author":"EA Bartlett","year":"2023","unstructured":"Bartlett EA, Yttredahl AA, Boldrini M et al (2023) In vivo serotonin 1A receptor hippocampal binding potential in depression and reported childhood adversity. Eur Psychiatry 66:e17. https:\/\/doi.org\/10.1192\/j.eurpsy.2023.4","journal-title":"Eur Psychiatry"},{"key":"3134_CR5","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1124\/pr.110.002642","volume":"63","author":"J-M Beaulieu","year":"2011","unstructured":"Beaulieu J-M, Gainetdinov RR (2011) The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev 63:182\u2013217. https:\/\/doi.org\/10.1124\/pr.110.002642","journal-title":"Pharmacol Rev"},{"key":"3134_CR6","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3389\/fncir.2016.00024","volume":"10","author":"M Bocchio","year":"2016","unstructured":"Bocchio M, McHugh SB, Bannerman DM et al (2016) Serotonin, amygdala and fear: assembling the puzzle. Front Neural Circuits 10:24. https:\/\/doi.org\/10.3389\/fncir.2016.00024","journal-title":"Front Neural Circuits"},{"key":"3134_CR7","doi-asserted-by":"publisher","first-page":"119996","DOI":"10.1016\/j.neuroimage.2023.119996","volume":"271","author":"L Borne","year":"2023","unstructured":"Borne L, Tian Y, Lupton MK et al (2023) Functional re-organization of hippocampal-cortical gradients during naturalistic memory processes. NeuroImage 271:119996. https:\/\/doi.org\/10.1016\/j.neuroimage.2023.119996","journal-title":"NeuroImage"},{"key":"3134_CR8","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1017\/S0033291720000410","volume":"50","author":"A-K Brehl","year":"2020","unstructured":"Brehl A-K, Kohn N, Schene AH, Fern\u00e1ndez G (2020) A mechanistic model for individualised treatment of anxiety disorders based on predictive neural biomarkers. Psychol Med 50:727\u2013736. https:\/\/doi.org\/10.1017\/S0033291720000410","journal-title":"Psychol Med"},{"key":"3134_CR9","doi-asserted-by":"publisher","first-page":"154","DOI":"10.3389\/fnbeh.2010.00154","volume":"4","author":"DE Bush","year":"2010","unstructured":"Bush DE, Caparosa EM, Gekker A, LeDoux J (2010) Beta-adrenergic receptors in the lateral nucleus of the amygdala contribute to the acquisition but not the consolidation of auditory fear conditioning. Front Behav Neurosci 4:154. https:\/\/doi.org\/10.3389\/fnbeh.2010.00154","journal-title":"Front Behav Neurosci"},{"key":"3134_CR10","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s40263-013-0071-0","volume":"27","author":"P Celada","year":"2013","unstructured":"Celada P, Bortolozzi A, Artigas F (2013) Serotonin 5-HT1A receptors as targets for agents to treat psychiatric disorders: rationale and current status of research. CNS Drugs 27:703\u2013716. https:\/\/doi.org\/10.1007\/s40263-013-0071-0","journal-title":"CNS Drugs"},{"key":"3134_CR11","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1001\/jamapsychiatry.2014.1087","volume":"71","author":"KR Cullen","year":"2014","unstructured":"Cullen KR, Westlund MK, Klimes-Dougan B et al (2014) Abnormal amygdala resting-state functional connectivity in adolescent depression. JAMA Psychiatry 71:1138\u20131147. https:\/\/doi.org\/10.1001\/jamapsychiatry.2014.1087","journal-title":"JAMA Psychiatry"},{"key":"3134_CR12","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.pneurobio.2009.10.010","volume":"90","author":"MP de la Mora","year":"2010","unstructured":"de la Mora MP, Gallegos-Cari A, Arizmendi-Garc\u00eda Y et al (2010) Role of dopamine receptor mechanisms in the amygdaloid modulation of fear and anxiety: Structural and functional analysis. Prog Neurobiol 90:198\u2013216. https:\/\/doi.org\/10.1016\/j.pneurobio.2009.10.010","journal-title":"Prog Neurobiol"},{"key":"3134_CR13","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1007\/s00441-018-2800-7","volume":"373","author":"E Edelmann","year":"2018","unstructured":"Edelmann E, Lessmann V (2018) Dopaminergic innervation and modulation of hippocampal networks. Cell Tissue Res 373:711\u2013727. https:\/\/doi.org\/10.1007\/s00441-018-2800-7","journal-title":"Cell Tissue Res"},{"key":"3134_CR14","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1016\/j.parkreldis.2012.05.022","volume":"18","author":"R Erro","year":"2012","unstructured":"Erro R, Pappat\u00e0 S, Amboni M et al (2012) Anxiety is associated with striatal dopamine transporter availability in newly diagnosed untreated Parkinson\u2019s disease patients. Parkinsonism Relat Disord 18:1034\u20131038. https:\/\/doi.org\/10.1016\/j.parkreldis.2012.05.022","journal-title":"Parkinsonism Relat Disord"},{"key":"3134_CR15","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1093\/scan\/nsn048","volume":"4","author":"MP Ewbank","year":"2009","unstructured":"Ewbank MP, Barnard PJ, Croucher CJ et al (2009) The amygdala response to images with impact. Soc Cogn Affect Neurosci 4:127\u2013133. https:\/\/doi.org\/10.1093\/scan\/nsn048","journal-title":"Soc Cogn Affect Neurosci"},{"key":"3134_CR16","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1038\/s41380-021-01400-x","volume":"27","author":"A Frick","year":"2022","unstructured":"Frick A, Bj\u00f6rkstrand J, Lubberink M et al (2022) Dopamine and fear memory formation in the human amygdala. Mol Psychiatry 27:1704\u20131711. https:\/\/doi.org\/10.1038\/s41380-021-01400-x","journal-title":"Mol Psychiatry"},{"key":"3134_CR17","doi-asserted-by":"publisher","first-page":"2779","DOI":"10.1097\/00001756-200108280-00036","volume":"12","author":"H Garavan","year":"2001","unstructured":"Garavan H, Pendergrass JC, Ross TJ et al (2001) Amygdala response to both positively and negatively valenced stimuli. NeuroReport 12:2779\u20132783","journal-title":"NeuroReport"},{"key":"3134_CR18","doi-asserted-by":"publisher","first-page":"E4914","DOI":"10.1073\/pnas.1609883113","volume":"113","author":"C Garrido Zinn","year":"2016","unstructured":"Garrido Zinn C, Clairis N, Silva Cavalcante LE et al (2016) Major neurotransmitter systems in dorsal hippocampus and basolateral amygdala control social recognition memory. Proc Natl Acad Sci 113:E4914\u2013E4919. https:\/\/doi.org\/10.1073\/pnas.1609883113","journal-title":"Proc Natl Acad Sci"},{"key":"3134_CR19","doi-asserted-by":"crossref","unstructured":"Gelfand AE, Diggle P, Guttorp P, Fuentes M (2010) Handbook of spatial statistics. CRC press","DOI":"10.1201\/9781420072884"},{"key":"3134_CR20","doi-asserted-by":"publisher","first-page":"107743","DOI":"10.1016\/j.neuropharm.2019.107743","volume":"158","author":"T Gener","year":"2019","unstructured":"Gener T, Campo AT, Alemany-Gonz\u00e1lez M et al (2019) Serotonin 5-HT1A, 5-HT2A and dopamine D2 receptors strongly influence prefronto-hippocampal neural networks in alert mice: contribution to the actions of risperidone. Neuropharmacology 158:107743. https:\/\/doi.org\/10.1016\/j.neuropharm.2019.107743","journal-title":"Neuropharmacology"},{"key":"3134_CR21","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/j.tins.2021.10.003","volume":"44","author":"S Genon","year":"2021","unstructured":"Genon S, Bernhardt BC, Joie RL et al (2021) The many dimensions of human hippocampal organization and (dys)function. Trends Neurosci 44:977\u2013989. https:\/\/doi.org\/10.1016\/j.tins.2021.10.003","journal-title":"Trends Neurosci"},{"key":"3134_CR22","unstructured":"Graaf R, Have ML, van Dorsselaer S (2010) De psychische gezondheid van de Nederlandse bevolking: NEMESIS-2: opzet en eerste resultaten. Trimbos-instituut [host]"},{"key":"3134_CR23","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/0304-3940(88)90457-0","volume":"87","author":"M Grilli","year":"1988","unstructured":"Grilli M, Nisoli E, Memo M et al (1988) Pharmacological characterization of D1 and D2 dopamine receptors in rat limbocortical areas. II. Dorsal hippocampus. Neurosci Lett 87:253\u2013258. https:\/\/doi.org\/10.1016\/0304-3940(88)90457-0","journal-title":"Neurosci Lett"},{"key":"3134_CR24","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/S0006-8993(99)01291-3","volume":"827","author":"FA Guarraci","year":"1999","unstructured":"Guarraci FA, Frohardt RJ, Kapp BS (1999) Amygdaloid D1 dopamine receptor involvement in Pavlovian fear conditioning. Brain Res 827:28\u201340. https:\/\/doi.org\/10.1016\/S0006-8993(99)01291-3","journal-title":"Brain Res"},{"key":"3134_CR25","doi-asserted-by":"publisher","first-page":"117061","DOI":"10.1016\/j.neuroimage.2020.117061","volume":"220","author":"KV Haak","year":"2020","unstructured":"Haak KV, Beckmann CF (2020) Understanding brain organisation in the face of functional heterogeneity and functional multiplicity. NeuroImage 220:117061. https:\/\/doi.org\/10.1016\/j.neuroimage.2020.117061","journal-title":"NeuroImage"},{"key":"3134_CR26","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.neuroimage.2017.06.075","volume":"170","author":"KV Haak","year":"2018","unstructured":"Haak KV, Marquand AF, Beckmann CF (2018) Connectopic mapping with resting-state fMRI. NeuroImage 170:83\u201394. https:\/\/doi.org\/10.1016\/j.neuroimage.2017.06.075","journal-title":"NeuroImage"},{"key":"3134_CR27","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.jchemneu.2003.10.003","volume":"26","author":"SN Haber","year":"2003","unstructured":"Haber SN (2003) The primate basal ganglia: parallel and integrative networks. J Chem Neuroanat 26:317\u2013330. https:\/\/doi.org\/10.1016\/j.jchemneu.2003.10.003","journal-title":"J Chem Neuroanat"},{"key":"3134_CR28","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1007\/s40653-022-00443-8","volume":"15","author":"JM Hagborg","year":"2022","unstructured":"Hagborg JM, Kalin T, Gerdner A (2022) The Childhood Trauma Questionnaire\u2014Short Form (CTQ-SF) used with adolescents\u2013methodological report from clinical and community samples. J Child Adolesc Trauma 15:1199\u20131213. https:\/\/doi.org\/10.1007\/s40653-022-00443-8","journal-title":"J Child Adolesc Trauma"},{"key":"3134_CR29","doi-asserted-by":"publisher","first-page":"e0260952","DOI":"10.1371\/journal.pone.0260952","volume":"16","author":"E Aarts","year":"2021","unstructured":"Healthy Brain Study consortium, Aarts E, Akkerman A et al (2021) Protocol of the Healthy Brain Study: an accessible resource for understanding the human brain and how it dynamically and individually operates in its bio-social context. PLoS ONE 16:e0260952. https:\/\/doi.org\/10.1371\/journal.pone.0260952","journal-title":"PLoS ONE"},{"key":"3134_CR30","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.neuroimage.2016.02.056","volume":"133","author":"S Hrybouski","year":"2016","unstructured":"Hrybouski S, Aghamohammadi-Sereshki A, Madan CR et al (2016) Amygdala subnuclei response and connectivity during emotional processing. NeuroImage 133:98\u2013110. https:\/\/doi.org\/10.1016\/j.neuroimage.2016.02.056","journal-title":"NeuroImage"},{"key":"3134_CR31","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/0166-4328(93)90093-6","volume":"58","author":"I Izquierdo","year":"1993","unstructured":"Izquierdo I, Medina JH, Bianchin M et al (1993) Memory processing by the limbic system: role of specific neurotransmitter systems. Behav Brain Res 58:91\u201398. https:\/\/doi.org\/10.1016\/0166-4328(93)90093-6","journal-title":"Behav Brain Res"},{"key":"3134_CR32","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/jcp.21533","volume":"217","author":"C Jonnakuty","year":"2008","unstructured":"Jonnakuty C, Gragnoli C (2008) What do we know about serotonin? J Cell Physiol 217:301\u2013306. https:\/\/doi.org\/10.1002\/jcp.21533","journal-title":"J Cell Physiol"},{"key":"3134_CR33","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/j.neuroimage.2010.12.060","volume":"55","author":"H Jovanovic","year":"2011","unstructured":"Jovanovic H, Perski A, Berglund H, Savic I (2011) Chronic stress is linked to 5-HT1A receptor changes and functional disintegration of the limbic networks. NeuroImage 55:1178\u20131188. https:\/\/doi.org\/10.1016\/j.neuroimage.2010.12.060","journal-title":"NeuroImage"},{"key":"3134_CR34","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s42003-023-04796-0","volume":"6","author":"Y Katsumi","year":"2023","unstructured":"Katsumi Y, Zhang J, Chen D et al (2023) Correspondence of functional connectivity gradients across human isocortex, cerebellum, and hippocampus. Commun Biol 6:401. https:\/\/doi.org\/10.1038\/s42003-023-04796-0","journal-title":"Commun Biol"},{"key":"3134_CR35","doi-asserted-by":"publisher","first-page":"116972","DOI":"10.1016\/j.neuroimage.2020.116972","volume":"218","author":"S Kharabian Masouleh","year":"2020","unstructured":"Kharabian Masouleh S, Plachti A, Hoffstaedter F et al (2020) Characterizing the gradients of structural covariance in the human hippocampus. NeuroImage 218:116972. https:\/\/doi.org\/10.1016\/j.neuroimage.2020.116972","journal-title":"NeuroImage"},{"key":"3134_CR36","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1002\/cne.20919","volume":"496","author":"T Kishi","year":"2006","unstructured":"Kishi T, Tsumori T, Yokota S, Yasui Y (2006) Topographical projection from the hippocampal formation to the amygdala: a combined anterograde and retrograde tracing study in the rat. J Comp Neurol 496:349\u2013368. https:\/\/doi.org\/10.1002\/cne.20919","journal-title":"J Comp Neurol"},{"key":"3134_CR38","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1016\/j.neuropsychologia.2011.02.010","volume":"49","author":"N Kohn","year":"2011","unstructured":"Kohn N, Kellermann T, Gur RC et al (2011) Gender differences in the neural correlates of humor processing: implications for different processing modes. Neuropsychologia 49:888\u2013897. https:\/\/doi.org\/10.1016\/j.neuropsychologia.2011.02.010","journal-title":"Neuropsychologia"},{"key":"3134_CR37","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.neuroimage.2013.11.001","volume":"87","author":"N Kohn","year":"2014","unstructured":"Kohn N, Eickhoff SB, Scheller M et al (2014) Neural network of cognitive emotion regulation\u2014an ALE meta-analysis and MACM analysis. NeuroImage 87:345\u2013355. https:\/\/doi.org\/10.1016\/j.neuroimage.2013.11.001","journal-title":"NeuroImage"},{"key":"3134_CR39","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3389\/fncel.2012.00015","volume":"6","author":"HJ Krugers","year":"2012","unstructured":"Krugers HJ, Karst H, Joels M (2012) Interactions between noradrenaline and corticosteroids in the brain: from electrical activity to cognitive performance. Front Cell Neurosci 6:15. https:\/\/doi.org\/10.3389\/fncel.2012.00015","journal-title":"Front Cell Neurosci"},{"key":"3134_CR40","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/nrn1825","volume":"7","author":"KS LaBar","year":"2006","unstructured":"LaBar KS, Cabeza R (2006) Cognitive neuroscience of emotional memory. Nat Rev Neurosci 7:54\u201364. https:\/\/doi.org\/10.1038\/nrn1825","journal-title":"Nat Rev Neurosci"},{"key":"3134_CR41","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.tins.2014.12.007","volume":"38","author":"E Likhtik","year":"2015","unstructured":"Likhtik E, Paz R (2015) Amygdala\u2013prefrontal interactions in (mal) adaptive learning. Trends Neurosci 38:158\u2013166. http:\/\/dx.doi.org\/10.1016\/j.tins.2014.12.007","journal-title":"Trends Neurosci"},{"key":"3134_CR42","doi-asserted-by":"publisher","first-page":"imag","DOI":"10.1162\/imag_a_00269","volume":"2","author":"X-S Liu","year":"2024","unstructured":"Liu X-S, Haak KV, Figa K et al (2024) Childhood adversity predicts striatal functional connectivity gradient changes after acute stress. Imaging Neurosci 2:imag\u20132\u201300269. https:\/\/doi.org\/10.1162\/imag_a_00269","journal-title":"Imaging Neurosci"},{"key":"3134_CR43","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1016\/j.biopsych.2004.10.011","volume":"57","author":"BK Madras","year":"2005","unstructured":"Madras BK, Miller GM, Fischman AJ (2005) The dopamine transporter and attention-deficit\/hyperactivity disorder. Biol Psychiatry 57:1397\u20131409. https:\/\/doi.org\/10.1016\/j.biopsych.2004.10.011","journal-title":"Biol Psychiatry"},{"key":"3134_CR44","doi-asserted-by":"publisher","first-page":"12574","DOI":"10.1073\/pnas.1608282113","volume":"113","author":"DS Margulies","year":"2016","unstructured":"Margulies DS, Ghosh SS, Goulas A et al (2016) Situating the default-mode network along a principal gradient of macroscale cortical organization. Proc Natl Acad Sci 113:12574\u201312579. https:\/\/doi.org\/10.1073\/pnas.1608282113","journal-title":"Proc Natl Acad Sci"},{"key":"3134_CR45","doi-asserted-by":"publisher","first-page":"0146","DOI":"10.1038\/s41562-017-0146","volume":"1","author":"AF Marquand","year":"2017","unstructured":"Marquand AF, Haak KV, Beckmann CF (2017) Functional corticostriatal connection topographies predict goal-directed behaviour in humans. Nat Hum Behav 1:0146. https:\/\/doi.org\/10.1038\/s41562-017-0146","journal-title":"Nat Hum Behav"},{"key":"3134_CR46","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1146\/annurev-psych-113011-143733","volume":"67","author":"M Moscovitch","year":"2016","unstructured":"Moscovitch M, Cabeza R, Winocur G, Nadel L (2016) Episodic memory and beyond: the hippocampus and neocortex in transformation. Annu Rev Psychol 67:105\u2013134. https:\/\/doi.org\/10.1146\/annurev-psych-113011-143733","journal-title":"Annu Rev Psychol"},{"key":"3134_CR47","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.neubiorev.2015.07.014","volume":"56","author":"PC Mulders","year":"2015","unstructured":"Mulders PC, van Eijndhoven PF, Schene AH et al (2015) Resting-state functional connectivity in major depressive disorder: a review. Neurosci Biobehav Rev 56:330\u2013344. https:\/\/doi.org\/10.1016\/j.neubiorev.2015.07.014","journal-title":"Neurosci Biobehav Rev"},{"key":"3134_CR48","doi-asserted-by":"publisher","first-page":"RP97658","DOI":"10.7554\/eLife.97658.3","volume":"13","author":"K Nordin","year":"2025","unstructured":"Nordin K, Pedersen R, Falahati F et al (2025) Two long-axis dimensions of hippocampal-cortical integration support memory function across the adult lifespan. eLife 13:RP97658. https:\/\/doi.org\/10.7554\/eLife.97658.3","journal-title":"eLife"},{"key":"3134_CR49","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.bbr.2008.02.023","volume":"195","author":"SO \u00d6gren","year":"2008","unstructured":"\u00d6gren SO, Eriksson TM, Elvander-Tottie E et al (2008) The role of 5-HT1A receptors in learning and memory. Behav Brain Res 195:54\u201377. https:\/\/doi.org\/10.1016\/j.bbr.2008.02.023","journal-title":"Behav Brain Res"},{"key":"3134_CR50","doi-asserted-by":"publisher","first-page":"e71846","DOI":"10.7554\/eLife.71846","volume":"11","author":"M Oldehinkel","year":"2022","unstructured":"Oldehinkel M, Llera A, Faber M et al (2022) Mapping dopaminergic projections in the human brain with resting-state fMRI. Elife 11:e71846. https:\/\/doi.org\/10.7554\/eLife.71846","journal-title":"Elife"},{"key":"3134_CR51","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.neubiorev.2016.09.010","volume":"76","author":"J Panksepp","year":"2017","unstructured":"Panksepp J, Lane RD, Solms M, Smith R (2017) Reconciling cognitive and affective neuroscience perspectives on the brain basis of emotional experience. Neurosci Biobehav Rev 76:187\u2013215. https:\/\/doi.org\/10.1016\/j.neubiorev.2016.09.010","journal-title":"Neurosci Biobehav Rev"},{"key":"3134_CR52","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1038\/sj.npp.1300992","volume":"31","author":"RV Parsey","year":"2006","unstructured":"Parsey RV, Olvet DM, Oquendo MA et al (2006) Higher 5-HT1A receptor binding potential during a major depressive episode predicts poor treatment response: preliminary data from a naturalistic study. Neuropsychopharmacology 31:1745\u20131749. https:\/\/doi.org\/10.1038\/sj.npp.1300992","journal-title":"Neuropsychopharmacology"},{"key":"3134_CR53","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.conb.2004.03.015","volume":"14","author":"EA Phelps","year":"2004","unstructured":"Phelps EA (2004) Human emotion and memory: interactions of the amygdala and hippocampal complex. Curr Opin Neurobiol 14:198\u2013202. https:\/\/doi.org\/10.1016\/j.conb.2004.03.015","journal-title":"Curr Opin Neurobiol"},{"key":"3134_CR54","doi-asserted-by":"publisher","first-page":"4595","DOI":"10.1093\/cercor\/bhy336","volume":"29","author":"A Plachti","year":"2019","unstructured":"Plachti A, Eickhoff SB, Hoffstaedter F et al (2019) Multimodal parcellations and extensive behavioral profiling tackling the hippocampus gradient. Cereb Cortex 29:4595\u20134612. https:\/\/doi.org\/10.1093\/cercor\/bhy336","journal-title":"Cereb Cortex"},{"key":"3134_CR55","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1515\/revneuro-2012-0082","volume":"24","author":"NK Popova","year":"2013","unstructured":"Popova NK, Naumenko VS (2013) 5-HT1A receptor as a key player in the brain 5-HT system. Rev Neurosci 24:191\u2013204. https:\/\/doi.org\/10.1515\/revneuro-2012-0082","journal-title":"Rev Neurosci"},{"key":"3134_CR56","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.tics.2013.03.005","volume":"17","author":"J Poppenk","year":"2013","unstructured":"Poppenk J, Evensmoen HR, Moscovitch M, Nadel L (2013) Long-axis specialization of the human hippocampus. Trends Cogn Sci 17:230\u2013240. http:\/\/dx.doi.org\/10.1016\/j.tics.2013.03.005","journal-title":"Trends Cogn Sci"},{"key":"3134_CR57","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.cortex.2019.04.015","volume":"119","author":"I Prze\u017adzik","year":"2019","unstructured":"Prze\u017adzik I, Faber M, Fern\u00e1ndez G et al (2019) The functional organisation of the hippocampus along its long axis is gradual and predicts recollection. Cortex 119:324\u2013335. https:\/\/doi.org\/10.1016\/j.cortex.2019.04.015","journal-title":"Cortex"},{"key":"3134_CR58","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.bbr.2014.07.052","volume":"277","author":"S Puglisi-Allegra","year":"2015","unstructured":"Puglisi-Allegra S, Andolina D (2015) Serotonin and stress coping. Behav Brain Res 277:58\u201367. https:\/\/doi.org\/10.1016\/j.bbr.2014.07.052","journal-title":"Behav Brain Res"},{"key":"3134_CR59","doi-asserted-by":"publisher","unstructured":"Quent JA, Song L, Liang X et al (2026) Graded encoding of spatial novelty scales in the human brain. Nat Commun 17, 303. https:\/\/doi.org\/10.1038\/s41467-025-67012-z","DOI":"10.1038\/s41467-025-67012-z"},{"key":"3134_CR60","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0925-4927(01)00120-2","volume":"108","author":"R Rajarethinam","year":"2001","unstructured":"Rajarethinam R, DeQuardo JR, Miedler J et al (2001) Hippocampus and amygdala in schizophrenia: assessment of the relationship of neuroanatomy to psychopathology. Psychiatry Res Neuroimaging 108:79\u201387. https:\/\/doi.org\/10.1016\/S0925-4927(01)00120-2","journal-title":"Psychiatry Res Neuroimaging"},{"key":"3134_CR61","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.biopsych.2006.06.004","volume":"60","author":"SL Rauch","year":"2006","unstructured":"Rauch SL, Shin LM, Phelps EA (2006) Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research\u2014past, present, and future. Biol Psychiatry 60:376\u2013382. https:\/\/doi.org\/10.1016\/j.biopsych.2006.06.004","journal-title":"Biol Psychiatry"},{"key":"3134_CR62","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/nn1190","volume":"7","author":"MP Richardson","year":"2004","unstructured":"Richardson MP, Strange BA, Dolan RJ (2004) Encoding of emotional memories depends on amygdala and hippocampus and their interactions. Nat Neurosci 7:278\u2013285. https:\/\/doi.org\/10.1038\/nn1190","journal-title":"Nat Neurosci"},{"key":"3134_CR63","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0005-7967(03)00074-3","volume":"42","author":"BF Rodriguez","year":"2004","unstructured":"Rodriguez BF, Bruce SE, Pagano ME et al (2004) Factor structure and stability of the Anxiety Sensitivity Index in a longitudinal study of anxiety disorder patients. Behav Res Ther 42:79\u201391. https:\/\/doi.org\/10.1016\/S0005-7967(03)00074-3","journal-title":"Behav Res Ther"},{"key":"3134_CR64","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.neuroimage.2008.11.030","volume":"45","author":"AK Roy","year":"2009","unstructured":"Roy AK, Shehzad Z, Margulies DS et al (2009) Functional connectivity of the human amygdala using resting state fMRI. NeuroImage 45:614\u2013626. https:\/\/doi.org\/10.1016\/j.neuroimage.2008.11.030","journal-title":"NeuroImage"},{"key":"3134_CR65","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/mpr.79","volume":"9","author":"AJ Rush","year":"2000","unstructured":"Rush AJ, Carmody T, Reimitz P (2000) The Inventory of Depressive Symptomatology (IDS): clinician (IDS-C) and self\u2010report (IDS\u2010SR) ratings of depressive symptoms. Int J Methods Psychiatr Res 9:45\u201359. https:\/\/doi.org\/10.1002\/mpr.79","journal-title":"Int J Methods Psychiatr Res"},{"key":"3134_CR66","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.neuron.2006.02.015","volume":"49","author":"U Rutishauser","year":"2006","unstructured":"Rutishauser U, Mamelak AN, Schuman EM (2006) Single-trial learning of novel stimuli by individual neurons of the human hippocampus-amygdala complex. Neuron 49:805\u2013813. https:\/\/doi.org\/10.1016\/j.neuron.2006.02.015","journal-title":"Neuron"},{"key":"3134_CR67","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s00429-025-02996-4","volume":"230","author":"C Saiz-Masvidal","year":"2025","unstructured":"Saiz-Masvidal C, De la Pe\u00f1a-Arteaga V, Bertol\u00edn S et al (2025) Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain. Brain Struct Funct 230:137. https:\/\/doi.org\/10.1007\/s00429-025-02996-4","journal-title":"Brain Struct Funct"},{"key":"3134_CR68","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.nbd.2012.06.001","volume":"52","author":"JB Savitz","year":"2013","unstructured":"Savitz JB, Drevets WC (2013) Neuroreceptor imaging in depression. Neurobiol Dis 52:49\u201365. https:\/\/doi.org\/10.1016\/j.nbd.2012.06.001","journal-title":"Neurobiol Dis"},{"key":"3134_CR69","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1007\/s00429-025-02976-8","volume":"230","author":"Y Serhan","year":"2025","unstructured":"Serhan Y, Darawshy S, Wei W et al (2025) Individual uniqueness of connectivity gradients is driven by the complexity of the embedded networks and their dispersion. Brain Struct Funct 230:110. https:\/\/doi.org\/10.1007\/s00429-025-02976-8","journal-title":"Brain Struct Funct"},{"key":"3134_CR70","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/npp.2009.83","volume":"35","author":"LM Shin","year":"2010","unstructured":"Shin LM, Liberzon I (2010) The neurocircuitry of fear, stress, and anxiety disorders. Neuropsychopharmacology 35:169\u2013191. https:\/\/doi.org\/10.1038\/npp.2009.83","journal-title":"Neuropsychopharmacology"},{"key":"3134_CR71","doi-asserted-by":"publisher","unstructured":"Stefanacci L, Amaral DG (2000) Topographic organization of cortical inputs to the lateral nucleus of the macaque monkey amygdala: a retrograde tracing study. J Comp Neurol 421:52\u201379. https:\/\/doi.org\/10.1002\/(sici)1096-9861(20000522)421:1%3C52::aid-cne4%3E3.0.co;2-o","DOI":"10.1002\/(sici)1096-9861(20000522)421:1%3C52::aid-cne4%3E3.0.co;2-o"},{"key":"3134_CR72","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/cne.10339","volume":"451","author":"L Stefanacci","year":"2002","unstructured":"Stefanacci L, Amaral DG (2002) Some observations on cortical inputs to the macaque monkey amygdala: an anterograde tracing study. J Comp Neurol 451:301\u2013323. https:\/\/doi.org\/10.1002\/cne.10339","journal-title":"J Comp Neurol"},{"key":"3134_CR73","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/nrn3785","volume":"15","author":"BA Strange","year":"2014","unstructured":"Strange BA, Witter MP, Lein ES, Moser EI (2014) Functional organization of the hippocampal longitudinal axis. Nat Rev Neurosci 15:655\u2013669. https:\/\/doi.org\/10.1038\/nrn3785","journal-title":"Nat Rev Neurosci"},{"key":"3134_CR74","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/s41398-018-0309-1","volume":"8","author":"MD Underwood","year":"2018","unstructured":"Underwood MD, Kassir SA, Bakalian MJ et al (2018) Serotonin receptors and suicide, major depression, alcohol use disorder and reported early life adversity. Transl Psychiatry 8,279. https:\/\/doi.org\/10.1038\/s41398-018-0309-1","journal-title":"Transl Psychiatry"},{"key":"3134_CR75","doi-asserted-by":"publisher","first-page":"e31269","DOI":"10.2196\/31269","volume":"3","author":"P van Eijndhoven","year":"2022","unstructured":"van Eijndhoven P, Collard R, Vrijsen J et al (2022) Measuring Integrated Novel Dimensions in Neurodevelopmental and Stress-Related Mental Disorders (MIND-SET): protocol for a cross-sectional comorbidity study from a Research Domain Criteria perspective. JMIRx Med 3:e31269. https:\/\/doi.org\/10.2196\/31269","journal-title":"JMIRx Med"},{"key":"3134_CR76","doi-asserted-by":"publisher","first-page":"7550","DOI":"10.1073\/pnas.0914892107","volume":"107","author":"MT van Kesteren","year":"2010","unstructured":"van Kesteren MT, Fern\u00e1ndez G, Norris DG, Hermans EJ (2010) Persistent schema-dependent hippocampal-neocortical connectivity during memory encoding and postencoding rest in humans. Proc Natl Acad Sci 107:7550\u20137555. https:\/\/doi.org\/10.1073\/pnas.0914892107","journal-title":"Proc Natl Acad Sci"},{"key":"3134_CR77","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.biopsych.2009.05.014","volume":"66","author":"HJ van Marle","year":"2009","unstructured":"van Marle HJ, Hermans EJ, Qin S, Fern\u00e1ndez G (2009) From specificity to sensitivity: how acute stress affects amygdala processing of biologically salient stimuli. Biol Psychiatry 66:649\u2013655. https:\/\/doi.org\/10.1016\/j.biopsych.2009.05.014","journal-title":"Biol Psychiatry"},{"key":"3134_CR78","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.neuroimage.2010.05.070","volume":"53","author":"HJ van Marle","year":"2010","unstructured":"van Marle HJ, Hermans EJ, Qin S, Fern\u00e1ndez G (2010) Enhanced resting-state connectivity of amygdala in the immediate aftermath of acute psychological stress. NeuroImage 53:348\u2013354. https:\/\/doi.org\/10.1016\/j.neuroimage.2010.05.070","journal-title":"NeuroImage"},{"key":"3134_CR79","doi-asserted-by":"publisher","first-page":"102176","DOI":"10.1016\/j.nicl.2020.102176","volume":"25","author":"J van Oort","year":"2020","unstructured":"van Oort J, Kohn N, Vrijsen J et al (2020) Absence of default mode downregulation in response to a mild psychological stressor marks stress-vulnerability across diverse psychiatric disorders. NeuroImage Clin 25:102176. https:\/\/doi.org\/10.1016\/j.nicl.2020.102176","journal-title":"NeuroImage Clin"},{"key":"3134_CR80","doi-asserted-by":"publisher","unstructured":"Vizi ES, Kiss JP (1998) Neurochemistry and pharmacology of the major hippocampal transmitter systems: synaptic and nonsynaptic interactions. Hippocampus 8:566\u2013607. https:\/\/doi.org\/10.1002\/(SICI)1098-1063(1998)8:6%3C566::AID-HIPO2%3E3.0.CO;2-W","DOI":"10.1002\/(SICI)1098-1063(1998)8:6%3C566::AID-HIPO2%3E3.0.CO;2-W"},{"key":"3134_CR81","doi-asserted-by":"publisher","first-page":"10154","DOI":"10.1073\/pnas.1803667115","volume":"115","author":"R Vos de Wael","year":"2018","unstructured":"Vos de Wael R, Larivi\u00e8re S, Caldairou B et al (2018) Anatomical and microstructural determinants of hippocampal subfield functional connectome embedding. Proc Natl Acad Sci 115:10154\u201310159. https:\/\/doi.org\/10.1073\/pnas.1803667115","journal-title":"Proc Natl Acad Sci"},{"key":"3134_CR82","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1002\/hipo.1993.4500030707","volume":"3","author":"MP Witter","year":"1993","unstructured":"Witter MP (1993) Organization of the entorhinal-hippocampal system: a review of current anatomical data. Hippocampus 3 Spec No:33-44","journal-title":"HIPPOCAMPUS-N Y-CHURCHILL LIVINGSTONE"},{"key":"3134_CR83","doi-asserted-by":"publisher","first-page":"e2403015121","DOI":"10.1073\/pnas.2403015121","volume":"121","author":"H Xie","year":"2024","unstructured":"Xie H, Illapani VSP, Reppert LT et al (2024) Longitudinal hippocampal axis in large-scale cortical systems underlying development and episodic memory. Proc Natl Acad Sci 121:e2403015121. https:\/\/doi.org\/10.1073\/pnas.2403015121","journal-title":"Proc Natl Acad Sci"}],"container-title":["Brain Structure and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-026-03134-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00429-026-03134-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-026-03134-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T01:25:12Z","timestamp":1781227512000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00429-026-03134-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,3]]},"references-count":83,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["3134"],"URL":"https:\/\/doi.org\/10.1007\/s00429-026-03134-4","relation":{},"ISSN":["1863-2661"],"issn-type":[{"value":"1863-2661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,3]]},"assertion":[{"value":"29 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The Healthy Brain Study was approved by the Institutional Review Board of Radboud University Medical Center. MIND-Set study was approved by the local medical research ethics committee (Commissie Mensgebonden Onderzoek Arnhem-Nijmegen).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}],"article-number":"80"}}