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There is considerable evidence for disruptions to the hippocampus and temporoparietal brain systems in psychotic disorders. The present study examines structure\u2013function relationships\u2014specifically, the relation of hippocampal volume with patterns of temporoparietal effective connectivity\u2014in youth at clinical high-risk for psychosis (CHR-P) and healthy controls (HCs). Participants at CHR-P and HCs completed clinical symptom measures and magnetic resonance imaging at baseline (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009388, 42.5% female, age\u2009=\u200919.8\u2009\u00b1\u20094.2) in the second cohort of the North American Prodrome Longitudinal Study. Group Iterative Multiple Model Estimation established a common functional network of temporoparietal effective connectivity in the full sample. Next, supervised (assuming the CHR-P and HC groups represent classes) and unsupervised (data-driven) clustering procedures interrogated effective connectivity parameters relevant to subsamples. Mean difference tests by unsupervised cluster membership determined whether clusters formed based on temporoparietal effective connectivity differed in hippocampal volume. Clusters were also compared on representation of CHR-P and positive and negative symptom totals to determine whether unsupervised clustering recovered clinical features. Unsupervised clustering generated two clusters that differed significantly in right hippocampal volume and attenuated positive and negative symptoms with small-to-medium effect sizes. The cluster demonstrating reduced right hippocampal volume reported greater symptoms. Unsupervised clustering did not recover diagnostic groups. Findings are consistent with literature indicating the transdiagnostic relevance of hippocampal volume to organizational properties of brain functional networks and patterns of temporoparietal connectivity.\n                  <\/jats:p>","DOI":"10.1007\/s00429-026-03161-1","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T03:11:24Z","timestamp":1786158684000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Right hippocampal volume and attenuated psychotic symptoms distinguish subgroups of youth with common patterns of temporoparietal effective connectivity"],"prefix":"10.1007","volume":"231","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5977-5797","authenticated-orcid":false,"given":"Katrina","family":"Aberizk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benson S.","family":"Ku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengyi","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H.","family":"Schleifer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean M.","family":"Addington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie E.","family":"Bearden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin S.","family":"Cadenhead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyrone D.","family":"Cannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo E.","family":"Carri\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matcheri","family":"Keshavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Mathalon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana O.","family":"Perkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott W.","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine F.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,8]]},"reference":[{"issue":"5","key":"3161_CR1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1177\/21677026221138819","volume":"11","author":"K Aberizk","year":"2023","unstructured":"Aberizk K, Sefik E, Addington J, Anticevic A, Bearden CE, Cadenhead KS et al (2023) Hippocampal connectivity with the default mode network is linked to hippocampal volume in the clinical high risk for psychosis syndrome and healthy individuals. 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KSC received speaking fees from Janssen. TDC has served as a consultant for Boehringer-Ingelheim and Lundbeck. DHM has served as a consultant for Boehringer-Ingelheim, Cadent Therapeutics, Recognify, and Syndisi. DOP has served as a consultant for Sunovion and Alkermes, received research support from Boehringer-Ingelheim, and received royalties from American Psychiatric Association Publishing. MSK has an advisor role in Alkermes and BMS. SWW has received research funding from Auspex, Pfizer, and Teva, served as a consultant for Boehringer-Ingelheim and Merck, received royalties from Oxford University Press, received speaking fees from the American Psychiatric Association and Medscape Features, owns stock as a partner in NW PharmaTech, and has been granted US patent no. 8492418 B2 for a method of treating prodromal schizophrenia with glycine agonists.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"117"}}