{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:04:42Z","timestamp":1789967082651,"version":"4.0.1"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Brain Struct Funct"],"DOI":"10.1007\/s00429-026-03177-7","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T08:32:10Z","timestamp":1787387530000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sexually dimorphic organization of extracellular matrix and perineuronal nets in the prairie vole (Microtus ochrogaster) social brain"],"prefix":"10.1007","volume":"231","author":[{"given":"Anal\u00eda E.","family":"Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3392-5117","authenticated-orcid":false,"given":"Natalia","family":"Uriarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zangrando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Camacho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal G.","family":"Paredes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Portillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9423-5578","authenticated-orcid":false,"given":"Javier","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,22]]},"reference":[{"key":"3177_CR1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.70104","volume":"533","author":"MC Acosta","year":"2025","unstructured":"Acosta MC, Warren ID, Saltzman W, Razak KA (2025) Sex-specific effects of experience with pups on perineuronal net expression in the biparental California mouse (Peromyscus californicus). J Comp Neurol 533:e70104. https:\/\/doi.org\/10.1002\/cne.70104","journal-title":"J Comp Neurol"},{"key":"3177_CR2","doi-asserted-by":"publisher","first-page":"e1626242024","DOI":"10.1523\/JNEUROSCI.1626-24.2024","volume":"45","author":"GM Alexander","year":"2025","unstructured":"Alexander GM, Nikolova VD, St\u00f6ber TM, Gruzdev A, Moy SS, Dudek SM (2025) Perineuronal nets on CA2 pyramidal cells and parvalbumin-expressing cells differentially regulate hippocampal-dependent memory. J Neurosci 45:e1626242024. https:\/\/doi.org\/10.1523\/JNEUROSCI.1626-24.2024","journal-title":"J Neurosci"},{"key":"3177_CR3","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1093\/ilar.45.1.35","volume":"45","author":"BJ Aragona","year":"2004","unstructured":"Aragona BJ, Wang Z (2004) The prairie vole (Microtus ochrogaster): an animal model for behavioral neuroendocrine research on pair bonding. ILAR J 45:35\u201345. https:\/\/doi.org\/10.1093\/ilar.45.1.35","journal-title":"ILAR J"},{"key":"3177_CR4","doi-asserted-by":"publisher","first-page":"321","DOI":"10.3390\/cells14050321","volume":"14","author":"S Auer","year":"2025","unstructured":"Auer S, Schicht M, Hoffmann L, Budday S, Frischknecht R, Bl\u00fcmcke I, Paulsen F (2025) The role of perineuronal nets in physiology and disease: insights from recent studies. Cells 14:321. https:\/\/doi.org\/10.3390\/cells14050321","journal-title":"Cells"},{"key":"3177_CR5","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.neuron.2017.06.007","volume":"95","author":"SB Banerjee","year":"2017","unstructured":"Banerjee SB, Gutzeit VA, Baman J, Aoued HS, Doshi NK, Liu RC, Ressler KJ (2017) Perineuronal nets in the adult sensory cortex are necessary for fear learning. Neuron 95:169-179.e3. https:\/\/doi.org\/10.1016\/j.neuron.2017.06.007","journal-title":"Neuron"},{"key":"3177_CR6","doi-asserted-by":"publisher","first-page":"14964","DOI":"10.1523\/JNEUROSCI.4812-10.2010","volume":"30","author":"D Bavelier","year":"2010","unstructured":"Bavelier D, Levi DM, Li RW, Dan Y, Hensch TK (2010) Removing brakes on adult brain plasticity: from molecular to behavioral interventions. J Neurosci 30:14964\u201314971. https:\/\/doi.org\/10.1523\/JNEUROSCI.4812-10.2010","journal-title":"J Neurosci"},{"key":"3177_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22189806","volume":"22","author":"M Bayassi-Jakowicka","year":"2021","unstructured":"Bayassi-Jakowicka M, Lietzau G, Czuba E, Steliga A, Wa\u015bkow M, Kowia\u0144ski P (2021) Neuroplasticity and multilevel system of connections determine the integrative role of nucleus accumbens in the brain reward system. Int J Mol Sci 22:9806. https:\/\/doi.org\/10.3390\/ijms22189806","journal-title":"Int J Mol Sci"},{"key":"3177_CR8","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1002\/cne.24383","volume":"526","author":"NL Beebe","year":"2018","unstructured":"Beebe NL, Schofield BR (2018) Perineuronal nets in subcortical auditory nuclei of four rodent species with differing hearing ranges. J Comp Neurol 526:972\u2013989. https:\/\/doi.org\/10.1002\/cne.24383","journal-title":"J Comp Neurol"},{"key":"3177_CR9","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s004410050538","volume":"283","author":"A Bertolotto","year":"1996","unstructured":"Bertolotto A, Manzardo E, Guglielmone R (1996) Immunohistochemical mapping of perineuronal nets containing chondroitin unsulfated proteoglycan in the rat central nervous system. Cell Tissue Res 283:283\u2013295. https:\/\/doi.org\/10.1007\/s004410050538","journal-title":"Cell Tissue Res"},{"key":"3177_CR10","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.1038\/s41380-022-01599-3","volume":"27","author":"A Besnard","year":"2022","unstructured":"Besnard A, Leroy F (2022) Top-down regulation of motivated behaviors via lateral septum sub-circuits. Mol Psychiatry 27:3119\u20133128. https:\/\/doi.org\/10.1038\/s41380-022-01599-3","journal-title":"Mol Psychiatry"},{"key":"3177_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/biology12060844","volume":"12","author":"SA Blumenthal","year":"2023","unstructured":"Blumenthal SA, Young LJ (2023) The neurobiology of love and pair bonding from human and animal perspectives. Biology (Basel) 12:844. https:\/\/doi.org\/10.3390\/biology12060844","journal-title":"Biology (Basel)"},{"key":"3177_CR12","doi-asserted-by":"publisher","first-page":"5735789","DOI":"10.1155\/2018\/5735789","volume":"2018","author":"PL Bozzelli","year":"2018","unstructured":"Bozzelli PL, Alaiyed S, Kim E, Villapol S, Conant K (2018) Proteolytic remodeling of perineuronal nets: effects on synaptic plasticity and neuronal population dynamics. Neural Plast 2018:5735789. https:\/\/doi.org\/10.1155\/2018\/5735789","journal-title":"Neural Plast"},{"key":"3177_CR13","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1002\/glia.440080306","volume":"8","author":"G Br\u00fcckner","year":"1993","unstructured":"Br\u00fcckner G, Brauer K, H\u00e4rtig W, Wolff JR, Rickmann MJ, Derouiche A, Delpech B, Girard N, Oertel WH, Reichenbach A (1993) Perineuronal nets provide a polyanionic, glia-associated form of microenvironment around certain neurons in many parts of the rat brain. Glia 8:183\u2013200. https:\/\/doi.org\/10.1002\/glia.440080306","journal-title":"Glia"},{"key":"3177_CR14","doi-asserted-by":"publisher","first-page":"5008","DOI":"10.1523\/JNEUROSCI.0291-20.2020","volume":"40","author":"H Carceller","year":"2020","unstructured":"Carceller H, Guirado R, Ripolles-Campos E, Teruel-Marti V, Nacher J (2020) Perineuronal nets regulate the inhibitory perisomatic input onto parvalbumin interneurons and \u03b3 activity in the prefrontal cortex. J Neurosci 40:5008\u20135018. https:\/\/doi.org\/10.1523\/JNEUROSCI.0291-20.2020","journal-title":"J Neurosci"},{"key":"3177_CR15","doi-asserted-by":"publisher","first-page":"6312","DOI":"10.1523\/JNEUROSCI.0245-16.2016","volume":"36","author":"KE Carstens","year":"2016","unstructured":"Carstens KE, Phillips ML, Pozzo-Miller L, Weinberg RJ, Dudek SM (2016) Perineuronal nets suppress plasticity of excitatory synapses on CA2 pyramidal neurons. J Neurosci 36:6312\u20136320. https:\/\/doi.org\/10.1523\/JNEUROSCI.0245-16.2016","journal-title":"J Neurosci"},{"key":"3177_CR16","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/0018-506x(87)90032-8","volume":"21","author":"CS Carter","year":"1987","unstructured":"Carter CS, Witt DM, Schneider J, Harris ZL, Volkening D (1987) Male stimuli are necessary for female sexual behavior and uterine growth in prairie voles (Microtus ochrogaster). Horm Behav 21:74\u201382. https:\/\/doi.org\/10.1016\/0018-506x(87)90032-8","journal-title":"Horm Behav"},{"key":"3177_CR17","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1002\/cne.20822","volume":"494","author":"D Carulli","year":"2006","unstructured":"Carulli D, Rhodes KE, Brown DJ, Bonnert TP, Pollack SJ, Oliver K, Strata P, Fawcett JW (2006) Composition of perineuronal nets in the adult rat cerebellum and the cellular origin of their components. J Comp Neurol 494:559\u2013577. https:\/\/doi.org\/10.1002\/cne.20822","journal-title":"J Comp Neurol"},{"key":"3177_CR18","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.neuron.2019.03.003","volume":"102","author":"DC Castro","year":"2019","unstructured":"Castro DC, Bruchas MR (2019) A motivational and neuropeptidergic hub: anatomical and functional diversity within the nucleus accumbens shell. Neuron 102:529\u2013552. https:\/\/doi.org\/10.1016\/j.neuron.2019.03.003","journal-title":"Neuron"},{"key":"3177_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2022.987229","volume":"16","author":"AE Castro","year":"2022","unstructured":"Castro AE, Dom\u00ednguez-Ordo\u00f1ez R, Young LJ, Camacho FJ, \u00c1vila-Gonz\u00e1lez D, Paredes RG, D\u00edaz NF, Portillo W (2022) Pair-bonding and social experience modulate new neurons survival in adult male and female prairie voles (Microtus ochrogaster). Front Neuroanat 16:987229. https:\/\/doi.org\/10.3389\/fnana.2022.987229","journal-title":"Front Neuroanat"},{"key":"3177_CR20","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/0165-0173(94)90006-x","volume":"19","author":"MR Celio","year":"1994","unstructured":"Celio MR, Bl\u00fcmcke I (1994) Perineuronal nets\u2013a specialized form of extracellular matrix in the adult nervous system. Brain Res Brain Res Rev 19:128\u2013145. https:\/\/doi.org\/10.1016\/0165-0173(94)90006-x","journal-title":"Brain Res Brain Res Rev"},{"key":"3177_CR21","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0304-3940(93)90579-a","volume":"162","author":"MR Celio","year":"1993","unstructured":"Celio MR, Chiquet-Ehrismann R (1993) \u201cPerineuronal nets\u201d around cortical interneurons expressing parvalbumin are rich in tenascin. Neurosci Lett 162:137\u2013140. https:\/\/doi.org\/10.1016\/0304-3940(93)90579-a","journal-title":"Neurosci Lett"},{"key":"3177_CR22","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/s0166-2236(98)01298-3","volume":"21","author":"MR Celio","year":"1998","unstructured":"Celio MR, Spreafico R, De Biasi S, Vitellaro-Zuccarello L (1998) Perineuronal nets: past and present. Trends Neurosci 21:510\u2013515. https:\/\/doi.org\/10.1016\/s0166-2236(98)01298-3","journal-title":"Trends Neurosci"},{"key":"3177_CR23","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.neubiorev.2020.04.007","volume":"113","author":"OY Chao","year":"2020","unstructured":"Chao OY, de Souza Silva MA, Yang Y-M, Huston JP (2020) The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: behavioral, anatomical and neurochemical properties. Neurosci Biobehav Rev 113:373\u2013407. https:\/\/doi.org\/10.1016\/j.neubiorev.2020.04.007","journal-title":"Neurosci Biobehav Rev"},{"key":"3177_CR24","doi-asserted-by":"publisher","first-page":"3274","DOI":"10.1002\/cne.25167","volume":"529","author":"A Ciccarelli","year":"2021","unstructured":"Ciccarelli A, Weijers D, Kwan W, Warner C, Bourne J, Gross CT (2021) Sexually dimorphic perineuronal nets in the rodent and primate reproductive circuit. J Comp Neurol 529:3274\u20133291. https:\/\/doi.org\/10.1002\/cne.25167","journal-title":"J Comp Neurol"},{"key":"3177_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynpai.2025.100181","volume":"18","author":"TN Dang","year":"2025","unstructured":"Dang TN, Van CN, Ochi R, Kuwamura H, Kurose T, Nakamura Y, Hisaoka-Nakashima K, Morioka N, Nishijo H, Fujita N, Urakawa S (2025) Voluntary exercise prevents and eradicates anxiety-like behavior by influencing parvalbumin-positive neurons, perineuronal nets, and microglia activation in corticolimbic regions of neuropathic pain rats. Neurobiol Pain 18:100181. https:\/\/doi.org\/10.1016\/j.ynpai.2025.100181","journal-title":"Neurobiol Pain"},{"key":"3177_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2491","volume":"4","author":"L de Vivo","year":"2013","unstructured":"de Vivo L, Landi S, Panniello M, Baroncelli L, Chierzi S, Mariotti L, Spolidoro M, Pizzorusso T, Maffei L, Ratto GM (2013) Extracellular matrix inhibits structural and functional plasticity of dendritic spines in the adult visual cortex. Nat Commun 4:1484. https:\/\/doi.org\/10.1038\/ncomms2491","journal-title":"Nat Commun"},{"key":"3177_CR27","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1038\/nrn1115","volume":"4","author":"A Dityatev","year":"2003","unstructured":"Dityatev A, Schachner M (2003) Extracellular matrix molecules and synaptic plasticity. Nat Rev Neurosci 4:456\u2013468. https:\/\/doi.org\/10.1038\/nrn1115","journal-title":"Nat Rev Neurosci"},{"issue":"8","key":"3177_CR28","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1007\/s00429-020-02137-z","volume":"225","author":"CM Drzewiecki","year":"2020","unstructured":"Drzewiecki CM, Willing J, Juraska JM (2020) Influences of age and pubertal status on number and intensity of perineuronal nets in the rat medial prefrontal cortex. Brain Struct Funct 225(8):2495\u20132507. https:\/\/doi.org\/10.1007\/s00429-020-02137-z","journal-title":"Brain Struct Funct"},{"key":"3177_CR29","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/s41386-021-01132-0","volume":"47","author":"NP Friedman","year":"2022","unstructured":"Friedman NP, Robbins TW (2022) The role of prefrontal cortex in cognitive control and executive function. Neuropsychopharmacology 47:72\u201389. https:\/\/doi.org\/10.1038\/s41386-021-01132-0","journal-title":"Neuropsychopharmacology"},{"key":"3177_CR30","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/j.tins.2021.10.003","volume":"44","author":"S Genon","year":"2021","unstructured":"Genon S, Bernhardt BC, La Joie R, Amunts K, Eickhoff SB (2021) The many dimensions of human hippocampal organization and (dys)function. Trends Neurosci 44:977\u2013989. https:\/\/doi.org\/10.1016\/j.tins.2021.10.003","journal-title":"Trends Neurosci"},{"key":"3177_CR31","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/7854_2013_264","volume":"17","author":"KL Gobrogge","year":"2014","unstructured":"Gobrogge KL (2014) Sex, drugs, and violence: neuromodulation of attachment and conflict in voles. Curr Top Behav Neurosci 17:229\u2013264. https:\/\/doi.org\/10.1007\/7854_2013_264","journal-title":"Curr Top Behav Neurosci"},{"key":"3177_CR32","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1126\/science.1174146","volume":"325","author":"N Gogolla","year":"2009","unstructured":"Gogolla N, Caroni P, L\u00fcthi A, Herry C (2009) Perineuronal nets protect fear memories from erasure. Science 325:1258\u20131261. https:\/\/doi.org\/10.1126\/science.1174146","journal-title":"Science"},{"key":"3177_CR33","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1002\/hipo.23164","volume":"30","author":"CL Grady","year":"2020","unstructured":"Grady CL (2020) Meta-analytic and functional connectivity evidence from functional magnetic resonance imaging for an anterior to posterior gradient of function along the hippocampal axis. Hippocampus 30:456\u2013471. https:\/\/doi.org\/10.1002\/hipo.23164","journal-title":"Hippocampus"},{"key":"3177_CR34","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1265","volume":"9","author":"BB Griffiths","year":"2019","unstructured":"Griffiths BB, Madden AMK, Edwards KA, Zup SL, Stary CM (2019) Age-dependent sexual dimorphism in hippocampal cornu ammonis-1 perineuronal net expression in rats. Brain Behav 9:e01265. https:\/\/doi.org\/10.1002\/brb3.1265","journal-title":"Brain Behav"},{"key":"3177_CR35","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1007\/s00429-021-02229-4","volume":"226","author":"JH Harkness","year":"2021","unstructured":"Harkness JH, Gonzalez AE, Bushana PN, Jorgensen ET, Hegarty DM, Di Nardo AA, Prochiantz A, Wisor JP, Aicher SA, Brown TE, Sorg BA (2021) Diurnal changes in perineuronal nets and parvalbumin neurons in the rat medial prefrontal cortex. Brain Struct Funct 226:1135\u20131153. https:\/\/doi.org\/10.1007\/s00429-021-02229-4","journal-title":"Brain Struct Funct"},{"key":"3177_CR36","doi-asserted-by":"publisher","first-page":"597","DOI":"10.4103\/1673-5374.266909","volume":"15","author":"HN Harris","year":"2020","unstructured":"Harris HN, Peng YB (2020) Evidence and explanation for the involvement of the nucleus accumbens in pain processing. Neural Regen Res 15:597\u2013605. https:\/\/doi.org\/10.4103\/1673-5374.266909","journal-title":"Neural Regen Res"},{"key":"3177_CR37","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.biopsych.2024.02.003","volume":"96","author":"MF Hazlett","year":"2024","unstructured":"Hazlett MF, Hall VL, Patel E, Halvorsen A, Calakos N, West AE (2024) The perineuronal net protein brevican acts in nucleus accumbens parvalbumin-expressing interneurons of adult mice to regulate excitatory synaptic inputs and motivated behaviors. Biol Psychiatry 96:694\u2013707. https:\/\/doi.org\/10.1016\/j.biopsych.2024.02.003","journal-title":"Biol Psychiatry"},{"key":"3177_CR38","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.1111\/ejn.13024","volume":"42","author":"N Horii-Hayashi","year":"2015","unstructured":"Horii-Hayashi N, Sasagawa T, Hashimoto T, Kaneko T, Takeuchi K, Nishi M (2015) A newly identified mouse hypothalamic area having bidirectional neural connections with the lateral septum: the perifornical area of the anterior hypothalamus rich in chondroitin sulfate proteoglycans. Eur J Neurosci 42:2322\u20132334. https:\/\/doi.org\/10.1111\/ejn.13024","journal-title":"Eur J Neurosci"},{"key":"3177_CR39","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1113\/jphysiol.1970.sp009022","volume":"206","author":"DH Hubel","year":"1970","unstructured":"Hubel DH, Wiesel TN (1970) The period of susceptibility to the physiological effects of unilateral eye closure in kittens. J Physiol 206:419\u2013436. https:\/\/doi.org\/10.1113\/jphysiol.1970.sp009022","journal-title":"J Physiol"},{"key":"3177_CR40","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s00429-019-02010-8","volume":"225","author":"A Hunyadi","year":"2020","unstructured":"Hunyadi A, Ga\u00e1l B, Matesz C, Meszar Z, Morawski M, Reimann K, Lendvai D, Alpar A, W\u00e9ber I, R\u00e1cz \u00c9 (2020) Distribution and classification of the extracellular matrix in the olfactory bulb. Brain Struct Funct 225:321\u2013344. https:\/\/doi.org\/10.1007\/s00429-019-02010-8","journal-title":"Brain Struct Funct"},{"key":"3177_CR41","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1002\/dneu.20974","volume":"71","author":"JCF Kwok","year":"2011","unstructured":"Kwok JCF, Dick G, Wang D, Fawcett JW (2011) Extracellular matrix and perineuronal nets in CNS repair. Dev Neurobiol 71:1073\u20131089. https:\/\/doi.org\/10.1002\/dneu.20974","journal-title":"Dev Neurobiol"},{"key":"3177_CR42","doi-asserted-by":"publisher","first-page":"ENEURO.0500","DOI":"10.1523\/ENEURO.0500-19.2020","volume":"7","author":"BYB Lau","year":"2020","unstructured":"Lau BYB, Layo DE, Emery B, Everett M, Kumar A, Stevenson P, Reynolds KG, Cherosky A, Bowyer S-AH, Roth S, Fisher DG, McCord RP, Krishnan K (2020) Lateralized expression of cortical perineuronal nets during maternal experience is dependent on MECP2. eNeuro 7:ENEURO.0500-19.2020. https:\/\/doi.org\/10.1523\/ENEURO.0500-19.2020","journal-title":"eNeuro"},{"key":"3177_CR43","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0315-18.2018","author":"M Laubach","year":"2018","unstructured":"Laubach M, Amarante LM, Swanson K, White SR (2018) What, if anything, is rodent prefrontal cortex? eNeuro. https:\/\/doi.org\/10.1523\/ENEURO.0315-18.2018","journal-title":"eNeuro"},{"key":"3177_CR44","doi-asserted-by":"publisher","first-page":"ENEURO.0379-16.","DOI":"10.1523\/ENEURO.0379-16.2017","volume":"4","author":"KK Lensj\u00f8","year":"2017","unstructured":"Lensj\u00f8 KK, Christensen AC, Tenn\u00f8e S, Fyhn M, Hafting T (2017) Differential expression and cell-type specificity of perineuronal nets in hippocampus, medial entorhinal cortex, and visual cortex examined in the rat and mouse. eNeuro 4:ENEURO.0379-16.2017. https:\/\/doi.org\/10.1523\/ENEURO.0379-16.2017","journal-title":"eNeuro"},{"key":"3177_CR45","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a018820","volume":"8","author":"DA Lim","year":"2016","unstructured":"Lim DA, Alvarez-Buylla A (2016) The adult ventricular-subventricular zone (V-SVZ) and olfactory bulb (OB) neurogenesis. Cold Spring Harb Perspect Biol 8:a018820. https:\/\/doi.org\/10.1101\/cshperspect.a018820","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"3177_CR46","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a018945","volume":"8","author":"P-M Lledo","year":"2016","unstructured":"Lledo P-M, Valley M (2016) Adult olfactory bulb neurogenesis. Cold Spring Harb Perspect Biol 8:a018945. https:\/\/doi.org\/10.1101\/cshperspect.a018945","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"3177_CR47","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1002\/cne.22789","volume":"520","author":"Z M\u00e9sz\u00e1r","year":"2012","unstructured":"M\u00e9sz\u00e1r Z, Girard F, Saper CB, Celio MR (2012) The lateral hypothalamic parvalbumin-immunoreactive (PV1) nucleus in rodents. J Comp Neurol 520:798\u2013815. https:\/\/doi.org\/10.1002\/cne.22789","journal-title":"J Comp Neurol"},{"key":"3177_CR48","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1146\/annurev-neuro-112210-112917","volume":"34","author":"K Mori","year":"2011","unstructured":"Mori K, Sakano H (2011) How is the olfactory map formed and interpreted in the mammalian brain? Annu Rev Neurosci 34:467\u2013499. https:\/\/doi.org\/10.1146\/annurev-neuro-112210-112917","journal-title":"Annu Rev Neurosci"},{"key":"3177_CR49","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1095\/biolreprod40.3.481","volume":"40","author":"RJ Nelson","year":"1989","unstructured":"Nelson RJ, Frank D, Smale L, Willoughby SB (1989) Photoperiod and temperature affect reproductive and nonreproductive functions in male prairie voles (Microtus ochrogaster). Biol Reprod 40:481\u2013485. https:\/\/doi.org\/10.1095\/biolreprod40.3.481","journal-title":"Biol Reprod"},{"key":"3177_CR50","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.neuron.2016.03.033","volume":"90","author":"L-L Oettl","year":"2016","unstructured":"Oettl L-L, Ravi N, Schneider M, Scheller MF, Schneider P, Mitre M, da Silva Gouveia M, Froemke RC, Chao MV, Young WS, Meyer-Lindenberg A, Grinevich V, Shusterman R, Kelsch W (2016) Oxytocin enhances social recognition by modulating cortical control of early olfactory processing. Neuron 90:609\u2013621. https:\/\/doi.org\/10.1016\/j.neuron.2016.03.033","journal-title":"Neuron"},{"key":"3177_CR51","doi-asserted-by":"publisher","first-page":"ENEURO.0034-19.","DOI":"10.1523\/ENEURO.0034-19.2020","volume":"7","author":"H Pantazopoulos","year":"2020","unstructured":"Pantazopoulos H, Gisabella B, Rexrode L, Benefield D, Yildiz E, Seltzer P, Valeri J, Chelini G, Reich A, Ardelt M, Berretta S (2020) Circadian rhythms of perineuronal net composition. eNeuro 7:ENEURO.0034-19.2020. https:\/\/doi.org\/10.1523\/ENEURO.0034-19.2020","journal-title":"eNeuro"},{"key":"3177_CR52","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1126\/science.1072699","volume":"298","author":"T Pizzorusso","year":"2002","unstructured":"Pizzorusso T, Medini P, Berardi N, Chierzi S, Fawcett JW, Maffei L (2002) Reactivation of ocular dominance plasticity in the adult visual cortex. Science 298:1248\u20131251. https:\/\/doi.org\/10.1126\/science.1072699","journal-title":"Science"},{"key":"3177_CR53","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aai8753","volume":"9","author":"D Riga","year":"2017","unstructured":"Riga D, Kramvis I, Koskinen MK, van Bokhoven P, van der Harst JE, Heistek TS, Timmerman AJ, van Nierop P, van der Schors RC, Pieneman AW, de Weger A, van Mourik Y, Schoffelmeer ANM, Mansvelder HD, Meredith RM, Hoogendijk WJG, Smit AB, Spijker S (2017) Hippocampal extracellular matrix alterations contribute to cognitive impairment associated with a chronic depressive-like state in rats. Sci Transl Med 9:eaai8753. https:\/\/doi.org\/10.1126\/scitranslmed.aai8753","journal-title":"Sci Transl Med"},{"key":"3177_CR54","doi-asserted-by":"publisher","first-page":"ENEURO.0315-21.","DOI":"10.1523\/ENEURO.0315-21.2021","volume":"8","author":"CA Rizzi-Wise","year":"2021","unstructured":"Rizzi-Wise CA, Wang DV (2021) Putting together pieces of the lateral septum: multifaceted functions and its neural pathways. eNeuro 8:ENEURO.0315-21.2021. https:\/\/doi.org\/10.1523\/ENEURO.0315-21.2021","journal-title":"eNeuro"},{"key":"3177_CR55","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/s0031-9384(98)00042-0","volume":"64","author":"RL Roberts","year":"1998","unstructured":"Roberts RL, Cushing BS, Carter CS (1998) Intraspecific variation in the induction of female sexual receptivity in prairie voles. Physiol Behav 64:209\u2013212. https:\/\/doi.org\/10.1016\/s0031-9384(98)00042-0","journal-title":"Physiol Behav"},{"key":"3177_CR56","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1111\/bcpt.13994","volume":"134","author":"T Santos-Silva","year":"2024","unstructured":"Santos-Silva T, Colodete DAE, Lisboa JRF, Silva Freitas \u00cd, Lopes CFB, Hadera V, Lima TSA, Souza AJ, Gomes FV (2024) Perineuronal nets as regulators of parvalbumin interneuron function: factors implicated in their formation and degradation. Basic Clin Pharmacol Toxicol 134:614\u2013628. https:\/\/doi.org\/10.1111\/bcpt.13994","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"3177_CR57","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1124\/pr.116.012484","volume":"68","author":"MD Scofield","year":"2016","unstructured":"Scofield MD, Heinsbroek JA, Gipson CD, Kupchik YM, Spencer S, Smith ACW, Roberts-Wolfe D, Kalivas PW (2016) The nucleus accumbens: mechanisms of addiction across drug classes reflect the importance of glutamate homeostasis. Pharmacol Rev 68:816\u2013871. https:\/\/doi.org\/10.1124\/pr.116.012484","journal-title":"Pharmacol Rev"},{"key":"3177_CR58","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/0306-4522(94)90044-2","volume":"58","author":"G Seeger","year":"1994","unstructured":"Seeger G, Brauer K, H\u00e4rtig W, Br\u00fcckner G (1994) Mapping of perineuronal nets in the rat brain stained by colloidal iron hydroxide histochemistry and lectin cytochemistry. Neuroscience 58:371\u2013388. https:\/\/doi.org\/10.1016\/0306-4522(94)90044-2","journal-title":"Neuroscience"},{"key":"3177_CR59","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.70189","volume":"14","author":"EK Shaughnessy","year":"2024","unstructured":"Shaughnessy EK, Horne BW, Huhman KL (2024) Perineuronal nets in Syrian hamsters: anatomical localization, sex differences, diurnal variation, and response to social stress. Brain Behav 14:e70189. https:\/\/doi.org\/10.1002\/brb3.70189","journal-title":"Brain Behav"},{"key":"3177_CR60","doi-asserted-by":"publisher","DOI":"10.1002\/cne.25603","volume":"532","author":"PN Siegler","year":"2024","unstructured":"Siegler PN, Shaughnessy EK, Horman B, Vierling TT, King DH, Patisaul HB, Huhman KL, Alexander GM, Dudek SM (2024) Identification of hippocampal area CA2 in hamster and vole brain. J Comp Neurol 532:e25603. https:\/\/doi.org\/10.1002\/cne.25603","journal-title":"J Comp Neurol"},{"key":"3177_CR61","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.brainresbull.2017.03.003","volume":"136","author":"I Song","year":"2018","unstructured":"Song I, Dityatev A (2018) Crosstalk between glia, extracellular matrix and neurons. Brain Res Bull 136:101\u2013108. https:\/\/doi.org\/10.1016\/j.brainresbull.2017.03.003","journal-title":"Brain Res Bull"},{"key":"3177_CR62","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.neubiorev.2020.07.015","volume":"118","author":"S Spijker","year":"2020","unstructured":"Spijker S, Koskinen M-K, Riga D (2020) Incubation of depression: ECM assembly and parvalbumin interneurons after stress. Neurosci Biobehav Rev 118:65\u201379. https:\/\/doi.org\/10.1016\/j.neubiorev.2020.07.015","journal-title":"Neurosci Biobehav Rev"},{"key":"3177_CR63","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/nrn3785","volume":"15","author":"BA Strange","year":"2014","unstructured":"Strange BA, Witter MP, Lein ES, Moser EI (2014) Functional organization of the hippocampal longitudinal axis. Nat Rev Neurosci 15:655\u2013669. https:\/\/doi.org\/10.1038\/nrn3785","journal-title":"Nat Rev Neurosci"},{"key":"3177_CR64","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1002\/j.2040-4603.2017.tb00738.x","volume":"7","author":"M Tabbaa","year":"2017","unstructured":"Tabbaa M, Paedae B, Liu Y, Wang Z (2017) Neuropeptide regulation of social attachment: the prairie vole model. Compr Physiol 7:81\u2013104. https:\/\/doi.org\/10.1002\/j.2040-4603.2017.tb00738.x","journal-title":"Compr Physiol"},{"key":"3177_CR65","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.semcdb.2018.09.011","volume":"89","author":"D Testa","year":"2019","unstructured":"Testa D, Prochiantz A, Di Nardo AA (2019) Perineuronal nets in brain physiology and disease. Semin Cell Dev Biol 89:125\u2013135. https:\/\/doi.org\/10.1016\/j.semcdb.2018.09.011","journal-title":"Semin Cell Dev Biol"},{"key":"3177_CR66","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s12565-018-0468-4","volume":"94","author":"Y Tsuneoka","year":"2019","unstructured":"Tsuneoka Y (2019) Molecular neuroanatomy of the mouse medial preoptic area with reference to parental behavior. Anat Sci Int 94:39\u201352. https:\/\/doi.org\/10.1007\/s12565-018-0468-4","journal-title":"Anat Sci Int"},{"key":"3177_CR67","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.ibror.2018.01.002","volume":"4","author":"H Ueno","year":"2018","unstructured":"Ueno H, Fujii K, Suemitsu S, Murakami S, Kitamura N, Wani K, Aoki S, Okamoto M, Ishihara T, Takao K (2018) Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex. IBRO Rep 4:22\u201337. https:\/\/doi.org\/10.1016\/j.ibror.2018.01.002","journal-title":"IBRO Rep"},{"key":"3177_CR68","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-62163-z","volume":"10","author":"N Uriarte","year":"2020","unstructured":"Uriarte N, Ferre\u00f1o M, M\u00e9ndez D, Nogueira J (2020) Reorganization of perineuronal nets in the medial preoptic area during the reproductive cycle in female rats. Sci Rep 10:5479","journal-title":"Sci Rep"},{"key":"3177_CR69","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/s41583-018-0072-6","volume":"19","author":"H Walum","year":"2018","unstructured":"Walum H, Young LJ (2018) The neural mechanisms and circuitry of the pair bond. Nat Rev Neurosci 19:643\u2013654. https:\/\/doi.org\/10.1038\/s41583-018-0072-6","journal-title":"Nat Rev Neurosci"},{"key":"3177_CR70","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/0006-8993(94)91784-1","volume":"650","author":"Z Wang","year":"1994","unstructured":"Wang Z, Smith W, Major DE, De Vries GJ (1994) Sex and species differences in the effects of cohabitation on vasopressin messenger RNA expression in the bed nucleus of the stria terminalis in prairie voles (Microtus ochrogaster) and meadow voles (Microtus pennsylvanicus). Brain Res 650:212\u2013218. https:\/\/doi.org\/10.1016\/0006-8993(94)91784-1","journal-title":"Brain Res"},{"key":"3177_CR71","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02648-0","volume":"9","author":"Y-C Wei","year":"2018","unstructured":"Wei Y-C, Wang S-R, Jiao Z-L, Zhang W, Lin J-K, Li X-Y, Li S-S, Zhang X, Xu X-H (2018) Medial preoptic area in mice is capable of mediating sexually dimorphic behaviors regardless of gender. Nat Commun 9:279. https:\/\/doi.org\/10.1038\/s41467-017-02648-0","journal-title":"Nat Commun"},{"key":"3177_CR72","doi-asserted-by":"publisher","first-page":"6647","DOI":"10.1523\/JNEUROSCI.5390-13.2014","volume":"34","author":"Y-X Xue","year":"2014","unstructured":"Xue Y-X, Xue L-F, Liu J-F, He J, Deng J-H, Sun S-C, Han H-B, Luo Y-X, Xu L-Z, Wu P, Lu L (2014) Depletion of perineuronal nets in the amygdala to enhance the erasure of drug memories. J Neurosci 34:6647\u20136658. https:\/\/doi.org\/10.1523\/JNEUROSCI.5390-13.2014","journal-title":"J Neurosci"},{"key":"3177_CR73","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.conb.2017.04.005","volume":"43","author":"R Zemla","year":"2017","unstructured":"Zemla R, Basu J (2017) Hippocampal function in rodents. Curr Opin Neurobiol 43:187\u2013197. https:\/\/doi.org\/10.1016\/j.conb.2017.04.005","journal-title":"Curr Opin Neurobiol"},{"key":"3177_CR74","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.714104","volume":"12","author":"N Zhang","year":"2021","unstructured":"Zhang N, Yan Z, Liu H, Yu M, He Y, Liu H, Liang C, Tu L, Wang L, Yin N, Han J, Scarcelli N, Yang Y, Wang C, Zeng T, Chen L-L, Xu Y (2021) Hypothalamic perineuronal nets are regulated by sex and dietary interventions. Front Physiol 12:714104. https:\/\/doi.org\/10.3389\/fphys.2021.714104","journal-title":"Front Physiol"},{"key":"3177_CR75","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1037\/bne0000555","volume":"137","author":"C Zhao","year":"2023","unstructured":"Zhao C, Riters LV (2023) The medial preoptic area and its projections to the ventral tegmental area and the periaqueductal gray are activated in response to social play behavior in juvenile rats. Behav Neurosci 137:223\u2013235. https:\/\/doi.org\/10.1037\/bne0000555","journal-title":"Behav Neurosci"}],"container-title":["Brain Structure and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-026-03177-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00429-026-03177-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00429-026-03177-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:15:44Z","timestamp":1789964144000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00429-026-03177-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,22]]},"references-count":75,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["3177"],"URL":"https:\/\/doi.org\/10.1007\/s00429-026-03177-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-9476005\/v1","asserted-by":"object"}]},"ISSN":["1863-2661"],"issn-type":[{"value":"1863-2661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,22]]},"assertion":[{"value":"20 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"122"}}