{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:00:53Z","timestamp":1791032453782,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,9,14]],"date-time":"2010-09-14T00:00:00Z","timestamp":1284422400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Microbiol Immunol"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1007\/s00430-010-0170-1","type":"journal-article","created":{"date-parts":[[2010,9,13]],"date-time":"2010-09-13T14:42:21Z","timestamp":1284388941000},"page":"29-38","source":"Crossref","is-referenced-by-count":52,"title":["Monoassociation with probiotic Lactobacillus delbrueckii UFV-H2b20 stimulates the immune system and protects germfree mice against Listeria monocytogenes infection"],"prefix":"10.1007","volume":"200","author":[{"given":"Liliane Martins","family":"dos Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f4nica Morais","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto Pereira","family":"de Souza Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Maria Esteves","family":"Arantes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques Robert","family":"Nicoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leda Quercia","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,9,14]]},"reference":[{"key":"170_CR1","unstructured":"FAO\/WHO (2001) Evaluation of health and nutritional properties of probiotics in food, including powder milk with live lactic acid bacteria. Food and Agriculture Organization of the United Nations and World Health Organization Expert Consultation Report. 1\u201334"},{"key":"170_CR2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/0884533608331177","volume":"24","author":"A Minocha","year":"2009","unstructured":"Minocha A (2009) Probiotics for preventive health. Nutr Clin Pract 24:227\u2013241","journal-title":"Nutr Clin Pract"},{"key":"170_CR3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s00535-008-2296-0","volume":"44","author":"AT Borchers","year":"2009","unstructured":"Borchers AT, Selmi C, Meyers FJ, Keen CL, Gershwin ME (2009) Probiotics and immunity. J Gastroenterol 44:26\u201346","journal-title":"J Gastroenterol"},{"key":"170_CR4","first-page":"182","volume":"36","author":"JTM Neves","year":"2005","unstructured":"Neves JTM, Floresta F, Moraes CA (2005) Partial characterization of ribosomal operons of Lactobacillus delbrueckii UFV H2b20. J Microbiol 36:182","journal-title":"J Microbiol"},{"key":"170_CR5","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1590\/S0100-879X1998001200009","volume":"31","author":"E Neumann","year":"1998","unstructured":"Neumann E, Oliveira MA, Cabral CM, Moura LN, Nicoli JR, Vieira EC, Cara DC, Podoprigora GI, Vieira LQ (1998) Monoassociation with Lactobacillus acidophilus UFV-H2b20 stimulates the immune defense mechanisms of germfree mice. Braz J Med Biol Res 31:1565\u20131573","journal-title":"Braz J Med Biol Res"},{"key":"170_CR6","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1574-695X.2002.tb00632.x","volume":"34","author":"ML Cross","year":"2002","unstructured":"Cross ML (2002) Microbes versus microbes: immune signals generated by probiotic lactobacilli and their role in protection against microbial pathogens. FEMS Immunol Med Microbiol 34:245\u2013253","journal-title":"FEMS Immunol Med Microbiol"},{"key":"170_CR7","doi-asserted-by":"crossref","first-page":"11080","DOI":"10.1021\/jf071786o","volume":"55","author":"L Chuang","year":"2007","unstructured":"Chuang L, Wu KG, Pai C, Hsieh PS, Tsai JJ, Yen JH, Lin MY (2007) Heat-killed cells of lactobacilli skew the immune response toward T helper 1 polarization in mouse splenocytes and dendritic cell-treated T cells. J Agric Food Chem 55:11080\u201311086","journal-title":"J Agric Food Chem"},{"key":"170_CR8","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.cyto.2007.11.014","volume":"41","author":"CA Dogi","year":"2008","unstructured":"Dogi CA, Galdeano CM, Perdigon G (2008) Gut immune stimulation by non pathogenic Gram(+) and Gram(\u2212) bacteria. Comparison with a probiotic strain. Cytokine 41:223\u2013231","journal-title":"Cytokine"},{"key":"170_CR9","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.micinf.2007.05.009","volume":"9","author":"M Lecuit","year":"2007","unstructured":"Lecuit M (2007) Human listeriosis and animal models. Microbes Infect 9:1216\u20131225","journal-title":"Microbes Infect"},{"key":"170_CR10","doi-asserted-by":"crossref","first-page":"5141","DOI":"10.4049\/jimmunol.153.11.5141","volume":"153","author":"PJ Leenen","year":"1994","unstructured":"Leenen PJ, Canono BP, Drevets DA, Voerman JS, Campbell PA (1994) TNF-alpha and IFN-gamma stimulate a macrophage precursor cell line to kill Listeria monocytogenes in a nitric oxide-independent manner. J Immunol 153:5141\u20135147","journal-title":"J Immunol"},{"key":"170_CR11","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1590\/S1517-83822001000100015","volume":"32","author":"LN Moura","year":"2001","unstructured":"Moura LN, Neumann E, Vieira LQ, Nicoli JR (2001) Protection by Lactobacillus acidophilus UFV-H2b20 against experimental oral infection with Salmonella enterica subsp. I ser. Typhimurium in gnotobiotic and conventional mice. Braz J Microbiol 32:66\u201369","journal-title":"Braz J Microbiol"},{"key":"170_CR12","first-page":"119","volume-title":"Handbook of laboratory animal science","author":"JR Pleasants","year":"1974","unstructured":"Pleasants JR (1974) Gnotobiotics. In: Melby EC, Altman NH (eds) Handbook of laboratory animal science. CRC Press, Cleveland, pp 119\u2013174"},{"key":"170_CR13","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/0006-291X(92)90813-Z","volume":"186","author":"EL Padgett","year":"1992","unstructured":"Padgett EL, Pruett SB (1992) Evaluation of nitrite production by human monocyte-derived macrophages. Biochem Biophys Res Commun 186:775\u2013781","journal-title":"Biochem Biophys Res Commun"},{"key":"170_CR14","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1128\/AEM.63.7.2747-2753.1997","volume":"63","author":"MF Bernet-Camard","year":"1997","unstructured":"Bernet-Camard MF, Lievin V, Brassart D, Neeser JR, Servin AL, Hudault S (1997) The human Lactobacillus acidophilus strain LA1 secretes a nonbacteriocin antibacterial substance(s) active in vitro and in vivo. Appl Environ Microbiol 63:2747\u20132753","journal-title":"Appl Environ Microbiol"},{"key":"170_CR15","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/j.1472-765X.2007.02250.x","volume":"45","author":"FH Bambirra","year":"2007","unstructured":"Bambirra FH, Lima KG, Franco BD, Cara DC, Nardi RM, Barbosa FH, Nicoli JR (2007) Protective effect of Lactobacillus sakei 2a against experimental challenge with Listeria monocytogenes in gnotobiotic mice. Lett Appl Microbiol 45:663\u2013667","journal-title":"Lett Appl Microbiol"},{"key":"170_CR16","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1128\/IAI.44.2.445-451.1984","volume":"44","author":"K Sato","year":"1984","unstructured":"Sato K (1984) Enhancement of host resistance against Listeria infection by Lactobacillus casei: role of macrophages. Infect Immun 44:445\u2013451","journal-title":"Infect Immun"},{"key":"170_CR17","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0168-1605(01)00699-7","volume":"73","author":"R Waard de","year":"2002","unstructured":"de Waard R, Garssen J, Bokken GC, Vos JG (2002) Antagonistic activity of Lactobacillus casei strain shirota against gastrointestinal Listeria monocytogenes infection in rats. Int J Food Microbiol 73:93\u2013100","journal-title":"Int J Food Microbiol"},{"key":"170_CR18","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1099\/00221287-106-1-165","volume":"106","author":"M Mitsuyama","year":"1978","unstructured":"Mitsuyama M, Takeya K, Nomoto K, Shimotori S (1978) Three phases of phagocyte contribution to resistance against Listeria monocytogenes. J Gen Microbiol 106:165\u2013171","journal-title":"J Gen Microbiol"},{"key":"170_CR19","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1189\/jlb.0402212","volume":"74","author":"V Veckman","year":"2003","unstructured":"Veckman V, Miettinen M, Matikainen S, Lande R, Giacomini E, Coccia EM, Julkunen I (2003) Lactobacilli and streptococci induce inflammatory chemokine production in human macrophages that stimulates Th1 cell chemotaxis. J Leukoc Biol 74:395\u2013402","journal-title":"J Leukoc Biol"},{"key":"170_CR20","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1365-2567.2005.02159.x","volume":"115","author":"AJ Macpherson","year":"2005","unstructured":"Macpherson AJ, Geuking MB, McCoy KD (2005) Immune responses that adapt the intestinal mucosa to commensal intestinal bacteria. Immunology 115:153\u2013162","journal-title":"Immunology"},{"key":"170_CR21","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nri2515","volume":"9","author":"JL Round","year":"2009","unstructured":"Round JL, Mazmanian SK (2009) The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol 9:313\u2013323","journal-title":"Nat Rev Immunol"},{"key":"170_CR22","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1023\/B:HIJO.0000039840.86420.b7","volume":"35","author":"HB Mikkelsen","year":"2004","unstructured":"Mikkelsen HB, Garbarsch C, Tranum-Jensen J, Thuneberg L (2004) Macrophages in the small intestinal muscularis externa of embryos, newborn and adult germ-free mice. J Mol Histol 35:377\u2013387","journal-title":"J Mol Histol"},{"key":"170_CR23","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1128\/IAI.64.8.3280-3287.1996","volume":"64","author":"H Inagaki","year":"1996","unstructured":"Inagaki H, Suzuki T, Nomoto K, Yoshikai Y (1996) Increased susceptibility to primary infection with Listeria monocytogenes in germfree mice may be due to lack of accumulation of L-selectin\u00a0+\u00a0CD44\u00a0+\u00a0T cells in sites of inflammation. Infect Immun 64:3280\u20133287","journal-title":"Infect Immun"},{"key":"170_CR24","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1271\/bbb.60464","volume":"71","author":"K Ishida-Fujii","year":"2007","unstructured":"Ishida-Fujii K, Sato R, Goto S, Yang XP, Kuboki H, Hirano S, Sato M (2007) Prevention of pathogenic Escherichia coli infection in mice and stimulation of macrophage activation in rats by an oral administration of probiotic Lactobacillus casei I-5. Biosci Biotechnol Biochem 71:866\u2013873","journal-title":"Biosci Biotechnol Biochem"},{"key":"170_CR25","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.2741\/2148","volume":"12","author":"LG Castanheira","year":"2007","unstructured":"Castanheira LG, Castro JM, Martins-Filho OA, Nicoli JR, Vieira LQ, Afonso LC (2007) Lactobacillus delbrueckii as a potential skin adjuvant for induction of type 1 immune responses. Front Biosci 12:1300\u20131307","journal-title":"Front Biosci"},{"key":"170_CR26","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1590\/S0100-879X2009000400008","volume":"42","author":"E Neumann","year":"2009","unstructured":"Neumann E, Ramos MG, Santos LM, Rodrigues AC, Vieira EC, Afonso LC, Nicoli JR, Vieira LQ (2009) Lactobacillus delbrueckii UFV-H2b20 induces type 1 cytokine production by mouse cells in vitro and in vivo. Braz J Med Biol Res 42:358\u2013367","journal-title":"Braz J Med Biol Res"},{"key":"170_CR27","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cell.2004.07.002","volume":"118","author":"S Rakoff-Nahoum","year":"2004","unstructured":"Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R (2004) Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118:229\u2013241","journal-title":"Cell"},{"key":"170_CR28","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1128\/CVI.00079-07","volume":"14","author":"S Voltan","year":"2007","unstructured":"Voltan S, Castagliuolo I, Elli M, Longo S, Brun P, D\u2019Inca R, Porzionato A, Macchi V, Palu G, Sturniolo GC, Morelli L, Martines D (2007) Aggregating phenotype in Lactobacillus crispatus determines intestinal colonization and TLR2 and TLR4 modulation in murine colonic mucosa. Clin Vaccine Immunol 14:1138\u20131148","journal-title":"Clin Vaccine Immunol"},{"key":"170_CR29","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1128\/IAI.64.4.1252-1258.1996","volume":"64","author":"A Nakane","year":"1996","unstructured":"Nakane A, Nishikawa S, Sasaki S, Miura T, Asano M, Kohanawa M, Ishiwata K, Minagawa T (1996) Endogenous interleukin-4, but not interleukin-10, is involved in suppression of host resistance against Listeria monocytogenes infection in interferon-depleted mice. Infect Immun 64:1252\u20131258","journal-title":"Infect Immun"},{"key":"170_CR30","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1574-695X.1996.tb00148.x","volume":"16","author":"S Nishikawa","year":"1996","unstructured":"Nishikawa S, Miura T, Sasaki S, Nakane A (1996) The protective role of endogenous cytokines in host resistance against an intragastric infection with Listeria monocytogenes in mice. FEMS Immunol Med Microbiol 16:291\u2013298","journal-title":"FEMS Immunol Med Microbiol"},{"key":"170_CR31","doi-asserted-by":"crossref","unstructured":"Samsom JN, Annema A, Geertsma MF, Langermans JA, Groeneveld PH, de HE, van FR (2000) Interleukin-10 has different effects on proliferation of Listeria monocytogenes in livers and spleens of mice. Infect Immun 68:4666\u20134672","DOI":"10.1128\/IAI.68.8.4666-4672.2000"},{"key":"170_CR32","doi-asserted-by":"crossref","first-page":"6112","DOI":"10.4049\/jimmunol.169.11.6112","volume":"169","author":"Y Cong","year":"2002","unstructured":"Cong Y, Weaver CT, Lazenby A, Elson CO (2002) Bacterial-reactive T regulatory cells inhibit pathogenic immune responses to the enteric flora. J Immunol 169:6112\u20136119","journal-title":"J Immunol"},{"key":"170_CR33","doi-asserted-by":"crossref","first-page":"e9009","DOI":"10.1371\/journal.pone.0009009","volume":"5","author":"S Lavasani","year":"2010","unstructured":"Lavasani S, Dzhambazov B, Nouri M, Fak F, Buske S, Molin G, Thorlacius H, Alenfall J, Jeppsson B, Westrom B (2010) A novel probiotic mixture exerts a therapeutic effect on experimental autoimmune encephalomyelitis mediated by IL-10 producing regulatory T cells. PLoS One 5:e9009","journal-title":"PLoS One"},{"key":"170_CR34","doi-asserted-by":"crossref","first-page":"8533","DOI":"10.4049\/jimmunol.179.12.8533","volume":"179","author":"DG Souza","year":"2007","unstructured":"Souza DG, Fagundes CT, Amaral FA, Cisalpino D, Sousa LP, Vieira AT, Pinho V, Nicoli JR, Vieira LQ, Fierro IM, Teixeira MM (2007) The required role of endogenously produced lipoxin A4 and annexin-1 for the production of IL-10 and inflammatory hyporesponsiveness in mice. J Immunol 179:8533\u20138543","journal-title":"J Immunol"},{"key":"170_CR35","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1084\/jem.20011502","volume":"195","author":"DJ Campbell","year":"2002","unstructured":"Campbell DJ, Butcher EC (2002) Rapid acquisition of tissue-specific homing phenotypes by CD4(+) T cells activated in cutaneous or mucosal lymphoid tissues. J Exp Med 195:135\u2013141","journal-title":"J Exp Med"},{"issue":"Suppl 1","key":"170_CR36","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1159\/000089775","volume":"73","author":"F Guarner","year":"2006","unstructured":"Guarner F (2006) Enteric flora in health and disease. Digestion 73(Suppl 1):5\u201312","journal-title":"Digestion"}],"container-title":["Medical Microbiology and Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00430-010-0170-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00430-010-0170-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00430-010-0170-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T08:13:04Z","timestamp":1685779984000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00430-010-0170-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,14]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["170"],"URL":"https:\/\/doi.org\/10.1007\/s00430-010-0170-1","relation":{},"ISSN":["0300-8584","1432-1831"],"issn-type":[{"value":"0300-8584","type":"print"},{"value":"1432-1831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,14]]}}}