{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T07:13:39Z","timestamp":1772954019286,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,3,6]],"date-time":"2012-03-06T00:00:00Z","timestamp":1330992000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Microbiol Immunol"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1007\/s00430-011-0223-0","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T22:15:35Z","timestamp":1330985735000},"page":"389-395","source":"Crossref","is-referenced-by-count":34,"title":["A pilot study of serum microRNA signatures as a novel biomarker for occult hepatitis B virus infection"],"prefix":"10.1007","volume":"201","author":[{"given":"Yuanyuan","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenxian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Zen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,3,6]]},"reference":[{"key":"223_CR1","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1002\/hep.23886","volume":"52","author":"M El Chaar","year":"2010","unstructured":"El Chaar M, Candotti D, Crowther RA, Allain JP (2010) Impact of hepatitis B virus surface protein mutations on the diagnosis of occult hepatitis B virus infection. Hepatology 52:1600\u20131610","journal-title":"Hepatology"},{"key":"223_CR2","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1136\/gut.2010.209148","volume":"59","author":"MF Yuen","year":"2010","unstructured":"Yuen MF, Lee CK, Wong DK, Fung J, Hung I, Hsu A, But DY, Cheung TK, Chan P, Yuen JC et al (2010) Prevalence of occult hepatitis B infection in a highly endemic area for chronic hepatitis B: a study of a large blood donor population. Gut 59:1389\u20131393","journal-title":"Gut"},{"key":"223_CR3","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1007\/s10620-010-1413-0","volume":"55","author":"P Schmeltzer","year":"2010","unstructured":"Schmeltzer P, Sherman KE (2010) Occult hepatitis B: clinical implications and treatment decisions. Dig Dis Sci 55:3328\u20133335","journal-title":"Dig Dis Sci"},{"key":"223_CR4","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.jhep.2009.05.020","volume":"51","author":"D Candotti","year":"2009","unstructured":"Candotti D, Allain JP (2009) Transfusion-transmitted hepatitis B virus infection. J Hepatol 51:798\u2013809","journal-title":"J Hepatol"},{"key":"223_CR5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.tracli.2003.11.007","volume":"11","author":"JP Allain","year":"2004","unstructured":"Allain JP (2004) Occult hepatitis B virus infection. Transfus Clin Biol 11:18\u201325","journal-title":"Transfus Clin Biol"},{"key":"223_CR6","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.patbio.2010.02.003","volume":"58","author":"G Raimondo","year":"2010","unstructured":"Raimondo G, Pollicino T, Romano L, Zanetti AR (2010) A 2010 update on occult hepatitis B infection. Pathol Biol (Paris) 58:254\u2013257","journal-title":"Pathol Biol (Paris)"},{"key":"223_CR7","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.jhep.2008.07.014","volume":"49","author":"G Raimondo","year":"2008","unstructured":"Raimondo G, Allain JP, Brunetto MR, Buendia MA, Chen DS, Colombo M, Craxi A, Donato F, Ferrari C, Gaeta GB et al (2008) Statements from the Taormina expert meeting on occult hepatitis B virus infection. J Hepatol 49:652\u2013657","journal-title":"J Hepatol"},{"key":"223_CR8","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S1665-2681(19)32072-1","volume":"4","author":"G Raimondo","year":"2005","unstructured":"Raimondo G, Cacciamo G, Saitta C (2005) Hepatitis B virus and hepatitis C virus co-infection: additive players in chronic liver disease? Ann Hepatol 4:100\u2013106","journal-title":"Ann Hepatol"},{"key":"223_CR9","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jhep.2006.10.007","volume":"46","author":"G Raimondo","year":"2007","unstructured":"Raimondo G, Pollicino T, Cacciola I, Squadrito G (2007) Occult hepatitis B virus infection. J Hepatol 46:160\u2013170","journal-title":"J Hepatol"},{"key":"223_CR10","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1053\/j.gastro.2008.02.017","volume":"134","author":"A Zerbini","year":"2008","unstructured":"Zerbini A, Pilli M, Boni C, Fisicaro P, Penna A, Di Vincenzo P, Giuberti T, Orlandini A, Raffa G, Pollicino T et al (2008) The characteristics of the cell-mediated immune response identify different profiles of occult hepatitis B virus infection. Gastroenterology 134:1470\u20131481","journal-title":"Gastroenterology"},{"key":"223_CR11","doi-asserted-by":"crossref","first-page":"11111","DOI":"10.1158\/0008-5472.CAN-07-2858","volume":"67","author":"JB Weidhaas","year":"2007","unstructured":"Weidhaas JB, Babar I, Nallur SM, Trang P, Roush S, Boehm M, Gillespie E, Slack FJ (2007) microRNAs as potential agents to alter resistance to cytotoxic anticancer therapy. Cancer Res 67:11111\u201311116","journal-title":"Cancer Res"},{"key":"223_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2006.08.028","volume":"302","author":"B Zhang","year":"2007","unstructured":"Zhang B, Pan X, Cobb GP, Anderson TA (2007) microRNAs as oncogenes and tumor suppressors. Dev Biol 302:1\u201312","journal-title":"Dev Biol"},{"key":"223_CR13","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1056\/NEJMe0808667","volume":"359","author":"FJ Slack","year":"2008","unstructured":"Slack FJ, Weidhaas JB (2008) microRNA in cancer prognosis. N Engl J Med 359:2720\u20132722","journal-title":"N Engl J Med"},{"key":"223_CR14","doi-asserted-by":"crossref","first-page":"12885","DOI":"10.1073\/pnas.0806202105","volume":"105","author":"F Pichiorri","year":"2008","unstructured":"Pichiorri F, Suh SS, Ladetto M, Kuehl M, Palumbo T, Drandi D, Taccioli C, Zanesi N, Alder H, Hagan JP et al (2008) microRNAs regulate critical genes associated with multiple myeloma pathogenesis. Proc Natl Acad Sci USA 105:12885\u201312890","journal-title":"Proc Natl Acad Sci USA"},{"key":"223_CR15","doi-asserted-by":"crossref","first-page":"8191","DOI":"10.1158\/0008-5472.CAN-08-1768","volume":"68","author":"F Petrocca","year":"2008","unstructured":"Petrocca F, Vecchione A, Croce CM (2008) Emerging role of miR-106b\u201325\/miR-17\u201392 clusters in the control of transforming growth factor beta signaling. Cancer Res 68:8191\u20138194","journal-title":"Cancer Res"},{"key":"223_CR16","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature02871","volume":"431","author":"V Ambros","year":"2004","unstructured":"Ambros V (2004) The functions of animal microRNAs. Nature 431:350\u2013355","journal-title":"Nature"},{"issue":"3","key":"223_CR17","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1002\/hep.24441","volume":"54","author":"H Guo","year":"2011","unstructured":"Guo H, Liu H, Mitchelson K, Rao H, Luo M, Xie L, Sun Y, Zhang L, Lu Y, Liu R et al (2011) microRNAs-372\/373 promote the expression of hepatitis B virus through the targeting of nuclear factor I\/B. Hepatology 54(3):808\u2013819","journal-title":"Hepatology"},{"key":"223_CR18","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1002\/hep.24195","volume":"53","author":"X Zhang","year":"2011","unstructured":"Zhang X, Zhang E, Ma Z, Pei R, Jiang M, Schlaak JF, Roggendorf M, Lu M (2011) Modulation of hepatitis B virus replication and hepatocyte differentiation by microRNA-1. Hepatology 53:1476\u20131485","journal-title":"Hepatology"},{"key":"223_CR19","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1002\/hep.22749","volume":"49","author":"S Ura","year":"2009","unstructured":"Ura S, Honda M, Yamashita T, Ueda T, Takatori H, Nishino R, Sunakozaka H, Sakai Y, Horimoto K, Kaneko S (2009) Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma. Hepatology 49:1098\u20131112","journal-title":"Hepatology"},{"key":"223_CR20","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/cr.2008.282","volume":"18","author":"X Chen","year":"2008","unstructured":"Chen X, Ba Y, Ma L, Cai X, Yin Y, Wang K, Guo J, Zhang Y, Chen J, Guo X et al (2008) Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 18:997\u20131006","journal-title":"Cell Res"},{"key":"223_CR21","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1373\/clinchem.2010.147553","volume":"56","author":"C Zhang","year":"2010","unstructured":"Zhang C, Wang C, Chen X, Yang C, Li K, Wang J, Dai J, Hu Z, Zhou X, Chen L et al (2010) Expression profile of microRNAs in serum: a fingerprint for esophageal squamous cell carcinoma. Clin Chem 56:1871\u20131879","journal-title":"Clin Chem"},{"key":"223_CR22","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1200\/JCO.2009.24.9342","volume":"28","author":"Z Hu","year":"2010","unstructured":"Hu Z, Chen X, Zhao Y, Tian T, Jin G, Shu Y, Chen Y, Xu L, Zen K, Zhang C, Shen H (2010) Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer. J Clin Oncol 28:1721\u20131726","journal-title":"J Clin Oncol"},{"key":"223_CR23","doi-asserted-by":"crossref","first-page":"9798","DOI":"10.1158\/0008-5472.CAN-10-1001","volume":"70","author":"LM Li","year":"2010","unstructured":"Li LM, Hu ZB, Zhou ZX, Chen X, Liu FY, Zhang JF, Shen HB, Zhang CY, Zen K (2010) Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma. Cancer Res 70:9798\u20139807","journal-title":"Cancer Res"},{"key":"223_CR24","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1038\/ncb1800","volume":"10","author":"J Skog","year":"2008","unstructured":"Skog J, Wurdinger T, van Rijn S, Meijer DH, Gainche L, Curry WT Jr, Carter BS, Krichevsky AM, Breakefield XO (2008) Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 10:1470\u20131476","journal-title":"Nat Cell Biol"},{"issue":"1","key":"223_CR25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ygyno.2008.08.036","volume":"112","author":"KE Resnick","year":"2008","unstructured":"Resnick KE, Alder H, Hagan JP, Richardson DL, Croce CM, Cohn DE (2008) The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform. Gynecol Oncol 112(1):55\u201359","journal-title":"Gynecol Oncol"},{"key":"223_CR26","doi-asserted-by":"crossref","first-page":"e3148","DOI":"10.1371\/journal.pone.0003148","volume":"3","author":"S Gilad","year":"2008","unstructured":"Gilad S, Meiri E, Yogev Y, Benjamin S, Lebanony D, Yerushalmi N, Benjamin H, Kushnir M, Cholakh H, Melamed N et al (2008) Serum microRNAs are promising novel biomarkers. PLoS ONE 3:e3148","journal-title":"PLoS ONE"},{"key":"223_CR27","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","volume":"105","author":"PS Mitchell","year":"2008","unstructured":"Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O\u2019Briant KC, Allen A et al (2008) Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA 105:10513\u201310518","journal-title":"Proc Natl Acad Sci USA"},{"key":"223_CR28","doi-asserted-by":"crossref","first-page":"R86","DOI":"10.1186\/ar3013","volume":"12","author":"K Murata","year":"2010","unstructured":"Murata K, Yoshitomi H, Tanida S, Ishikawa M, Nishitani K, Ito H, Nakamura T (2010) Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis. Arthr Res Ther 12:R86","journal-title":"Arthr Res Ther"},{"key":"223_CR29","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1128\/JCM.39.1.362-364.2001","volume":"39","author":"H Naito","year":"2001","unstructured":"Naito H, Hayashi S, Abe K (2001) Rapid and specific genotyping system for hepatitis B virus corresponding to six major genotypes by PCR using type-specific primers. J Clin Microbiol 39:362\u2013364","journal-title":"J Clin Microbiol"},{"key":"223_CR30","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.jhep.2009.12.024","volume":"52","author":"S Shimizu","year":"2010","unstructured":"Shimizu S, Takehara T, Hikita H, Kodama T, Miyagi T, Hosui A, Tatsumi T, Ishida H, Noda T, Nagano H et al (2010) The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma. J Hepatol 52:698\u2013704","journal-title":"J Hepatol"},{"key":"223_CR31","doi-asserted-by":"crossref","first-page":"6704","DOI":"10.1158\/0008-5472.CAN-09-1298","volume":"69","author":"Y Li","year":"2009","unstructured":"Li Y, Van den Boom TG II, Kong D, Wang Z, Ali S, Philip PA, Sarkar FH (2009) Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells. Cancer Res 69:6704\u20136712","journal-title":"Cancer Res"},{"key":"223_CR32","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1126\/science.1113329","volume":"309","author":"CL Jopling","year":"2005","unstructured":"Jopling CL, Yi M, Lancaster AM, Lemon SM, Sarnow P (2005) Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA. Science 309:1577\u20131581","journal-title":"Science"},{"key":"223_CR33","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1101\/sqb.2006.71.022","volume":"71","author":"CL Jopling","year":"2006","unstructured":"Jopling CL, Norman KL, Sarnow P (2006) Positive and negative modulation of viral and cellular mRNAs by liver-specific microRNA miR-122. Cold Spring Harb Symp Quant Biol 71:369\u2013376","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"223_CR34","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cmet.2006.01.005","volume":"3","author":"C Esau","year":"2006","unstructured":"Esau C, Davis S, Murray SF, Yu XX, Pandey SK, Pear M, Watts L, Booten SL, Graham M, McKay R et al (2006) miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab 3:87\u201398","journal-title":"Cell Metab"},{"key":"223_CR35","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/hep.22982","volume":"50","author":"CE Rogler","year":"2009","unstructured":"Rogler CE, Levoci L, Ader T, Massimi A, Tchaikovskaya T, Norel R, Rogler LE (2009) microRNA-23b cluster microRNAs regulate transforming growth factor-beta\/bone morphogenetic protein signaling and liver stem cell differentiation by targeting Smads. Hepatology 50:575\u2013584","journal-title":"Hepatology"},{"key":"223_CR36","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.coph.2009.05.003","volume":"9","author":"E Tsitsiou","year":"2009","unstructured":"Tsitsiou E, Lindsay MA (2009) microRNAs and the immune response. Curr Opin Pharmacol 9:514\u2013520","journal-title":"Curr Opin Pharmacol"},{"key":"223_CR37","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.devcel.2008.03.012","volume":"14","author":"J Lu","year":"2008","unstructured":"Lu J, Guo S, Ebert BL, Zhang H, Peng X, Bosco J, Pretz J, Schlanger R, Wang JY, Mak RH et al (2008) microRNA-mediated control of cell fate in megakaryocyte\u2013erythrocyte progenitors. Dev Cell 14:843\u2013853","journal-title":"Dev Cell"},{"key":"223_CR38","doi-asserted-by":"crossref","first-page":"7080","DOI":"10.1073\/pnas.0702409104","volume":"104","author":"B Zhou","year":"2007","unstructured":"Zhou B, Wang S, Mayr C, Bartel DP, Lodish HF (2007) miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely. Proc Natl Acad Sci USA 104:7080\u20137085","journal-title":"Proc Natl Acad Sci USA"},{"key":"223_CR39","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cell.2007.07.021","volume":"131","author":"C Xiao","year":"2007","unstructured":"Xiao C, Calado DP, Galler G, Thai TH, Patterson HC, Wang J, Rajewsky N, Bender TP, Rajewsky K (2007) miR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell 131:146\u2013159","journal-title":"Cell"}],"container-title":["Medical Microbiology and Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00430-011-0223-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00430-011-0223-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00430-011-0223-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T18:16:10Z","timestamp":1593800170000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00430-011-0223-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,6]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["223"],"URL":"https:\/\/doi.org\/10.1007\/s00430-011-0223-0","relation":{},"ISSN":["0300-8584","1432-1831"],"issn-type":[{"value":"0300-8584","type":"print"},{"value":"1432-1831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,6]]}}}