{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:59:05Z","timestamp":1791295145301,"version":"4.1.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T00:00:00Z","timestamp":1400025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Microbiol Immunol"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1007\/s00430-014-0338-1","type":"journal-article","created":{"date-parts":[[2014,5,13]],"date-time":"2014-05-13T17:54:33Z","timestamp":1400003673000},"page":"303-314","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Increased expressions of NKp44, NKp46 on NK\/NKT-like cells are associated with impaired cytolytic function in self-limiting hepatitis E infection"],"prefix":"10.1007","volume":"203","author":[{"given":"Rumki","family":"Das","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Tripathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,5,14]]},"reference":[{"key":"338_CR1","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1002\/hep.24674","volume":"54","author":"R Aggarwal","year":"2011","unstructured":"Aggarwal R, Jameel S (2011) Hepatitis E. Hepatology 54:2218\u20132226","journal-title":"Hepatology"},{"key":"338_CR2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00430-011-0210-5","volume":"201","author":"A Krumbholz","year":"2012","unstructured":"Krumbholz A, Mohn U, Lange J et al (2012) Prevalence of hepatitis E virus specific antibodies in humans with occupational exposure to pigs. Med Microbiol Immunol 201:239\u2013244","journal-title":"Med Microbiol Immunol"},{"key":"338_CR3","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00430-011-0221-2","volume":"201","author":"P Dremsek","year":"2012","unstructured":"Dremsek P, Wenzel JJ, Johne R et al (2012) Seroprevalence study in forestry workers from eastern Germany using novel genotype 3-and rat hepatitis E virus-specific immunoglobulin G ELISAs. Med Microbiol Immunol 201:189\u2013200","journal-title":"Med Microbiol Immunol"},{"key":"338_CR4","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1089\/vim.2006.0053","volume":"20","author":"R Srivastava","year":"2007","unstructured":"Srivastava R, Aggarwal R, Jameel S et al (2007) Cellular immune responses in acute hepatitis E virus infection to the viral open reading frame 2 protein. Viral Immunol 20:56\u201365","journal-title":"Viral Immunol"},{"key":"338_CR5","doi-asserted-by":"crossref","first-page":"e31822","DOI":"10.1371\/journal.pone.0031822","volume":"7","author":"AS Tripathy","year":"2012","unstructured":"Tripathy AS, Das R, Rathod SB, Arankalle VA (2012) Cytokine profiles, CTL response and T cell frequencies in the peripheral blood of acute patients and individuals recovered from Hepatitis E infection. PLoS ONE 7:e31822","journal-title":"PLoS ONE"},{"key":"338_CR6","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ni1583","volume":"9","author":"WM Yokoyama","year":"2008","unstructured":"Yokoyama WM (2008) Mistaken notions about natural killer cells. Nat Immunol 9:481\u2013485","journal-title":"Nat Immunol"},{"key":"338_CR7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev.immunol.23.021704.115526","volume":"23","author":"LL Lanier","year":"2005","unstructured":"Lanier LL (2005) NK cell recognition. Annu Rev Immunol 23:225\u2013274","journal-title":"Annu Rev Immunol"},{"key":"338_CR8","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0952-7915(00)00241-7","volume":"13","author":"CA Biron","year":"2001","unstructured":"Biron CA, Brossay L (2001) NK cells and NKT cells in innate defense against viral infections. Curr Opin Immunol 13:458\u2013464","journal-title":"Curr Opin Immunol"},{"key":"338_CR9","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ni1582","volume":"9","author":"E Vivier","year":"2008","unstructured":"Vivier E, Tomasello E, Baratin M, Walzer T, Ugolini S (2008) Functions of natural killer cells. Nat Immunol 9:503\u2013510","journal-title":"Nat Immunol"},{"key":"338_CR10","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/nrc928","volume":"2","author":"MJ Smyth","year":"2002","unstructured":"Smyth MJ, Hayakawa Y, Takeda K, Yagita H (2002) New aspects of natural-killer-cell surveillance and therapy of cancer. Nat Rev Cancer 2:850\u2013861","journal-title":"Nat Rev Cancer"},{"key":"338_CR11","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/nri1199","volume":"3","author":"DH Raulet","year":"2003","unstructured":"Raulet DH (2003) Roles of the NKG2D immunoreceptor and its ligands. Nat Rev Immunol 3:781\u2013790","journal-title":"Nat Rev Immunol"},{"key":"338_CR12","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.immunol.19.1.197","volume":"19","author":"A Moretta","year":"2001","unstructured":"Moretta A, Bottino C, Vitale M, Pende D, Cantoni C, Mingari MC, Biassoni R, Moretta L (2001) Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu Rev Immunol 19:197\u2013223","journal-title":"Annu Rev Immunol"},{"key":"338_CR13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.smim.2006.03.002","volume":"18","author":"L Moretta","year":"2006","unstructured":"Moretta L, Bottino C, Pende D, Castriconi R, Mingari MC, Moretta A (2006) Surface NK receptors and their ligands on tumor cells. Semin Immunol 18:151\u2013158","journal-title":"Semin Immunol"},{"key":"338_CR14","doi-asserted-by":"crossref","first-page":"21327","DOI":"10.1016\/S0021-9258(18)54636-6","volume":"266","author":"M Fukuda","year":"1991","unstructured":"Fukuda M (1991) Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking. J Biol Chem 266:21327\u201321330","journal-title":"J Biol Chem"},{"key":"338_CR15","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nri911","volume":"2","author":"JA Trapani","year":"2002","unstructured":"Trapani JA, Smyth MJ (2002) Functional significance of the perforin\/granzyme cell death pathway. Nat Rev Immunol 2:735\u2013747","journal-title":"Nat Rev Immunol"},{"key":"338_CR16","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.0818-9641.2004.01261.x","volume":"82","author":"SL Dommelen Van","year":"2004","unstructured":"Van Dommelen SL, Degli-Esposti MA (2004) NKT cells and viral immunity. Immunol Cell Biol 82:332\u2013341","journal-title":"Immunol Cell Biol"},{"key":"338_CR17","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.exger.2007.05.002","volume":"42","author":"E Peralbo","year":"2007","unstructured":"Peralbo E, Alonso C, Solana R (2007) Invariant NKT and NKT-like lymphocytes: two different T cell subsets that are differentially affected by ageing. Exp Gerontol 42:703\u2013708","journal-title":"Exp Gerontol"},{"key":"338_CR18","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1136\/gut.2007.130963","volume":"57","author":"L Golden-Mason","year":"2008","unstructured":"Golden-Mason L, Madrigal-Estebas L, McGrath E, Conroy MJ, Ryan EJ et al (2008) Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus following single source exposure. Gut 57:1121\u20131128","journal-title":"Gut"},{"key":"338_CR19","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1111\/j.1365-2893.2008.01036.x","volume":"15","author":"R Srivastava","year":"2008","unstructured":"Srivastava R, Aggarwal R, Bhagat MR, Chowdhury A, Naik S (2008) Alterations in natural killer cells and natural killer T cells during acute viral hepatitis E. J Viral Hepat 15:910\u2013916","journal-title":"J Viral Hepat"},{"key":"338_CR20","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1365-2893.2010.01338.x","volume":"18","author":"SB Prabhu","year":"2010","unstructured":"Prabhu SB, Gupta P, Durgapal H, Rath S, Gupta SD et al (2010) Study of cellular immune response against Hepatitis E Virus (HEV). J Viral Hepat 18:587\u2013594","journal-title":"J Viral Hepat"},{"key":"338_CR21","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1365-2893.2006.00801.x","volume":"14","author":"VA Arankalle","year":"2007","unstructured":"Arankalle VA, Lole KS, Deshmukh TM, Chobe LP, Gandhe SS (2007) Evaluation of human (genotype-1) and swine (genotype-4)-ORF-2 based ELISAs for anti-HEV IgM and IgG detection in an endemic country and search for type-4human HEV infections. J Viral Hepat 14:435\u2013445","journal-title":"J Viral Hepat"},{"key":"338_CR22","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000214862","volume":"52","author":"S Saravanabalaji","year":"2009","unstructured":"Saravanabalaji S, Tripathy AS, Dhoot RR, Chadha MS, Kakrani AL, Arankalle VA (2009) Viral load, antibody titers and recombinant open reading frame 2 protein- induced TH1\/TH2 cytokines and cellular immune responses in self-limiting and fulminant hepatitis E. Intervirology 52:78\u201385","journal-title":"Intervirology"},{"key":"338_CR23","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.vaccine.2008.11.097","volume":"27","author":"VA Arankalle","year":"2009","unstructured":"Arankalle VA, Lole KS, Deshmukh TM, Srivastava S, Shaligram US (2009) Challenge studies in Rhesus monkeys immunized with candidate hepatitis E vaccines: DNA, DNA-prime-protein-boost and DNA-protein encapsulated in liposomes. Vaccine 27:1032\u20131039","journal-title":"Vaccine"},{"key":"338_CR24","doi-asserted-by":"crossref","first-page":"e415","DOI":"10.1111\/j.1365-2893.2011.01457.x","volume":"18","author":"AS Tripathy","year":"2011","unstructured":"Tripathy AS, Das R, Chadha MS, Arankalle VA (2011) Epidemic of Hepatitis B with high mortality in India: association of fulminant disease with lack of CCL4 and natural killer T cells. J Viral Hepat. 18:e415\u2013e422","journal-title":"J Viral Hepat."},{"key":"338_CR25","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.humimm.2012.12.010","volume":"74","author":"R Das","year":"2013","unstructured":"Das R, Rathod SB, Alagarasu K, Arankalle VA, Tripathy AS (2013) Altered expressions of peripheral CD11c, CD80, CD83 markers and associations of HLA class II allele and haplotypes in self-limiting Hepatitis E infection. Hum Immunol 74:277\u2013285","journal-title":"Hum Immunol"},{"key":"338_CR26","doi-asserted-by":"crossref","first-page":"e49135","DOI":"10.1371\/journal.pone.0049135","volume":"7","author":"J Zhao","year":"2012","unstructured":"Zhao J, Li Y, Jin L, Zhang S, Fan R et al (2012) Natural killer cells are characterized by the concomitantly increased interferon-\u03b3 and cytotoxicity in acute resolved hepatitis B patients. PLoS ONE 7:e49135","journal-title":"PLoS ONE"},{"key":"338_CR27","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1084\/jem.192.7.921","volume":"192","author":"K Kakimi","year":"2000","unstructured":"Kakimi K, Guidotti LG, Koezuka Y, Chisari FV (2000) Natural killer T cells activation inhibits hepatitis B virus replication in vivo. J Exp Med 192:921\u2013930","journal-title":"J Exp Med"},{"key":"338_CR28","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.immunol.19.1.197","volume":"19","author":"A Moretta","year":"2001","unstructured":"Moretta A, Bottino C, Vitale M, Pende D, Cantoni C, Mingari MC, Biassoni R, Moretta L (2001) Activating receptors and coreceptors involved in human natural killer cell-mediate cytolysis. Annu Rev Immunol 19:197\u2013223","journal-title":"Annu Rev Immunol"},{"key":"338_CR29","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1146\/annurev.immunol.17.1.189","volume":"17","author":"CA Biron","year":"1999","unstructured":"Biron CA, Nguyen KB, Pien GC, Cousens LP, Salazar-Mather TP (1999) Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu Rev Immunol 17:189\u2013220","journal-title":"Annu Rev Immunol"},{"key":"338_CR30","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1002\/1521-4141(200112)31:12<3546::AID-IMMU3546>3.0.CO;2-W","volume":"31","author":"A Maria De","year":"2001","unstructured":"De Maria A, Biassoni R, Fogli M, Rizzi M, Cantoni C et al (2001) Identification, molecular cloning and functional characterization of NKp46 and NKp30 natural cytotoxicity receptors in Macaca fascicularis NK cells. Eur J Immunol 31:3546\u20133556","journal-title":"Eur J Immunol"},{"key":"338_CR31","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1002\/eji.200324141","volume":"33","author":"A Maria De","year":"2003","unstructured":"De Maria A, Fogli M, Costa P, Murdaca G, Puppo F et al (2003) The impaired NK cell cytolytic function in viremic HIV-1 infection is associated with a reduced surface expression of natural cytotoxicity receptors (NKp46, NKp30 and NKp44). Eur J Immunol 33:2410\u20132418","journal-title":"Eur J Immunol"},{"key":"338_CR32","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1002\/eji.200425251","volume":"34","author":"M Fogli","year":"2004","unstructured":"Fogli M, Costa P, Murdaca G, Setti M, Mingari MC et al (2004) Significant NK cell activation associated with decreased cytolytic function in peripheral blood of HIV-1-infected patients. Eur J Immunol 34:2313\u20132321","journal-title":"Eur J Immunol"},{"key":"338_CR33","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1002\/hep.23896","volume":"52","author":"L Golden-Mason","year":"2010","unstructured":"Golden-Mason L, Cox AL, Randall JA, Cheng L, Rosen HR (2010) Increased natural killer cell cytotoxicity and NKp30 expression protects against hepatitis C virus infection in high-risk individuals and inhibits replication in vitro. Hepatology 52:1581\u20131589","journal-title":"Hepatology"},{"key":"338_CR34","doi-asserted-by":"crossref","first-page":"12557","DOI":"10.1128\/JVI.00838-11","volume":"85","author":"JC Yoon","year":"2011","unstructured":"Yoon JC, Lim JB, Park JH, Lee JM (2011) Cell-to-cell contact with hepatitis C virus infected cells reduces functional capacity of natural killer cells. J Virol 85:12557\u201312569","journal-title":"J Virol"},{"key":"338_CR35","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/hep.25723","volume":"56","author":"S Varchetta","year":"2012","unstructured":"Varchetta S, Mele D, Mantovani S, Oliviero B, Cremonesi E et al (2012) Impaired intrahepatic natural killer cell cytotoxic function in chronic hepatitis C virus infection. Hepatology 56:841\u2013849","journal-title":"Hepatology"},{"key":"338_CR36","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1136\/gutjnl-2013-304472","volume":"63","author":"T Pembroke","year":"2014","unstructured":"Pembroke T, Christian A, Jones E, Hills RK, Wang EC et al (2014) The paradox of NKp46\u00a0+\u00a0natural killer cells: drivers of severe hepatitis C virus-induced pathology but in vivo resistance to interferon \u03b1 treatment. Gut 63:515\u2013524","journal-title":"Gut"},{"key":"338_CR37","doi-asserted-by":"crossref","first-page":"4148","DOI":"10.1128\/JVI.02340-09","volume":"84","author":"H Mao","year":"2010","unstructured":"Mao H, Tu W, Liu Y, Qin G, Zheng J et al (2010) Inhibition of human natural killer cell activity by influenza virions and hemagglutinin. J Virol 84:4148\u20134157","journal-title":"J Virol"},{"key":"338_CR38","doi-asserted-by":"crossref","first-page":"4672","DOI":"10.1182\/blood-2012-08-453738","volume":"121","author":"K Krzewski","year":"2013","unstructured":"Krzewski K, Gil-Krzewska A, Nguyen V, Peruzzi G, Coligan JE (2013) LAMP1\/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity. Blood 121:4672\u20134683","journal-title":"Blood"},{"key":"338_CR39","doi-asserted-by":"crossref","unstructured":"Zhang J, Zhang XF, Zhou C, et al. (2013) Protection against hepatitis E virus infection by naturally acquired and vaccine-induced immunity. Clin Microbiol Infect. doi: 10.1111\/1469-0691.12419","DOI":"10.1111\/1469-0691.12419"},{"key":"338_CR40","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1189\/jlb.0606409","volume":"81","author":"N Ralainirina","year":"2007","unstructured":"Ralainirina N, Poli A, Michel T, Poos L, Andre`s E, Hentges F, Zimmer J (2007) Control of NK cell functions by CD4+ CD25+ regulatory T cells. J Leuko Biol 81:144\u2013153","journal-title":"J Leuko Biol"},{"key":"338_CR41","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1084\/jem.20051511","volume":"202","author":"F Ghiringhelli","year":"2005","unstructured":"Ghiringhelli F, M\u00e9nard C, Terme M (2005) CD4+ CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor\u2014dependent manner. J Exp Med 202:1075\u20131085","journal-title":"J Exp Med"},{"key":"338_CR42","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.1073\/pnas.0730640100","volume":"100","author":"R Castriconi","year":"2003","unstructured":"Castriconi R, Cantoni C, Della Chiesa M, Vitale M, Marcenaro E et al (2003) Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells. Proc Natl Acad Sci U S A 100:4120\u20134125","journal-title":"Proc Natl Acad Sci U S A"},{"key":"338_CR43","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/jvh.12125","volume":"21","author":"SB Rathod","year":"2014","unstructured":"Rathod SB, Das R, Thanapati S, Arankalle VA, Tripathy AS (2014) Suppressive activity and altered conventional phenotype markers\/mediators of regulatory T cells in patients with self-limiting Hepatitis E. J Viral Hepat 21:141\u2013151","journal-title":"J Viral Hepat"}],"container-title":["Medical Microbiology and Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00430-014-0338-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00430-014-0338-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00430-014-0338-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T14:17:53Z","timestamp":1648995473000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00430-014-0338-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,14]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["338"],"URL":"https:\/\/doi.org\/10.1007\/s00430-014-0338-1","relation":{},"ISSN":["0300-8584","1432-1831"],"issn-type":[{"value":"0300-8584","type":"print"},{"value":"1432-1831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,14]]}}}