{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T05:10:14Z","timestamp":1781932214669,"version":"3.54.5"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2014,5,11]],"date-time":"2014-05-11T00:00:00Z","timestamp":1399766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Microbiol Immunol"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1007\/s00430-014-0339-0","type":"journal-article","created":{"date-parts":[[2014,5,10]],"date-time":"2014-05-10T15:56:27Z","timestamp":1399737387000},"page":"315-322","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Th1 and Th2 immune response to P30 and ROP18 peptides in human toxoplasmosis"],"prefix":"10.1007","volume":"203","author":[{"given":"Elizabeth","family":"Torres-Morales","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Taborda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nestor","family":"Cardona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"De-la-Torre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Sepulveda-Arias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel Alfonso","family":"Patarroyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Enrique","family":"Gomez-Marin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,5,11]]},"reference":[{"key":"339_CR1","unstructured":"G\u00f3mez-Marin JE (2010) Toxoplasmosis. In: Gomez-Marin JE. Protozoologia m\u00e9dica: Protozoos par\u00e1sitos en el contexto latinoamericano, 1st ed. Editorial Manual Moderno, Bogot\u00e1, p 65"},{"key":"339_CR2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.pt.2012.12.004","volume":"29","author":"LJ Robertson","year":"2013","unstructured":"Robertson LJ, van der Giessen JW, Batz MB, Kojima M, Cahill S (2013) Have foodborne parasites finally become a global concern? Trends Parasitol 29:101\u2013103","journal-title":"Trends Parasitol"},{"issue":"5","key":"339_CR3","doi-asserted-by":"crossref","first-page":"e1195","DOI":"10.1371\/journal.pntd.0001195","volume":"5","author":"J G\u00f3mez-Marin","year":"2011","unstructured":"G\u00f3mez-Marin J, de-la-Torre A, Angel-Muller E, Rubio J et al (2011) First Colombian multicentric newborn screening for congenital toxoplasmosis. PLoS Negl Trop Dis 5(5):e1195","journal-title":"PLoS Negl Trop Dis"},{"key":"339_CR4","first-page":"704","volume":"9","author":"AF Fatoohi","year":"2002","unstructured":"Fatoohi AF, Cozon GJ, Greenland T, Ferrandiz J, Bienvenu J, Picot S, Peyron F (2002) Cellular immune responses to recombinant antigens in pregnant women chronically infected with Toxoplasma gondii. Clin Diagn Lab Immunol 9:704\u2013707","journal-title":"Clin Diagn Lab Immunol"},{"issue":"5","key":"339_CR5","doi-asserted-by":"crossref","first-page":"e63201","DOI":"10.1371\/journal.pone.0063201","volume":"8","author":"\u00c9A Mendes","year":"2013","unstructured":"Mendes \u00c9A, Fonseca FG, Cas\u00e9rio BM, Colina JP, Gazzinelli RT, Caetano BC (2013) Recombinant vaccines against T. gondii: comparison between homologous and heterologous vaccination protocols using two viral vectors expressing SAG1. PLoS One 8(5):e63201","journal-title":"PLoS One"},{"key":"339_CR6","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.exppara.2006.02.005","volume":"114","author":"H Siachoque","year":"2006","unstructured":"Siachoque H, Guzman F, Burgos J, Patarroyo ME, Gomez-Marin JE (2006) Toxoplasma gondii: immunogenicity and protection by P30 peptides in a murine model. Exp Parasitol 114:62\u201365","journal-title":"Exp Parasitol"},{"key":"339_CR7","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1007\/s00436-013-3458-4","volume":"112","author":"Q Tao","year":"2013","unstructured":"Tao Q, Fang R, Zhang W, Wang Y, Cheng J, Li Y, Fang K, Khan MK, Hu M, Zhou Y, Zhao J (2013) Protective immunity induced by a DNA vaccine-encoding Toxoplasma gondii microneme protein 11 against acute toxoplasmosis in BALB\/c mice. Parasitol Res 112:2871\u20132877","journal-title":"Parasitol Res"},{"key":"339_CR8","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1007\/s00436-013-3425-0","volume":"112","author":"D Qu","year":"2013","unstructured":"Qu D, Han J, Du A (2013) Evaluation of protective effect of multiantigenic DNA vaccine encoding MIC3 and ROP18 antigen segments of Toxoplasma gondii in mice. Parasitol Res 112:2593\u20132599","journal-title":"Parasitol Res"},{"key":"339_CR9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1365-3024.2008.01029.x","volume":"30","author":"JC Sepulveda-Arias","year":"2008","unstructured":"Sepulveda-Arias JC, Kempf MC, Wiehr S, Wedekind D, Hedrich HJ, Gross U, Herrmann T (2008) Control of Toxoplasma gondii infection by athymic LEW-Whn rnu rats. Parasite Immunol 30:323\u2013333","journal-title":"Parasite Immunol"},{"issue":"6","key":"339_CR10","doi-asserted-by":"crossref","first-page":"e1003449","DOI":"10.1371\/journal.ppat.1003449","volume":"9","author":"V Feliu","year":"2013","unstructured":"Feliu V, Vasseur V, Grover HS, Chu HH, Brown MJ, Wang J, Boyle JP, Robey EA, Shastri N, Blanchard N (2013) Location of the CD8 T cell epitope within the antigenic precursor determines immunogenicity and protection against the Toxoplasma gondii parasite. PLoS Pathog 9(6):e1003449","journal-title":"PLoS Pathog"},{"key":"339_CR11","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1016\/j.vaccine.2010.03.028","volume":"28","author":"TG Tan","year":"2010","unstructured":"Tan TG, Mui E, Cong H et al (2010) Identification of T. gondii epitopes, adjuvants, and host genetic factors that influence protection of mice and humans. Vaccine 28:3977\u20133989","journal-title":"Vaccine"},{"key":"339_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.humimm.2011.10.006","volume":"73","author":"H Cong","year":"2012","unstructured":"Cong H, Mui EJ, Witola WH et al (2012) Toxoplasma gondii HLA-B*0702-restricted GRA7(20-28) peptide with adjuvants and a universal helper T cell epitope elicits CD8(+) T cells producing interferon-gamma and reduces parasite burden in HLA-B*0702 mice. Human Immunol 73:1\u201310","journal-title":"Human Immunol"},{"key":"339_CR13","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/eye.2008.219","volume":"23","author":"A de-la-Torre","year":"2009","unstructured":"de-la-Torre A, Lopez-Castillo C, Gomez-Marin JE (2009) Incidence and clinical characteristics in a Colombian cohort of ocular toxoplasmosis. Eye 23:1090\u20131093","journal-title":"Eye"},{"key":"339_CR14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.exppara.2009.06.017","volume":"123","author":"N Cardona","year":"2009","unstructured":"Cardona N, de-la-Torre A, Siachoque H, Patarroyo MA, Gomez-Marin JE (2009) Toxoplasma gondii: P30 peptides recognition pattern in human toxoplasmosis. Exp Parasitol 123:199\u2013202","journal-title":"Exp Parasitol"},{"key":"339_CR15","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1126\/science.1133643","volume":"314","author":"S Taylor","year":"2006","unstructured":"Taylor S, Barragan A, Su C et al (2006) A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii. Science 314:1776\u20131780","journal-title":"Science"},{"key":"339_CR16","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1128\/CDLI.5.6.745-748.1998","volume":"5","author":"S Kahi","year":"1998","unstructured":"Kahi S, Cozon GJN, Greenland T, Wallon M, Gay-Andrieu F, Peyron F (1998) Rapid flow cytometric method to explore cellular immunity against Toxoplasma gondii in humans. Clin Diag Lab Immunol 5:745\u2013748","journal-title":"Clin Diag Lab Immunol"},{"key":"339_CR17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10384-005-0295-8","volume":"50","author":"F Fatoohi","year":"2006","unstructured":"Fatoohi F, Cozon GJ, Wallon M, Kodjikian L, Peyron F (2006) Systemic T cell response to Toxoplasma gondii antigen in patients with ocular toxoplasmosis. Jpn J Ophthalmol 50:103\u2013110","journal-title":"Jpn J Ophthalmol"},{"issue":"11","key":"339_CR18","doi-asserted-by":"crossref","first-page":"e2541","DOI":"10.1371\/journal.pntd.0002541","volume":"7","author":"A de-la-Torre","year":"2013","unstructured":"de-la-Torre A, Sauer A, Bourcier T, Speeg-Schatz C, Ballonzoli L, Ajzenberg D, Sundar N, Grigg ME, Villard O, Brunet J, Pfaff A, Gomez-Marin J, Candolfi E (2013) Severe Southamerican ocular toxoplasmosis is associated with decreased IFN-gamma\/IL-17A and increased IL-6\/IL-13 intraocular levels. PLoS Neglected Trop Dis 7(11):e2541. doi: 10.1371\/journal.pntd.0002541","journal-title":"PLoS Neglected Trop Dis"},{"key":"339_CR19","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.actatropica.2005.10.001","volume":"97","author":"C Gallego","year":"2006","unstructured":"Gallego C, Saavedra-Matiz C, G\u00f3mez-Mar\u00edn JE (2006) Direct genotyping of animal and human isolates of Toxoplasma gondii from Colombia (South America). Acta Trop 97:161\u2013167","journal-title":"Acta Trop"},{"key":"339_CR20","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.parint.2013.10.012","volume":"63","author":"V S\u00e1nchez","year":"2014","unstructured":"S\u00e1nchez V, de-la-Torre A, G\u00f3mez Mar\u00edn JE (2014) Characterization of ROP18 alleles in human toxoplasmosis. Parasitol Int 63:463\u2013469","journal-title":"Parasitol Int"},{"key":"339_CR21","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.micinf.2008.04.001","volume":"10","author":"S Morisset","year":"2008","unstructured":"Morisset S, Peyron F, Lobry JR et al (2008) Serotyping of Toxoplasma gondii: striking homogeneous pattern between symptomatic and asymptomatic infections within Europe and South America. Microbes Infect 10:742\u2013747","journal-title":"Microbes Infect"},{"key":"339_CR22","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nature05395","volume":"445","author":"JP Saeij","year":"2007","unstructured":"Saeij JP, Coller S, Boyle JP, Jerome ME, White MW, Boothroyd JC (2007) Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue. Nature 445:324\u2013327","journal-title":"Nature"},{"key":"339_CR23","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1046\/j.1365-2249.1999.01019.x","volume":"117","author":"S Kahi","year":"1999","unstructured":"Kahi S, Cozon GJ, Pinon JM et al (1999) A switch towards Th2 during serological rebound in children with congenital toxoplasmosis. Clin Exp Immunol 117:524\u2013528","journal-title":"Clin Exp Immunol"},{"key":"339_CR24","first-page":"623","volume":"116","author":"R McLeod","year":"1990","unstructured":"McLeod R, Mack DG, Boyer K et al (1990) Phenotypes and functions of lymphocytes in congenital toxoplasmosis. J Lab Clin Med 116:623\u2013635","journal-title":"J Lab Clin Med"},{"key":"339_CR25","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1084\/jem.178.3.1041","volume":"178","author":"A D\u2019Andrea","year":"1993","unstructured":"D\u2019Andrea A, Aste-Amezaga M, Valiante NM, Ma X, Kubin M, Trinchieri G (1993) Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor\/IL-12 synthesis in accessory cells. J Exp Med 178:1041\u20131048","journal-title":"J Exp Med"},{"key":"339_CR26","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000101051","volume":"74","author":"M Kato","year":"2007","unstructured":"Kato M, Claveria FG, Maki Y et al (2007) Reactivity of synthetic SAG1 (p30) peptide sequences with RH, S273 and Beverley strain-induced anti-Toxoplasma gondii antibodies. Pathobiology 74:50\u201356","journal-title":"Pathobiology"}],"container-title":["Medical Microbiology and Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00430-014-0339-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00430-014-0339-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00430-014-0339-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T08:17:55Z","timestamp":1597825075000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00430-014-0339-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,11]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["339"],"URL":"https:\/\/doi.org\/10.1007\/s00430-014-0339-0","relation":{},"ISSN":["0300-8584","1432-1831"],"issn-type":[{"value":"0300-8584","type":"print"},{"value":"1432-1831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,11]]}}}