{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T21:01:46Z","timestamp":1788123706665,"version":"build-2803163510"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T00:00:00Z","timestamp":1539129600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T00:00:00Z","timestamp":1539129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Microbiol Immunol"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1007\/s00430-018-0567-9","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T18:31:09Z","timestamp":1539196269000},"page":"631-640","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Identification of complement-related host genetic risk factors associated with influenza A(H1N1)pdm09 outcome: challenges ahead"],"prefix":"10.1007","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4695-5753","authenticated-orcid":false,"given":"Fani","family":"Chatzopoulou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Gioula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Kioumis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Chatzidimitriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Exindari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,10]]},"reference":[{"key":"567_CR1","unstructured":"WHO (2014) World health organization: influenza (seasonal). http:\/\/www.who.int\/mediacentre\/factsheets\/fs211\/en\/. Accessed Sep 2017"},{"issue":"7249","key":"567_CR2","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1038\/nature08157","volume":"459","author":"G Neumann","year":"2009","unstructured":"Neumann G, Noda T, Kawaoka Y (2009) Emergence and pandemic potential of swine-origin H1N1 influenza virus. Nature 459(7249):931\u2013939. https:\/\/doi.org\/10.1038\/nature08157","journal-title":"Nature"},{"issue":"22","key":"567_CR3","first-page":"682","volume":"59","author":"CDC","year":"2010","unstructured":"CDC (2010) Deaths and hospitalizations related to 2009 pandemic influenza A (H1N1)\u2014Greece, May 2009\u2013February 2010. MMWR Morb Mortal Wkly Rep 59(22):682\u2013686","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"567_CR4","doi-asserted-by":"publisher","first-page":"RRN1194","DOI":"10.1371\/currents.RRN1194","volume":"2","author":"M Athanasiou","year":"2010","unstructured":"Athanasiou M, Lytras T, Spala G, Triantafyllou E, Gkolfinopoulou K, Theocharopoulos G, Patrinos S, Danis K, Detsis M, Tsiodras S, Bonovas S, Panagiotopoulos T (2010) Fatal cases associated with pandemic influenza A (H1N1) reported in Greece. PLoS Curr 2:RRN1194. https:\/\/doi.org\/10.1371\/currents.RRN1194","journal-title":"PLoS Curr"},{"key":"567_CR5","doi-asserted-by":"publisher","DOI":"10.2807\/ese.16.44.20004-en","author":"M Athanasiou","year":"2011","unstructured":"Athanasiou M, Baka A, Andreopoulou A, Spala G, Karageorgou K, Kostopoulos L, Patrinos S, Sideroglou T, Triantafyllou E, Mentis A, Malisiovas N, Lytras T, Tsiodras S, Panagiotopoulos T, Bonovas S (2011) Influenza surveillance during the post-pandemic influenza 2010\/11 season in Greece, 04 October 2010\u201322 May 2011. Euro Surveill. https:\/\/doi.org\/10.2807\/ese.16.44.20004-en","journal-title":"Euro Surveill"},{"issue":"2","key":"567_CR6","first-page":"150","volume":"17","author":"A Melidou","year":"2013","unstructured":"Melidou A, Exindari M, Gioula G, Malisiovas N (2013) Severity of the two post-pandemic influenza seasons 2010\u201311 and 2011\u201312 in Northern Greece. Hippokratia 17(2):150\u2013152","journal-title":"Hippokratia"},{"issue":"6","key":"567_CR7","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/S2213-2600(14)70034-7","volume":"2","author":"AC Hayward","year":"2014","unstructured":"Hayward AC, Fragaszy EB, Bermingham A, Wang L, Copas A, Edmunds WJ, Ferguson N, Goonetilleke N, Harvey G, Kovar J, Lim MS, McMichael A, Millett ER, Nguyen-Van-Tam JS, Nazareth I, Pebody R, Tabassum F, Watson JM, Wurie FB, Johnson AM, Zambon M, Flu Watch G (2014) Comparative community burden and severity of seasonal and pandemic influenza: results of the flu watch cohort study. Lancet Respir Med 2(6):445\u2013454. https:\/\/doi.org\/10.1016\/S2213-2600(14)70034-7","journal-title":"Lancet Respir Med"},{"issue":"2","key":"567_CR8","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1128\/CMR.05012-11","volume":"25","author":"VC Cheng","year":"2012","unstructured":"Cheng VC, To KK, Tse H, Hung IF, Yuen KY (2012) Two years after pandemic influenza A\/2009\/H1N1: what have we learned? Clin Microbiol Rev 25(2):223\u2013263. https:\/\/doi.org\/10.1128\/CMR.05012-11","journal-title":"Clin Microbiol Rev"},{"key":"567_CR9","unstructured":"CDC (2017) People at high risk of developing flu-related complications. Centers for disease control and prevention. https:\/\/www.cdc.gov\/flu\/about\/disease\/high_risk.htm. Accessed Sep 2017"},{"key":"567_CR10","first-page":"150","volume-title":"Influenza report 2006","author":"G van Zyl","year":"2006","unstructured":"van Zyl G (2006) Laboratory Findings. In: Kamps B, Hoffmann C, Preiser W (eds) Influenza report 2006. Flying Publisher, Paris, pp\u00a0150\u2013159"},{"issue":"9","key":"567_CR11","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/S1473-3099(12)70121-4","volume":"12","author":"FS Dawood","year":"2012","unstructured":"Dawood FS, Iuliano AD, Reed C, Meltzer MI, Shay DK, Cheng PY, Bandaranayake D, Breiman RF, Brooks WA, Buchy P, Feikin DR, Fowler KB, Gordon A, Hien NT, Horby P, Huang QS, Katz MA, Krishnan A, Lal R, Montgomery JM, Molbak K, Pebody R, Presanis AM, Razuri H, Steens A, Tinoco YO, Wallinga J, Yu H, Vong S, Bresee J, Widdowson MA (2012) Estimated global mortality associated with the first 12\u00a0months of 2009 pandemic influenza A H1N1 virus circulation: a modelling study. Lancet Infect Dis 12(9):687\u2013695. https:\/\/doi.org\/10.1016\/S1473-3099(12)70121-4","journal-title":"Lancet Infect Dis"},{"issue":"20","key":"567_CR12","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1056\/NEJMoa0906453","volume":"361","author":"K Hancock","year":"2009","unstructured":"Hancock K, Veguilla V, Lu X, Zhong W, Butler EN, Sun H, Liu F, Dong L, DeVos JR, Gargiullo PM, Brammer TL, Cox NJ, Tumpey TM, Katz JM (2009) Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus. N Engl J Med 361(20):1945\u20131952. https:\/\/doi.org\/10.1056\/NEJMoa0906453","journal-title":"N Engl J Med"},{"issue":"Suppl 2","key":"567_CR13","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1111\/irv.12079","volume":"7","author":"P Horby","year":"2013","unstructured":"Horby P, Nguyen NY, Dunstan SJ, Baillie JK (2013) An updated systematic review of the role of host genetics in susceptibility to influenza. Influenza Other Respir Viruses 7 Suppl 2:37\u201341. https:\/\/doi.org\/10.1111\/irv.12079","journal-title":"Influenza Other Respir Viruses"},{"issue":"3","key":"567_CR14","doi-asserted-by":"publisher","first-page":"e33180","DOI":"10.1371\/journal.pone.0033180","volume":"7","author":"P Horby","year":"2012","unstructured":"Horby P, Nguyen NY, Dunstan SJ, Baillie JK (2012) The role of host genetics in susceptibility to influenza: a systematic review. PLoS One 7(3):e33180. https:\/\/doi.org\/10.1371\/journal.pone.0033180","journal-title":"PLoS One"},{"issue":"3","key":"567_CR15","doi-asserted-by":"publisher","first-page":"e0118772","DOI":"10.1371\/journal.pone.0118772","volume":"10","author":"AF Ribeiro","year":"2015","unstructured":"Ribeiro AF, Pellini AC, Kitagawa BY, Marques D, Madalosso G, de Cassia Nogueira Figueira G, Fred J, Albernaz RK, Carvalhanas TR, Zanetta DM (2015) Risk factors for death from Influenza A(H1N1)pdm09, state of Sao Paulo, Brazil, 2009. PLoS One 10(3):e0118772. https:\/\/doi.org\/10.1371\/journal.pone.0118772","journal-title":"PLoS One"},{"issue":"1","key":"567_CR16","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1086\/524064","volume":"197","author":"FS Albright","year":"2008","unstructured":"Albright FS, Orlando P, Pavia AT, Jackson GG, Cannon Albright LA (2008) Evidence for a heritable predisposition to death due to influenza. J Infect Dis 197(1):18\u201324. https:\/\/doi.org\/10.1086\/524064","journal-title":"J Infect Dis"},{"issue":"4","key":"567_CR17","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1073\/pnas.0707659105","volume":"105","author":"M Gottfredsson","year":"2008","unstructured":"Gottfredsson M, Halldorsson BV, Jonsson S, Kristjansson M, Kristjansson K, Kristinsson KG, Love A, Blondal T, Viboud C, Thorvaldsson S, Helgason A, Gulcher JR, Stefansson K, Jonsdottir I (2008) Lessons from the past: familial aggregation analysis of fatal pandemic influenza (Spanish flu) in Iceland in 1918. Proc Natl Acad Sci USA 105(4):1303\u20131308. https:\/\/doi.org\/10.1073\/pnas.0707659105","journal-title":"Proc Natl Acad Sci USA"},{"issue":"38","key":"567_CR18","doi-asserted-by":"publisher","first-page":"16410","DOI":"10.1073\/pnas.0907439106","volume":"106","author":"Q Li","year":"2009","unstructured":"Li Q, Brass AL, Ng A, Hu Z, Xavier RJ, Liang TJ, Elledge SJ (2009) A genome-wide genetic screen for host factors required for hepatitis C virus propagation. Proc Natl Acad Sci USA 106(38):16410\u201316415. https:\/\/doi.org\/10.1073\/pnas.0907439106","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"567_CR19","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/j.cell.2009.12.017","volume":"139","author":"AL Brass","year":"2009","unstructured":"Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, Elledge SJ (2009) The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell 139(7):1243\u20131254. https:\/\/doi.org\/10.1016\/j.cell.2009.12.017","journal-title":"Cell"},{"issue":"7282","key":"567_CR20","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1038\/nature08699","volume":"463","author":"R K\u00f6nig","year":"2010","unstructured":"K\u00f6nig R, Stertz S, Zhou Y, Inoue A, Hoffmann HH, Bhattacharyya S, Alamares JG, Tscherne DM, Ortigoza MB, Liang Y, Gao Q, Andrews SE, Bandyopadhyay S, De Jesus P, Tu BP, Pache L, Shih C, Orth A, Bonamy G, Miraglia L, Ideker T, Garcia-Sastre A, Young JA, Palese P, Shaw ML, Chanda SK (2010) Human host factors required for influenza virus replication. Nature 463(7282):813\u2013817. https:\/\/doi.org\/10.1038\/nature08699","journal-title":"Nature"},{"key":"567_CR21","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.coviro.2015.04.010","volume":"14","author":"KK To","year":"2015","unstructured":"To KK, Zhou J, Chan JF, Yuen KY (2015) Host genes and influenza pathogenesis in humans: an emerging paradigm. Curr Opin Virol 14:7\u201315. https:\/\/doi.org\/10.1016\/j.coviro.2015.04.010","journal-title":"Curr Opin Virol"},{"issue":"3","key":"567_CR22","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1183\/09031936.00020611","volume":"39","author":"J Zuniga","year":"2012","unstructured":"Zuniga J, Buendia-Roldan I, Zhao Y, Jimenez L, Torres D, Romo J, Ramirez G, Cruz A, Vargas-Alarcon G, Sheu CC, Chen F, Su L, Tager AM, Pardo A, Selman M, Christiani DC (2012) Genetic variants associated with severe pneumonia in A\/H1N1 influenza infection. Eur Respir J 39(3):604\u2013610. https:\/\/doi.org\/10.1183\/09031936.00020611","journal-title":"Eur Respir J"},{"issue":"5","key":"567_CR23","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.coviro.2013.07.005","volume":"3","author":"TY Lin","year":"2013","unstructured":"Lin TY, Brass AL (2013) Host genetic determinants of influenza pathogenicity. Curr Opin Virol 3(5):531\u2013536. https:\/\/doi.org\/10.1016\/j.coviro.2013.07.005","journal-title":"Curr Opin Virol"},{"issue":"6822","key":"567_CR24","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1038\/35057149","volume":"409","author":"R Sachidanandam","year":"2001","unstructured":"Sachidanandam R, Weissman D, Schmidt SC, Kakol JM, Stein LD, Marth G, Sherry S, Mullikin JC, Mortimore BJ, Willey DL, Hunt SE, Cole CG, Coggill PC, Rice CM, Ning Z, Rogers J, Bentley DR, Kwok PY, Mardis ER, Yeh RT, Schultz B, Cook L, Davenport R, Dante M, Fulton L, Hillier L, Waterston RH, McPherson JD, Gilman B, Schaffner S, Van Etten WJ, Reich D, Higgins J, Daly MJ, Blumenstiel B, Baldwin J, Stange-Thomann N, Zody MC, Linton L, Lander ES, Altshuler D, International SNPMWG (2001) A map of human genome sequence variation containing 1.42\u00a0million single nucleotide polymorphisms. Nature 409(6822):928\u2013933. https:\/\/doi.org\/10.1038\/35057149","journal-title":"Nature"},{"issue":"5366","key":"567_CR25","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1126\/science.280.5366.1077","volume":"280","author":"DG Wang","year":"1998","unstructured":"Wang DG, Fan JB, Siao CJ, Berno A, Young P, Sapolsky R, Ghandour G, Perkins N, Winchester E, Spencer J, Kruglyak L, Stein L, Hsie L, Topaloglou T, Hubbell E, Robinson E, Mittmann M, Morris MS, Shen N, Kilburn D, Rioux J, Nusbaum C, Rozen S, Hudson TJ, Lipshutz R, Chee M, Lander ES (1998) Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science 280(5366):1077\u20131082","journal-title":"Science"},{"issue":"7311","key":"567_CR26","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/nature09298","volume":"467","author":"C International HapMap","year":"2010","unstructured":"International HapMap C, Altshuler DM, Gibbs RA, Peltonen L, Altshuler DM, Gibbs RA, Peltonen L, Dermitzakis E, Schaffner SF, Yu F, Peltonen L, Dermitzakis E, Bonnen PE, Altshuler DM, Gibbs RA, de Bakker PI, Deloukas P, Gabriel SB, Gwilliam R, Hunt S, Inouye M, Jia X, Palotie A, Parkin M, Whittaker P, Yu F, Chang K, Hawes A, Lewis LR, Ren Y, Wheeler D, Gibbs RA, Muzny DM, Barnes C, Darvishi K, Hurles M, Korn JM, Kristiansson K, Lee C, McCarrol SA, Nemesh J, Dermitzakis E, Keinan A, Montgomery SB, Pollack S, Price AL, Soranzo N, Bonnen PE, Gibbs RA, Gonzaga-Jauregui C, Keinan A, Price AL, Yu F, Anttila V, Brodeur W, Daly MJ, Leslie S, McVean G, Moutsianas L, Nguyen H, Schaffner SF, Zhang Q, Ghori MJ, McGinnis R, McLaren W, Pollack S, Price AL, Schaffner SF, Takeuchi F, Grossman SR, Shlyakhter I, Hostetter EB, Sabeti PC, Adebamowo CA, Foster MW, Gordon DR, Licinio J, Manca MC, Marshall PA, Matsuda I, Ngare D, Wang VO, Reddy D, Rotimi CN, Royal CD, Sharp RR, Zeng C, Brooks LD, McEwen JE (2010) Integrating common and rare genetic variation in diverse human populations. Nature 467(7311):52\u201358. https:\/\/doi.org\/10.1038\/nature09298","journal-title":"Nature"},{"issue":"7395","key":"567_CR27","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nature10921","volume":"484","author":"AR Everitt","year":"2012","unstructured":"Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB, Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam P (2012) IFITM3 restricts the morbidity and mortality associated with influenza. Nature 484(7395):519\u2013523. https:\/\/doi.org\/10.1038\/nature10921","journal-title":"Nature"},{"issue":"3","key":"567_CR28","doi-asserted-by":"publisher","first-page":"e204","DOI":"10.1016\/j.ijid.2011.11.012","volume":"16","author":"A Antonopoulou","year":"2012","unstructured":"Antonopoulou A, Baziaka F, Tsaganos T, Raftogiannis M, Koutoukas P, Spyridaki A, Mouktaroudi M, Kotsaki A, Savva A, Georgitsi M, Giamarellos-Bourboulis EJ (2012) Role of tumor necrosis factor gene single nucleotide polymorphisms in the natural course of 2009 influenza A H1N1 virus infection. Int J Infect Dis 16(3):e204\u2013e208. https:\/\/doi.org\/10.1016\/j.ijid.2011.11.012","journal-title":"Int J Infect Dis"},{"issue":"4","key":"567_CR29","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1093\/infdis\/jis378","volume":"206","author":"J Zhou","year":"2012","unstructured":"Zhou J, To KK, Dong H, Cheng ZS, Lau CC, Poon VK, Fan YH, Song YQ, Tse H, Chan KH, Zheng BJ, Zhao GP, Yuen KY (2012) A functional variation in CD55 increases the severity of 2009 pandemic H1N1 influenza A virus infection. J Infect Dis 206(4):495\u2013503. https:\/\/doi.org\/10.1093\/infdis\/jis378","journal-title":"J Infect Dis"},{"issue":"10","key":"567_CR30","doi-asserted-by":"publisher","first-page":"e0139681","DOI":"10.1371\/journal.pone.0139681","volume":"10","author":"A Maestri","year":"2015","unstructured":"Maestri A, Sortica VA, Tovo-Rodrigues L, Santos MC, Barbagelata L, Moraes MR, Alencar de Mello W, Gusmao L, Sousa RC, Emanuel Batista Dos Santos S (2015) Siaalpha2-3Galbeta1- receptor genetic variants are associated with influenza A(H1N1)pdm09 severity. PLoS One 10(10):e0139681. https:\/\/doi.org\/10.1371\/journal.pone.0139681","journal-title":"PLoS One"},{"key":"567_CR31","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1186\/1471-2334-12-299","volume":"12","author":"G Morales-Garcia","year":"2012","unstructured":"Morales-Garcia G, Falfan-Valencia R, Garcia-Ramirez RA, Camarena A, Ramirez-Venegas A, Castillejos-Lopez M, Perez-Rodriguez M, Gonzalez-Bonilla C, Grajales-Muniz C, Borja-Aburto V, Mejia-Arangure JM (2012) Pandemic influenza A\/H1N1 virus infection and TNF, LTA, IL1B, IL6, IL8, and CCL polymorphisms in Mexican population: a case\u2013control study. BMC Infect Dis 12:299. https:\/\/doi.org\/10.1186\/1471-2334-12-299","journal-title":"BMC Infect Dis"},{"issue":"4","key":"567_CR32","doi-asserted-by":"publisher","first-page":"6216","DOI":"10.18632\/oncotarget.14053","volume":"8","author":"Y Zhang","year":"2017","unstructured":"Zhang Y, Zhang Z, Cao L, Lin J, Yang Z, Zhang X (2017) A common CD55 rs2564978 variant is associated with the susceptibility of non-small cell lung cancer. Oncotarget 8(4):6216\u20136221. https:\/\/doi.org\/10.18632\/oncotarget.14053","journal-title":"Oncotarget"},{"issue":"1\u20132","key":"567_CR33","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S0162-3109(00)80301-X","volume":"49","author":"U Kishore","year":"2000","unstructured":"Kishore U, Reid KB (2000) C1q: structure, function, and receptors. Immunopharmacology 49(1\u20132):159\u2013170","journal-title":"Immunopharmacology"},{"issue":"5","key":"567_CR34","doi-asserted-by":"publisher","first-page":"R167","DOI":"10.1186\/cc9259","volume":"14","author":"JF Bermejo-Martin","year":"2010","unstructured":"Bermejo-Martin JF, Martin-Loeches I, Rello J, Anton A, Almansa R, Xu L, Lopez-Campos G, Pumarola T, Ran L, Ramirez P, Banner D, Ng DC, Socias L, Loza A, Andaluz D, Maravi E, Gomez-Sanchez MJ, Gordon M, Gallegos MC, Fernandez V, Aldunate S, Leon C, Merino P, Blanco J, Martin-Sanchez F, Rico L, Varillas D, Iglesias V, Marcos MA, Gandia F, Bobillo F, Nogueira B, Rojo S, Resino S, Castro C, Ortiz de Lejarazu R, Kelvin D (2010) Host adaptive immunity deficiency in severe pandemic influenza. Crit Care 14(5):R167. https:\/\/doi.org\/10.1186\/cc9259","journal-title":"Crit Care"},{"key":"567_CR35","unstructured":"CDC (2009) CDC protocol of realtime RTPCR for swine influenza A(H1N1). World health organisation. http:\/\/www.who.int\/csr\/resources\/publications\/swineflu\/CDCrealtimeRTPCRprotocol_20090428.pdf. Accessed Sep 2017"},{"issue":"Suppl 2","key":"567_CR36","doi-asserted-by":"publisher","first-page":"S27","DOI":"10.1086\/511159","volume":"44","author":"LA Mandell","year":"2007","unstructured":"Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, Dowell SF, File TM Jr, Musher DM, Niederman MS, Torres A, Whitney CG,, American Thoracic S (2007) Infectious diseases society of A. infectious diseases society of America\/American thoracic society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 44(Suppl 2):S27\u2013S72. https:\/\/doi.org\/10.1086\/511159","journal-title":"Clin Infect Dis"},{"key":"567_CR37","volume-title":"Multiple comparisons using R","author":"F Bretz","year":"2010","unstructured":"Bretz F, Hothorn T, Westfall P (2010) Multiple comparisons using R. Chapman and Hall\/CRC, Boca Raton"},{"key":"567_CR38","unstructured":"WHO (2009) Pandemic (H1N1) 2009\u2014update 109. WHO global alert and response [online]. http:\/\/www.who.int\/csr\/don\/2010_07_16\/en\/index.html Accessed Sep 2017"},{"issue":"9","key":"567_CR39","doi-asserted-by":"publisher","first-page":"e0135983","DOI":"10.1371\/journal.pone.0135983","volume":"10","author":"K Garcia-Etxebarria","year":"2015","unstructured":"Garcia-Etxebarria K, Bracho MA, Galan JC, Pumarola T, Castilla J, Ortiz de Lejarazu R, Rodriguez-Dominguez M, Quintela I, Bonet N, Garcia-Garcera M, Dominguez A, Gonzalez-Candelas F, Calafell F, Cases C, Controls in Pandemic Influenza Working G (2015) No major host genetic risk factor contributed to A(H1N1)2009 influenza severity. PLoS One 10(9):e0135983. https:\/\/doi.org\/10.1371\/journal.pone.0135983","journal-title":"PLoS One"},{"issue":"1","key":"567_CR40","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1093\/infdis\/jix235","volume":"216","author":"N Lee","year":"2017","unstructured":"Lee N, Cao B, Ke C, Lu H, Hu Y, Tam CHT, Ma RCW, Guan D, Zhu Z, Li H, Lin M, Wong RYK, Yung IMH, Hung TN, Kwok K, Horby P, Hui DSC, Chan MCW, Chan PKS (2017) IFITM3, TLR3, and CD55 gene SNPs and cumulative genetic risks for severe outcomes in Chinese patients with H7N9\/H1N1pdm09 influenza. J Infect Dis 216(1):97\u2013104. https:\/\/doi.org\/10.1093\/infdis\/jix235","journal-title":"J Infect Dis"},{"issue":"2","key":"567_CR41","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.virol.2010.12.045","volume":"411","author":"KA Stoermer","year":"2011","unstructured":"Stoermer KA, Morrison TE (2011) Complement and viral pathogenesis. Virology 411(2):362\u2013373. https:\/\/doi.org\/10.1016\/j.virol.2010.12.045","journal-title":"Virology"},{"issue":"8","key":"567_CR42","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1002\/eji.1830210820","volume":"21","author":"MR Clark","year":"1991","unstructured":"Clark MR, Stuart SG, Kimberly RP, Ory PA, Goldstein IM (1991) A single amino acid distinguishes the high-responder from the low-responder form of Fc receptor II on human monocytes. Eur J Immunol 21(8):1911\u20131916. https:\/\/doi.org\/10.1002\/eji.1830210820","journal-title":"Eur J Immunol"},{"issue":"3","key":"567_CR43","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1034\/j.1399-0039.2003.00037.x","volume":"61","author":"NM van Sorge","year":"2003","unstructured":"van Sorge NM, van der Pol WL, van de Winkel JG (2003) FcgammaR polymorphisms: Implications for function, disease susceptibility and immunotherapy. Tissue Antigens 61(3):189\u2013202","journal-title":"Tissue Antigens"},{"key":"567_CR44","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1186\/s13104-016-2096-1","volume":"9","author":"A Maestri","year":"2016","unstructured":"Maestri A, Sortica VA, Ferreira DL, de Almeida Ferreira J, Amador MA, de Mello WA, Santos SE, Sousa RC (2016) The His131Arg substitution in the FCGR2A gene (rs1801274) is not associated with the severity of influenza A(H1N1)pdm09 infection. BMC Res Notes 9:296. https:\/\/doi.org\/10.1186\/s13104-016-2096-1","journal-title":"BMC Res Notes"}],"container-title":["Medical Microbiology and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00430-018-0567-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00430-018-0567-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00430-018-0567-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T05:18:13Z","timestamp":1744175893000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00430-018-0567-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,10]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["567"],"URL":"https:\/\/doi.org\/10.1007\/s00430-018-0567-9","relation":{},"ISSN":["0300-8584","1432-1831"],"issn-type":[{"value":"0300-8584","type":"print"},{"value":"1432-1831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,10]]},"assertion":[{"value":"2 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures included in this work were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. To this end, the ethical approval of this study has been provided by the \u201cBioethics Committee of the Medical School of the Aristotle University of Thessaloniki\u201d (protocol approval number 432).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}