{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:18:02Z","timestamp":1790338682534,"version":"4.1.0"},"reference-count":120,"publisher":"Springer Science and Business Media LLC","issue":"3-4","license":[{"start":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T00:00:00Z","timestamp":1553731200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T00:00:00Z","timestamp":1553731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["KK.01.1.1.01.0006"],"award-info":[{"award-number":["KK.01.1.1.01.0006"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DC015980-01A1"],"award-info":[{"award-number":["R01 DC015980-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI089956"],"award-info":[{"award-number":["AI089956"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004488","name":"Hrvatska Zaklada za Znanost","doi-asserted-by":"publisher","award":["IP-2018-01-9086"],"award-info":[{"award-number":["IP-2018-01-9086"]}],"id":[{"id":"10.13039\/501100004488","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1292, TP11"],"award-info":[{"award-number":["SFB1292, TP11"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Microbiol Immunol"],"published-print":{"date-parts":[[2019,8,1]]},"DOI":"10.1007\/s00430-019-00600-1","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T08:03:15Z","timestamp":1553760195000},"page":"415-429","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Role of antibodies in confining cytomegalovirus after reactivation from latency: three decades\u2019 r\u00e9sum\u00e9"],"prefix":"10.1007","volume":"208","author":[{"given":"Astrid","family":"Krmpoti\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Podlech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias J.","family":"Reddehase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Britt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stipan","family":"Jonji\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,3,28]]},"reference":[{"key":"600_CR1","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1146\/annurev.mi.41.100187.002551","volume":"41","author":"B Roizman","year":"1987","unstructured":"Roizman B, Sears AE (1987) An inquiry into the mechanisms of herpes simplex virus latency. Annu Rev Microbiol 41:543\u2013571. https:\/\/doi.org\/10.1146\/annurev.mi.41.100187.002551","journal-title":"Annu Rev Microbiol"},{"issue":"Suppl 2","key":"600_CR2","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1016\/S1386-6532(02)00087-2","volume":"25","author":"MJ Reddehase","year":"2002","unstructured":"Reddehase MJ, Podlech J, Grzimek NK (2002) Mouse models of cytomegalovirus latency: overview. J Clin Virol 25(Suppl 2):S23\u2013S36","journal-title":"J Clin Virol"},{"key":"600_CR3","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-019-00581-1","author":"E Elder","year":"2019","unstructured":"Elder E, Sinclair J (2019) HCMV latency: what regulates the regulators? Med Microbiol Immunol. https:\/\/doi.org\/10.1007\/s00430-019-00581-1","journal-title":"Med Microbiol Immunol"},{"key":"600_CR4","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-019-00592-y","author":"MJ Reddehase","year":"2019","unstructured":"Reddehase MJ, Lemmermann NA (2019) Cellular reservoirs of latent cytomegaloviruses. Med Microbiol Immunol. https:\/\/doi.org\/10.1007\/s00430-019-00592-y","journal-title":"Med Microbiol Immunol"},{"key":"600_CR5","first-page":"1","volume-title":"Cytomegaloviruses: from molecular pathogenesis to intervention","author":"SB Boppana","year":"2013","unstructured":"Boppana SB, Britt WJ (2013) Synopsis of clinical aspects of human cytomegalovirus disease. In: Reddehase MJ (ed) Cytomegaloviruses: from molecular pathogenesis to intervention, vol\u00a02. Caister Academic Press, Norfolk, pp\u00a01\u201326"},{"key":"600_CR6","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s00430-007-0066-x","volume":"197","author":"M Ho","year":"2008","unstructured":"Ho M (2008) The history of cytomegalovirus and its diseases. Med Microbiol Immunol 197:65\u201373. https:\/\/doi.org\/10.1007\/s00430-007-0066-x","journal-title":"Med Microbiol Immunol"},{"issue":"Suppl 4","key":"600_CR7","doi-asserted-by":"publisher","first-page":"S6","DOI":"10.1016\/j.jcv.2009.09.002","volume":"46","author":"MJ Cannon","year":"2009","unstructured":"Cannon MJ (2009) Congenital cytomegalovirus (CMV) epidemiology and awareness. J Clin Virol 46(Suppl 4):S6\u2013S10. https:\/\/doi.org\/10.1016\/j.jcv.2009.09.002","journal-title":"J Clin Virol"},{"key":"600_CR8","doi-asserted-by":"publisher","first-page":"e02392","DOI":"10.1128\/JVI.02392-16","volume":"91","author":"WJ Britt","year":"2017","unstructured":"Britt WJ (2017) Congenital human cytomegalovirus infection and the enigma of maternal immunity. J Virol 91:e02392\u2013e02316. https:\/\/doi.org\/10.1128\/JVI.02392-16","journal-title":"J Virol"},{"key":"600_CR9","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s00430-015-0415-0","volume":"204","author":"JG Sissons","year":"2015","unstructured":"Sissons JG, Wills MR (2015) How understanding immunology contributes to managing CMV disease in immunosuppressed patients: now and in future. Med Microbiol Immunol 204:307\u2013316. https:\/\/doi.org\/10.1007\/s00430-015-0415-0","journal-title":"Med Microbiol Immunol"},{"key":"600_CR10","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1038\/nri932","volume":"2","author":"MJ Reddehase","year":"2002","unstructured":"Reddehase MJ (2002) Antigens and immunoevasins: opponents in cytomegalovirus immune surveillance. Nat Rev Immunol 2:831\u2013844. https:\/\/doi.org\/10.1038\/nri932","journal-title":"Nat Rev Immunol"},{"key":"600_CR11","doi-asserted-by":"publisher","first-page":"294","DOI":"10.3389\/fimmu.2016.00294","volume":"7","author":"MJ Reddehase","year":"2016","unstructured":"Reddehase MJ (2016) Mutual interference between cytomegalovirus and reconstitution of protective immunity after hematopoietic cell transplantation. Front Immunol 7:294. https:\/\/doi.org\/10.3389\/fimmu.2016.00294","journal-title":"Front Immunol"},{"key":"600_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/v10120693","author":"MJ Reddehase","year":"2018","unstructured":"Reddehase MJ, Lemmermann NAW (2018) Mouse model of cytomegalovirus disease and immunotherapy in the immunocompromised host: predictions for medical translation that survived the \u201ctest of time\u201d. Viruses. https:\/\/doi.org\/10.3390\/v10120693","journal-title":"Viruses"},{"key":"600_CR13","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1128\/jvi.55.2.264-273.1985","volume":"55","author":"MJ Reddehase","year":"1985","unstructured":"Reddehase MJ, Weiland F, M\u00fcnch K, Jonjic S, L\u00fcske A, Koszinowski UH (1985) Interstitial murine cytomegalovirus pneumonia after irradiation: characterization of cells that limit viral replication during established infection of the lungs. J Virol 55:264\u2013273","journal-title":"J Virol"},{"key":"600_CR14","first-page":"119","volume-title":"Cytomegaloviruses from molecular pathogenesis to intervention","author":"WJ Britt","year":"2013","unstructured":"Britt WJ, Cekinovic D, Jonjic S (2013) Murine model of neonatal cytomegalovirus infection. In: Reddehase MJ (ed) Cytomegaloviruses from molecular pathogenesis to intervention, vol\u00a01. Caister Academic Press, Norfolk, pp\u00a0119\u2013141"},{"key":"600_CR15","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1128\/jvi.62.3.1061-1065.1988","volume":"62","author":"MJ Reddehase","year":"1988","unstructured":"Reddehase MJ, Jonjic S, Weiland F, Mutter W, Koszinowski UH (1988) Adoptive immunotherapy of murine cytomegalovirus adrenalitis in the immunocompromised host: CD4-helper-independent antiviral function of CD8-positive memory T lymphocytes derived from latently infected donors. J Virol 62:1061\u20131065","journal-title":"J Virol"},{"key":"600_CR16","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1084\/jem.169.4.1199","volume":"169","author":"S Jonji\u0107","year":"1989","unstructured":"Jonji\u0107 S, Mutter W, Weiland F, Reddehase MJ, Koszinowski UH (1989) Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4 + T lymphocytes. J Exp Med 169:1199\u20131212","journal-title":"J Exp Med"},{"key":"600_CR17","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1128\/jvi.66.4.1977-1984.1992","volume":"66","author":"P Lucin","year":"1992","unstructured":"Lucin P, Pavic I, Polic B, Jonjic S, Koszinowski UH (1992) Gamma interferon-dependent clearance of cytomegalovirus infection in salivary glands. J Virol 66:1977\u20131984","journal-title":"J Virol"},{"issue":"8","key":"600_CR18","doi-asserted-by":"publisher","first-page":"e1002214","DOI":"10.1371\/journal.ppat.1002214","volume":"7","author":"SM Walton","year":"2011","unstructured":"Walton SM, Mandaric S, Torti N, Zimmermann A, Hengel H, Oxenius A (2011) Absence of cross-presenting cells in the salivary gland and viral immune evasion confine cytomegalovirus immune control to effector CD4 T cells. PLoS Pathog 7(8):e1002214. https:\/\/doi.org\/10.1371\/journal.ppat.1002214","journal-title":"PLoS Pathog"},{"key":"600_CR19","doi-asserted-by":"crossref","first-page":"5457","DOI":"10.1128\/jvi.64.11.5457-5464.1990","volume":"64","author":"S Jonjic","year":"1990","unstructured":"Jonjic S, Pavic I, Lucin P, Rukavina D, Koszinowski UH (1990) Efficacious control of cytomegalovirus infection after long-term depletion of CD8 + T lymphocytes. J Virol 64:5457\u20135464","journal-title":"J Virol"},{"key":"600_CR20","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1099\/0022-1317-77-2-217","volume":"77","author":"B Poli\u0107","year":"1996","unstructured":"Poli\u0107 B, Jonji\u0107 S, Pavi\u0107 I, Crnkovi\u0107 I, Zorica I, Hengel H, Lucin P, Koszinowski UH (1996) Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo. J Gen Virol 77:217\u2013225. https:\/\/doi.org\/10.1099\/0022-1317-77-2-217","journal-title":"J Gen Virol"},{"key":"600_CR21","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1099\/0022-1317-79-9-2099","volume":"79","author":"J Podlech","year":"1998","unstructured":"Podlech J, Holtappels R, Wirtz N, Steffens HP, Reddehase MJ (1998) Reconstitution of CD8 T cells is essential for the prevention of multiple-organ cytomegalovirus histopathology after bone marrow transplantation. J Gen Virol 79:2099\u20132104. https:\/\/doi.org\/10.1099\/0022-1317-79-9-2099","journal-title":"J Gen Virol"},{"key":"600_CR22","doi-asserted-by":"crossref","first-page":"7496","DOI":"10.1128\/JVI.74.16.7496-7507.2000","volume":"74","author":"J Podlech","year":"2000","unstructured":"Podlech J, Holtappels R, Pahl-Seibert MF, Steffens HP, Reddehase MJ (2000) Murine model of interstitial cytomegalovirus pneumonia in syngeneic bone marrow transplantation: persistence of protective pulmonary CD8-T-cell infiltrates after clearance of acute infection. J Virol 74:7496\u20137507","journal-title":"J Virol"},{"key":"600_CR23","first-page":"353","volume-title":"Cytomegaloviruses: from molecular pathogenesis to intervention","author":"R Holtappels","year":"2013","unstructured":"Holtappels R, Ebert S, Podlech J, Fink A, B\u00f6hm V, Lemmermann NAW, Freitag K, Renzaho A, Thomas D, Reddehase MJ (2013) Murine model for cytoimmunotherapy of CMV disease after hematopoietic cell transplantation. In: Reddehase MJ (ed) Cytomegaloviruses: from molecular pathogenesis to intervention, vol\u00a02. Caister Academic Press, Norfolk, pp\u00a0353\u2013381"},{"key":"600_CR24","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1099\/0022-1317-72-1-149","volume":"72","author":"HE Farrell","year":"1991","unstructured":"Farrell HE, Shellam GR (1991) Protection against murine cytomegalovirus infection by passive transfer of neutralizing and non-neutralizing monoclonal antibodies. J Gen Virol 72:149\u2013156. https:\/\/doi.org\/10.1099\/0022-1317-72-1-149","journal-title":"J Gen Virol"},{"key":"600_CR25","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/infdis\/143.2.231","volume":"143","author":"JD Shanley","year":"1981","unstructured":"Shanley JD, Jordan MC, Stevens JG (1981) Modification by adoptive humoral immunity of murine cytomegalovirus infection. J Infect Dis 143:231\u2013237","journal-title":"J Infect Dis"},{"key":"600_CR26","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/350423a0","volume":"350","author":"D Kitamura","year":"1991","unstructured":"Kitamura D, Roes J, Kuhn R, Rajewsky K (1991) A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature 350:423\u2013426. https:\/\/doi.org\/10.1038\/350423a0","journal-title":"Nature"},{"key":"600_CR27","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1084\/jem.179.5.1713","volume":"179","author":"S Jonjic","year":"1994","unstructured":"Jonjic S, Pavic I, Polic B, Crnkovic I, Lucin P, Koszinowski UH (1994) Antibodies are not essential for the resolution of primary cytomegalovirus infection but limit dissemination of recurrent virus. J Exp Med 179:1713\u20131717","journal-title":"J Exp Med"},{"key":"600_CR28","doi-asserted-by":"publisher","first-page":"e1006601","DOI":"10.1371\/journal.ppat.1006601","volume":"13","author":"A Bootz","year":"2017","unstructured":"Bootz A, Karbach A, Spindler J, Kropff B, Reuter N, Sticht H, Winkler TH, Britt WJ, Mach M (2017) Protective capacity of neutralizing and non-neutralizing antibodies against glycoprotein B of cytomegalovirus. PLoS Pathog 13:e1006601. https:\/\/doi.org\/10.1371\/journal.ppat.1006601","journal-title":"PLoS Pathog"},{"key":"600_CR29","doi-asserted-by":"publisher","first-page":"3472","DOI":"10.1182\/blood-2007-06-095414","volume":"110","author":"K Klenovsek","year":"2007","unstructured":"Klenovsek K, Weisel F, Schneider A, Appelt U, Jonjic S, Messerle M, Bradel-Tretheway B, Winkler TH, Mach M (2007) Protection from CMV infection in immunodeficient hosts by adoptive transfer of memory B cells. Blood 110:3472\u20133479. https:\/\/doi.org\/10.1182\/blood-2007-06-095414","journal-title":"Blood"},{"key":"600_CR30","doi-asserted-by":"publisher","first-page":"12172","DOI":"10.1128\/JVI.01214-08","volume":"82","author":"D Cekinovic","year":"2008","unstructured":"Cekinovic D, Golemac M, Pugel EP, Tomac J, Cicin-Sain L, Slavuljica I, Bradford R, Misch S, Winkler TH, Mach M, Britt WJ, Jonjic S (2008) Passive immunization reduces murine cytomegalovirus-induced brain pathology in newborn mice. J Virol 82:12172\u201312180. https:\/\/doi.org\/10.1128\/JVI.01214-08","journal-title":"J Virol"},{"key":"600_CR31","doi-asserted-by":"publisher","first-page":"4532","DOI":"10.1172\/JCI43961","volume":"120","author":"I Slavuljica","year":"2010","unstructured":"Slavuljica I, Busche A, Babi\u0107 M, Mitrovi\u0107 M, Ga\u0161parovi\u0107 I, Cekinovi\u0107 D, Markova Car E, Pernjak Pugel E, Cikovi\u0107 A, Lisni\u0107 VJ, Britt WJ, Koszinowski U, Messerle M, Krmpoti\u0107 A, Jonji\u0107 S (2010) Recombinant mouse cytomegalovirus expressing a ligand for the NKG2D receptor is attenuated and has improved vaccine properties. J Clin Invest 120:4532\u20134545. https:\/\/doi.org\/10.1172\/JCI43961","journal-title":"J Clin Invest"},{"key":"600_CR32","doi-asserted-by":"publisher","first-page":"991","DOI":"10.3389\/fimmu.2018.00991","volume":"9","author":"L Hirsl","year":"2018","unstructured":"Hirsl L, Brizic I, Jenus T, Juranic Lisnic V, Reichel JJ, Jurkovic S, Krmpotic A, Jonjic S (2018) Murine CMV expressing the high affinity NKG2D ligand MULT-1: a model for the development of cytomegalovirus-based vaccines. Front Immunol 9:991. https:\/\/doi.org\/10.3389\/fimmu.2018.00991","journal-title":"Front Immunol"},{"key":"600_CR33","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1128\/iai.10.4.966-969.1974","volume":"10","author":"MB Gardner","year":"1974","unstructured":"Gardner MB, Officer JE, Parker J, Estes JD, Rongey RW (1974) Induction of disseminated virulent cytomegalovirus infection by immunosuppression of naturally chronically infected wild mice. Infect Immun 10:966\u2013969","journal-title":"Infect Immun"},{"key":"600_CR34","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1099\/0022-1317-37-2-419","volume":"37","author":"MC Jordan","year":"1977","unstructured":"Jordan MC, Shanley JD, Stevens JG (1977) Immunosuppression reactivates and disseminates latent murine cytomegalovirus. J Gen Virol 37:419\u2013423. https:\/\/doi.org\/10.1099\/0022-1317-37-2-419","journal-title":"J Gen Virol"},{"key":"600_CR35","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/267721a0","volume":"267","author":"DR Mayo","year":"1977","unstructured":"Mayo DR, Armstrong JA, Ho M (1977) Reactivation of murine cytomegalovirus by cyclophosphamide. Nature 267:721\u2013723","journal-title":"Nature"},{"key":"600_CR36","doi-asserted-by":"crossref","first-page":"5360","DOI":"10.1128\/jvi.67.9.5360-5366.1993","volume":"67","author":"M Balthesen","year":"1993","unstructured":"Balthesen M, Messerle M, Reddehase MJ (1993) Lungs are a major organ site of cytomegalovirus latency and recurrence. J Virol 67:5360\u20135366","journal-title":"J Virol"},{"key":"600_CR37","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1084\/jem.179.1.185","volume":"179","author":"MJ Reddehase","year":"1994","unstructured":"Reddehase MJ, Balthesen M, Rapp M, Jonjic S, Pavic I, Koszinowski UH (1994) The conditions of primary infection define the load of latent viral genome in organs and the risk of recurrent cytomegalovirus disease. J Exp Med 179:185\u2013193","journal-title":"J Exp Med"},{"key":"600_CR38","doi-asserted-by":"crossref","first-page":"8612","DOI":"10.1128\/JVI.73.10.8612-8622.1999","volume":"73","author":"SK Kurz","year":"1999","unstructured":"Kurz SK, Reddehase MJ (1999) Patchwork pattern of transcriptional reactivation in the lungs indicates sequential checkpoints in the transition from murine cytomegalovirus latency to recurrence. J Virol 73:8612\u20138622","journal-title":"J Virol"},{"key":"600_CR39","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.antiviral.2009.12.004","volume":"85","author":"MR Forster","year":"2010","unstructured":"Forster MR, Trgovcich J, Zimmerman P, Chang A, Miller C, Klenerman P, Cook CH (2010) Antiviral prevention of sepsis induced cytomegalovirus reactivation in immunocompetent mice. Antiviral Res 85:496\u2013503. https:\/\/doi.org\/10.1016\/j.antiviral.2009.12.004","journal-title":"Antiviral Res"},{"key":"600_CR40","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1128\/JVI.72.3.1797-1804.1998","volume":"72","author":"HP Steffens","year":"1998","unstructured":"Steffens HP, Kurz S, Holtappels R, Reddehase MJ (1998) Preemptive CD8 T-cell immunotherapy of acute cytomegalovirus infection prevents lethal disease, limits the burden of latent viral genomes, and reduces the risk of virus recurrence. J Virol 72:1797\u20131804","journal-title":"J Virol"},{"key":"600_CR41","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1084\/jem.188.6.1047","volume":"188","author":"B Polic","year":"1998","unstructured":"Polic B, Hengel H, Krmpotic A, Trgovcich J, Pavic I, Luccaronin P, Jonjic S, Koszinowski UH (1998) Hierarchical and redundant lymphocyte subset control precludes cytomegalovirus replication during latent infection. J Exp Med 188:1047\u20131054","journal-title":"J Exp Med"},{"key":"600_CR42","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.micinf.2003.09.007","volume":"5","author":"A Krmpotic","year":"2003","unstructured":"Krmpotic A, Bubic I, Polic B, Lucin P, Jonjic S (2003) Pathogenesis of murine cytomegalovirus infection. Microbes Infect 5:1263\u20131277","journal-title":"Microbes Infect"},{"key":"600_CR43","doi-asserted-by":"publisher","first-page":"10436","DOI":"10.1128\/JVI.01248-06","volume":"80","author":"CO Simon","year":"2006","unstructured":"Simon CO, Holtappels R, Tervo HM, B\u00f6hm V, D\u00e4ubner T, Oehrlein-Karpi SA, K\u00fchnapfel B, Renzaho A, Strand D, Podlech J, Reddehase MJ, Grzimek NK (2006) CD8 T cells control cytomegalovirus latency by epitope-specific sensing of transcriptional reactivation. J Virol 80:10436\u201310456. https:\/\/doi.org\/10.1128\/JVI.01248-06","journal-title":"J Virol"},{"key":"600_CR44","first-page":"315","volume":"325","author":"MJ Reddehase","year":"2008","unstructured":"Reddehase MJ, Simon CO, Seckert CK, Lemmermann N, Grzimek NK (2008) Murine model of cytomegalovirus latency and reactivation. Curr Top Microbiol Immunol 325:315\u2013331","journal-title":"Curr Top Microbiol Immunol"},{"key":"600_CR45","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s00430-012-0273-y","volume":"201","author":"CK Seckert","year":"2012","unstructured":"Seckert CK, Griessl M, B\u00fcttner JK, Scheller S, Simon CO, Kropp KA, Renzaho A, K\u00fchnapfel B, Grzimek NK, Reddehase MJ (2012) Viral latency drives \u2018memory inflation\u2019: a unifying hypothesis linking two hallmarks of cytomegalovirus infection. Med Microbiol Immunol 201:551\u2013566. https:\/\/doi.org\/10.1007\/s00430-012-0273-y","journal-title":"Med Microbiol Immunol"},{"key":"600_CR46","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s00430-015-0412-3","volume":"204","author":"CA Biron","year":"2015","unstructured":"Biron CA, Tarrio ML (2015) Immunoregulatory cytokine networks: 60 years of learning from murine cytomegalovirus. Med Microbiol Immunol 204:345\u2013354. https:\/\/doi.org\/10.1007\/s00430-015-0412-3","journal-title":"Med Microbiol Immunol"},{"key":"600_CR47","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s00430-008-0095-0","volume":"197","author":"N Wirtz","year":"2008","unstructured":"Wirtz N, Schader SI, Holtappels R, Simon CO, Lemmermann NA, Reddehase MJ, Podlech J (2008) Polyclonal cytomegalovirus-specific antibodies not only prevent virus dissemination from the portal of entry but also inhibit focal virus spread within target tissues. Med Microbiol Immunol 197:151\u2013158. https:\/\/doi.org\/10.1007\/s00430-008-0095-0","journal-title":"Med Microbiol Immunol"},{"key":"600_CR48","doi-asserted-by":"publisher","first-page":"8869","DOI":"10.1128\/JVI.00870-09","volume":"83","author":"CK Seckert","year":"2009","unstructured":"Seckert CK, Renzaho A, Tervo HM, Krause C, Deegen P, K\u00fchnapfel B, Reddehase MJ, Grzimek NK (2009) Liver sinusoidal endothelial cells are a site of murine cytomegalovirus latency and reactivation. J Virol 83:8869\u20138884. https:\/\/doi.org\/10.1128\/JVI.00870-09","journal-title":"J Virol"},{"key":"600_CR49","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.chom.2008.02.014","volume":"3","author":"T Sacher","year":"2008","unstructured":"Sacher T, Podlech J, Mohr CA, Jordan S, Ruzsics Z, Reddehase MJ, Koszinowski UH (2008) The major virus-producing cell type during murine cytomegalovirus infection, the hepatocyte, is not the source of virus dissemination in the host. Cell Host Microbe 3:263\u2013272. https:\/\/doi.org\/10.1016\/j.chom.2008.02.014","journal-title":"Cell Host Microbe"},{"key":"600_CR50","doi-asserted-by":"publisher","first-page":"e1002366","DOI":"10.1371\/journal.ppat.1002366","volume":"7","author":"T Sacher","year":"2011","unstructured":"Sacher T, Andrassy J, Kalnins A, D\u00f6lken L, Jordan S, Podlech J, Ruzsics Z, Jauch KW, Reddehase MJ, Koszinowski UH (2011) Shedding light on the elusive role of endothelial cells in cytomegalovirus dissemination. PLoS Pathog 7:e1002366. https:\/\/doi.org\/10.1371\/journal.ppat.1002366","journal-title":"PLoS Pathog"},{"key":"600_CR51","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s00430-015-0405-2","volume":"204","author":"J Podlech","year":"2015","unstructured":"Podlech J, Reddehase MJ, Adler B, Lemmermann NA (2015) Principles for studying in vivo attenuation of virus mutants: defining the role of the cytomegalovirus gH\/gL\/gO complex as a paradigm. Med Microbiol Immunol 204:295\u2013305. https:\/\/doi.org\/10.1007\/s00430-015-0405-2","journal-title":"Med Microbiol Immunol"},{"key":"600_CR52","doi-asserted-by":"publisher","first-page":"e1004640","DOI":"10.1371\/journal.ppat.1004640","volume":"11","author":"NA Lemmermann","year":"2015","unstructured":"Lemmermann NA, Krmpotic A, Podlech J, Brizic I, Prager A, Adler H, Karbach A, Wu Y, Jonjic S, Reddehase MJ, Adler B (2015) Non-redundant and redundant roles of cytomegalovirus gH\/gL complexes in host organ entry and intra-tissue spread. PLoS Pathog 11:e1004640. https:\/\/doi.org\/10.1371\/journal.ppat.1004640","journal-title":"PLoS Pathog"},{"key":"600_CR53","doi-asserted-by":"publisher","first-page":"e1003493","DOI":"10.1371\/journal.ppat.1003493","volume":"9","author":"FM Wagner","year":"2013","unstructured":"Wagner FM, Brizic I, Prager A, Trsan T, Arapovic M, Lemmermann NA, Podlech J, Reddehase MJ, Lemnitzer F, Bosse JB, Gimpfl M, Marcinowski L, MacDonald M, Adler H, Koszinowski UH, Adler B (2013) The viral chemokine MCK-2 of murine cytomegalovirus promotes infection as part of a gH\/gL\/MCK-2 complex. PLoS Pathog 9:e1003493. https:\/\/doi.org\/10.1371\/journal.ppat.1003493","journal-title":"PLoS Pathog"},{"issue":"4","key":"600_CR54","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1080\/14767058.2017.1387890","volume":"32","author":"D Blazquez-Gamero","year":"2019","unstructured":"Blazquez-Gamero D, Galindo Izquierdo A, Del Rosal T, Baquero-Artigao F, Izquierdo Mendez N, Soriano-Ramos M, Rojo Conejo P, Gonzalez-Tome MI, Garcia-Burguillo A, Perez Perez N, Sanchez V, Ramos-Amador JT, De la Calle M (2019) Prevention and treatment of fetal cytomegalovirus infection with cytomegalovirus hyperimmune globulin: a multicenter study in Madrid. J Matern Fetal Neonatal Med 32(4):617\u2013625. https:\/\/doi.org\/10.1080\/14767058.2017.1387890","journal-title":"J Matern Fetal Neonatal Med"},{"key":"600_CR55","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S1083-8791(01)80005-7","volume":"7","author":"M Boeckh","year":"2001","unstructured":"Boeckh M, Bowden RA, Storer B, Chao NJ, Spielberger R, Tierney DK, Gallez-Hawkins G, Cunningham T, Blume KG, Levitt D, Zaia JA (2001) Randomized, placebo-controlled, double-blind study of a cytomegalovirus-specific monoclonal antibody (MSL-109) for prevention of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 7:343\u2013351","journal-title":"Biol Blood Marrow Transplant"},{"key":"600_CR56","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1056\/NEJMoa1310214","volume":"370","author":"MG Revello","year":"2014","unstructured":"Revello MG, Lazzarotto T, Guerra B, Spinillo A, Ferrazzi E, Kustermann A, Guaschino S, Vergani P, Todros T, Frusca T, Arossa A, Furione M, Rognoni V, Rizzo N, Gabrielli L, Klersy C, Gerna G, Group CS (2014) A randomized trial of hyperimmune globulin to prevent congenital cytomegalovirus. N Engl J Med 370:1316\u20131326. https:\/\/doi.org\/10.1056\/NEJMoa1310214","journal-title":"N Engl J Med"},{"key":"600_CR57","doi-asserted-by":"crossref","first-page":"12","DOI":"10.7326\/0003-4819-106-1-12","volume":"106","author":"DJ Winston","year":"1987","unstructured":"Winston DJ, Ho WG, Lin CH, Bartoni K, Budinger MD, Gale RP, Champlin RE (1987) Intravenous immune globulin for prevention of cytomegalovirus infection and interstitial pneumonia after bone marrow transplantation. Ann Intern Med 106:12\u201318","journal-title":"Ann Intern Med"},{"key":"600_CR58","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/infdis\/147.1.40","volume":"147","author":"RF Pass","year":"1983","unstructured":"Pass RF, Griffiths PD, August AM (1983) Antibody response to cytomegalovirus after renal transplantation: comparison of patients with primary and recurrent infections. J Infect Dis 147:40\u201346","journal-title":"J Infect Dis"},{"key":"600_CR59","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0022-3476(81)80662-2","volume":"98","author":"AS Yeager","year":"1981","unstructured":"Yeager AS, Grumet FC, Hafleigh EB, Arvin AM, Bradley JS, Prober CG (1981) Prevention of transfusion-acquired cytomegalovirus infections in newborn infants. J Pediatr 98:281\u2013287","journal-title":"J Pediatr"},{"key":"600_CR60","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/jmv.1890390303","volume":"39","author":"B Kropff","year":"1993","unstructured":"Kropff B, Landini MP, Mach M (1993) An ELISA using recombinant proteins for the detection of neutralizing antibodies against human cytomegalovirus. J Med Virol 39:187\u2013195","journal-title":"J Med Virol"},{"key":"600_CR61","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1399-0012.1997.tb00847.x","volume":"11","author":"ME Falagas","year":"1997","unstructured":"Falagas ME, Snydman DR, Ruthazer R, Griffith J, Werner BG, Freeman R, Rohrer R (1997) Cytomegalovirus immune globulin (CMVIG) prophylaxis is associated with increased survival after orthotopic liver transplantation. The Boston Center for Liver Transplantation CMVIG Study Group. Clin Transplant 11:432\u2013437","journal-title":"Clin Transplant"},{"key":"600_CR62","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1093\/clinids\/12.Supplement_7.S839","volume":"12","author":"DR Snydman","year":"1990","unstructured":"Snydman DR (1990) Cytomegalovirus immunoglobulins in the prevention and treatment of cytomegalovirus disease. Rev Infect Dis 12:839\u2013848","journal-title":"Rev Infect Dis"},{"key":"600_CR63","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1056\/nejm198710223171703","volume":"317","author":"DR Snydman","year":"1987","unstructured":"Snydman DR, Werner BG, Heinze-Lacey B, Berardi VP, Tilney NL, Kirkman RL, Milford EL, Cho SI, Bush HL, Levey AS et al (1987) Use of cytomegalovirus immune globulin to prevent cytomegalovirus disease in renal-transplant recipients. N Engl J Med 317:1049\u20131054. https:\/\/doi.org\/10.1056\/nejm198710223171703","journal-title":"N Engl J Med"},{"key":"600_CR64","doi-asserted-by":"publisher","first-page":"S19","DOI":"10.1097\/tp.0000000000001096","volume":"100","author":"F Rea","year":"2016","unstructured":"Rea F, Potena L, Yonan N, Wagner F, Calabrese F (2016) Cytomegalovirus hyper immunoglobulin for CMV prophylaxis in thoracic transplantation. Transplantation 100:S19\u2013S26. https:\/\/doi.org\/10.1097\/tp.0000000000001096","journal-title":"Transplantation"},{"key":"600_CR65","doi-asserted-by":"crossref","first-page":"8","DOI":"10.7326\/0003-4819-139-1-200307010-00007","volume":"139","author":"C Cordonnier","year":"2003","unstructured":"Cordonnier C, Chevret S, Legrand M, Rafi H, Dhedin N, Lehmann B, Bassompierre F, Gluckman E (2003) Should immunoglobulin therapy be used in allogeneic stem-cell transplantation? A randomized, double-blind, dose effect, placebo-controlled, multicenter trial. Ann Intern Med 139:8\u201318","journal-title":"Ann Intern Med"},{"key":"600_CR66","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/sj.bmt.1703109","volume":"28","author":"DJ Winston","year":"2001","unstructured":"Winston DJ, Antin JH, Wolff SN, Bierer BE, Small T, Miller KB, Linker C, Kaizer H, Lazarus HM, Petersen FB, Cowan MJ, Ho WG, Wingard JR, Schiller GJ, Territo MC, Jiao J, Petrarca MA, Tonetta SA (2001) A multicenter, randomized, double-blind comparison of different doses of intravenous immunoglobulin for prevention of graft-versus-host disease and infection after allogeneic bone marrow transplantation. Bone Marrow Transplant 28:187\u2013196. https:\/\/doi.org\/10.1038\/sj.bmt.1703109","journal-title":"Bone Marrow Transplant"},{"key":"600_CR67","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1016\/j.bbmt.2017.05.005","volume":"23","author":"H Abdel-Azim","year":"2017","unstructured":"Abdel-Azim H, Elshoury A, Mahadeo KM, Parkman R, Kapoor N (2017) Humoral immune reconstitution kinetics after allogeneic hematopoietic stem cell transplantation in children: a maturation block of IGM memory B cells may lead to impaired antibody immune reconstitution. Biol Blood Marrow Transplant 23:1437\u20131446. https:\/\/doi.org\/10.1016\/j.bbmt.2017.05.005","journal-title":"Biol Blood Marrow Transplant"},{"key":"600_CR68","doi-asserted-by":"publisher","first-page":"e12706","DOI":"10.1111\/tid.12706","volume":"19","author":"S Bourassa-Blanchette","year":"2017","unstructured":"Bourassa-Blanchette S, Knoll G, Tay J, Bredeson C, Cameron DW, Cowan J (2017) A national survey of screening and management of hypogammaglobulinemia in Canadian transplantation centers. Transpl Infect Dis 19:e12706. https:\/\/doi.org\/10.1111\/tid.12706","journal-title":"Transpl Infect Dis"},{"key":"600_CR69","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.bbmt.2008.11.024","volume":"15","author":"LJ D\u2019Orsogna","year":"2009","unstructured":"D\u2019Orsogna LJ, Wright MP, Krueger RG, McKinnon EJ, Buffery SI, Witt CS, Staples N, Loh R, Cannell PK, Christiansen FT, French MA (2009) Allogeneic hematopoietic stem cell transplantation recipients have defects of both switched and igm memory B cells. Biol Blood Marrow Transplant 15:795\u2013803. https:\/\/doi.org\/10.1016\/j.bbmt.2008.11.024","journal-title":"Biol Blood Marrow Transplant"},{"key":"600_CR70","doi-asserted-by":"publisher","first-page":"2718","DOI":"10.1182\/blood-2017-05-781849","volume":"130","author":"J Heimall","year":"2017","unstructured":"Heimall J, Logan BR, Cowan MJ, Notarangelo LD, Griffith LM, Puck JM, Kohn DB, Pulsipher MA, Parikh S, Martinez C, Kapoor N, O\u2019Reilly R, Boyer M, Pai SY, Goldman F, Burroughs L, Chandra S, Kletzel M, Thakar M, Connelly J, Cuvelier G, Davila Saldana BJ, Shereck E, Knutsen A, Sullivan KE, DeSantes K, Gillio A, Haddad E, Petrovic A, Quigg T, Smith AR, Stenger E, Yin Z, Shearer WT, Fleisher T, Buckley RH, Dvorak CC (2017) Immune reconstitution and survival of 100 SCID patients post-hematopoietic cell transplant: a PIDTC natural history study. Blood 130:2718\u20132727. https:\/\/doi.org\/10.1182\/blood-2017-05-781849","journal-title":"Blood"},{"key":"600_CR71","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.iac.2018.08.005","volume":"39","author":"B Kaplan","year":"2019","unstructured":"Kaplan B, Bonagura VR (2019) Secondary hypogammaglobulinemia: an increasingly recognized complication of treatment with immunomodulators and after solid organ transplantation. Immunol Allergy Clin N Am 39:31\u201347. https:\/\/doi.org\/10.1016\/j.iac.2018.08.005","journal-title":"Immunol Allergy Clin N Am"},{"key":"600_CR72","doi-asserted-by":"publisher","first-page":"e12863","DOI":"10.1111\/tid.12863","volume":"20","author":"R Yamazaki","year":"2018","unstructured":"Yamazaki R, Kikuchi T, Kato J, Sakurai M, Koda Y, Hashida R, Yamane Y, Abe R, Hasegawa N, Okamoto S, Mori T (2018) Recurrent bacterial pneumonia due to immunoglobulin G2 subclass deficiency after allogeneic hematopoietic stem cell transplantation: efficacy of immunoglobulin replacement. Transpl Infect Dis 20:e12863. https:\/\/doi.org\/10.1111\/tid.12863","journal-title":"Transpl Infect Dis"},{"key":"600_CR73","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1001\/archopht.1997.01100160698006","volume":"115","author":"Anonymous","year":"1997","unstructured":"Anonymous (1997) MSL-109 adjuvant therapy for cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome: the monoclonal antibody cytomegalovirus retinitis trial. The Studies of Ocular Complications of AIDS Research Group. AIDS Clinical Trials Group. Arch Ophthalmol 115:1528\u20131536","journal-title":"Arch Ophthalmol"},{"key":"600_CR74","doi-asserted-by":"publisher","first-page":"e01794","DOI":"10.1128\/aac.01794-16","volume":"61","author":"JH Ishida","year":"2017","unstructured":"Ishida JH, Patel A, Mehta AK, Gatault P, McBride JM, Burgess T, Derby MA, Snydman DR, Emu B, Feierbach B, Fouts AE, Maia M, Deng R, Rosenberger CM, Gennaro LA, Striano NS, Liao XC, Tavel JA (2017) Phase 2 randomized, double-blind, placebo-controlled trial of RG7667, a combination monoclonal antibody, for prevention of cytomegalovirus infection in high-risk kidney transplant recipients. Antimicrob Agents Chemother 61:e01794\u2013e01716. https:\/\/doi.org\/10.1128\/aac.01794-16","journal-title":"Antimicrob Agents Chemother"},{"key":"600_CR75","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1016\/s0140-6736(11)60136-0","volume":"377","author":"PD Griffiths","year":"2011","unstructured":"Griffiths PD, Stanton A, McCarrell E, Smith C, Osman M, Harber M, Davenport A, Jones G, Wheeler DC, O\u2019Beirne J, Thorburn D, Patch D, Atkinson CE, Pichon S, Sweny P, Lanzman M, Woodford E, Rothwell E, Old N, Kinyanjui R, Haque T, Atabani S, Luck S, Prideaux S, Milne RS, Emery VC, Burroughs AK (2011) Cytomegalovirus glycoprotein-B vaccine with MF59 adjuvant in transplant recipients: a phase 2 randomised placebo-controlled trial. Lancet 377:1256\u20131263. https:\/\/doi.org\/10.1016\/s0140-6736(11)60136-0","journal-title":"Lancet"},{"key":"600_CR76","doi-asserted-by":"publisher","first-page":"CD006501","DOI":"10.1002\/14651858.CD006501.pub2","volume":"4","author":"P Raanani","year":"2008","unstructured":"Raanani P, Gafter-Gvili A, Paul M, Ben-Bassat I, Leibovici L, Shpilberg O (2008) Immunoglobulin prophylaxis in hematological malignancies and hematopoietic stem cell transplantation. Cochrane Database Syst Rev 4:CD006501. https:\/\/doi.org\/10.1002\/14651858.CD006501.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"600_CR77","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1200\/JCO.2008.16.8450","volume":"27","author":"P Raanani","year":"2009","unstructured":"Raanani P, Gafter-Gvili A, Paul M, Ben-Bassat I, Leibovici L, Shpilberg O (2009) Immunoglobulin prophylaxis in hematopoietic stem cell transplantation: systematic review and meta-analysis. J Clin Oncol 27:770\u2013781","journal-title":"J Clin Oncol"},{"key":"600_CR78","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1126\/science.1352912","volume":"257","author":"SR Riddell","year":"1992","unstructured":"Riddell SR, Watanabe KS, Goodrich JM, Li CR, Agha ME, Greenberg PD (1992) Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones. Science 257:238\u2013241","journal-title":"Science"},{"key":"600_CR79","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1056\/NEJM199510193331603","volume":"333","author":"EA Walter","year":"1995","unstructured":"Walter EA, Greenberg PD, Gilbert MJ, Finch RJ, Watanabe KS, Thomas ED, Riddell SR (1995) Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N Engl J Med 333:1038\u20131044","journal-title":"N Engl J Med"},{"key":"600_CR80","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1093\/ije\/28.6.1176","volume":"28","author":"FT Cutts","year":"1999","unstructured":"Cutts FT, Vynnycky E (1999) Modelling the incidence of congenital rubella syndrome in developing countries. Int J Epidemiol 28:1176\u20131184","journal-title":"Int J Epidemiol"},{"key":"600_CR81","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0095-5108(18)30710-3","volume":"15","author":"BJ Freij","year":"1988","unstructured":"Freij BJ, South MA, Sever JL (1988) Maternal rubella and the congenital rubella syndrome. Clin Perinatol 15:247\u2013257","journal-title":"Clin Perinatol"},{"key":"600_CR82","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/infdis\/161.2.214","volume":"161","author":"WJ Britt","year":"1989","unstructured":"Britt WJ, Vugler L (1989) Antiviral antibody responses in mothers and their newborn infants with clinical and subclinical congenital cytomegalovirus infections. J Infect Dis 161:214\u2013219","journal-title":"J Infect Dis"},{"key":"600_CR83","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1093\/infdis\/158.5.917","volume":"158","author":"CA Alford","year":"1988","unstructured":"Alford CA, Hayes K, Britt W (1988) Primary cytomegalovirus infection in pregnancy: comparison of antibody responses to virus-encoded proteins between women with and without intrauterine infection. J Infect Dis 158:917\u2013924","journal-title":"J Infect Dis"},{"key":"600_CR84","doi-asserted-by":"publisher","first-page":"e59863","DOI":"10.1371\/journal.pone.0059863","volume":"8","author":"D Lilleri","year":"2013","unstructured":"Lilleri D, Kabanova A, Revello MG, Percivalle E, Sarasini A, Genini E, Sallusto F, Lanzavecchia A, Corti D, Gerna G (2013) Fetal human cytomegalovirus transmission correlates with delayed maternal antibodies to gH\/gL\/pUL128-130-131 complex during primary infection. PLoS One 8:e59863. https:\/\/doi.org\/10.1371\/journal.pone.0059863","journal-title":"PLoS One"},{"key":"600_CR85","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1093\/infdis\/171.5.1115","volume":"171","author":"SB Boppana","year":"1995","unstructured":"Boppana SB, Britt WJ (1995) Antiviral antibody responses and intrauterine transmission after primary maternal cytomegalovirus infection. J Infect Dis 171:1115\u20131121","journal-title":"J Infect Dis"},{"key":"600_CR86","doi-asserted-by":"publisher","unstructured":"Lilleri D, Gerna G (2017) Maternal immune correlates of protection from human cytomegalovirus transmission to the fetus after primary infection in pregnancy. Rev Med Virol 27 (2). https:\/\/doi.org\/10.1002\/rmv.1921","DOI":"10.1002\/rmv.1921"},{"key":"600_CR87","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1002\/jmv.23691","volume":"85","author":"M Furione","year":"2013","unstructured":"Furione M, Rognoni V, Sarasini A, Zavattoni M, Lilleri D, Gerna G, Revello MG (2013) Slow increase in IgG avidity correlates with prevention of human cytomegalovirus transmission to the fetus. J Med Virol 85:1960\u20131967. https:\/\/doi.org\/10.1002\/jmv.23691","journal-title":"J Med Virol"},{"key":"600_CR88","doi-asserted-by":"publisher","first-page":"3728","DOI":"10.1073\/pnas.1814835116","volume":"116","author":"AL Vanarsdall","year":"2019","unstructured":"Vanarsdall AL, Chin AL, Liu J, Jardetzky TS, Mudd JO, Orloff SL, Streblow D, Mussi-Pinhata MM, Yamamoto AY, Duarte G, Britt WJ, Johnson DC (2019) HCMV trimer- and pentamer-specific antibodies synergize for virus neutralization but do not correlate with congenital transmission. Proc Natl Acad Sci USA 116:3728\u20133733. https:\/\/doi.org\/10.1073\/pnas.1814835116","journal-title":"Proc Natl Acad Sci USA"},{"key":"600_CR89","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1093\/infdis\/175.3.533","volume":"175","author":"K Schoppel","year":"1997","unstructured":"Schoppel K, Kropff B, Schmidt C, Vornhagen R, Mach M (1997) The humoral immune response against human cytomegalovirus is characterized by a delayed synthesis of glycoprotein-specific antibodies. J Infect Dis 175:533\u2013544","journal-title":"J Infect Dis"},{"key":"600_CR90","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1093\/infdis\/jiv769","volume":"213","author":"N Dauby","year":"2016","unstructured":"Dauby N, Sartori D, Kummert C, Lecomte S, Haelterman E, Delforge ML, Donner C, Mach M, Marchant A (2016) Limited effector memory B-cell response to envelope glycoprotein B during primary human cytomegalovirus infection. J Infect Dis 213:1642\u20131650. https:\/\/doi.org\/10.1093\/infdis\/jiv769","journal-title":"J Infect Dis"},{"key":"600_CR91","doi-asserted-by":"publisher","first-page":"e02392","DOI":"10.1128\/jvi.02392-16","volume":"91","author":"WJ Britt","year":"2017","unstructured":"Britt WJ (2017) Congenital HCMV infection and the enigma of maternal immunity. J Virol 91:e02392\u2013e02316. https:\/\/doi.org\/10.1128\/jvi.02392-16","journal-title":"J Virol"},{"key":"600_CR92","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1093\/infdis\/jiy321","volume":"218","author":"MM Mussi-Pinhata","year":"2018","unstructured":"Mussi-Pinhata MM, Yamamoto AY, Aragon DC, Duarte G, Fowler KB, Boppana S, Britt WJ (2018) Seroconversion for cytomegalovirus infection during pregnancy and fetal infection in a highly seropositive population: \u201cthe BraCHS study\u201d. J Infect Dis 218:1200\u20131204. https:\/\/doi.org\/10.1093\/infdis\/jiy321","journal-title":"J Infect Dis"},{"key":"600_CR93","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1097\/INF.0b013e3181723d55","volume":"27","author":"L Dar","year":"2008","unstructured":"Dar L, Pati SK, Patro AR, Deorari AK, Rai S, Kant S, Broor S, Fowler KB, Britt WJ, Boppana SB (2008) Congenital cytomegalovirus infection in a highly seropositive semi-urban population in India. Pediatr Infect Dis J 27:841\u2013843. https:\/\/doi.org\/10.1097\/INF.0b013e3181723d55","journal-title":"Pediatr Infect Dis J"},{"key":"600_CR94","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.1093\/cid\/ciq085","volume":"52","author":"C Wang","year":"2011","unstructured":"Wang C, Zhang X, Bialek S, Cannon MJ (2011) Attribution of congenital cytomegalovirus infection to primary versus non-primary maternal infection. Clin Infect Dis 52:e11\u2013e13. https:\/\/doi.org\/10.1093\/cid\/ciq085","journal-title":"Clin Infect Dis"},{"key":"600_CR95","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1128\/CMR.00062-12","volume":"26","author":"S Manicklal","year":"2013","unstructured":"Manicklal S, Emery VC, Lazzarotto T, Boppana SB, Gupta RK (2013) The \u201csilent\u201d global burden of congenital cytomegalovirus. Clin Microbiol Rev 26:86\u2013102. https:\/\/doi.org\/10.1128\/CMR.00062-12","journal-title":"Clin Microbiol Rev"},{"key":"600_CR96","doi-asserted-by":"publisher","first-page":"e00030","DOI":"10.1128\/jvi.00030-18","volume":"92","author":"SR Permar","year":"2018","unstructured":"Permar SR, Schleiss MR, Plotkin SA (2018) Advancing our understanding of protective maternal immunity as a guide for development of vaccines to reduce congenital cytomegalovirus infections. J Virol 92:e00030\u2013e00018. https:\/\/doi.org\/10.1128\/jvi.00030-18","journal-title":"J Virol"},{"key":"600_CR97","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1002\/uog.19164","volume":"53","author":"KO Kagan","year":"2018","unstructured":"Kagan KO, Enders M, Schampera MS, Baeumel E, Hoopmann M, Geipel A, Berg C, Goelz R, De Catte L, Wallwiener D, Brucker S, Adler SP, Jahn G, Hamprecht K (2018) Prevention of maternal-fetal transmission of CMV by hyperimmunoglobulin (HIG) administered after a primary maternal CMV infectionin early gestation. Ultrasound Obstet Gynecol 53:383\u2013389. https:\/\/doi.org\/10.1002\/uog.19164","journal-title":"Ultrasound Obstet Gynecol"},{"key":"600_CR98","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1128\/jvi.63.5.1995-2001.1989","volume":"63","author":"U Utz","year":"1989","unstructured":"Utz U, Britt W, Vugler L, Mach M (1989) Identification of a neutralizing epitope on glycoprotein gp58 of human cytomegalovirus. J Virol 63:1995\u20132001","journal-title":"J Virol"},{"key":"600_CR99","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1006\/viro.1996.0040","volume":"216","author":"K Schoppel","year":"1996","unstructured":"Schoppel K, Hassfurther E, Britt W, Ohlin M, Borrebaeck CA, Mach M (1996) Antibodies specific for the antigenic domain 1 of glycoprotein B (gpUL55) of human cytomegalovirus bind to different substructures. Virology 216:133\u2013145","journal-title":"Virology"},{"key":"600_CR100","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1099\/0022-1317-80-8-2183","volume":"80","author":"A Speckner","year":"1999","unstructured":"Speckner A, Glykofrydes D, Ohlin M, Mach M (1999) Antigenic domain 1 of human cytomegalovirus glycoprotein B induces a multitude of different antibodies which, when combined, results in incomplete virus neutralization. J Gen Virol 80:2183\u20132191","journal-title":"J Gen Virol"},{"key":"600_CR101","doi-asserted-by":"publisher","first-page":"e1002999","DOI":"10.1371\/journal.ppat.1002999","volume":"8","author":"B Kropff","year":"2012","unstructured":"Kropff B, Burkhardt C, Schott J, Nentwich J, Fisch T, Britt W, Mach M (2012) Glycoprotein N of human cytomegalovirus protects the virus from neutralizing antibodies. PLoS Pathog 8:e1002999. https:\/\/doi.org\/10.1371\/journal.ppat.1002999","journal-title":"PLoS Pathog"},{"key":"600_CR102","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/0042-6822(92)90771-G","volume":"188","author":"S Chou","year":"1992","unstructured":"Chou S (1992) Comparative analysis of sequence variation in gp116 and gp55 components of glycoprotein B of human cytomegalovirus. Virology 188:388\u2013390","journal-title":"Virology"},{"key":"600_CR103","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1099\/vir.0.18704-0","volume":"84","author":"S Pignatelli","year":"2003","unstructured":"Pignatelli S, Dal Monte P, Rossini G, Chou S, Gojobori T, Hanada K, Guo JJ, Rawlinson W, Britt W, Mach M, Landini MP (2003) Human cytomegalovirus glycoprotein N (gpUL73-gN) genomic variants: identification of a novel subgroup, geographical distribution and evidence of positive selective pressure. J Gen Virol 84:647\u2013655","journal-title":"J Gen Virol"},{"key":"600_CR104","doi-asserted-by":"crossref","first-page":"10841","DOI":"10.1128\/JVI.76.21.10841-10848.2002","volume":"76","author":"L Rasmussen","year":"2002","unstructured":"Rasmussen L, Geissler A, Cowan C, Chase A, Winters M (2002) The genes encoding the gCIII complex of human cytomegalovirus exist in highly diverse combinations in clinical isolates. J Virol 76:10841\u201310848","journal-title":"J Virol"},{"key":"600_CR105","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1128\/jcm.22.5.768-771.1985","volume":"22","author":"RG Faix","year":"1985","unstructured":"Faix RG (1985) Cytomegalovirus antigenic heterogeneity can cause false-negative results in indirect hemagglutination and complement fixation antibody assays. J Clin Microbiol 22:768\u2013771","journal-title":"J Clin Microbiol"},{"key":"600_CR106","first-page":"64","volume":"23","author":"WJ Britt","year":"1991","unstructured":"Britt WJ (1991) Recent advances in the identification of significant human cytomegalovirus-encoded proteins. Transplant Proc 23:64\u201369","journal-title":"Transplant Proc"},{"key":"600_CR107","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1128\/jvi.66.3.1303-1311.1992","volume":"66","author":"M Urban","year":"1992","unstructured":"Urban M, Britt W, Mach M (1992) The dominant linear neutralizing antibody-binding site of glycoprotein gp86 of human cytomegalovirus is strain specific. J Virol 66:1303\u20131311","journal-title":"J Virol"},{"key":"600_CR108","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1128\/JVI.73.2.878-886.1999","volume":"73","author":"MKK Schoppel","year":"1999","unstructured":"Schoppel MKK, Amvrossiadis N, Mach M (1999) Strain-specific neutralization of human cytomegalovirus isolates of human sera. J Virol 73:878\u2013886","journal-title":"J Virol"},{"key":"600_CR109","doi-asserted-by":"publisher","unstructured":"Pati SK, Novak Z, Purser M, Arora N, Mach M, Britt WJ, Boppana SB Strain-specific neutralizing antibody responses against human cytomegalovirus envelope glycoprotein N. Clin Vaccine Immunol 19:909\u2013913. https:\/\/doi.org\/10.1128\/CVI.00092-12","DOI":"10.1128\/CVI.00092-12"},{"key":"600_CR110","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1128\/JVI.73.2.878-886.1999","volume":"73","author":"M Klein","year":"1999","unstructured":"Klein M, Schoppel K, Amvrossiadis N, Mach M (1999) Strain-specific neutralization of human cytomegalovirus isolates by human sera. J Virol 73:878\u2013886","journal-title":"J Virol"},{"key":"600_CR111","doi-asserted-by":"publisher","first-page":"8927","DOI":"10.1128\/jvi.00434-13","volume":"87","author":"N Spindler","year":"2013","unstructured":"Spindler N, Rucker P, Potzsch S, Diestel U, Sticht H, Martin-Parras L, Winkler TH, Mach M (2013) Characterization of a discontinuous neutralizing epitope on glycoprotein B of human cytomegalovirus. J Virol 87:8927\u20138939. https:\/\/doi.org\/10.1128\/jvi.00434-13","journal-title":"J Virol"},{"key":"600_CR112","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1128\/jvi.02393-14","volume":"89","author":"AK Wiegers","year":"2015","unstructured":"Wiegers AK, Sticht H, Winkler TH, Britt WJ, Mach M (2015) Identification of a neutralizing epitope within antigenic domain 5 of glycoprotein B of human cytomegalovirus. J Virol 89:361\u2013372. https:\/\/doi.org\/10.1128\/jvi.02393-14","journal-title":"J Virol"},{"key":"600_CR113","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0022-3476(96)70279-2","volume":"128","author":"JF Bale","year":"1996","unstructured":"Bale JF, Petheram SJ, Souza IE, Murph JR (1996) Cytomegalovirus reinfection in young children. J Pediatr 128:347\u2013352","journal-title":"J Pediatr"},{"key":"600_CR114","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1093\/infdis\/150.6.952","volume":"150","author":"WL Drew","year":"1984","unstructured":"Drew WL, Sweet ES, Miner RC, Mocarski ES (1984) Multiple infections by cytomegalovirus in patients with acquired immune deficiency syndrome: documentation by Southern blot hybridization. J Infect Dis 150:952\u2013953","journal-title":"J Infect Dis"},{"key":"600_CR115","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/infdis\/159.1.123","volume":"159","author":"AC Collier","year":"1989","unstructured":"Collier AC, Chandler SH, Handsfield HH, Corey L, McDougall JK (1989) Identification of multiple strains of cytomegalovirus in homosexual men. J Infect Dis 159:123\u2013126","journal-title":"J Infect Dis"},{"key":"600_CR116","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/infdis\/155.4.655","volume":"155","author":"SH Chandler","year":"1987","unstructured":"Chandler SH, Handsfield HH, McDougall JK (1987) Isolation of multiple strains of cytomegalovirus from women attending a clinic for sexually transmitted disease. J Infect Dis 155:655\u2013660","journal-title":"J Infect Dis"},{"key":"600_CR117","volume-title":"Kidney transplant rejection: diagnosis and treatment","author":"RH Rubin","year":"1986","unstructured":"Rubin RH, Colvin RB (1986) Cytomegalovirus infection in renal transplantion: clinical importance and control. In: Williams GM, Burdick JF, Solez K (eds) Kidney transplant rejection: diagnosis and treatment. Dekker, New York"},{"key":"600_CR118","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1056\/NEJM200105033441804","volume":"344","author":"SB Boppana","year":"2001","unstructured":"Boppana SB, Rivera LB, Fowler KB, Mach M, Britt WJ (2001) Intrauterine transmission of cytomegalovirus to infants of women with preconceptional immunity. N Engl J Med 344:1366\u20131371","journal-title":"N Engl J Med"},{"key":"600_CR119","doi-asserted-by":"crossref","first-page":"297.e291","DOI":"10.1016\/j.ajog.2009.11.018","volume":"202","author":"AY Yamamoto","year":"2010","unstructured":"Yamamoto AY, Mussi-Pinhata MM, Boppana SB, Novak Z, Wagatsuma VM, Oliviera PD, Duarte G, Britt WJ (2010) Human cytomegalovirus reinfection is associated with intrauterine transmission in a highly cytomegalovirus-immune maternal population. Am J Obstet Gynecol 202:297.e291\u2013297","journal-title":"Am J Obstet Gynecol"},{"key":"600_CR120","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.coviro.2014.08.001","volume":"8","author":"N Renzette","year":"2014","unstructured":"Renzette N, Gibson L, Jensen JD, Kowalik TF (2014) Human cytomegalovirus intrahost evolution\u2014a new avenue for understanding and controlling herpesvirus infections. Curr Opin Virol 8:109\u2013115","journal-title":"Curr Opin Virol"}],"container-title":["Medical Microbiology and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00430-019-00600-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00430-019-00600-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00430-019-00600-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T05:15:22Z","timestamp":1744175722000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00430-019-00600-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,28]]},"references-count":120,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2019,8,1]]}},"alternative-id":["600"],"URL":"https:\/\/doi.org\/10.1007\/s00430-019-00600-1","relation":{},"ISSN":["0300-8584","1432-1831"],"issn-type":[{"value":"0300-8584","type":"print"},{"value":"1432-1831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,28]]},"assertion":[{"value":"26 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}