{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:45:41Z","timestamp":1775695541402,"version":"3.50.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:00:00Z","timestamp":1668211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:00:00Z","timestamp":1668211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"ANID de Chile","award":["COVID0557"],"award-info":[{"award-number":["COVID0557"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Microbiol Immunol"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1007\/s00430-022-00753-6","type":"journal-article","created":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T10:02:58Z","timestamp":1668247378000},"page":"25-34","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Reduced neutralization against Delta, Gamma, Mu, and Omicron BA.1 variants of SARS-CoV-2 from previous non-Omicron infection"],"prefix":"10.1007","volume":"212","author":[{"given":"Paola","family":"Pidal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constanza","family":"Airola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Araujo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Mar\u00eda","family":"Menjiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor San","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Bruneau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monserrat","family":"Balanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coral","family":"Elgueta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Fasce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Teresa","family":"Valenzuela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariel","family":"Orellana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5299-7928","authenticated-orcid":false,"given":"Eugenio","family":"Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,12]]},"reference":[{"key":"753_CR1","unstructured":"World Health Organization. Weekly operational update on COVID-19, 1 March 2022, Issue No. 93. https:\/\/www.who.int\/publications\/m\/item\/weekly-operational-update-on-covid-19\u20141-march-2022"},{"key":"753_CR2","unstructured":"Ministerio de Salud. Informe Epidemiol\u00f3gico N\u00ba180 Enfermedad por SARS-CoV-2 (COVID-19), 06 de Abril 2022. https:\/\/www.minsal.cl\/wp-content\/uploads\/2022\/04\/Informe_Epidemiol\u00f3gico-180.pdf"},{"key":"753_CR3","doi-asserted-by":"publisher","first-page":"4704","DOI":"10.1038\/s41467-020-18450-4","volume":"11","author":"AT Huang","year":"2020","unstructured":"Huang AT, Garcia-Carreras B, Hitchings MDT et al (2020) A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity. Nat Commun 11:4704. https:\/\/doi.org\/10.1038\/s41467-020-18450-4","journal-title":"Nat Commun"},{"key":"753_CR4","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1038\/s41591-021-01377-8","volume":"27","author":"DS Khoury","year":"2021","unstructured":"Khoury DS, Cromer D, Reynaldi A et al (2021) Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection. Nat Med 27:1205\u20131211. https:\/\/doi.org\/10.1038\/s41591-021-01377-8","journal-title":"Nat Med"},{"key":"753_CR5","doi-asserted-by":"publisher","first-page":"100040","DOI":"10.1016\/j.xcrm.2020.100040","volume":"1","author":"MS Suthar","year":"2020","unstructured":"Suthar MS, Zimmerman MG, Kauffman RC et al (2020) Rapid generation of neutralizing antibody responses in COVID-19 patients. Cell Rep Med 1:100040. https:\/\/doi.org\/10.1016\/j.xcrm.2020.100040","journal-title":"Cell Rep Med"},{"key":"753_CR6","doi-asserted-by":"publisher","first-page":"4334","DOI":"10.1002\/jmv.26939","volume":"93","author":"MT Valenzuela","year":"2021","unstructured":"Valenzuela MT, Urquidi C, Rodriguez N et al (2021) Development of neutralizing antibody responses against SARS-CoV-2 in COVID-19 patients. J Med Virol 93:4334\u20134341. https:\/\/doi.org\/10.1002\/jmv.26939","journal-title":"J Med Virol"},{"key":"753_CR7","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/s41586-020-2456-9","volume":"584","author":"DF Robbiani","year":"2020","unstructured":"Robbiani DF, Gaebler C, Muecksch F et al (2020) Convergent antibody responses to SARS-CoV-2 in convalescent individuals. Nature 584:437\u2013442. https:\/\/doi.org\/10.1038\/s41586-020-2456-9","journal-title":"Nature"},{"key":"753_CR8","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1038\/s41591-020-0965-6","volume":"26","author":"QX Long","year":"2020","unstructured":"Long QX, Tang XJ, Shi QL et al (2020) Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections. Nat Med 26:1200\u20131204. https:\/\/doi.org\/10.1038\/s41591-020-0965-6","journal-title":"Nat Med"},{"key":"753_CR9","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1126\/science.abd7728","volume":"370","author":"A Wajnberg","year":"2020","unstructured":"Wajnberg A, Amanat F, Firpo A et al (2020) Robust neutralizing antibodies to SARS-CoV-2 infection persist for months. Science 370:1227\u20131230. https:\/\/doi.org\/10.1126\/science.abd7728","journal-title":"Science"},{"key":"753_CR10","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.3390\/microorganisms9071542","volume":"9","author":"S Cherian","year":"2021","unstructured":"Cherian S, Potdar V, Jadhav S et al (2021) SARS-CoV-2 spike mutations, L452R, T478K, E484Q and P681R, in the second wave of COVID-19 in Maharashtra, India. Microorganisms 9:1542. https:\/\/doi.org\/10.3390\/microorganisms9071542","journal-title":"Microorganisms"},{"key":"753_CR11","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1126\/science.abl8506","volume":"374","author":"M McCallum","year":"2021","unstructured":"McCallum M, Walls AC, Sprouse KR et al (2021) Molecular basis of immune evasion by the Delta and Kappa SARS-CoV-2 variants. Science 374:1621\u20131626. https:\/\/doi.org\/10.1126\/science.abl8506","journal-title":"Science"},{"key":"753_CR12","unstructured":"Delta Variant Report. Available online: https:\/\/outbreak.info\/situation-reports\/delta. Accessed on 8 Sept 2022"},{"key":"753_CR13","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1016\/j.cell.2020.09.037","volume":"183","author":"L Piccoli","year":"2020","unstructured":"Piccoli L, Park YJ, Tortorici MA et al (2020) Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology. Cell 183:1024-1042.e21. https:\/\/doi.org\/10.1016\/j.cell.2020.09.037","journal-title":"Cell"},{"key":"753_CR14","doi-asserted-by":"publisher","unstructured":"Greaney AJ, Loes AN, Gentles LE et al (2021) Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infection. Sci Transl Med 13:eabi9915. https:\/\/doi.org\/10.1126\/scitranslmed.abi9915","DOI":"10.1126\/scitranslmed.abi9915"},{"key":"753_CR15","unstructured":"WHO. Classification of Omicron (B.1.1.529) (2021) SARS-CoV-2 Variant of Concern. https:\/\/www.who.int\/news\/item\/26-11-2021-classification-ofomicron-(b.1.1.529)-sars-cov-2-variant-of-concern"},{"key":"753_CR16","doi-asserted-by":"publisher","first-page":"n2943","DOI":"10.1136\/bmj.n2943","volume":"375","author":"I Torjesen","year":"2021","unstructured":"Torjesen I (2021) Covid-19: Omicron may be more transmissible than other variants and partly resistant to existing vaccines, scientists fear. BMJ 375:n2943. https:\/\/doi.org\/10.1136\/bmj.n2943","journal-title":"BMJ"},{"key":"753_CR17","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1016\/S0140-6736(21)02758-6","volume":"398","author":"SSA Karim","year":"2021","unstructured":"Karim SSA, Karim QA (2021) Omicron SARS-CoV-2 variant: a new chapter in the COVID-19 pandemic. Lancet 398:2126\u20132128. https:\/\/doi.org\/10.1016\/S0140-6736(21)02758-6 (Erratum in: Lancet 399(10320):142 (2022 Jan 8))","journal-title":"Lancet"},{"key":"753_CR18","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/s41586-020-2895-3","volume":"592","author":"JA Plante","year":"2021","unstructured":"Plante JA, Liu Y, Liu J et al (2021) Spike mutation D614G alters SARS-CoV-2 fitness. Nature 592:116\u2013121. https:\/\/doi.org\/10.1038\/s41586-020-2895-3 (Erratum in: Nature 595(7865):E1 (2021July))","journal-title":"Nature"},{"key":"753_CR19","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1038\/s41586-021-04245-0","volume":"602","author":"Y Liu","year":"2022","unstructured":"Liu Y, Liu J, Plante KS (2022) The N501Y spike substitution enhances SARS-CoV-2 infection and transmission. Nature 602:294\u2013299. https:\/\/doi.org\/10.1038\/s41586-021-04245-0","journal-title":"Nature"},{"key":"753_CR20","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/s41591-021-01294-w","volume":"27","author":"RE Chen","year":"2021","unstructured":"Chen RE, Zhang X, Case JB et al (2021) Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies. Nat Med 27:717\u2013726. https:\/\/doi.org\/10.1038\/s41591-021-01294-w","journal-title":"Nat Med"},{"key":"753_CR21","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/s41467-020-20789-7","volume":"12","author":"Z Ku","year":"2021","unstructured":"Ku Z, Xie X, Davidson E et al (2021) Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape. Nat Commun 12:469. https:\/\/doi.org\/10.1038\/s41467-020-20789-7 (Erratum in: Nat Commun 12(1):4177 (2021 July 1))","journal-title":"Nat Commun"},{"key":"753_CR22","unstructured":"Omicron Variant Report. Available online: https:\/\/outbreak.info\/situation-reports\/omicron. Accessed on 8 Sept 2022"},{"key":"753_CR23","unstructured":"WHO Tracking SARS-CoV-2 Variants. Available online: https:\/\/www.who.int\/en\/activities\/tracking-SARS-CoV-2-variants. Accessed on 8 Sept 2022"},{"key":"753_CR24","unstructured":"Omicron Variant Report. Available online: https:\/\/outbreak.info\/situation-reports\/gamma. Accessed on 8 Sept 2022"},{"key":"753_CR25","doi-asserted-by":"publisher","first-page":"105038","DOI":"10.1016\/j.meegid.2021.105038","volume":"95","author":"K Laiton-Donato","year":"2021","unstructured":"Laiton-Donato K, Franco-Mu\u00f1oz C, \u00c1lvarez-D\u00edaz D et al (2021) Characterization of the emerging B.1.621 variant of interest of SARS-CoV-2. Infect Genet Evol 95:105038. https:\/\/doi.org\/10.1016\/j.meegid.2021.105038","journal-title":"Infect Genet Evol"},{"key":"753_CR26","unstructured":"Mu Variant Report. Available online: https:\/\/outbreak.info\/situation-reports\/mu?loc=COL&loc=GBR&selected=Worldwide&overlay=false. Accessed on 8 Sept 2022"},{"key":"753_CR27","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s12916-022-02312-5","volume":"20","author":"M Schubert","year":"2022","unstructured":"Schubert M, Bertoglio F, Steinke S et al (2022) Human serum from SARS-CoV-2-vaccinated and COVID-19 patients shows reduced binding to the RBD of SARS-CoV-2 Omicron variant. BMC Med 20:102. https:\/\/doi.org\/10.1186\/s12916-022-02312-5","journal-title":"BMC Med"},{"key":"753_CR28","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.cell.2021.12.046","volume":"185","author":"W Dejnirattisai","year":"2022","unstructured":"Dejnirattisai W, Huo J, Zhou D et al (2022) SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses. Cell 185:467-484.e15. https:\/\/doi.org\/10.1016\/j.cell.2021.12.046","journal-title":"Cell"},{"key":"753_CR29","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/s41586-021-04388-0","volume":"602","author":"L Liu","year":"2022","unstructured":"Liu L, Iketani S, Guo Y et al (2022) Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2. Nature 602:676\u2013681. https:\/\/doi.org\/10.1038\/s41586-021-04388-0","journal-title":"Nature"},{"key":"753_CR30","doi-asserted-by":"publisher","unstructured":"Sievers BL, Chakraborty S, Xue Y et al (2022) Antibodies elicited by SARS-CoV-2 infection or mRNA vaccines have reduced neutralizing activity against Beta and Omicron pseudoviruses. Sci Transl Med 14:eabn7842. https:\/\/doi.org\/10.1126\/scitranslmed.abn7842","DOI":"10.1126\/scitranslmed.abn7842"},{"key":"753_CR31","doi-asserted-by":"publisher","unstructured":"Seaman MS, Siedner MJ, Boucau J et al (2022) Vaccine breakthrough infection with the SARS-CoV-2 Delta or Omicron (BA.1) variant leads to distinct profiles of neutralizing antibody responses. medRxiv (Preprint) 3:2022.03.02.22271731. https:\/\/doi.org\/10.1101\/2022.03.02.22271731","DOI":"10.1101\/2022.03.02.22271731"},{"key":"753_CR32","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/s41586-021-04389-z","volume":"602","author":"D Planas","year":"2022","unstructured":"Planas D, Saunders N, Maes P et al (2022) Considerable escape of SARS-CoV-2 Omicron to antibody neutralization. Nature 602:671\u2013675. https:\/\/doi.org\/10.1038\/s41586-021-04389-z","journal-title":"Nature"},{"key":"753_CR33","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1056\/NEJMoa066092","volume":"357","author":"IJ Amanna","year":"2007","unstructured":"Amanna IJ, Carlson NE, Slifka MK (2007) Duration of humoral immunity to common viral and vaccine antigens. N Engl J Med 357:1903\u20131915. https:\/\/doi.org\/10.1056\/NEJMoa066092","journal-title":"N Engl J Med"},{"key":"753_CR34","doi-asserted-by":"publisher","unstructured":"Dan JM, Mateus J, Kato Y et al (2021) Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection. Science 371:eabf4063. https:\/\/doi.org\/10.1126\/science.abf4063","DOI":"10.1126\/science.abf4063"},{"key":"753_CR35","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1038\/s41564-020-00813-8","volume":"5","author":"J Seow","year":"2020","unstructured":"Seow J, Graham C, Merrick B et al (2020) Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans. Nat Microbiol 5:1598\u20131607. https:\/\/doi.org\/10.1038\/s41564-020-00813-8","journal-title":"Nat Microbiol"},{"key":"753_CR36","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1093\/infdis\/jiaa618","volume":"223","author":"KHD Crawford","year":"2021","unstructured":"Crawford KHD, Dingens AS, Eguia R et al (2021) Dynamics of neutralizing antibody titers in the months after severe acute respiratory syndrome coronavirus 2 infection. J Infect Dis 223:197\u2013205. https:\/\/doi.org\/10.1093\/infdis\/jiaa618","journal-title":"J Infect Dis"},{"key":"753_CR37","doi-asserted-by":"publisher","first-page":"2588","DOI":"10.1182\/blood.2020008367","volume":"136","author":"J Perreault","year":"2020","unstructured":"Perreault J, Tremblay T, Fournier MJ et al (2020) Waning of SARS-CoV-2 RBD antibodies in longitudinal convalescent plasma samples within 4 months after symptom onset. Blood 136:2588\u20132591. https:\/\/doi.org\/10.1182\/blood.2020008367","journal-title":"Blood"},{"key":"753_CR38","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1056\/NEJMc2025179","volume":"383","author":"FJ Ibarrondo","year":"2020","unstructured":"Ibarrondo FJ, Fulcher JA, Goodman-Meza D et al (2020) Rapid decay of anti-SARS-CoV-2 antibodies in persons with mild Covid-19. N Engl J Med 383:1085\u20131087. https:\/\/doi.org\/10.1056\/NEJMc2025179","journal-title":"N Engl J Med"},{"key":"753_CR39","doi-asserted-by":"publisher","first-page":"2688","DOI":"10.1093\/cid\/ciaa721","volume":"71","author":"X Wang","year":"2020","unstructured":"Wang X, Guo X, Xin Q et al (2020) Neutralizing antibody responses to severe acute respiratory syndrome coronavirus 2 in coronavirus disease 2019 inpatients and convalescent patients. Clin Infect Dis 71:2688\u20132694. https:\/\/doi.org\/10.1093\/cid\/ciaa721","journal-title":"Clin Infect Dis"},{"key":"753_CR40","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.immuni.2020.10.004","volume":"53","author":"TJ Ripperger","year":"2020","unstructured":"Ripperger TJ, Uhrlaub JL, Watanabe M et al (2020) Orthogonal SARS-CoV-2 serological assays enable surveillance of low-prevalence communities and reveal durable humoral immunity. Immunity 53:925-933.e4. https:\/\/doi.org\/10.1016\/j.immuni.2020.10.004","journal-title":"Immunity"},{"key":"753_CR41","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.ejim.2021.05.010","volume":"89","author":"E Terpos","year":"2021","unstructured":"Terpos E, Stellas D, Rosati M et al (2021) SARS-CoV-2 antibody kinetics eight months from COVID-19 onset: persistence of spike antibodies but loss of neutralizing antibodies in 24% of convalescent plasma donors. Eur J Intern Med 89:87\u201396. https:\/\/doi.org\/10.1016\/j.ejim.2021.05.010","journal-title":"Eur J Intern Med"},{"key":"753_CR42","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1038\/s41467-021-21111-9","volume":"12","author":"S Marot","year":"2021","unstructured":"Marot S, Malet I, Leducq V et al (2021) Rapid decline of neutralizing antibodies against SARS-CoV-2 among infected healthcare workers. Nat Commun 12:844. https:\/\/doi.org\/10.1038\/s41467-021-21111-9","journal-title":"Nat Commun"},{"key":"753_CR43","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/s41577-020-0321-6","volume":"20","author":"A Iwasaki","year":"2020","unstructured":"Iwasaki A, Yang Y (2020) The potential danger of suboptimal antibody responses in COVID-19. Nat Rev Immunol 20:339\u2013341. https:\/\/doi.org\/10.1038\/s41577-020-0321-6","journal-title":"Nat Rev Immunol"},{"key":"753_CR44","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/s41467-022-28544-w","volume":"13","author":"J Zou","year":"2022","unstructured":"Zou J, Xia H, Xie X et al (2022) Neutralization against Omicron SARS-CoV-2 from previous non-Omicron infection. Nat Commun 13:852. https:\/\/doi.org\/10.1038\/s41467-022-28544-w","journal-title":"Nat Commun"},{"key":"753_CR45","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/s41586-022-04399-5","volume":"602","author":"JM Carre\u00f1o","year":"2022","unstructured":"Carre\u00f1o JM, Alshammary H, Tcheou J et al (2022) Activity of convalescent and vaccine serum against SARS-CoV-2 Omicron. Nature 602:682\u2013688. https:\/\/doi.org\/10.1038\/s41586-022-04399-5","journal-title":"Nature"},{"key":"753_CR46","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.3201\/eid2808.220584","volume":"28","author":"EF de Oliveira-Filho","year":"2022","unstructured":"de Oliveira-Filho EF, Rincon-Orozco B et al (2022) Effectiveness of naturally acquired and vaccine-induced immune responses to SARS-CoV-2 Mu variant. Emerg Infect Dis 28:1708\u20131712. https:\/\/doi.org\/10.3201\/eid2808.220584","journal-title":"Emerg Infect Dis"},{"key":"753_CR47","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1080\/22221751.2021.1913973","volume":"10","author":"A Rockstroh","year":"2021","unstructured":"Rockstroh A, Wolf J, Fertey J et al (2021) Correlation of humoral immune responses to different SARS-CoV-2 antigens with virus neutralizing antibodies and symptomatic severity in a German COVID-19 cohort. Emerg Microbes Infect 10:774\u2013781. https:\/\/doi.org\/10.1080\/22221751.2021.1913973","journal-title":"Emerg Microbes Infect"},{"key":"753_CR48","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41586-022-04465-y","volume":"603","author":"J Liu","year":"2022","unstructured":"Liu J, Chandrashekar A, Sellers D (2022) Vaccines elicit highly conserved cellular immunity to SARS-CoV-2 Omicron. Nature 603:493\u2013496. https:\/\/doi.org\/10.1038\/s41586-022-04465-y","journal-title":"Nature"},{"key":"753_CR49","doi-asserted-by":"publisher","first-page":"801431","DOI":"10.3389\/fimmu.2022.801431","volume":"13","author":"A Mazzoni","year":"2022","unstructured":"Mazzoni A, Vanni A, Spinicci M et al (2022) SARS-CoV-2 spike-specific CD4 + T cell response is conserved against variants of concern, including Omicron. Front Immunol 13:801431. https:\/\/doi.org\/10.3389\/fimmu.2022.801431","journal-title":"Front Immunol"},{"key":"753_CR50","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1126\/science.abn8652","volume":"375","author":"M McCallum","year":"2022","unstructured":"McCallum M, Czudnochowski N, Rosen LE et al (2022) Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement. Science 375:864\u2013868. https:\/\/doi.org\/10.1126\/science.abn8652","journal-title":"Science"}],"container-title":["Medical Microbiology and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00430-022-00753-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00430-022-00753-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00430-022-00753-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T21:36:52Z","timestamp":1676324212000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00430-022-00753-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,12]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["753"],"URL":"https:\/\/doi.org\/10.1007\/s00430-022-00753-6","relation":{},"ISSN":["0300-8584","1432-1831"],"issn-type":[{"value":"0300-8584","type":"print"},{"value":"1432-1831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,12]]},"assertion":[{"value":"9 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Participants consented to follow-up with sampling and provide access to epidemiological and clinical information related to COVID-19 available in the Hospital's epidemiology unit.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The protocol was approved by Scientific-Ethics Committee Andres Bello University, of Metropolitan Region, Chile, through the document No. 021\/2020 date August 10, 2020.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}