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Despite this, the immune response against\n                    <jats:italic>C. auris<\/jats:italic>\n                    infection is still not well understood. Hosts fight\n                    <jats:italic>Candida<\/jats:italic>\n                    infections through the immune system that recognizes pathogen-associated molecular patterns such as \u03b2-glucan, mannan, and chitin on the fungal cell wall. In this study, levels of \u03b2-glucan and mannan exposures in\n                    <jats:italic>C. auris<\/jats:italic>\n                    grown under different physiologically relevant stimuli were quantified by flow cytometry-based analysis. Lactate, hypoxia, and sublethal concentration of fluconazole trigger a decrease in surface \u03b2-glucan while low pH triggers an increase in \u03b2-glucan. There is no inverse pattern between exposure levels of \u03b2-glucan and mannan in the cell wall architecture among the three clades. To determine the effect of cell wall remodeling on the immune response, a phagocytosis assay was performed, followed by quantification of released cytokines by ELISA. Lactate-induced decrease in \u03b2-glucan leads to reduced uptake of\n                    <jats:italic>C. auris<\/jats:italic>\n                    by PMA-differentiated THP-1 and RAW 264.7 macrophages. Furthermore, reduced production of CCL3\/MIP-1\u237a but not TNF-\u237a and IL-10 were observed. An in vivo infection analysis using silkworms reveals that a reduction in \u03b2-glucan triggers an increase in the virulence of\n                    <jats:italic>C. auris<\/jats:italic>\n                    . This study demonstrates that \u03b2-glucan alteration occurs in\n                    <jats:italic>C. auris<\/jats:italic>\n                    and serves as an escape mechanism from immune cells leading to increased virulence.\n                  <\/jats:p>","DOI":"10.1007\/s00430-024-00795-y","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T03:01:46Z","timestamp":1720148506000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Alteration of \u03b2-glucan in the emerging fungal pathogen Candida auris leads to immune evasion and increased virulence"],"prefix":"10.1007","volume":"213","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9194-1177","authenticated-orcid":false,"given":"Shiela Marie Gines","family":"Selisana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9276-8209","authenticated-orcid":false,"given":"Xinyue","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eny","family":"Mahfudhoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3180-1460","authenticated-orcid":false,"given":"Anom","family":"Bowolaksono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6616-8565","authenticated-orcid":false,"given":"Anna","family":"Rozaliyani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2652-4529","authenticated-orcid":false,"given":"Kanami","family":"Orihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6732-5043","authenticated-orcid":false,"given":"Susumu","family":"Kajiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"795_CR1","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1007\/s12281-012-0094-x","volume":"6","author":"ME Brandt","year":"2012","unstructured":"Brandt ME, Lockhart SR (2012) Recent taxonomic developments with Candida and other opportunistic yeasts. 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